(data stored in ACNUC8465 zone)

HOGENOM: HS11_PE366

ID   HS11_PE366                           STANDARD;      PRT;   191 AA.
AC   HS11_PE366; P84095; P35238; Q8NI04;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Rho-related GTP-binding protein RhoG;Flags: Precursor;
DE   (HS11.PE366).
GN   Name=RHOG; Synonyms=ARHG;
OS   HOMO SAPIENS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini;
OC   Hominoidea; Hominidae; Homininae; Homo.
OX   NCBI_TaxID=9606;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS HS11.PE366.
CC       Homo sapiens chromosome 11 GRCh37  sequence 1..134946516 annotated by
CC       Ensembl
CC   -!- ANNOTATIONS ORIGIN:RHOG_HUMAN
CC   -!- FUNCTION: Required for the formation of membrane ruffles during
CC       macropinocytosis. Plays a role in cell migration and is required
CC       for the formation of cup-like structures during trans-endothelial
CC       migration of leukocytes. In case of Salmonella enterica infection,
CC       activated by SopB and ARHGEF26/SGEF, which induces cytoskeleton
CC       rearrangements and promotes bacterial entry.
CC   -!- SUBUNIT: Interacts with ARHGEF26. Interacts with ARHGEF16.
CC   -!- INTERACTION:
CC       Q92556:ELMO1; NbExp=3; IntAct=EBI-446579, EBI-346417;
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor; Cytoplasmic
CC       side (Potential).
CC   -!- SIMILARITY: Belongs to the small GTPase superfamily. Rho family.
CC   -!- GENE_FAMILY: HOG000233974 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Homo_sapiens;ENSG00000177105;ENST00000396978;ENSP00000380175.
DR   EMBL; AF498974; - ;
DR   EMBL; AY563952; - ;
DR   EMBL; BC104177; - ;
DR   EMBL; BC104178; - ;
DR   EMBL; BT019872; - ;
DR   EMBL; CH471158; - ;
DR   EMBL; CR450335; - ;
DR   EMBL; CR542105; - ;
DR   EMBL; L11317; - ;
DR   EMBL; X61587; - ;
DR   UniProtKB/Swiss-Prot; P84095; P35238; Q8NI04; -.
DR   EMBL; L11317; AAA60268.1; -; mRNA.
DR   EMBL; X61587; CAA43784.1; -; mRNA.
DR   EMBL; AF498974; AAM21121.1; -; mRNA.
DR   EMBL; AY563952; AAS75333.1; -; mRNA.
DR   IPI; IPI00017342; -.
DR   PIR; S25722; TVHURG.
DR   RefSeq; NP_001656.2; NM_001665.3.
DR   UniGene; Hs.501728; -.
DR   ProteinModelPortal; P84095; -.
DR   SMR; P84095; 1-177.
DR   IntAct; P84095; 2.
DR   STRING; P84095; -.
DR   PhosphoSite; P84095; -.
DR   PeptideAtlas; P84095; -.
DR   PRIDE; P84095; -.
DR   Ensembl; ENST00000351018; ENSP00000339467; ENSG00000177105.
DR   Ensembl; ENST00000396978; ENSP00000380175; ENSG00000177105.
DR   Ensembl; ENST00000396979; ENSP00000380176; ENSG00000177105.
DR   GeneID; 391; -.
DR   KEGG; hsa:391; -.
DR   UCSC; uc001lyu.2; human.
DR   CTD; 391; -.
DR   GeneCards; GC11M003581; -.
DR   H-InvDB; HIX0035905; -.
DR   HGNC; HGNC:672; RHOG.
DR   HPA; HPA039871; -.
DR   MIM; 179505; gene.
DR   neXtProt; NX_P84095; -.
DR   PharmGKB; PA24955; -.
DR   eggNOG; prNOG04730; -.
DR   InParanoid; P84095; -.
DR   OMA; ARSCILL; -.
DR   OrthoDB; EOG49KFRK; -.
DR   PhylomeDB; P84095; -.
DR   Reactome; REACT_11044; Signaling by Rho GTPases.
DR   Reactome; REACT_14797; Signaling by GPCR.
DR   Reactome; REACT_18266; Axon guidance.
DR   Reactome; REACT_604; Hemostasis.
DR   NextBio; 1631; -.
DR   ArrayExpress; P84095; -.
DR   Bgee; P84095; -.
DR   CleanEx; HS_RHOG; -.
DR   Genevestigator; P84095; -.
DR   GermOnline; ENSG00000177105; Homo sapiens.
DR   GO; GO:0005829; C:cytosol; EXP:Reactome.
DR   GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003924; F:GTPase activity; IDA:MGI.
DR   GO; GO:0005515; F:protein binding; IPI:UniProtKB.
DR   GO; GO:0030036; P:actin cytoskeleton organization; IDA:MGI.
DR   GO; GO:0032863; P:activation of Rac GTPase activity; IMP:UniProtKB.
DR   GO; GO:0007411; P:axon guidance; TAS:Reactome.
DR   GO; GO:0060326; P:cell chemotaxis; IMP:UniProtKB.
DR   GO; GO:0030168; P:platelet activation; TAS:Reactome.
DR   GO; GO:0008284; P:positive regulation of cell proliferation; TAS:ProtInc.
DR   GO; GO:0090004; P:positive regulation of establishment of protein localization in plasma membrane; IMP:UniProtKB.
DR   GO; GO:0045893; P:positive regulation of transcription, DNA-dependent; IDA:MGI.
DR   GO; GO:0016601; P:Rac protein signal transduction; IDA:MGI.
DR   GO; GO:0007266; P:Rho protein signal transduction; IDA:MGI.
DR   InterPro; IPR005225; Small_GTP-bd_dom.
DR   InterPro; IPR001806; Small_GTPase.
DR   InterPro; IPR003578; Small_GTPase_Rho.
DR   Pfam; PF00071; Ras; 1.
DR   PRINTS; PR00449; RASTRNSFRMNG.
DR   SMART; SM00174; RHO; 1.
DR   TIGRFAMs; TIGR00231; Small_GTP; 1.
DR   PROSITE; PS51420; RHO; 1.
DR   HOGENOMDNA; HS11.PE366; -.
KW   ENSG000001771051755old_1320000031; ENSP000003801757901old_1320000031;
KW   Q6ICQ8_HUMAN; AF498974; AY563952; BC104177; BC104178; BT019872; CH471158;
KW   CR542105; L11317; X61587;
KW   ADP-ribosylation; Cell membrane; Complete proteome; GTP-binding;
KW   Lipoprotein; Membrane; Methylation; Nucleotide-binding; Prenylation;
KW   Reference proteome.
SQ   SEQUENCE   191 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MQSIKCVVVG DGAVGKTCLL ICYTTNAFPK EYIPTVFDNY SAQSAVDGRT VNLNLWDTAG
     QEEYDRLRTL SYPQTNVFVI CFSIASPPSY ENVRHKWHPE VCHHCPDVPI LLVGTKKDLR
     AQPDTLRRLK EQGQAPITPQ QGQALAKQIH AVRYLECSAL QQDGVKEVFA EAVRAVLNPT
     PIKRGRSCIL L
//

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