(data stored in ACNUC25403 zone)

HOGENOM: HS11_PE2666

ID   HS11_PE2666                          STANDARD;      PRT;   426 AA.
AC   HS11_PE2666;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Pannexin-1; (HS11.PE2666).
GN   Name=PANX1; Synonyms=MRS1; ORFNames=UNQ2529/PRO6028;
OS   HOMO SAPIENS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini;
OC   Hominoidea; Hominidae; Homininae; Homo.
OX   NCBI_TaxID=9606;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS HS11.PE2666.
CC       Homo sapiens chromosome 11 GRCh37  sequence 1..134946516 annotated by
CC       Ensembl
CC   -!- ANNOTATIONS ORIGIN:PANX1_HUMAN
CC   -!- FUNCTION: Structural component of the gap junctions and the
CC       hemichannels. May play a role as a Ca(2+)-leak channel to regulate
CC       ER Ca(2+) homeostasis.
CC   -!- SUBUNIT: Homohexamer. Forms homomeric or PANX1/PANX2-heteromeric
CC       intercellular channels on coexpression in paired Xenopus oocytes
CC       (By similarity).
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein
CC       (Potential). Cell junction, gap junction. Endoplasmic reticulum
CC       membrane; Multi-pass membrane protein (Potential).
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q96RD7-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q96RD7-2; Sequence=VSP_011476;
CC   -!- SIMILARITY: Belongs to the pannexin family.
CC   -!- WEB RESOURCE: Name=Wikipedia; Note=Pannexin entry;
CC       URL="http://en.wikipedia.org/wiki/Pannexin";
CC   -!- GENE_FAMILY: HOG000063721 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Homo_sapiens;ENSG00000110218;ENST00000227638;ENSP00000227638.
DR   EMBL; AF093239; - ;
DR   EMBL; AF283661; - ;
DR   EMBL; AF283662; - ;
DR   EMBL; AF283663; - ;
DR   EMBL; AF398506; - ;
DR   EMBL; AF398507; - ;
DR   EMBL; AF398508; - ;
DR   EMBL; AF398509; - ;
DR   EMBL; AK074897; - ;
DR   EMBL; AY048509; - ;
DR   EMBL; AY359023; - ;
DR   EMBL; BC016931; - ;
DR   EMBL; FM201789; - ;
DR   UniProtKB/Swiss-Prot; Q96RD7; O75968; Q543A0; Q6UW26; Q96AM9; Q96L77; Q96RS5; -.
DR   EMBL; AF093239; AAC61779.1; -; mRNA.
DR   EMBL; AF398509; AAK91714.1; -; mRNA.
DR   EMBL; AF398508; AAK91713.1; -; Genomic_DNA.
DR   EMBL; AF398506; AAK91713.1; JOINED; Genomic_DNA.
DR   EMBL; AF398507; AAK91713.1; JOINED; Genomic_DNA.
DR   EMBL; AY048509; AAL06604.1; -; Genomic_DNA.
DR   EMBL; AY359023; AAQ89382.1; -; mRNA.
DR   EMBL; AK074897; BAC11276.1; -; mRNA.
DR   EMBL; AP003966; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC016931; AAH16931.1; -; mRNA.
DR   EMBL; AF283663; AAK73361.1; -; Genomic_DNA.
DR   EMBL; AF283661; AAK73361.1; JOINED; Genomic_DNA.
DR   EMBL; AF283662; AAK73361.1; JOINED; Genomic_DNA.
DR   IPI; IPI00455165; -.
DR   IPI; IPI00455166; -.
DR   RefSeq; NP_056183.2; NM_015368.3.
DR   UniGene; Hs.591976; -.
DR   ProteinModelPortal; Q96RD7; -.
DR   MINT; MINT-3379479; -.
