(data stored in ACNUC32233 zone)

HOGENOM: HS14_PE850

ID   HS14_PE850                           STANDARD;      PRT;   2332 AA.
AC   HS14_PE850; Q59FP5;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   Flags: Fragments;
DE   SubName: Full=Spectrin, beta, erythrocytic (HS14.PE850) (Includes
DE   spherocytosis, clinical type I) variant;Flags: Fragment; .
OS   HOMO SAPIENS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini;
OC   Hominoidea; Hominidae; Homininae; Homo.
OX   NCBI_TaxID=9606;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS HS14.PE850.
CC       Homo sapiens chromosome 14 GRCh37  sequence 1..107289540 annotated by
CC       Ensembl
CC   -!- ANNOTATIONS ORIGIN:Q59FP5_HUMAN
CC   -!- SIMILARITY: Contains 1 PH domain.
CC   -!- GENE_FAMILY: HOG000007281 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Homo_sapiens;ENSG00000070182;ENST00000389723;ENSP00000374373.
DR   EMBL; AB209415; - ;
DR   EMBL; AF013172; - ;
DR   EMBL; AF013173; - ;
DR   EMBL; AF013174; - ;
DR   EMBL; AF013175; - ;
DR   EMBL; AF013176; - ;
DR   EMBL; AF013177; - ;
DR   EMBL; AF013178; - ;
DR   EMBL; AF013179; - ;
DR   EMBL; AF013180; - ;
DR   EMBL; AF013181; - ;
DR   EMBL; AF013182; - ;
DR   EMBL; AF013183; - ;
DR   EMBL; AF013184; - ;
DR   EMBL; AF013185; - ;
DR   EMBL; AF013186; - ;
DR   EMBL; AF013187; - ;
DR   EMBL; EF151925; - ;
DR   UniProtKB/Swiss-Prot; Q59FP5; -.
DR   EMBL; AB209415; BAD92652.1; -; mRNA.
DR   IPI; IPI00914949; -.
DR   RefSeq; NP_000338.3; NM_000347.5.
DR   RefSeq; NP_001020029.1; NM_001024858.2.
DR   UniGene; Hs.417303; -.
DR   ProteinModelPortal; Q59FP5; -.
DR   SMR; Q59FP5; 177-284, 1068-1277, 1591-2087, 2185-2290.
DR   STRING; Q59FP5; -.
DR   PRIDE; Q59FP5; -.
DR   GeneID; 6710; -.
DR   KEGG; hsa:6710; -.
DR   UCSC; uc001xhr.1; human.
DR   CTD; 6710; -.
DR   HGNC; HGNC:11274; SPTB.
DR   OMA; TAESFHR; -.
DR   NextBio; 26166; -.
DR   ArrayExpress; Q59FP5; -.
DR   Bgee; Q59FP5; -.
DR   GO; GO:0008091; C:spectrin; IEA:InterPro.
DR   GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR   GO; GO:0005200; F:structural constituent of cytoskeleton; IEA:InterPro.
DR   InterPro; IPR001589; Actinin_actin-bd_CS.
DR   InterPro; IPR001715; CH-domain.
DR   InterPro; IPR011993; PH_type.
DR   InterPro; IPR001849; Pleckstrin_homology.
DR   InterPro; IPR018159; Spectrin/alpha-actinin.
DR   InterPro; IPR016343; Spectrin_bsu.
DR   InterPro; IPR001605; Spectrin_PH.
DR   InterPro; IPR002017; Spectrin_repeat.
DR   Gene3D; G3DSA:1.10.418.10; Calponin-homology; 2.
DR   Gene3D; G3DSA:2.30.29.30; PH_type; 1.
DR   Pfam; PF00307; CH; 2.
DR   Pfam; PF00169; PH; 1.
DR   Pfam; PF00435; Spectrin; 17.
DR   PIRSF; PIRSF002297; Spectrin_beta_subunit; 1.
DR   PRINTS; PR00683; SPECTRINPH.
DR   SMART; SM00033; CH; 2.
DR   SMART; SM00233; PH; 1.
DR   SMART; SM00150; SPEC; 17.
DR   SUPFAM; SSF47576; Calponin-homology; 1.
DR   PROSITE; PS00019; ACTININ_1; 1.
DR   PROSITE; PS00020; ACTININ_2; 1.
DR   PROSITE; PS50021; CH; 2.
DR   PROSITE; PS50003; PH_DOMAIN; 1.
DR   HOGENOMDNA; HS14.PE850; -.
KW   ENSG000000701821755old_1320000031; ENSP000003743737901old_1320000031;
KW   O14724_HUMAN; O14725_HUMAN; O14726_HUMAN; Q59FP5_HUMAN; Q71VF8_HUMAN;
