(data stored in ACNUC25403 zone)

HOGENOM: HS11_PE3228

ID   HS11_PE3228                          STANDARD;      PRT;   392 AA.
AC   HS11_PE3228; Q96QZ0;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Pannexin-3; (HS11.PE3228).
GN   Name=PANX3;
OS   HOMO SAPIENS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini;
OC   Hominoidea; Hominidae; Homininae; Homo.
OX   NCBI_TaxID=9606;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS HS11.PE3228.
CC       Homo sapiens chromosome 11 GRCh37  sequence 1..134946516 annotated by
CC       Ensembl
CC   -!- ANNOTATIONS ORIGIN:PANX3_HUMAN
CC   -!- FUNCTION: Structural component of the gap junctions and the
CC       hemichannels.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein
CC       (Potential). Cell junction, gap junction.
CC   -!- SIMILARITY: Belongs to the pannexin family.
CC   -!- WEB RESOURCE: Name=Wikipedia; Note=Pannexin entry;
CC       URL="http://en.wikipedia.org/wiki/Pannexin";
CC   -!- GENE_FAMILY: HOG000063721 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Homo_sapiens;ENSG00000154143;ENST00000284288;ENSP00000284288.
DR   EMBL; AF406650; - ;
DR   UniProtKB/Swiss-Prot; Q96QZ0; -.
DR   EMBL; AF406650; AAK95655.1; -; mRNA.
DR   IPI; IPI00045156; -.
DR   RefSeq; NP_443191.1; NM_052959.2.
DR   UniGene; Hs.99235; -.
DR   ProteinModelPortal; Q96QZ0; -.
DR   IntAct; Q96QZ0; 1.
DR   STRING; Q96QZ0; -.
DR   TCDB; 1.A.25.2.3; gap junction-forming innexin family.
DR   PRIDE; Q96QZ0; -.
DR   Ensembl; ENST00000284288; ENSP00000284288; ENSG00000154143.
DR   GeneID; 116337; -.
DR   KEGG; hsa:116337; -.
DR   UCSC; uc001qah.1; human.
DR   CTD; 116337; -.
DR   GeneCards; GC11P120423; -.
DR   H-InvDB; HIX0035897; -.
DR   HGNC; HGNC:20573; PANX3.
DR   MIM; 608422; gene.
DR   neXtProt; NX_Q96QZ0; -.
DR   PharmGKB; PA134920643; -.
DR   eggNOG; prNOG05454; -.
DR   GeneTree; ENSGT00390000009703; -.
DR   InParanoid; Q96QZ0; -.
DR   OMA; MSLAFAQ; -.
DR   OrthoDB; EOG4R7V9Z; -.
DR   PhylomeDB; Q96QZ0; -.
DR   NextBio; 79868; -.
DR   ArrayExpress; Q96QZ0; -.
DR   Bgee; Q96QZ0; -.
DR   CleanEx; HS_PANX3; -.
DR   Genevestigator; Q96QZ0; -.
DR   GermOnline; ENSG00000154143; Homo sapiens.
DR   GO; GO:0005921; C:gap junction; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR   GO; GO:0055077; F:gap junction hemi-channel activity; ISS:UniProtKB.
DR   GO; GO:0005216; F:ion channel activity; IEA:UniProtKB-KW.
DR   GO; GO:0034214; P:protein hexamerization; ISS:UniProtKB.
DR   InterPro; IPR000990; Innexin.
DR   Pfam; PF00876; Innexin; 1.
DR   PROSITE; PS51013; PANNEXIN; 1.
DR   HOGENOMDNA; HS11.PE3228; -.
KW   ENSG000001541431755old_1320000031; ENSP000002842887901old_1320000031;
KW   AF406650;
KW   Cell junction; Cell membrane; Complete proteome; Gap junction;
KW   Glycoprotein; Ion transport; Ionic channel; Membrane; Polymorphism;
KW   Reference proteome; Transmembrane; Transmembrane helix; Transport.
SQ   SEQUENCE   392 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MSLAHTAAEY MLSDALLPDR RGPRLKGLRL ELPLDRIVKF VAVGSPLLLM SLAFAQEFSS
     GSPISCFSPS NFSIRQAAYV DSSCWDSLLH HKQDGPGQDK MKSLWPHKAL PYSLLALALL
     MYLPVLLWQY AAVPALSSDL LFIISELDKS YNRSIRLVQH MLKIRQKSSD PYVFWNELEK
     ARKERYFEFP LLERYLACKQ RSHSLVATYL LRNSLLLIFT SATYLYLGHF HLDVFFQEEF
     SCSIKTGLLS DETHVPNLIT CRLTSLSIFQ IVSLSSVAIY TILVPVIIYN LTRLCRWDKR
     LLSVYEMLPA FDLLSRKMLG CPINDLNVIL LFLRANISEL ISFSWLSVLC VLKDTTTQKH
     NIDTVVDFMT LLAGLEPSKP KHLTNSACDE HP
//

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