(data stored in ACNUC31108 zone)

HOGENOM: HS12_PE147

ID   HS12_PE147                           STANDARD;      PRT;   228 AA.
AC   HS12_PE147; P21926; D3DUQ9; Q5J7W6; Q96ES4;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=CD9 antigen;AltName: Full=5H9 antigen;AltName: Full=Cell
DE   growth-inhibiting gene 2 protein;AltName: Full=Leukocyte antigen
DE   MIC3;AltName: Full=Motility-related protein; Short=MRP-1;AltName:
DE   Full=Tetraspanin-29; Short=Tspan-29;AltName: Full=p24;AltName:
DE   CD_antigen=CD9; (HS12.PE147).
GN   Name=CD9; Synonyms=MIC3, TSPAN29; ORFNames=GIG2;
OS   HOMO SAPIENS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini;
OC   Hominoidea; Hominidae; Homininae; Homo.
OX   NCBI_TaxID=9606;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS HS12.PE147.
CC       Homo sapiens chromosome 12 GRCh37  sequence 1..133841895 annotated by
CC       Ensembl
CC   -!- ANNOTATIONS ORIGIN:CD9_HUMAN
CC   -!- FUNCTION: Involved in platelet activation and aggregation.
CC       Regulates paranodal junction formation. Involved in cell adhesion,
CC       cell motility and tumor metastasis. Required for sperm-egg fusion.
CC   -!- SUBUNIT: Forms both disulfide-linked homodimers and higher
CC       homooligomers as well as heterooligomers with other members of the
CC       tetraspanin family. Associates with CR2/CD21 and with
CC       PTGFRN/CD9P1. Interacts directly with IGSF8.
CC   -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC   -!- TISSUE SPECIFICITY: Expressed by a variety of hematopoietic and
CC       epithelial cells.
CC   -!- PTM: Protein exists in three forms with molecular masses between
CC       22 and 27 kDa, and is known to carry covalently linked fatty
CC       acids.
CC   -!- SIMILARITY: Belongs to the tetraspanin (TM4SF) family.
CC   -!- WEB RESOURCE: Name=SeattleSNPs;
CC       URL="http://pga.gs.washington.edu/data/cd9/";
CC   -!- GENE_FAMILY: HOG000230651 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Homo_sapiens;ENSG00000010278;ENST00000382518;ENSP00000371958.
DR   EMBL; AB079244; - ;
DR   EMBL; AC006057; - ;
DR   EMBL; AK298431; - ;
DR   EMBL; AY422198; - ;
DR   EMBL; AY423720; - ;
DR   EMBL; BC011988; - ;
DR   EMBL; CH471116; - ;
DR   EMBL; L08118; - ;
DR   EMBL; L08119; - ;
DR   EMBL; L08120; - ;
DR   EMBL; L08121; - ;
DR   EMBL; L08122; - ;
DR   EMBL; L08123; - ;
DR   EMBL; L08124; - ;
DR   EMBL; L08125; - ;
DR   EMBL; L34068; - ;
DR   EMBL; M38690; - ;
DR   EMBL; S60462; - ;
DR   EMBL; S60463; - ;
DR   EMBL; S60464; - ;
DR   EMBL; S60465; - ;
DR   EMBL; S60472; - ;
DR   EMBL; S60489; - ;
DR   EMBL; S60699; - ;
DR   EMBL; S60700; - ;
DR   EMBL; X60111; - ;
DR   UniProtKB/Swiss-Prot; P21926; D3DUQ9; Q5J7W6; Q96ES4; -.
DR   EMBL; M38690; AAA80320.1; -; mRNA.
DR   EMBL; L34068; AAA59982.1; -; mRNA.
DR   EMBL; X60111; CAA42708.1; -; mRNA.
DR   EMBL; S60489; AAC60586.1; -; Genomic_DNA.
DR   EMBL; S60462; AAC60586.1; JOINED; Genomic_DNA.
DR   EMBL; S60463; AAC60586.1; JOINED; Genomic_DNA.
DR   EMBL; S60464; AAC60586.1; JOINED; Genomic_DNA.
DR   EMBL; S60700; AAC60586.1; JOINED; Genomic_DNA.
DR   EMBL; S60699; AAC60586.1; JOINED; Genomic_DNA.
DR   EMBL; S60465; AAC60586.1; JOINED; Genomic_DNA.
DR   EMBL; S60472; AAC60586.1; JOINED; Genomic_DNA.
DR   EMBL; L08118; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; L08119; AAA51954.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; L08120; AAA51955.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; L08121; AAA51956.1; -; Genomic_DNA.
DR   EMBL; L08122; AAA51957.1; -; Genomic_DNA.
