(data stored in ACNUC21562 zone)

HOGENOM: HS11_PE778

ID   HS11_PE778                           STANDARD;      PRT;   322 AA.
AC   HS11_PE778; Q96LB0; B0M0L1; Q8TDE0; Q8TDE1;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Mas-related G-protein coupled receptor member X3;AltName:
DE   Full=Sensory neuron-specific G-protein coupled receptor 1/2;
DE   (HS11.PE778).
GN   Name=MRGPRX3; Synonyms=MRGX3, SNSR1, SNSR2;
OS   HOMO SAPIENS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini;
OC   Hominoidea; Hominidae; Homininae; Homo.
OX   NCBI_TaxID=9606;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS HS11.PE778.
CC       Homo sapiens chromosome 11 GRCh37  sequence 1..134946516 annotated by
CC       Ensembl
CC   -!- ANNOTATIONS ORIGIN:MRGX3_HUMAN
CC   -!- FUNCTION: Orphan receptor. Probably involved in the function of
CC       nociceptive neurons. May regulate nociceptor function and/or
CC       development, including the sensation or modulation of pain.
CC       Potently activated by enkephalins (By similarity).
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- TISSUE SPECIFICITY: Uniquely localized in a subset of small dorsal
CC       root and trigeminal sensory neurons.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       Mas subfamily.
CC   -!- GENE_FAMILY: HOG000015412 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Homo_sapiens;ENSG00000179826;ENST00000396275;ENSP00000379571.
DR   EMBL; AF474987; - ;
DR   EMBL; AF474988; - ;
DR   EMBL; AY042215; - ;
DR   EMBL; BC067292; - ;
DR   EMBL; CH471064; - ;
DR   EMBL; EU432126; - ;
DR   UniProtKB/Swiss-Prot; Q96LB0; B0M0L1; Q8TDE0; Q8TDE1; -.
DR   EMBL; AY042215; AAK91806.1; -; Genomic_DNA.
DR   EMBL; AF474987; AAL86878.2; -; Genomic_DNA.
DR   EMBL; AF474988; AAL86879.2; -; Genomic_DNA.
DR   EMBL; EU432126; ABY87925.1; -; mRNA.
DR   EMBL; AC090099; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH471064; EAW68417.1; -; Genomic_DNA.
DR   EMBL; BC067292; AAH67292.1; -; mRNA.
DR   IPI; IPI00102131; -.
DR   RefSeq; NP_473372.3; NM_054031.3.
DR   UniGene; Hs.380177; -.
DR   ProteinModelPortal; Q96LB0; -.
DR   SMR; Q96LB0; 107-138.
DR   STRING; Q96LB0; -.
DR   PRIDE; Q96LB0; -.
DR   Ensembl; ENST00000314568; ENSP00000314065; ENSG00000179826.
DR   Ensembl; ENST00000396275; ENSP00000379571; ENSG00000179826.
DR   GeneID; 117195; -.
DR   KEGG; hsa:117195; -.
DR   CTD; 117195; -.
DR   GeneCards; GC11P017825; -.
DR   H-InvDB; HIX0035991; -.
DR   HGNC; HGNC:17980; MRGPRX3.
DR   MIM; 607229; gene.
DR   neXtProt; NX_Q96LB0; -.
DR   PharmGKB; PA142671336; -.
DR   eggNOG; prNOG15554; -.
DR   GeneTree; ENSGT00550000074531; -.
DR   InParanoid; Q96LB0; -.
DR   OMA; LEWMFCD; -.
DR   OrthoDB; EOG4MW86R; -.
DR   NextBio; 80160; -.
DR   ArrayExpress; Q96LB0; -.
DR   Bgee; Q96LB0; -.
DR   CleanEx; HS_MRGPRX3; -.
DR   Genevestigator; Q96LB0; -.
DR   GermOnline; ENSG00000179826; Homo sapiens.
DR   GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004930; F:G-protein coupled receptor activity; IEA:UniProtKB-KW.
DR   InterPro; IPR000276; 7TM_GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_supfam.
DR   Pfam; PF00001; 7tm_1; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
DR   HOGENOMDNA; HS11.PE778; -.
KW   ENSG000001798261755old_1320000031; ENSP000003795717901old_1320000031;
KW   AF474987; AF474988; AY042215; BC067292; CH471064; EU432126;
KW   Cell membrane; Complete proteome; G-protein coupled receptor;
KW   Membrane; Polymorphism; Receptor; Reference proteome; Transducer;
KW   Transmembrane; Transmembrane helix.
SQ   SEQUENCE   322 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MDSTIPVLGT ELTPINGREE TPCYKQTLSF TGLTCIVSLV ALTGNAVVLW LLGCRMRRNA
     VSIYILNLVA ADFLFLSGHI ICSPLRLINI RHPISKILSP VMTFPYFIGL SMLSAISTER
     CLSILWPIWY HCRRPRYLSS VMCVLLWALS LLRSILEWMF CDFLFSGANS VWCETSDFIT
     IAWLVFLCVV LCGSSLVLLV RILCGSRKMP LTRLYVTILL TVLVFLLCGL PFGIQWALFS
     RIHLDWKVLF CHVHLVSIFL SALNSSANPI IYFFVGSFRQ RQNRQNLKLV LQRALQDTPE
     VDEGGGWLPQ ETLELSGSRL EQ
//

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