(data stored in ACNUC10243 zone)

HOGENOM: HS12_PE1278

ID   HS12_PE1278                          STANDARD;      PRT;   372 AA.
AC   HS12_PE1278; P09651; A8K4Z8; Q3MIB7; Q6PJZ7;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Heterogeneous nuclear ribonucleoprotein A1; Short=hnRNP
DE   A1;AltName: Full=Helix-destabilizing protein;AltName: Full=Single-strand
DE   RNA-binding protein;AltName: Full=hnRNP core protein A1; (HS12.PE1278).
GN   Name=HNRNPA1; Synonyms=HNRPA1;
OS   HOMO SAPIENS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini;
OC   Hominoidea; Hominidae; Homininae; Homo.
OX   NCBI_TaxID=9606;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS HS12.PE1278.
CC       Homo sapiens chromosome 12 GRCh37  sequence 1..133841895 annotated by
CC       Ensembl
CC   -!- ANNOTATIONS ORIGIN:ROA1_HUMAN
CC   -!- FUNCTION: Involved in the packaging of pre-mRNA into hnRNP
CC       particles, transport of poly(A) mRNA from the nucleus to the
CC       cytoplasm and may modulate splice site selection. May play a role
CC       in HCV RNA replication.
CC   -!- SUBUNIT: Identified in the spliceosome C complex. Identified in a
CC       mRNP granule complex, at least composed of ACTB, ACTN4, DHX9, ERG,
CC       HNRNPA1, HNRNPA2B1, HNRNPAB, HNRNPD, HNRNPL, HNRNPR, HNRNPU,
CC       HSPA1, HSPA8, IGF2BP1, ILF2, ILF3, NCBP1, NCL, PABPC1, PABPC4,
CC       PABPN1, RPLP0, RPS3, RPS3A, RPS4X, RPS8, RPS9, SYNCRIP, TROVE2,
CC       YBX1 and untranslated mRNAs. Interacts with SEPT6. Interacts with
CC       HCV NS5B and with the 5'-UTR and 3'-UTR of HCV RNA.
CC   -!- SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Note=Localized in
CC       cytoplasmic mRNP granules containing untranslated mRNAs. Shuttles
CC       continuously between the nucleus and the cytoplasm along with
CC       mRNA. Component of ribonucleosomes. In the course of viral
CC       infection, colocalizes with HCV NS5B at speckles in the cytoplasm
CC       in a HCV-replication dependent manner.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=3;
CC       Name=A1-B;
CC         IsoId=P09651-1; Sequence=Displayed;
CC       Name=A1-A;
CC         IsoId=P09651-2; Sequence=VSP_005824;
CC         Note=Is twenty times more abundant than isoform A1-B;
CC       Name=2;
CC         IsoId=P09651-3; Sequence=VSP_034076;
CC         Note=No experimental confirmation available;
CC   -!- PTM: Arg-194, Arg-206 and Arg-225 are dimethylated, probably to
CC       asymmetric dimethylarginine.
CC   -!- PTM: Sumoylated.
CC   -!- SIMILARITY: Contains 2 RRM (RNA recognition motif) domains.
CC   -!- GENE_FAMILY: HOG000234442 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Homo_sapiens;ENSG00000135486;ENST00000340913;ENSP00000341826.
DR   EMBL; AC078778; - ;
DR   EMBL; AK291113; - ;
DR   EMBL; BC002355; - ;
DR   EMBL; BC009600; - ;
DR   EMBL; BC012158; - ;
DR   EMBL; BC033714; - ;
DR   EMBL; BC052296; - ;
DR   EMBL; BC070315; - ;
DR   EMBL; BC074502; - ;
DR   EMBL; BC103707; - ;
DR   EMBL; CH471054; - ;
DR   EMBL; X04347; - ;
DR   EMBL; X06747; - ;
DR   EMBL; X12671; - ;
DR   EMBL; X79536; - ;
DR   UniProtKB/Swiss-Prot; P09651; A8K4Z8; Q3MIB7; Q6PJZ7; -.
DR   EMBL; X12671; CAA31191.1; -; Genomic_DNA.
DR   EMBL; X06747; CAA29922.1; -; mRNA.
DR   EMBL; X79536; CAA56072.1; -; mRNA.
