(data stored in ACNUC29543 zone)

HOGENOM: HS12_PE2132

ID   HS12_PE2132                          STANDARD;      PRT;   261 AA.
AC   HS12_PE2132; Q6NS38; Q5XLE3;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Alpha-ketoglutarate-dependent dioxygenase alkB homolog 2;
DE   EC=1.14.11 -;AltName: Full=Alkylated DNA repair protein alkB homolog
DE   2;AltName: Full=Oxy DC1; (HS12.PE2132).
GN   Name=ALKBH2; Synonyms=ABH2;
OS   HOMO SAPIENS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini;
OC   Hominoidea; Hominidae; Homininae; Homo.
OX   NCBI_TaxID=9606;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS HS12.PE2132.
CC       Homo sapiens chromosome 12 GRCh37  sequence 1..133841895 annotated by
CC       Ensembl
CC   -!- ANNOTATIONS ORIGIN:ALKB2_HUMAN
CC   -!- FUNCTION: Dioxygenase that repairs alkylated DNA and RNA
CC       containing 1-methyladenine and 3-methylcytosine by oxidative
CC       demethylation. Can also repair alkylated DNA containing 1-
CC       ethenoadenine (in vitro). Has strong preference for double-
CC       stranded DNA. Has low efficiency with single-stranded substrates.
CC       Requires molecular oxygen, alpha-ketoglutarate and iron.
CC   -!- COFACTOR: Binds 1 Fe(2+) ion per subunit.
CC   -!- ENZYME REGULATION: Activated by ascorbate and magnesium ions.
CC   -!- SUBCELLULAR LOCATION: Nucleus. Note=Detected in replication foci
CC       during S-phase.
CC   -!- TISSUE SPECIFICITY: Detected in colon, small intestine, ovary,
CC       testis, prostate, skeletal muscle, heart, liver and urinary
CC       bladder.
CC   -!- SIMILARITY: Belongs to the alkB family.
CC   -!- SIMILARITY: Contains 1 Fe2OG dioxygenase domain.
CC   -!- GENE_FAMILY: HOG000207105 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Homo_sapiens;ENSG00000189046;ENST00000429722;ENSP00000398181.
DR   EMBL; AY754389; - ;
DR   EMBL; BC070489; - ;
DR   UniProtKB/Swiss-Prot; Q6NS38; Q5XLE3; -.
DR   EMBL; AY754389; AAV28301.1; -; mRNA.
DR   EMBL; BC070489; AAH70489.1; -; mRNA.
DR   IPI; IPI00055405; -.
DR   RefSeq; NP_001001655.1; NM_001001655.2.
DR   RefSeq; NP_001138846.1; NM_001145374.1.
DR   RefSeq; NP_001138847.1; NM_001145375.1.
DR   UniGene; Hs.374458; -.
DR   PDB; 3BTX; X-ray; 2.00 A; A=56-258.
DR   PDB; 3BTY; X-ray; 2.35 A; A=56-258.
DR   PDB; 3BTZ; X-ray; 3.00 A; A=57-258.
DR   PDB; 3BU0; X-ray; 2.50 A; A=56-258.
DR   PDB; 3BUC; X-ray; 2.59 A; A=56-258.
DR   PDB; 3H8O; X-ray; 2.50 A; A=56-261.
DR   PDB; 3H8R; X-ray; 1.77 A; A=56-261.
DR   PDB; 3H8X; X-ray; 2.50 A; A=56-261.
DR   PDBsum; 3BTX; -.
DR   PDBsum; 3BTY; -.
DR   PDBsum; 3BTZ; -.
DR   PDBsum; 3BU0; -.
DR   PDBsum; 3BUC; -.