KW   Q71VG0_HUMAN; Q71VG1_HUMAN; Q71VG2_HUMAN; AB209415; AF013172; AF013173;
KW   AF013175; AF013176; AF013177; AF013178; AF013179; AF013180; AF013181;
KW   AF013183; AF013184; AF013185; AF013186; AF013187; EF151925;
KW   Actin-binding; Repeat.
SQ   SEQUENCE   2332 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     EPADMTSATE FENVGNQPPY SRINARWDAP DDELDNDNSS ARLFERSRIK ALADEREVVQ
     KKTFTKWVNS HLARVSCRIT DLYKDLRDGR MLIKLLEVLS GEMLPKPTKG KMRIHCLENV
     DKALQFLKEQ RVHLENMGSH DIVDGNHRLV LGLIWTIILR FQIQDIVVQT QEGRETRSAK
     DALLLWCQMK TAGYPHVNVT NFTSSWKDGL AFNALIHKHR PDLIDFDKLK DSNARHNLEH
     AFNVAERQLG IIPLLDPEDV FTENPDEKSI ITYVVAFYHY FSKMKVLAVE GKRVGKVIDH
     AIETEKMIEK YSGLASDLLT WIEQTITVLN SRKFANSLTG VQQQLQAFST YRTVEKPPKF
     QEKGNLEVLL FTIQSRMRAN NQKVYTPHDG KLVSDINRAW ESLEEAEYRR ELALRNELIR
     QEKLEQLARR FDRKAAMRET WLSENQRLVA QDNFGYDLAA VEAAKKKHEA IETDTAAYEE
     RVRALEDLAQ ELEKENYHDQ KRITARKDNI LRLWSYLQEL LQSRRQRLET TLALQKLFQD
     MLHSIDWMDE IKAHLLSAEF GKHLLEVEDL LQKHKLMEAD IAIQGDKVKA ITAATLKFTE
     GKGYQPCDPQ VIQDRISHLE QCFEELSNMA AGRKAQLEQS KRLWKFFWEM DEAESWIKEK
     EQIYSSLDYG KDLTSVLILQ RKHKAFEDEL RGLDAHLEQI FQEAHGMVAR KQFGHPQIEA
     RIKEVSAQWD QLKDLAAFCK KNLQDAENFF QFQGDADDLK AWLQDAHRLL SGEDVGQDEG
     ATRALGKKHK DFLEELEESR GVMEHLEQQA QGFPEEFRDS PDVTHRLQAL RELYQQVVAQ
     ADLRQQRLQE ALDLYTVFGE TDACELWMGE KEKWLAEMEM PDTLEDLEVV QHRFDILDQE
     MKTLMTQIDG VNLAANSLVE SGHPRSREVK QYQDHLNTRW QAFQTLVSER REAVDSALRV
     HNYCVDCEET SKWITDKTKV VESTKDLGRD LAGIIAIQRK LSGLERDVAA IQARVDALER
     ESQQLMDSHP EQKEDIGQRQ KHLEELWQGL QQSLQGQEDL LGEVSQLQAF LQDLDDFQAW
     LSITQKAVAS EDMPESLPEA EQLLQQHAGI KDEIDGHQDS YQRVKESGEK VIQGQTDPEY
     LLLGQRLEGL DTGWNALGRM WESRSHTLAQ CLGFQEFQKD AKQAEAILSN QEYTLAHLEP
     PDSLEAAEAG IRKFEDFLGS MENNRDKVLS PVDSGNKLVA EGNLYSDKIK EKVQLIEDRH
     RKNNEKAQEA SVLLRDNLEL QNFLQNCQEL TLWINDKLLT SQDVSYDEAR NLHNKWLKHQ
     AFVAELASHE GWLENIDAEG KQLMDEKPQF TALVSQKLEA LHRLWDELQA TTKEKTQHLS
     AARSSDLRLQ THADLNKWIS AMEDQLRSDD PGKDLTSVNR MLAKLKRVED QVNVRKEELG
     ELFAQVPSMG EEGGDADLSI EKRFLDLLEP LGRRKKQLES SRAKLQISRD LEDETLWVEE
     RLPLAQSADY GTNLQTVQLF MKKNQTLQNE ILGHTPRVED VLQRGQQLVE AAEIDCQDLE
     ERLGHLQSSW DRLREAAAGR LQRLRDANEA QQYYLDADEA EAWIGEQELY VISDEIPKDE
     EGAIVMLKRH LRQQRAVEDY GRNIKQLASR AQGLLSAGHP EGEQIIRLQG QVDKHYAGLK
     DVAEERKRKL ENMYHLFQLK RETDDLEQWI SEKELVASSP EMGQDFDHVT LLRDKFRDFA
     RETGAIGQER VDNVNAFIER LIDAGHSEAA TIAEWKDGLN EMWADLLELI DTRMQLLAAS
     YDLHRYFYTG AEILGLIDEK HRELPEDVGL DASTAESFHR VHTAFERELH LLGVQVQQFQ
     DVATRLQTAY AGEKAEAIQN KEQEVSAAWQ ALLDACAGRR TQLVDTADKF RFFSMARDLL
     SWMESIIRQI ETQERPRDVS SVELLMKYHQ GINAEIETRS KNFSACLELG ESLLQRQHQA
     SEEIREKLQQ VMSRRKEMNE KWEARWERLR MLLEVCQFSR DASVAEAWLI AQEPYLASGD
     FGHTVDSVEK LIKRHEAFEK STASWAERFA ALEKPTTLEL KERQIAERPA EETGPQEEEG
     ETAGEAPVSH HAATERTSPG EEEGTWPQNL QQPPPPGQHK DGQKSTGDER PTTEPLFKVL
     DTPLSEGDEP ATLPAPRDHG QSVQMEGYLG RKHDLEGPNK KASNRSWNNL YCVLRNSELT
     FYKDAKNLAL GMPYHGEEPL ALRHAICEIA ANYKKKKHVF KLRLSNGSEW LFHGKDEEEM
     LSWLQGVSTA INESQSIRVK AQSLPLPSLS GPDASLGKKD KEKRFSFFPK KK
//

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