(data stored in ACNUC1829 zone)

HOGENOM: HS11_PE284

ID   HS11_PE284                           STANDARD;      PRT;   236 AA.
AC   HS11_PE284; P60033; P18582; Q5U0J6;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=CD81 antigen;AltName: Full=26 kDa cell surface protein
DE   TAPA-1;AltName: Full=Target of the antiproliferative antibody 1;AltName:
DE   Full=Tetraspanin-28; Short=Tspan-28;AltName: CD_antigen=CD81;
DE   (HS11.PE284).
GN   Name=CD81; Synonyms=TAPA1, TSPAN28;
OS   HOMO SAPIENS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini;
OC   Hominoidea; Hominidae; Homininae; Homo.
OX   NCBI_TaxID=9606;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS HS11.PE284.
CC       Homo sapiens chromosome 11 GRCh37  sequence 1..134946516 annotated by
CC       Ensembl
CC   -!- ANNOTATIONS ORIGIN:CD81_HUMAN
CC   -!- FUNCTION: May play an important role in the regulation of lymphoma
CC       cell growth. Interacts with a 16-kDa Leu-13 protein to form a
CC       complex possibly involved in signal transduction. May acts a the
CC       viral receptor for HCV.
CC   -!- SUBUNIT: Plays a critical role in HCV attachment and/or cell entry
CC       by interacting with HCV E1/E2 glycoproteins heterodimer. Interacts
CC       directly with IGSF8.
CC   -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC   -!- TISSUE SPECIFICITY: Hematolymphoid, neuroectodermal and
CC       mesenchymal tumor cell lines.
CC   -!- PTM: Not glycosylated (Probable).
CC   -!- DISEASE: Defects in CD81 are the cause of immunodeficiency common
CC       variable type 6 (CVID6) [MIM:613496]; also called antibody
CC       deficiency due to CD81 defect. CVID6 is a primary immunodeficiency
CC       characterized by antibody deficiency, hypogammaglobulinemia,
CC       recurrent bacterial infections and an inability to mount an
CC       antibody response to antigen. The defect results from a failure of
CC       B-cell differentiation and impaired secretion of immunoglobulins;
CC       the numbers of circulating B cells is usually in the normal range,
CC       but can be low.
CC   -!- SIMILARITY: Belongs to the tetraspanin (TM4SF) family.
CC   -!- GENE_FAMILY: HOG000230651 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Homo_sapiens;ENSG00000110651;ENST00000263645;ENSP00000263645.
DR   EMBL; BC002978; - ;
DR   EMBL; BC093047; - ;
DR   EMBL; BT019507; - ;
DR   EMBL; BT019508; - ;
DR   EMBL; EF064749; - ;
DR   EMBL; M33680; - ;
DR   UniProtKB/Swiss-Prot; P60033; P18582; Q5U0J6; -.
DR   EMBL; M33680; AAA36663.1; -; mRNA.
DR   EMBL; BT019507; AAV38314.1; -; mRNA.
DR   EMBL; BT019508; AAV38315.1; -; mRNA.
DR   EMBL; EF064749; ABK41932.1; -; Genomic_DNA.
DR   EMBL; AC129929; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC124057; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC002978; AAH02978.1; -; mRNA.
DR   EMBL; BC093047; AAH93047.1; -; mRNA.
DR   IPI; IPI00000190; -.
DR   PIR; A35649; A35649.
DR   RefSeq; NP_004347.1; NM_004356.3.
DR   UniGene; Hs.54457; -.
DR   PDB; 1G8Q; X-ray; 1.60 A; A/B=113-201.
DR   PDB; 1IV5; X-ray; 2.60 A; A/B=113-201.