DR   PDBsum; 3H8O; -.
DR   PDBsum; 3H8R; -.
DR   PDBsum; 3H8X; -.
DR   ProteinModelPortal; Q6NS38; -.
DR   SMR; Q6NS38; 56-258.
DR   IntAct; Q6NS38; 1.
DR   STRING; Q6NS38; -.
DR   PRIDE; Q6NS38; -.
DR   Ensembl; ENST00000343075; ENSP00000343021; ENSG00000189046.
DR   Ensembl; ENST00000429722; ENSP00000398181; ENSG00000189046.
DR   Ensembl; ENST00000435370; ENSP00000398509; ENSG00000189046.
DR   GeneID; 121642; -.
DR   KEGG; hsa:121642; -.
DR   UCSC; uc001tnx.1; human.
DR   CTD; 121642; -.
DR   GeneCards; GC12M106544; -.
DR   H-InvDB; HIX0036774; -.
DR   HGNC; HGNC:32487; ALKBH2.
DR   HPA; CAB011198; -.
DR   MIM; 610602; gene.
DR   neXtProt; NX_Q6NS38; -.
DR   PharmGKB; PA143485292; -.
DR   eggNOG; prNOG08807; -.
DR   GeneTree; ENSGT00530000063618; -.
DR   InParanoid; Q6NS38; -.
DR   OMA; HRDDEKE; -.
DR   OrthoDB; EOG4N8R5T; -.
DR   PhylomeDB; Q6NS38; -.
DR   Reactome; REACT_216; DNA Repair.
DR   DrugBank; DB00126; Vitamin C.
DR   NextBio; 80790; -.
DR   ArrayExpress; Q6NS38; -.
DR   Bgee; Q6NS38; -.
DR   CleanEx; HS_ALKBH2; -.
DR   Genevestigator; Q6NS38; -.
DR   GermOnline; ENSG00000189046; Homo sapiens.
DR   GO; GO:0005654; C:nucleoplasm; EXP:Reactome.
DR   GO; GO:0051747; F:cytosine C-5 DNA demethylase activity; IDA:UniProtKB.
DR   GO; GO:0003684; F:damaged DNA binding; EXP:Reactome.
DR   GO; GO:0043734; F:DNA-N1-methyladenine dioxygenase activity; IDA:UniProtKB.
DR   GO; GO:0008198; F:ferrous iron binding; IDA:UniProtKB.
DR   GO; GO:0016702; F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporDR   GO; GO:0006307; P:DNA dealkylation involved in DNA repair; IDA:UniProtKB.
DR   GO; GO:0006307; P:DNA dealkylation involved in DNA repair; IDA:UniProtKB.
DR   GO; GO:0035511; P:oxidative DNA demethylation; IDA:UniProtKB.
DR   InterPro; IPR005123; Oxoglutarate/Fe-dep_oxygenase.
DR   Pfam; PF03171; 2OG-FeII_Oxy; 1.
DR   PROSITE; PS51471; FE2OG_OXY; 1.
DR   HOGENOMDNA; HS12.PE2132; -.
KW   ENSG000001890461755old_1320000031; ENSP000003981817901old_1320000031;
KW   AY754389; BC070489;
KW   3D-structure; Complete proteome; Dioxygenase; DNA damage; DNA repair;
KW   Iron; Magnesium; Metal-binding; Nucleus; Oxidoreductase; Polymorphism;
KW   Reference proteome.
SQ   SEQUENCE   261 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MDRFLVKGAQ GGLLRKQEEQ EPTGEEPAVL GGDKESTRKR PRREAPGNGG HSAGPSWRHI
     RAEGLDCSYT VLFGKAEADE IFQELEKEVE YFTGALARVQ VFGKWHSVPR KQATYGDAGL
     TYTFSGLTLS PKPWIPVLER IRDHVSGVTG QTFNFVLINR YKDGCDHIGE HRDDERELAP
     GSPIASVSFG ACRDFVFRHK DSRGKSPSRR VAVVRLPLAH GSLLMMNHPT NTHWYHSLPV
     RKKVLAPRVN LTFRKILLTK K
//

If you have problems or comments...

PBIL Back to PBIL home page