(data stored in ACNUC31108 zone)

HOGENOM: HS12_PE1720

ID   HS12_PE1720                          STANDARD;      PRT;   237 AA.
AC   HS12_PE1720; P19075; B2R7T7; Q9BS78;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Tetraspanin-8; Short=Tspan-8;AltName: Full=Transmembrane 4
DE   superfamily member 3;AltName: Full=Tumor-associated antigen CO-029;
DE   (HS12.PE1720).
GN   Name=TSPAN8; Synonyms=TM4SF3;
OS   HOMO SAPIENS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini;
OC   Hominoidea; Hominidae; Homininae; Homo.
OX   NCBI_TaxID=9606;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS HS12.PE1720.
CC       Homo sapiens chromosome 12 GRCh37  sequence 1..133841895 annotated by
CC       Ensembl
CC   -!- ANNOTATIONS ORIGIN:TSN8_HUMAN
CC   -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC   -!- TISSUE SPECIFICITY: Gastric, colon, rectal, and pancreatic
CC       carcinomas.
CC   -!- SIMILARITY: Belongs to the tetraspanin (TM4SF) family.
CC   -!- GENE_FAMILY: HOG000230651 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Homo_sapiens;ENSG00000127324;ENST00000247829;ENSP00000247829.
DR   EMBL; AK223022; - ;
DR   EMBL; AK313112; - ;
DR   EMBL; BC005246; - ;
DR   EMBL; CH471054; - ;
DR   EMBL; M35252; - ;
DR   UniProtKB/Swiss-Prot; P19075; B2R7T7; Q9BS78; -.
DR   EMBL; M35252; AAA35709.1; -; mRNA.
DR   EMBL; AK313112; BAG35934.1; -; mRNA.
DR   EMBL; CH471054; EAW97257.1; -; Genomic_DNA.
DR   EMBL; BC005246; AAH05246.1; -; mRNA.
DR   IPI; IPI00015872; -.
DR   PIR; A36056; A36056.
DR   RefSeq; NP_004607.1; NM_004616.2.
DR   UniGene; Hs.170563; -.
DR   ProteinModelPortal; P19075; -.
DR   STRING; P19075; -.
DR   PhosphoSite; P19075; -.
DR   PRIDE; P19075; -.
DR   Ensembl; ENST00000247829; ENSP00000247829; ENSG00000127324.
DR   Ensembl; ENST00000393330; ENSP00000377003; ENSG00000127324.
DR   GeneID; 7103; -.
DR   KEGG; hsa:7103; -.
DR   UCSC; uc001swj.1; human.
DR   CTD; 7103; -.
DR   GeneCards; GC12M068568; -.
DR   H-InvDB; HIX0010819; -.
DR   HGNC; HGNC:11855; TSPAN8.
DR   HPA; CAB026009; -.
DR   MIM; 600769; gene.
DR   neXtProt; NX_P19075; -.
DR   PharmGKB; PA36556; -.
DR   eggNOG; prNOG05837; -.
DR   InParanoid; P19075; -.
DR   OMA; LYCQIGN; -.
DR   OrthoDB; EOG4WDDD2; -.
DR   PhylomeDB; P19075; -.
DR   NextBio; 27789; -.
DR   ArrayExpress; P19075; -.
DR   Bgee; P19075; -.
DR   CleanEx; HS_TSPAN8; -.
DR   Genevestigator; P19075; -.
DR   GermOnline; ENSG00000127324; Homo sapiens.
DR   GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005764; C:lysosome; TAS:ProtInc.
DR   GO; GO:0004871; F:signal transducer activity; TAS:ProtInc.
DR   GO; GO:0006486; P:protein glycosylation; TAS:ProtInc.
DR   InterPro; IPR018499; Tetraspanin.
DR   InterPro; IPR018503; Tetraspanin_CS.
DR   InterPro; IPR008952; Tetraspanin_EC2.
DR   InterPro; IPR000301; Tetraspanin_subgr.
DR   Pfam; PF00335; Tetraspannin; 1.
DR   PRINTS; PR00259; TMFOUR.
DR   SUPFAM; SSF48652; Tetraspanin; 1.
DR   PROSITE; PS00421; TM4_1; 1.
DR   HOGENOMDNA; HS12.PE1720; -.
KW   ENSG000001273241755old_1320000031; ENSP000002478297901old_1320000031;
KW   Q53GA9_HUMAN; AK223022; AK313112; BC005246; CH471054; M35252;
KW   Complete proteome; Glycoprotein; Membrane; Polymorphism;
KW   Reference proteome; Transmembrane; Transmembrane helix.
SQ   SEQUENCE   237 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MAGVSACIKY SMFTFNFLFW LCGILILALA IWVRVSNDSQ AIFGSEDVGS SSYVAVDILI
     AVGAIIMILG FLGCCGAIKE SRCMLLLFFI GLLLILLLQV ATGILGAVFK SKSDRIVNET
     LYENTKLLSA TGESEKQFQE AIIVFQEEFK CCGLVNGAAD WGNNFQHYPE LCACLDKQRP
     CQSYNGKQVY KETCISFIKD FLAKNLIIVI GISFGLAVIE ILGLVFSMVL YCQIGNK
//

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