(data stored in ACNUC31108 zone)

HOGENOM: HS12_PE1338

ID   HS12_PE1338                          STANDARD;      PRT;   238 AA.
AC   HS12_PE1338; P08962; Q5TZP3; Q9UCG6;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=CD63 antigen;AltName: Full=Granulophysin;AltName:
DE   Full=Lysosomal-associated membrane protein 3; Short=LAMP-3;AltName:
DE   Full=Melanoma-associated antigen ME491;AltName: Full=OMA81H;AltName:
DE   Full=Ocular melanoma-associated antigen;AltName: Full=Tetraspanin-30;
DE   Short=Tspan-30;AltName: CD_antigen=CD63; (HS12.PE1338).
GN   Name=CD63; Synonyms=MLA1, TSPAN30;
OS   HOMO SAPIENS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini;
OC   Hominoidea; Hominidae; Homininae; Homo.
OX   NCBI_TaxID=9606;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS HS12.PE1338.
CC       Homo sapiens chromosome 12 GRCh37  sequence 1..133841895 annotated by
CC       Ensembl
CC   -!- ANNOTATIONS ORIGIN:CD63_HUMAN
CC   -!- FUNCTION: This antigen is associated with early stages of melanoma
CC       tumor progression. May play a role in growth regulation.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC       Lysosome membrane; Multi-pass membrane protein. Late endosome
CC       membrane; Multi-pass membrane protein. Note=Also found in Weibel-
CC       Palade bodies of endothelial cells. Located in platelet dense
CC       granules.
CC   -!- TISSUE SPECIFICITY: Dysplastic nevi, radial growth phase primary
CC       melanomas, hematopoietic cells, tissue macrophages.
CC   -!- MISCELLANEOUS: Lack of expression of CD63 in platelets has been
CC       observed in a patient with Hermansky-Pudlak syndrome (HPS).
CC       Hermansky-Pudlak syndrome (HPS) is a genetically heterogeneous,
CC       rare, autosomal recessive disorder characterized by oculocutaneous
CC       albinism, bleeding due to platelet storage pool deficiency, and
CC       lysosomal storage defects. This syndrome results from defects of
CC       diverse cytoplasmic organelles including melanosomes, platelet
CC       dense granules and lysosomes. Ceroid storage in the lungs is
CC       associated with pulmonary fibrosis, a common cause of premature
CC       death in individuals with HPS.
CC   -!- SIMILARITY: Belongs to the tetraspanin (TM4SF) family.
CC   -!- GENE_FAMILY: HOG000230651 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Homo_sapiens;ENSG00000135404;ENST00000257857;ENSP00000257857.
DR   EMBL; AF508304; - ;
DR   EMBL; AK311893; - ;
DR   EMBL; BC002349; - ;
DR   EMBL; BC013017; - ;
DR   EMBL; BT007073; - ;
DR   EMBL; BT020137; - ;
DR   EMBL; BT020138; - ;
DR   EMBL; CH471054; - ;
DR   EMBL; CR542096; - ;
DR   EMBL; M58485; - ;
DR   EMBL; M59907; - ;
DR   EMBL; S93788; - ;
DR   EMBL; X07982; - ;
DR   EMBL; X62654; - ;
DR   UniProtKB/Swiss-Prot; P08962; Q5TZP3; Q9UCG6; -.
DR   EMBL; X07982; CAA30792.1; -; mRNA.
DR   EMBL; M59907; AAA63235.1; -; mRNA.
DR   EMBL; M58485; -; NOT_ANNOTATED_CDS; mRNA.