DR   EMBL; AK291113; BAF83802.1; -; mRNA.
DR   EMBL; AC078778; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH471054; EAW96761.1; -; Genomic_DNA.
DR   EMBL; BC002355; AAH02355.1; -; mRNA.
DR   EMBL; BC009600; AAH09600.1; -; mRNA.
DR   EMBL; BC012158; AAH12158.1; -; mRNA.
DR   EMBL; BC033714; AAH33714.1; -; mRNA.
DR   EMBL; BC052296; AAH52296.1; -; mRNA.
DR   EMBL; BC070315; AAH70315.1; -; mRNA.
DR   EMBL; BC074502; AAH74502.1; -; mRNA.
DR   EMBL; BC103707; AAI03708.1; -; mRNA.
DR   EMBL; X04347; CAA27874.1; -; mRNA.
DR   IPI; IPI00215965; -.
DR   IPI; IPI00465365; -.
DR   IPI; IPI00797148; -.
DR   PIR; S02061; S02061.
DR   PIR; S12520; S12520.
DR   RefSeq; NP_002127.1; NM_002136.2.
DR   RefSeq; NP_112420.1; NM_031157.2.
DR   UniGene; Hs.546261; -.
DR   UniGene; Hs.655424; -.
DR   PDB; 1HA1; X-ray; 1.75 A; A=1-184.
DR   PDB; 1L3K; X-ray; 1.10 A; A=1-196.
DR   PDB; 1PGZ; X-ray; 2.60 A; A=2-195.
DR   PDB; 1PO6; X-ray; 2.10 A; A=8-189.
DR   PDB; 1U1K; X-ray; 2.00 A; A=1-196.
DR   PDB; 1U1L; X-ray; 2.00 A; A=1-196.
DR   PDB; 1U1M; X-ray; 2.00 A; A=1-196.
DR   PDB; 1U1N; X-ray; 2.10 A; A=1-196.
DR   PDB; 1U1O; X-ray; 2.00 A; A=1-196.
DR   PDB; 1U1P; X-ray; 1.90 A; A=1-196.
DR   PDB; 1U1Q; X-ray; 1.80 A; A=1-196.
DR   PDB; 1U1R; X-ray; 1.80 A; A=1-196.
DR   PDB; 1UP1; X-ray; 1.90 A; A=3-184.
DR   PDB; 2H4M; X-ray; 3.05 A; C/D=309-357.
DR   PDB; 2UP1; X-ray; 2.10 A; A=8-190.
DR   PDBsum; 1HA1; -.
DR   PDBsum; 1L3K; -.
DR   PDBsum; 1PGZ; -.
DR   PDBsum; 1PO6; -.
DR   PDBsum; 1U1K; -.
DR   PDBsum; 1U1L; -.
DR   PDBsum; 1U1M; -.
DR   PDBsum; 1U1N; -.
DR   PDBsum; 1U1O; -.
DR   PDBsum; 1U1P; -.
DR   PDBsum; 1U1Q; -.
DR   PDBsum; 1U1R; -.
DR   PDBsum; 1UP1; -.
DR   PDBsum; 2H4M; -.
DR   PDBsum; 2UP1; -.
DR   ProteinModelPortal; P09651; -.
DR   SMR; P09651; 8-190.
DR   DisProt; DP00324; -.
DR   DIP; DIP-29338N; -.
DR   IntAct; P09651; 49.
DR   MINT; MINT-1035550; -.
DR   STRING; P09651; -.
DR   PhosphoSite; P09651; -.
DR   SWISS-2DPAGE; P09651; -.
DR   Aarhus/Ghent-2DPAGE; 207; NEPHGE.
DR   Aarhus/Ghent-2DPAGE; 2114; NEPHGE.
DR   Aarhus/Ghent-2DPAGE; 3612; NEPHGE.
DR   PRIDE; P09651; -.
DR   Ensembl; ENST00000340913; ENSP00000341826; ENSG00000135486.
DR   Ensembl; ENST00000420780; ENSP00000391986; ENSG00000135486.
DR   GeneID; 3178; -.
DR   KEGG; hsa:3178; -.
DR   UCSC; uc001sfl.1; human.
DR   UCSC; uc001sfn.1; human.
DR   UCSC; uc009zng.1; human.
DR   CTD; 3178; -.