DR   STRING; Q96RD7; -.
DR   TCDB; 1.A.25.2.1; gap junction-forming innexin family.
DR   PhosphoSite; Q96RD7; -.
DR   PRIDE; Q96RD7; -.
DR   Ensembl; ENST00000227638; ENSP00000227638; ENSG00000110218.
DR   GeneID; 24145; -.
DR   KEGG; hsa:24145; -.
DR   UCSC; uc001peq.2; human.
DR   CTD; 24145; -.
DR   GeneCards; GC11P089937; -.
DR   H-InvDB; HIX0010028; -.
DR   HGNC; HGNC:8599; PANX1.
DR   HPA; HPA016930; -.
DR   MIM; 608420; gene.
DR   neXtProt; NX_Q96RD7; -.
DR   PharmGKB; PA32929; -.
DR   eggNOG; prNOG11535; -.
DR   GeneTree; ENSGT00390000009703; -.
DR   InParanoid; Q96RD7; -.
DR   OMA; LAVDKMV; -.
DR   OrthoDB; EOG4HT8SW; -.
DR   Reactome; REACT_13685; Synaptic Transmission.
DR   Reactome; REACT_6900; Immune System.
DR   NextBio; 46835; -.
DR   ArrayExpress; Q96RD7; -.
DR   Bgee; Q96RD7; -.
DR   CleanEx; HS_PANX1; -.
DR   Genevestigator; Q96RD7; -.
DR   GermOnline; ENSG00000110218; Homo sapiens.
DR   GO; GO:0032059; C:bleb; IDA:BHF-UCL.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005921; C:gap junction; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005262; F:calcium channel activity; IMP:UniProtKB.
DR   GO; GO:0055077; F:gap junction hemi-channel activity; IDA:UniProtKB.
DR   GO; GO:0022840; F:leak channel activity; IMP:UniProtKB.
DR   GO; GO:0005102; F:receptor binding; IPI:UniProtKB.
DR   GO; GO:0050718; P:positive regulation of interleukin-1 beta secretion; IDA:BHF-UCL.
DR   GO; GO:0034214; P:protein hexamerization; IDA:UniProtKB.
DR   GO; GO:0007268; P:synaptic transmission; TAS:Reactome.
DR   InterPro; IPR000990; Innexin.
DR   Pfam; PF00876; Innexin; 1.
DR   PROSITE; PS51013; PANNEXIN; 1.
DR   HOGENOMDNA; HS11.PE2666; -.
KW   ENSG000001102181755old_1320000031; ENSP000002276387901old_1320000031;
KW   B6ETL5_HUMAN; AF093239; AF283661; AF283662; AF283663; AF398506; AF398507;
KW   AF398509; AK074897; AY048509; AY359023; BC016931; FM201789;
KW   Alternative splicing; Calcium; Calcium channel; Calcium transport;
KW   Cell junction; Cell membrane; Complete proteome;
KW   Endoplasmic reticulum; Gap junction; Glycoprotein; Ion transport;
KW   Ionic channel; Membrane; Polymorphism; Reference proteome;
KW   Transmembrane; Transmembrane helix; Transport.
SQ   SEQUENCE   426 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MAIAQLATEY VFSDFLLKEP TEPKFKGLRL ELAVDKMVTC IAVGLPLLLI SLAFAQEISI
     GTQISCFSPS SFSWRQAAFV DSYCWAAVQQ KNSLQSESGN LPLWLHKFFP YILLLFAILL
     YLPPLFWRFA AAPHICSDLK FIMEELDKVY NRAIKAAKSA RDLDMRDGAC SVPGVTENLG
     QSLWEVSESH FKYPIVEQYL KTKKNSNNLI IKYISCRLLT LIIILLACIY LGYYFSLSSL
     SDEFVCSIKS GILRNDSTVP DQFQCKLIAV GIFQLLSVIN LVVYVLLAPV VVYTLFVPFR
     QKTDVLKVYE ILPTFDVLHF KSEGYNDLSL YNLFLEENIS EVKSYKCLKV LENIKSSGQG
     IDPMLLLTNL GMIKMDVVDG KTPMSAEMRE EQGNQTAELQ GMNIDSETKA NNGEKNARQR
     LLDSSC
//

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