DR   EMBL; S93788; AAB21617.1; -; mRNA.
DR   EMBL; X62654; CAA44519.1; -; Genomic_DNA.
DR   EMBL; AK311893; BAG34834.1; -; mRNA.
DR   EMBL; CR542096; CAG46893.1; -; mRNA.
DR   EMBL; BT007073; AAP35736.1; -; mRNA.
DR   EMBL; BT020137; AAV38939.1; -; mRNA.
DR   EMBL; BT020138; AAV38940.1; -; mRNA.
DR   EMBL; CH471054; EAW96827.1; -; Genomic_DNA.
DR   EMBL; BC002349; AAH02349.1; -; mRNA.
DR   EMBL; BC013017; AAH13017.1; -; mRNA.
DR   IPI; IPI00215998; -.
DR   PIR; I38016; I38016.
DR   RefSeq; NP_001771.1; NM_001780.4.
DR   UniGene; Hs.445570; -.
DR   ProteinModelPortal; P08962; -.
DR   IntAct; P08962; 7.
DR   MINT; MINT-2981823; -.
DR   STRING; P08962; -.
DR   PRIDE; P08962; -.
DR   Ensembl; ENST00000257857; ENSP00000257857; ENSG00000135404.
DR   GeneID; 967; -.
DR   KEGG; hsa:967; -.
DR   UCSC; uc001shm.1; human.
DR   CTD; 967; -.
DR   GeneCards; GC12M053159; -.
DR   H-InvDB; HIX0010704; -.
DR   HGNC; HGNC:1692; CD63.
DR   HPA; CAB026356; -.
DR   HPA; HPA010088; -.
DR   MIM; 155740; gene.
DR   neXtProt; NX_P08962; -.
DR   eggNOG; prNOG15980; -.
DR   InParanoid; P08962; -.
DR   OMA; EFNKDFR; -.
DR   OrthoDB; EOG4HX51Z; -.
DR   PhylomeDB; P08962; -.
DR   Reactome; REACT_604; Hemostasis.
DR   NextBio; 4044; -.
DR   ArrayExpress; P08962; -.
DR   Bgee; P08962; -.
DR   CleanEx; HS_CD63; -.
DR   Genevestigator; P08962; -.
DR   GermOnline; ENSG00000135404; Homo sapiens.
DR   GO; GO:0005887; C:integral to plasma membrane; TAS:ProtInc.
DR   GO; GO:0031902; C:late endosome membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005765; C:lysosomal membrane; TAS:ProtInc.
DR   GO; GO:0031088; C:platelet dense granule membrane; EXP:Reactome.
DR   GO; GO:0030168; P:platelet activation; TAS:Reactome.
DR   GO; GO:0002576; P:platelet degranulation; TAS:Reactome.
DR   InterPro; IPR018499; Tetraspanin.
DR   InterPro; IPR018503; Tetraspanin_CS.
DR   InterPro; IPR008952; Tetraspanin_EC2.
DR   InterPro; IPR000301; Tetraspanin_subgr.
DR   Pfam; PF00335; Tetraspannin; 1.
DR   PRINTS; PR00259; TMFOUR.
DR   SUPFAM; SSF48652; Tetraspanin; 1.
DR   PROSITE; PS00421; TM4_1; 1.
DR   HOGENOMDNA; HS12.PE1338; -.
KW   ENSG000001354041755old_1320000031; ENSP000002578577901old_1320000031;
KW   Q8N6Z9_HUMAN; AF508304; AK311893; BC002349; BC013017; BT007073; BT020137;
KW   CH471054; CR542096; M58485; M59907; S93788; X07982; X62654;
KW   Cell membrane; Complete proteome; Direct protein sequencing; Endosome;
KW   Glycoprotein; Lysosome; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
SQ   SEQUENCE   238 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MAVEGGMKCV KFLLYVLLLA FCACAVGLIA VGVGAQLVLS QTIIQGATPG SLLPVVIIAV
     GVFLFLVAFV GCCGACKENY CLMITFAIFL SLIMLVEVAA AIAGYVFRDK VMSEFNNNFR
     QQMENYPKNN HTASILDRMQ ADFKCCGAAN YTDWEKIPSM SKNRVPDSCC INVTVGCGIN
     FNEKAIHKEG CVEKIGGWLR KNVLVVAAAA LGIAFVEVLG IVFACCLVKS IRSGYEVM
//

If you have problems or comments...

PBIL Back to PBIL home page