(data stored in ACNUC8465 zone)

HOGENOM: HS12_PE2467

ID   HS12_PE2467                          STANDARD;      PRT;   211 AA.
AC   HS12_PE2467; Q9HBH0; Q8WVB1; Q9NXH6;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Rho-related GTP-binding protein RhoF;AltName: Full=Rho
DE   family GTPase Rif;AltName: Full=Rho in filopodia;Flags: Precursor;
DE   (HS12.PE2467).
GN   Name=RHOF; Synonyms=ARHF, RIF;
OS   HOMO SAPIENS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini;
OC   Hominoidea; Hominidae; Homininae; Homo.
OX   NCBI_TaxID=9606;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS HS12.PE2467.
CC       Homo sapiens chromosome 12 GRCh37  sequence 1..133841895 annotated by
CC       Ensembl
CC   -!- ANNOTATIONS ORIGIN:RHOF_HUMAN
CC   -!- FUNCTION: Plasma membrane-associated small GTPase which cycles
CC       between an active GTP-bound and an inactive GDP-bound state.
CC       Causes the formation of thin, actin-rich surface projections
CC       called filopodia. Functions cooperatively with CDC42 and Rac to
CC       generate additional structures, increasing the diversity of actin-
CC       based morphology.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor; Cytoplasmic
CC       side (Potential). Cytoplasm, cytoskeleton.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q9HBH0-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q9HBH0-2; Sequence=VSP_013571, VSP_013572;
CC         Note=No experimental confirmation available;
CC   -!- SIMILARITY: Belongs to the small GTPase superfamily. Rho family.
CC   -!- GENE_FAMILY: HOG000233974 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Homo_sapiens;ENSG00000139725;ENST00000267205;ENSP00000267205.
DR   EMBL; AF239923; - ;
DR   EMBL; AK000254; - ;
DR   EMBL; AK289482; - ;
DR   EMBL; BC018208; - ;
DR   UniProtKB/Swiss-Prot; Q9HBH0; Q8WVB1; Q9NXH6; -.
DR   EMBL; AF239923; AAG24952.1; -; mRNA.
DR   EMBL; AK000254; BAA91034.1; -; mRNA.
DR   EMBL; BC018208; AAH18208.1; -; mRNA.
DR   IPI; IPI00307458; -.
DR   IPI; IPI00382965; -.
DR   RefSeq; NP_061907.2; NM_019034.2.
DR   UniGene; Hs.644504; -.
DR   UniGene; Hs.707579; -.
DR   UniGene; Hs.720066; -.
DR   ProteinModelPortal; Q9HBH0; -.
DR   SMR; Q9HBH0; 12-194.
DR   STRING; Q9HBH0; -.
DR   PhosphoSite; Q9HBH0; -.
DR   PRIDE; Q9HBH0; -.
DR   Ensembl; ENST00000267205; ENSP00000267205; ENSG00000139725.
DR   GeneID; 54509; -.
DR   KEGG; hsa:54509; -.
DR   UCSC; uc001ubb.1; human.
DR   UCSC; uc001ubd.2; human.
DR   CTD; 54509; -.
DR   GeneCards; GC12M119227; -.
DR   H-InvDB; HIX0022113; -.
DR   HGNC; HGNC:15703; RHOF.
DR   neXtProt; NX_Q9HBH0; -.
DR   PharmGKB; PA24954; -.
DR   eggNOG; prNOG06196; -.
DR   GeneTree; ENSGT00550000074256; -.
DR   InParanoid; Q9HBH0; -.
DR   OMA; GPGRKEL; -.
DR   OrthoDB; EOG4NCMDQ; -.
DR   PhylomeDB; Q9HBH0; -.
DR   Reactome; REACT_11044; Signaling by Rho GTPases.
DR   NextBio; 56882; -.
DR   ArrayExpress; Q9HBH0; -.
DR   Bgee; Q9HBH0; -.
DR   CleanEx; HS_RHOF; -.
DR   Genevestigator; Q9HBH0; -.
DR   GermOnline; ENSG00000139725; Homo sapiens.
DR   GO; GO:0005856; C:cytoskeleton; NAS:UniProtKB.
DR   GO; GO:0005829; C:cytosol; TAS:Reactome.
DR   GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003924; F:GTPase activity; NAS:UniProtKB.
DR   GO; GO:0007015; P:actin filament organization; IDA:UniProtKB.
DR   GO; GO:0051056; P:regulation of small GTPase mediated signal transduction; TAS:Reactome.
DR   GO; GO:0007264; P:small GTPase mediated signal transduction; TAS:Reactome.
DR   InterPro; IPR005225; Small_GTP-bd_dom.
DR   InterPro; IPR001806; Small_GTPase.
DR   InterPro; IPR003578; Small_GTPase_Rho.
DR   Pfam; PF00071; Ras; 1.
DR   PRINTS; PR00449; RASTRNSFRMNG.
DR   SMART; SM00174; RHO; 1.
DR   TIGRFAMs; TIGR00231; Small_GTP; 1.
DR   PROSITE; PS51420; RHO; 1.
DR   HOGENOMDNA; HS12.PE2467; -.
KW   ENSG000001397251755old_1320000031; ENSP000002672057901old_1320000031;
KW   A8K0B7_HUMAN; AF239923; AK000254; AK289482; BC018208;
KW   Alternative splicing; Cell membrane; Complete proteome; Cytoplasm;
KW   Cytoskeleton; GTP-binding; Lipoprotein; Membrane; Methylation;
KW   Nucleotide-binding; Prenylation; Reference proteome.
SQ   SEQUENCE   211 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MDAPGALAQT AAPGPGRKEL KIVIVGDGGC GKTSLLMVYS QGSFPEHYAP SVFEKYTASV
     TVGSKEVTLN LYDTAGQEDY DRLRPLSYQN THLVLICYDV MNPTSYDNVL IKWFPEVTHF
     CRGIPMVLIG CKTDLRKDKE QLRKLRAAQL EPITYMQGLS ACEQIRAALY LECSAKFREN
     VEDVFREAAK VALSALKKAQ RQKKRRLCLL L
//

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