DR   GeneCards; GC12P051713; -.
DR   HGNC; HGNC:5031; HNRNPA1.
DR   HPA; CAB010894; -.
DR   HPA; HPA001666; -.
DR   MIM; 164017; gene.
DR   neXtProt; NX_P09651; -.
DR   PharmGKB; PA162391113; -.
DR   eggNOG; prNOG15016; -.
DR   GeneTree; ENSGT00550000074566; -.
DR   InParanoid; P09651; -.
DR   OMA; IEVEIMT; -.
DR   OrthoDB; EOG4HQDKF; -.
DR   Pathway_Interaction_DB; ar_pathway; Coregulation of Androgen receptor activity.
DR   Reactome; REACT_1675; mRNA Processing.
DR   Reactome; REACT_71; Gene Expression.
DR   NextBio; 12614; -.
DR   ArrayExpress; P09651; -.
DR   Bgee; P09651; -.
DR   CleanEx; HS_HNRNPA1; -.
DR   Genevestigator; P09651; -.
DR   GermOnline; ENSG00000135486; Homo sapiens.
DR   GO; GO:0071013; C:catalytic step 2 spliceosome; IDA:UniProtKB.
DR   GO; GO:0005737; C:cytoplasm; IDA:HGNC.
DR   GO; GO:0030530; C:heterogeneous nuclear ribonucleoprotein complex; TAS:ProtInc.
DR   GO; GO:0005730; C:nucleolus; IDA:HPA.
DR   GO; GO:0005654; C:nucleoplasm; IDA:HGNC.
DR   GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR   GO; GO:0005515; F:protein binding; IPI:IntAct.
DR   GO; GO:0003697; F:single-stranded DNA binding; IDA:HGNC.
DR   GO; GO:0044419; P:interspecies interaction between organisms; IEA:UniProtKB-KW.
DR   GO; GO:0051028; P:mRNA transport; IEA:UniProtKB-KW.
DR   GO; GO:0051170; P:nuclear import; IDA:HGNC.
DR   InterPro; IPR012677; Nucleotide-bd_a/b_plait.
DR   InterPro; IPR000504; RRM_dom.
DR   Gene3D; G3DSA:3.30.70.330; a_b_plait_nuc_bd; 1.
DR   Pfam; PF00076; RRM_1; 2.
DR   SMART; SM00360; RRM; 2.
DR   PROSITE; PS50102; RRM; 2.
DR   HOGENOMDNA; HS12.PE1278; -.
KW   ENSG000001354861755old_1320000031; ENSP000003418267901old_1320000031;
KW   AC078778; AK291113; BC002355; BC009600; BC012158; BC033714; BC052296;
KW   BC074502; BC103707; CH471054; X04347; X06747; X12671; X79536;
KW   3D-structure; Acetylation; Alternative splicing; Complete proteome;
KW   Cytoplasm; Direct protein sequencing; Host-virus interaction;
KW   Isopeptide bond; Methylation; mRNA processing; mRNA splicing;
KW   mRNA transport; Nucleus; Phosphoprotein; Polymorphism;
KW   Reference proteome; Repeat; Ribonucleoprotein; RNA-binding;
KW   Spliceosome; Transport; Ubl conjugation.
SQ   SEQUENCE   372 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MSKSESPKEP EQLRKLFIGG LSFETTDESL RSHFEQWGTL TDCVVMRDPN TKRSRGFGFV
     TYATVEEVDA AMNARPHKVD GRVVEPKRAV SREDSQRPGA HLTVKKIFVG GIKEDTEEHH
     LRDYFEQYGK IEVIEIMTDR GSGKKRGFAF VTFDDHDSVD KIVIQKYHTV NGHNCEVRKA
     LSKQEMASAS SSQRGRSGSG NFGGGRGGGF GGNDNFGRGG NFSGRGGFGG SRGGGGYGGS
     GDGYNGFGND GGYGGGGPGY SGGSRGYGSG GQGYGNQGSG YGGSGSYDSY NNGGGGGFGG
     GSGSNFGGGG SYNDFGNYNN QSSNFGPMKG GNFGGRSSGP YGGGGQYFAK PRNQGGYGGS
     SSSSSYGSGR RF
//

If you have problems or comments...

PBIL Back to PBIL home page