(data stored in ACNUC9552 zone)

HOGENOM: HS14_PE246

ID   HS14_PE246                           STANDARD;      PRT;   193 AA.
AC   HS14_PE246; Q92843; A8K0F4; Q2M3U0; Q5U0H4;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Bcl-2-like protein 2; Short=Bcl2-L-2;AltName:
DE   Full=Apoptosis regulator Bcl-W; (HS14.PE246).
GN   Name=BCL2L2; Synonyms=BCLW, KIAA0271;
OS   HOMO SAPIENS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini;
OC   Hominoidea; Hominidae; Homininae; Homo.
OX   NCBI_TaxID=9606;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS HS14.PE246.
CC       Homo sapiens chromosome 14 GRCh37  sequence 1..107289540 annotated by
CC       Ensembl
CC   -!- ANNOTATIONS ORIGIN:B2CL2_HUMAN
CC   -!- FUNCTION: Promotes cell survival. Blocks dexamethasone-induced
CC       apoptosis. Mediates survival of postmitotic Sertoli cells by
CC       suppressing death-promoting activity of BAX.
CC   -!- INTERACTION:
CC       Q9BXH1:BBC3; NbExp=2; IntAct=EBI-707714, EBI-519884;
CC       O43521:BCL2L11; NbExp=2; IntAct=EBI-707714, EBI-526406;
CC       P55957:BID; NbExp=2; IntAct=EBI-707714, EBI-519672;
CC       Q13323:BIK; NbExp=2; IntAct=EBI-707714, EBI-700794;
CC       Q91ZE9:Bmf (xeno); NbExp=2; IntAct=EBI-707714, EBI-708032;
CC   -!- SUBCELLULAR LOCATION: Mitochondrion membrane; Peripheral membrane
CC       protein. Note=Loosely associated with the mitochondrial membrane
CC       in healthy cells. During apoptosis, tightly bound to the membrane.
CC   -!- TISSUE SPECIFICITY: Expressed (at protein level) in a wide range
CC       of tissues with highest levels in brain, spinal cord, testis,
CC       pancreas, heart, spleen and mammary glands. Moderate levels found
CC       in thymus, ovary and small intestine. Not detected in salivary
CC       gland, muscle or liver. Also expressed in cell lines of myeloid,
CC       fibroblast and epithelial origin. Not detected in most lymphoid
CC       cell lines.
CC   -!- DOMAIN: The BH4 motif seems to be involved in the anti-apoptotic
CC       function.
CC   -!- DOMAIN: The BH1 and BH2 motifs form a hydrophobic groove which
CC       acts as a docking site for the BH3 domain of some pro-apoptotic
CC       proteins. The C-terminal residues of BCL2L2 fold into the BH3-
CC       binding cleft and modulate pro-survival activity by regulating
CC       ligand access. When BH3 domain-containing proteins bind, they
CC       displace the C-terminus, allowing its insertion into the membrane
CC       and neutralizing the pro-survival activity of BCL2L2.
CC   -!- SIMILARITY: Belongs to the Bcl-2 family.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAA19666.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
CC   -!- GENE_FAMILY: HOG000056452 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Homo_sapiens;ENSG00000129473;ENST00000250405;ENSP00000250405.
DR   EMBL; AK289519; - ;
DR   EMBL; AL049829; - ;
DR   EMBL; BC021198; - ;
DR   EMBL; BC104789; - ;
DR   EMBL; BC113522; - ;
DR   EMBL; BT019549; - ;
DR   EMBL; CH471078; - ;
DR   EMBL; D87461; - ;
DR   EMBL; U59747; - ;
DR   UniProtKB/Swiss-Prot; Q92843; A8K0F4; Q2M3U0; Q5U0H4; -.
DR   EMBL; U59747; AAB09055.1; -; mRNA.
