(data stored in ACNUC8465 zone)

HOGENOM: HS15_PE311

ID   HS15_PE311                           STANDARD;      PRT;   236 AA.
AC   HS15_PE311; Q96L33; Q2KHQ5; Q8TDW6;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Rho-related GTP-binding protein RhoV;AltName:
DE   Full=CDC42-like GTPase 2;AltName: Full=GTP-binding protein-like
DE   2;AltName: Full=Rho GTPase-like protein ARHV;AltName: Full=Wnt-1
DE   responsive Cdc42 homolog 2; Short=WRCH-2; (HS15.PE311).
GN   Name=RHOV; Synonyms=ARHV, WRCH2;
OS   HOMO SAPIENS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini;
OC   Hominoidea; Hominidae; Homininae; Homo.
OX   NCBI_TaxID=9606;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS HS15.PE311.
CC       Homo sapiens chromosome 15 GRCh37  sequence 1..102521392 annotated by
CC       Ensembl
CC   -!- ANNOTATIONS ORIGIN:RHOV_HUMAN
CC   -!- FUNCTION: Plays a role in the control of the actin cytoskeleton
CC       via activation of the JNK pathway (By similarity).
CC   -!- COFACTOR: Magnesium (By similarity).
CC   -!- SUBUNIT: Interacts with PAK2 (By similarity).
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor; Cytoplasmic
CC       side (By similarity). Endosome membrane; Lipid-anchor; Cytoplasmic
CC       side (By similarity). Note=Treatment with TNF activates endosomal
CC       but not plasma membrane RHOV (By similarity).
CC   -!- TISSUE SPECIFICITY: Highly expressed in pancreas, placenta, and
CC       fetal brain.
CC   -!- SIMILARITY: Belongs to the small GTPase superfamily. Rho family.
CC   -!- GENE_FAMILY: HOG000233974 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Homo_sapiens;ENSG00000104140;ENST00000220507;ENSP00000220507.
DR   EMBL; AB079131; - ;
DR   EMBL; AY059636; - ;
DR   EMBL; BC105020; - ;
DR   EMBL; BC105022; - ;
DR   EMBL; BC112945; - ;
DR   EMBL; CH471125; - ;
DR   UniProtKB/Swiss-Prot; Q96L33; Q2KHQ5; Q8TDW6; -.
DR   EMBL; AB079131; BAB86363.1; -; mRNA.
DR   EMBL; AY059636; AAL17966.1; -; mRNA.
DR   EMBL; CH471125; EAW92459.1; -; Genomic_DNA.
DR   EMBL; BC105020; AAI05021.1; -; mRNA.
DR   EMBL; BC105022; AAI05023.1; -; mRNA.
DR   EMBL; BC112945; AAI12946.2; -; mRNA.
DR   IPI; IPI00154827; -.
DR   RefSeq; NP_598378.3; NM_133639.3.
DR   UniGene; Hs.447901; -.
DR   HSSP; P60763; 2C2H.
DR   ProteinModelPortal; Q96L33; -.
DR   SMR; Q96L33; 31-208.
DR   STRING; Q96L33; -.
DR   Ensembl; ENST00000220507; ENSP00000220507; ENSG00000104140.
DR   GeneID; 171177; -.
DR   KEGG; hsa:171177; -.
DR   UCSC; uc001znd.1; human.
DR   CTD; 171177; -.
DR   GeneCards; GC15M018012; -.
DR   H-InvDB; HIX0038068; -.
DR   HGNC; HGNC:18313; RHOV.
DR   HPA; HPA043713; -.
DR   neXtProt; NX_Q96L33; -.
DR   PharmGKB; PA38313; -.
DR   GeneTree; ENSGT00560000076971; -.
DR   InParanoid; Q96L33; -.
DR   OrthoDB; EOG4255TJ; -.
DR   PhylomeDB; Q96L33; -.
DR   Reactome; REACT_11044; Signaling by Rho GTPases.
DR   NextBio; 89215; -.
DR   ArrayExpress; Q96L33; -.
DR   Bgee; Q96L33; -.
DR   CleanEx; HS_RHOV; -.
DR   Genevestigator; Q96L33; -.
DR   GO; GO:0005829; C:cytosol; TAS:Reactome.
DR   GO; GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0051056; P:regulation of small GTPase mediated signal transduction; TAS:Reactome.
DR   GO; GO:0007264; P:small GTPase mediated signal transduction; TAS:Reactome.
DR   InterPro; IPR005225; Small_GTP-bd_dom.
DR   InterPro; IPR001806; Small_GTPase.
DR   InterPro; IPR003578; Small_GTPase_Rho.
DR   Pfam; PF00071; Ras; 1.
DR   PRINTS; PR00449; RASTRNSFRMNG.
DR   SMART; SM00174; RHO; 1.
DR   TIGRFAMs; TIGR00231; Small_GTP; 1.
DR   PROSITE; PS51420; RHO; 1.
DR   HOGENOMDNA; HS15.PE311; -.
KW   ENSG000001041401755old_1320000031; ENSP000002205077901old_1320000031;
KW   AB079131; AY059636; BC105020; BC105022; BC112945; CH471125;
KW   Cell membrane; Complete proteome; Endosome; GTP-binding; Lipoprotein;
KW   Magnesium; Membrane; Metal-binding; Nucleotide-binding; Palmitate;
KW   Reference proteome.
SQ   SEQUENCE   236 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MPPRELSEAE PPPLRAPTPP PRRRSAPPEL GIKCVLVGDG AVGKSSLIVS YTCNGYPARY
     RPTALDTFSV QVLVDGAPVR IELWDTAGQE DFDRLRSLCY PDTDVFLACF SVVQPSSFQN
     ITEKWLPEIR THNPQAPVLL VGTQADLRDD VNVLIQLDQG GREGPVPQPQ AQGLAEKIRA
     CCYLECSALT QKNLKEVFDS AILSAIEHKA RLEKKLNAKG VRTLSRCRWK KFFCFV
//

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