DR   PDB; 2AVZ; Model; -; A=1-236.
DR   PDBsum; 1G8Q; -.
DR   PDBsum; 1IV5; -.
DR   PDBsum; 2AVZ; -.
DR   ProteinModelPortal; P60033; -.
DR   SMR; P60033; 113-200.
DR   IntAct; P60033; 4.
DR   MINT; MINT-5001104; -.
DR   STRING; P60033; -.
DR   PhosphoSite; P60033; -.
DR   PRIDE; P60033; -.
DR   Ensembl; ENST00000263645; ENSP00000263645; ENSG00000110651.
DR   GeneID; 975; -.
DR   KEGG; hsa:975; -.
DR   UCSC; uc001lwf.1; human.
DR   CTD; 975; -.
DR   GeneCards; GC11P002188; -.
DR   H-InvDB; HIX0009363; -.
DR   HGNC; HGNC:1701; CD81.
DR   HPA; CAB002507; -.
DR   HPA; HPA007234; -.
DR   MIM; 186845; gene.
DR   MIM; 613496; phenotype.
DR   neXtProt; NX_P60033; -.
DR   Orphanet; 77303; Common variable immunodeficiency due to an intrinsic B cell defect.
DR   PharmGKB; PA26240; -.
DR   eggNOG; prNOG11124; -.
DR   GeneTree; ENSGT00590000082836; -.
DR   OrthoDB; EOG4X97J1; -.
DR   PhylomeDB; P60033; -.
DR   Reactome; REACT_6900; Immune System.
DR   NextBio; 4090; -.
DR   ArrayExpress; P60033; -.
DR   Bgee; P60033; -.
DR   CleanEx; HS_CD81; -.
DR   Genevestigator; P60033; -.
DR   GermOnline; ENSG00000110651; Homo sapiens.
DR   GO; GO:0005887; C:integral to plasma membrane; IDA:UniProtKB.
DR   GO; GO:0005515; F:protein binding; IPI:UniProtKB.
DR   GO; GO:0000187; P:activation of MAPK activity; IDA:UniProtKB.
DR   GO; GO:0008283; P:cell proliferation; TAS:ProtInc.
DR   GO; GO:0006661; P:phosphatidylinositol biosynthetic process; IDA:UniProtKB.
DR   GO; GO:0043128; P:positive regulation of 1-phosphatidylinositol 4-kinase activity; IDA:UniProtKB.
DR   GO; GO:0008284; P:positive regulation of cell proliferation; IDA:UniProtKB.
DR   GO; GO:0050731; P:positive regulation of peptidyl-tyrosine phosphorylation; IDA:UniProtKB.
DR   GO; GO:0008104; P:protein localization; IDA:UniProtKB.
DR   GO; GO:0050776; P:regulation of immune response; TAS:Reactome.
DR   GO; GO:0046813; P:virion attachment, binding of host cell surface receptor; TAS:UniProtKB.
DR   InterPro; IPR023396; CD81_extracellular.
DR   InterPro; IPR018499; Tetraspanin.
DR   InterPro; IPR018503; Tetraspanin_CS.
DR   InterPro; IPR008952; Tetraspanin_EC2.
DR   InterPro; IPR000301; Tetraspanin_subgr.
DR   Gene3D; G3DSA:1.10.1450.10; G3DSA:1.10.1450.10; 1.
DR   Pfam; PF00335; Tetraspannin; 1.
DR   PRINTS; PR00259; TMFOUR.
DR   SUPFAM; SSF48652; Tetraspanin; 1.
DR   PROSITE; PS00421; TM4_1; 1.
DR   HOGENOMDNA; HS11.PE284; -.
KW   ENSG000001106511755old_1320000031; ENSP000002636457901old_1320000031;
KW   BC002978; BC093047; BT019507; BT019508; EF064749; M33680;
KW   3D-structure; Complete proteome; Disulfide bond;
KW   Host-virus interaction; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
SQ   SEQUENCE   236 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MGVEGCTKCI KYLLFVFNFV FWLAGGVILG VALWLRHDPQ TTNLLYLELG DKPAPNTFYV
     GIYILIAVGA VMMFVGFLGC YGAIQESQCL LGTFFTCLVI LFACEVAAGI WGFVNKDQIA
     KDVKQFYDQA LQQAVVDDDA NNAKAVVKTF HETLDCCGSS TLTALTTSVL KNNLCPSGSN
     IISNLFKEDC HQKIDDLFSG KLYLIGIAAI VVAVIMIFEM ILSMVLCCGI RNSSVY
//

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