(data stored in ACNUC21562 zone)

HOGENOM: HS11_PE826

ID   HS11_PE826                           STANDARD;      PRT;   322 AA.
AC   HS11_PE826; Q96LB2; Q4V9L2; Q8TDD8; Q8TDD9;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Mas-related G-protein coupled receptor member X1;AltName:
DE   Full=Sensory neuron-specific G-protein coupled receptor 3/4;
DE   (HS11.PE826).
GN   Name=MRGPRX1; Synonyms=MRGX1, SNSR3, SNSR4;
OS   HOMO SAPIENS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini;
OC   Hominoidea; Hominidae; Homininae; Homo.
OX   NCBI_TaxID=9606;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS HS11.PE826.
CC       Homo sapiens chromosome 11 GRCh37  sequence 1..134946516 annotated by
CC       Ensembl
CC   -!- ANNOTATIONS ORIGIN:MRGX1_HUMAN
CC   -!- FUNCTION: Orphan receptor. Probably involved in the function of
CC       nociceptive neurons. May regulate nociceptor function and/or
CC       development, including the sensation or modulation of pain.
CC       Potently activated by enkephalins including BAM22 (bovine adrenal
CC       medulla peptide 22) and BAM (8-22). BAM22 is the most potent
CC       compound and evoked a large and dose-dependent release of
CC       intracellular calcium in stably transfected cells. G(alpha)q
CC       proteins are involved in the calcium-signaling pathway. Activated
CC       by the antimalarial drug, chloroquine. May mediate chloroquine-
CC       induced itch, in an histamine-independent manner.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- TISSUE SPECIFICITY: Uniquely localized in a subset of small dorsal
CC       root and trigeminal sensory neurons.
CC   -!- MISCELLANEOUS: Activation of this receptor requires concentrations
CC       that exceed the chloroquine concentrations observed in plasma of
CC       patients undergoing chloroquine treatment. However chloroquine
CC       accumulates at much higher level in the skin where the receptor is
CC       located. Chloroquine-induced itch is very common among black
CC       Africans (up to 70%) but less common in other populations.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       Mas subfamily.
CC   -!- GENE_FAMILY: HOG000015412 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Homo_sapiens;ENSG00000170255;ENST00000302797;ENSP00000305766.
DR   EMBL; AB065846; - ;
DR   EMBL; AB083628; - ;
DR   EMBL; AC023078; - ;
DR   EMBL; AF474989; - ;
DR   EMBL; AF474990; - ;
DR   EMBL; AY042213; - ;
DR   EMBL; BC096835; - ;
DR   EMBL; EU883578; - ;
DR   UniProtKB/Swiss-Prot; Q96LB2; Q4V9L2; Q8TDD8; Q8TDD9; -.
DR   EMBL; AY042213; AAK91804.1; -; Genomic_DNA.
DR   EMBL; AF474989; AAL86880.2; -; Genomic_DNA.
DR   EMBL; AF474990; AAL86881.1; -; Genomic_DNA.
DR   EMBL; AB065846; BAC06064.1; -; Genomic_DNA.
DR   EMBL; AB083628; BAB89341.1; -; Genomic_DNA.
DR   EMBL; AC023078; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC096835; AAH96835.1; -; mRNA.
DR   IPI; IPI00064964; -.
DR   RefSeq; NP_671732.3; NM_147199.3.
DR   UniGene; Hs.711459; -.
DR   ProteinModelPortal; Q96LB2; -.
DR   SMR; Q96LB2; 107-138.
DR   STRING; Q96LB2; -.
DR   PRIDE; Q96LB2; -.
DR   Ensembl; ENST00000302797; ENSP00000305766; ENSG00000170255.
DR   GeneID; 259249; -.
DR   KEGG; hsa:259249; -.
DR   UCSC; uc001mpg.1; human.
DR   CTD; 259249; -.
DR   GeneCards; GC11M018639; -.
DR   H-InvDB; HIX0036068; -.
DR   HGNC; HGNC:17962; MRGPRX1.
DR   MIM; 607227; gene.
DR   neXtProt; NX_Q96LB2; -.
DR   PharmGKB; PA142671334; -.
DR   eggNOG; prNOG09618; -.
DR   GeneTree; ENSGT00550000074531; -.
DR   OMA; ETLCYKQ; -.
DR   OrthoDB; EOG4MW86R; -.
DR   PhylomeDB; Q96LB2; -.
DR   NextBio; 93086; -.
DR   ArrayExpress; Q96LB2; -.
DR   Bgee; Q96LB2; -.
DR   CleanEx; HS_MRGPRX1; -.
DR   Genevestigator; Q96LB2; -.
DR   GermOnline; ENSG00000170255; Homo sapiens.
DR   GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004930; F:G-protein coupled receptor activity; IEA:UniProtKB-KW.
DR   GO; GO:0006953; P:acute-phase response; IEA:UniProtKB-KW.
DR   InterPro; IPR000276; 7TM_GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_supfam.
DR   Pfam; PF00001; 7tm_1; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
DR   HOGENOMDNA; HS11.PE826; -.
KW   ENSG000001702551755old_1320000031; ENSP000003057667901old_1320000031;
KW   B5B0C6_HUMAN; AB065846; AB083628; AC023078; AF474989; AF474990; AY042213;
KW   EU883578;
KW   Acute phase; Cell membrane; Complete proteome;
KW   G-protein coupled receptor; Glycoprotein; Membrane; Polymorphism;
KW   Receptor; Reference proteome; Transducer; Transmembrane;
KW   Transmembrane helix.
SQ   SEQUENCE   322 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MDPTISTLDT ELTPINGTEE TLCYKQTLSL TVLTCIVSLV GLTGNAVVLW LLGCRMRRNA
     FSIYILNLAA ADFLFLSGRL IYSLLSFISI PHTISKILYP VMMFSYFAGL SFLSAVSTER
     CLSVLWPIWY RCHRPTHLSA VVCVLLWALS LLRSILEWML CGFLFSGADS AWCQTSDFIT
     VAWLIFLCVV LCGSSLVLLI RILCGSRKIP LTRLYVTILL TVLVFLLCGL PFGIQFFLFL
     WIHVDREVLF CHVHLVSIFL SALNSSANPI IYFFVGSFRQ RQNRQNLKLV LQRALQDASE
     VDEGGGQLPE EILELSGSRL EQ
//

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