DR   EMBL; D87461; BAA19666.2; ALT_INIT; mRNA.
DR   EMBL; BT019549; AAV38356.1; -; mRNA.
DR   EMBL; AK289519; BAF82208.1; -; mRNA.
DR   EMBL; AL049829; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH471078; EAW66169.1; -; Genomic_DNA.
DR   EMBL; BC021198; AAH21198.1; -; mRNA.
DR   EMBL; BC104789; AAI04790.1; -; mRNA.
DR   EMBL; BC113522; AAI13523.1; -; mRNA.
DR   IPI; IPI00023787; -.
DR   RefSeq; NP_001186768.1; NM_001199839.1.
DR   RefSeq; NP_004041.1; NM_004050.4.
DR   UniGene; Hs.410026; -.
DR   PDB; 1MK3; NMR; -; A=2-171.
DR   PDB; 1O0L; NMR; -; A=1-183.
DR   PDB; 1ZY3; NMR; -; A=2-171.
DR   PDBsum; 1MK3; -.
DR   PDBsum; 1O0L; -.
DR   PDBsum; 1ZY3; -.
DR   ProteinModelPortal; Q92843; -.
DR   SMR; Q92843; 1-183.
DR   DIP; DIP-33700N; -.
DR   IntAct; Q92843; 11.
DR   STRING; Q92843; -.
DR   PhosphoSite; Q92843; -.
DR   PRIDE; Q92843; -.
DR   Ensembl; ENST00000250405; ENSP00000250405; ENSG00000129473.
DR   GeneID; 599; -.
DR   KEGG; hsa:599; -.
DR   UCSC; uc001wjg.2; human.
DR   CTD; 599; -.
DR   GeneCards; GC14P003892; -.
DR   HGNC; HGNC:995; BCL2L2.
DR   HPA; CAB002048; -.
DR   HPA; CAB040539; -.
DR   MIM; 601931; gene.
DR   neXtProt; NX_Q92843; -.
DR   PharmGKB; PA25307; -.
DR   eggNOG; prNOG12634; -.
DR   GeneTree; ENSGT00530000062935; -.
DR   InParanoid; Q92843; -.
DR   OMA; RMATPAS; -.
DR   OrthoDB; EOG4RBQKR; -.
DR   NextBio; 2439; -.
DR   ArrayExpress; Q92843; -.
DR   Bgee; Q92843; -.
DR   CleanEx; HS_BCL2L2; -.
DR   Genevestigator; Q92843; -.
DR   GermOnline; ENSG00000129473; Homo sapiens.
DR   GO; GO:0031966; C:mitochondrial membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005515; F:protein binding; IPI:IntAct.
DR   GO; GO:0006916; P:anti-apoptosis; TAS:ProtInc.
DR   GO; GO:0006915; P:apoptosis; IEA:UniProtKB-KW.
DR   GO; GO:0007283; P:spermatogenesis; TAS:ProtInc.
DR   InterPro; IPR013280; Apop_reg_BclW.
DR   InterPro; IPR002475; Bcl2-like_apoptosis.
DR   InterPro; IPR000712; Bcl2_BH.
DR   InterPro; IPR020717; Bcl2_BH1_motif_CS.
DR   InterPro; IPR020726; Bcl2_BH2_motif_CS.
DR   InterPro; IPR003093; Bcl2_BH4.
DR   InterPro; IPR020731; Bcl2_BH4_motif_CS.
DR   Pfam; PF00452; Bcl-2; 1.
DR   Pfam; PF02180; BH4; 1.
DR   PRINTS; PR01865; APOPREGBCLW.
DR   PRINTS; PR01862; BCL2FAMILY.
DR   SMART; SM00337; BCL; 1.
DR   SMART; SM00265; BH4; 1.
DR   PROSITE; PS50062; BCL2_FAMILY; 1.
DR   PROSITE; PS01080; BH1; 1.
DR   PROSITE; PS01258; BH2; 1.
DR   PROSITE; PS01260; BH4_1; 1.
DR   PROSITE; PS50063; BH4_2; 1.
DR   HOGENOMDNA; HS14.PE246; -.
KW   ENSG000001294731755old_1320000031; ENSP000002504057901old_1320000031;
KW   AK289519; AL049829; BC021198; BC104789; BC113522; BT019549; CH471078;
KW   U59747;
KW   3D-structure; Apoptosis; Complete proteome; Membrane; Mitochondrion;
KW   Phosphoprotein; Polymorphism; Reference proteome.
SQ   SEQUENCE   193 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MATPASAPDT RALVADFVGY KLRQKGYVCG AGPGEGPAAD PLHQAMRAAG DEFETRFRRT
     FSDLAAQLHV TPGSAQQRFT QVSDELFQGG PNWGRLVAFF VFGAALCAES VNKEMEPLVG
     QVQEWMVAYL ETQLADWIHS SGGWAEFTAL YGDGALEEAR RLREGNWASV RTVLTGAVAL
     GALVTVGAFF ASK
//

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