DR   EMBL; L08123; AAA51958.1; -; Genomic_DNA.
DR   EMBL; L08124; AAA51959.1; -; Genomic_DNA.
DR   EMBL; L08125; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AB079244; BAE71132.1; -; mRNA.
DR   EMBL; AY423720; AAS00483.1; -; mRNA.
DR   EMBL; AY422198; AAQ87878.1; -; Genomic_DNA.
DR   EMBL; CH471116; EAW88812.1; -; Genomic_DNA.
DR   EMBL; CH471116; EAW88813.1; -; Genomic_DNA.
DR   EMBL; BC011988; AAH11988.1; -; mRNA.
DR   IPI; IPI00215997; -.
DR   PIR; A46123; A40402.
DR   RefSeq; NP_001760.1; NM_001769.3.
DR   UniGene; Hs.114286; -.
DR   UniGene; Hs.712104; -.
DR   ProteinModelPortal; P21926; -.
DR   SMR; P21926; 111-191.
DR   DIP; DIP-1122N; -.
DR   STRING; P21926; -.
DR   PRIDE; P21926; -.
DR   Ensembl; ENST00000009180; ENSP00000009180; ENSG00000010278.
DR   Ensembl; ENST00000382518; ENSP00000371958; ENSG00000010278.
DR   GeneID; 928; -.
DR   KEGG; hsa:928; -.
DR   UCSC; uc001qnp.1; human.
DR   CTD; 928; -.
DR   GeneCards; GC12P006179; -.
DR   H-InvDB; HIX0010357; -.
DR   HGNC; HGNC:1709; CD9.
DR   HPA; CAB002490; -.
DR   MIM; 143030; gene.
DR   neXtProt; NX_P21926; -.
DR   PharmGKB; PA26247; -.
DR   eggNOG; prNOG19686; -.
DR   GeneTree; ENSGT00590000082836; -.
DR   InParanoid; P21926; -.
DR   OMA; DICPKKD; -.
DR   OrthoDB; EOG402WT9; -.
DR   PhylomeDB; P21926; -.
DR   Pathway_Interaction_DB; a6b1_a6b4_integrin_pathway; a6b1 and a6b4 Integrin signaling.
DR   Reactome; REACT_604; Hemostasis.
DR   NextBio; 3846; -.
DR   ArrayExpress; P21926; -.
DR   Bgee; P21926; -.
DR   CleanEx; HS_CD9; -.
DR   Genevestigator; P21926; -.
DR   GermOnline; ENSG00000010278; Homo sapiens.
DR   GO; GO:0005887; C:integral to plasma membrane; NAS:UniProtKB.
DR   GO; GO:0031092; C:platelet alpha granule membrane; EXP:Reactome.
DR   GO; GO:0007155; P:cell adhesion; IDA:UniProtKB.
DR   GO; GO:0006928; P:cellular component movement; IDA:UniProtKB.
DR   GO; GO:0007342; P:fusion of sperm to egg plasma membrane; IDA:UniProtKB.
DR   GO; GO:0030913; P:paranodal junction assembly; ISS:UniProtKB.
DR   GO; GO:0030168; P:platelet activation; NAS:UniProtKB.
DR   GO; GO:0002576; P:platelet degranulation; TAS:Reactome.
DR   InterPro; IPR023396; CD81_extracellular.
DR   InterPro; IPR018499; Tetraspanin.
DR   InterPro; IPR018503; Tetraspanin_CS.
DR   InterPro; IPR008952; Tetraspanin_EC2.
DR   InterPro; IPR000301; Tetraspanin_subgr.
DR   Gene3D; G3DSA:1.10.1450.10; G3DSA:1.10.1450.10; 1.
DR   Pfam; PF00335; Tetraspannin; 1.
DR   PRINTS; PR00259; TMFOUR.
DR   SUPFAM; SSF48652; Tetraspanin; 1.
DR   PROSITE; PS00421; TM4_1; 1.
DR   HOGENOMDNA; HS12.PE147; -.
KW   ENSG000000102781755old_1320000031; ENSP000003719587901old_1320000031;
KW   A6NNI4_HUMAN; B4DPP0_HUMAN; D3DUQ9_HUMAN; AB079244; AC006057; AK298431;
KW   AY423720; BC011988; CH471116; L08118; L08119; L08120; L08121; L08122;
KW   L08124; L08125; L34068; M38690; S60462; S60463; S60464; S60465; S60472;
KW   S60699; S60700; X60111;
KW   Cell adhesion; Complete proteome; Direct protein sequencing;
KW   Disulfide bond; Fertilization; Glycoprotein; Lipoprotein; Membrane;
KW   Palmitate; Reference proteome; Transmembrane; Transmembrane helix.
SQ   SEQUENCE   228 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MPVKGGTKCI KYLLFGFNFI FWLAGIAVLA IGLWLRFDSQ TKSIFEQETN NNNSSFYTGV
     YILIGAGALM MLVGFLGCCG AVQESQCMLG LFFGFLLVIF AIEIAAAIWG YSHKDEVIKE
     VQEFYKDTYN KLKTKDEPQR ETLKAIHYAL NCCGLAGGVE QFISDICPKK DVLETFTVKS
     CPDAIKEVFD NKFHIIGAVG IGIAVVMIFG MIFSMILCCA IRRNREMV
//

If you have problems or comments...

PBIL Back to PBIL home page