(data stored in ACNUC21562 zone)

HOGENOM: HS11_PE829

ID   HS11_PE829                           STANDARD;      PRT;   330 AA.
AC   HS11_PE829;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Mas-related G-protein coupled receptor member X2;
DE   (HS11.PE829).
GN   Name=MRGPRX2; Synonyms=MRGX2;
OS   HOMO SAPIENS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini;
OC   Hominoidea; Hominidae; Homininae; Homo.
OX   NCBI_TaxID=9606;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS HS11.PE829.
CC       Homo sapiens chromosome 11 GRCh37  sequence 1..134946516 annotated by
CC       Ensembl
CC   -!- ANNOTATIONS ORIGIN:MRGX2_HUMAN
CC   -!- FUNCTION: Orphan receptor. Probably involved in the function of
CC       nociceptive neurons. May regulate nociceptor function and/or
CC       development, including the sensation or modulation of pain.
CC       Cortistatin-14 seems to be a high potency ligand at this receptor.
CC       Cortistatin has several biological functions including roles in
CC       sleep regulation locomotor activity, and cortical function. In
CC       receptor-expressing cells, cortistatin-stimulated increases in
CC       intracellular Ca(2+) but had no effect on basal or forskolin-
CC       stimulated cAMP levels, suggesting that this receptor is G(q)-
CC       coupled.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- TISSUE SPECIFICITY: Has a limited expression profile, both
CC       peripheral and within the central nervous system, with highest
CC       levels in dorsal root ganglion.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       Mas subfamily.
CC   -!- GENE_FAMILY: HOG000015412 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Homo_sapiens;ENSG00000183695;ENST00000329773;ENSP00000333800.
DR   EMBL; AB065811; - ;
DR   EMBL; AB083626; - ;
DR   EMBL; AY042214; - ;
DR   EMBL; AY651130; - ;
DR   EMBL; AY651131; - ;
DR   EMBL; AY651132; - ;
DR   EMBL; AY651133; - ;
DR   EMBL; AY651134; - ;
DR   EMBL; AY651135; - ;
DR   EMBL; AY651136; - ;
DR   EMBL; AY651137; - ;
DR   EMBL; AY651138; - ;
DR   EMBL; AY651139; - ;
DR   EMBL; AY651140; - ;
DR   EMBL; AY651141; - ;
DR   EMBL; AY651142; - ;
DR   EMBL; AY651143; - ;
DR   EMBL; AY651144; - ;
DR   EMBL; AY651145; - ;
DR   EMBL; AY651146; - ;
DR   EMBL; AY651147; - ;
DR   EMBL; AY651148; - ;
DR   EMBL; AY651149; - ;
DR   EMBL; AY651150; - ;
DR   EMBL; AY651151; - ;
DR   EMBL; AY651152; - ;
DR   EMBL; AY651153; - ;
DR   EMBL; AY651154; - ;
DR   EMBL; AY651155; - ;
DR   EMBL; AY651156; - ;
DR   EMBL; AY651157; - ;
DR   EMBL; AY651158; - ;
DR   EMBL; AY651159; - ;
DR   EMBL; AY651160; - ;
DR   EMBL; AY651161; - ;
DR   EMBL; AY845175; - ;
DR   EMBL; AY845176; - ;
DR   EMBL; BC063450; - ;
DR   EMBL; EU883579; - ;
DR   UniProtKB/Swiss-Prot; Q96LB1; B5B0C7; Q4QXW4; Q4QXW7; Q4QXX0; Q4QXX2; Q4QXX3; Q4QXX4; -.
DR   UniProtKB/Swiss-Prot; Q4QXX6; Q4QXX7; -.
DR   EMBL; AY042214; AAK91805.1; -; Genomic_DNA.
DR   EMBL; AB083626; BAB89339.1; -; Genomic_DNA.
DR   EMBL; AB065811; BAC06030.1; -; Genomic_DNA.
DR   EMBL; AY651130; AAW70043.1; -; Genomic_DNA.
DR   EMBL; AY651131; AAW70044.1; -; Genomic_DNA.
DR   EMBL; AY651132; AAW70045.1; -; Genomic_DNA.
DR   EMBL; AY651133; AAW70046.1; -; Genomic_DNA.
DR   EMBL; AY651134; AAW70047.1; -; Genomic_DNA.
DR   EMBL; AY651135; AAW70048.1; -; Genomic_DNA.
DR   EMBL; AY651136; AAW70049.1; -; Genomic_DNA.
DR   EMBL; AY651137; AAW70050.1; -; Genomic_DNA.
DR   EMBL; AY651138; AAW70051.1; -; Genomic_DNA.
DR   EMBL; AY651139; AAW70052.1; -; Genomic_DNA.
DR   EMBL; AY651140; AAW70053.1; -; Genomic_DNA.
DR   EMBL; AY651141; AAW70054.1; -; Genomic_DNA.
DR   EMBL; AY651142; AAW70055.1; -; Genomic_DNA.
DR   EMBL; AY651143; AAW70056.1; -; Genomic_DNA.
DR   EMBL; AY651144; AAW70057.1; -; Genomic_DNA.
DR   EMBL; AY651145; AAW70058.1; -; Genomic_DNA.
DR   EMBL; AY651146; AAW70059.1; -; Genomic_DNA.
DR   EMBL; AY651147; AAW70060.1; -; Genomic_DNA.
DR   EMBL; AY651148; AAW70061.1; -; Genomic_DNA.
DR   EMBL; AY651149; AAW70062.1; -; Genomic_DNA.
DR   EMBL; AY651150; AAW70063.1; -; Genomic_DNA.
DR   EMBL; AY651151; AAW70064.1; -; Genomic_DNA.
DR   EMBL; AY651152; AAW70065.1; -; Genomic_DNA.
DR   EMBL; AY651153; AAW70066.1; -; Genomic_DNA.
DR   EMBL; AY651154; AAW70067.1; -; Genomic_DNA.
DR   EMBL; AY651155; AAW70068.1; -; Genomic_DNA.
DR   EMBL; AY651156; AAW70069.1; -; Genomic_DNA.
DR   EMBL; AY651157; AAW70070.1; -; Genomic_DNA.
DR   EMBL; AY651158; AAW70071.1; -; Genomic_DNA.
DR   EMBL; AY651159; AAW70072.1; -; Genomic_DNA.
DR   EMBL; AY651160; AAW70073.1; -; Genomic_DNA.
DR   EMBL; AY651161; AAW70074.1; -; Genomic_DNA.
DR   EMBL; AY845175; AAW70082.1; -; Genomic_DNA.
DR   EMBL; AY845176; AAW70083.1; -; Genomic_DNA.
DR   EMBL; EU883579; ACG60653.1; -; Genomic_DNA.
DR   EMBL; BC063450; AAH63450.1; -; mRNA.
DR   IPI; IPI00064965; -.
DR   RefSeq; NP_473371.1; NM_054030.2.
DR   UniGene; Hs.350566; -.
DR   ProteinModelPortal; Q96LB1; -.
DR   SMR; Q96LB1; 29-172.
DR   STRING; Q96LB1; -.
DR   PRIDE; Q96LB1; -.
DR   Ensembl; ENST00000329773; ENSP00000333800; ENSG00000183695.
DR   GeneID; 117194; -.
DR   KEGG; hsa:117194; -.
DR   UCSC; uc001mph.1; human.
DR   CTD; 117194; -.
DR   GeneCards; GC11M018759; -.
DR   H-InvDB; HIX0035988; -.
DR   HGNC; HGNC:17983; MRGPRX2.
DR   MIM; 607228; gene.
DR   neXtProt; NX_Q96LB1; -.
DR   PharmGKB; PA142671335; -.
DR   eggNOG; prNOG19252; -.
DR   GeneTree; ENSGT00550000074531; -.
DR   InParanoid; Q96LB1; -.
DR   OMA; FLILWIW; -.
DR   OrthoDB; EOG4MW86R; -.
DR   PhylomeDB; Q96LB1; -.
DR   NextBio; 80156; -.
DR   ArrayExpress; Q96LB1; -.
DR   Bgee; Q96LB1; -.
DR   Genevestigator; Q96LB1; -.
DR   GermOnline; ENSG00000183695; Homo sapiens.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004930; F:G-protein coupled receptor activity; IDA:UniProtKB.
DR   GO; GO:0042923; F:neuropeptide binding; IPI:UniProtKB.
DR   GO; GO:0019233; P:sensory perception of pain; NAS:UniProtKB.
DR   GO; GO:0030431; P:sleep; NAS:UniProtKB.
DR   InterPro; IPR000276; 7TM_GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_supfam.
DR   Pfam; PF00001; 7tm_1; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
DR   HOGENOMDNA; HS11.PE829; -.
KW   ENSG000001836951755old_1320000031; ENSP000003338007901old_1320000031;
KW   AB065811; AB083626; AY042214; AY651130; AY651131; AY651132; AY651133;
KW   AY651135; AY651136; AY651137; AY651138; AY651139; AY651140; AY651141;
KW   AY651143; AY651144; AY651145; AY651146; AY651147; AY651148; AY651149;
KW   AY651151; AY651152; AY651153; AY651154; AY651155; AY651156; AY651157;
KW   AY651159; AY651160; AY651161; AY845175; AY845176; BC063450; EU883579;
KW   Cell membrane; Complete proteome; G-protein coupled receptor;
KW   Membrane; Polymorphism; Receptor; Reference proteome; Transducer;
KW   Transmembrane; Transmembrane helix.
SQ   SEQUENCE   330 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MDPTTPAWGT ESTTVNGNDQ ALLLLCGKET LIPVFLILFI ALVGLVGNGF VLWLLGFRMR
     RNAFSVYVLS LAGADFLFLC FQIINCLVYL SNFFCSISIN FPSFFTTVMT CAYLAGLSML
     STVSTERCLS VLWPIWYRCR RPRHLSAVVC VLLWALSLLL SILEGKFCGF LFSDGDSGWC
     QTFDFITAAW LIFLFMVLCG SSLALLVRIL CGSRGLPLTR LYLTILLTVL VFLLCGLPFG
     IQWFLILWIW KDSDVLFCHI HPVSVVLSSL NSSANPIIYF FVGSFRKQWR LQQPILKLAL
     QRALQDIAEV DHSEGCFRQG TPEMSRSSLV
//

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