(data stored in ACNUC18858 zone)

HOGENOM: HS15_PE807

ID   HS15_PE807                           STANDARD;      PRT;   438 AA.
AC   HS15_PE807; O95395;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Beta-1,3-galactosyl-O-glycosyl-glycoprotein
DE   beta-1,6-N-acetylglucosaminyltransferase 3; EC=2.4.1.102; EC=2.4.1
DE   150;AltName: Full=C2GnT-mucin type; Short=C2GnT-M;
DE   Short=hC2GnT-M;AltName: Full=Core 2/core 4
DE   beta-1,6-N-acetylglucosaminyltransferase; Short=C2/4GnT; (HS15.PE807).
GN   Name=GCNT3;
OS   HOMO SAPIENS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini;
OC   Hominoidea; Hominidae; Homininae; Homo.
OX   NCBI_TaxID=9606;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS HS15.PE807.
CC       Homo sapiens chromosome 15 GRCh37  sequence 1..102521392 annotated by
CC       Ensembl
CC   -!- ANNOTATIONS ORIGIN:GCNT3_HUMAN
CC   -!- FUNCTION: Glycosyltransferase that can synthesize all known mucin
CC       beta 6 N-acetylglucosaminides. Mediates core 2 and core 4 O-glycan
CC       branching, 2 important steps in mucin-type biosynthesis. Has also
CC       I-branching enzyme activity by converting linear into branched
CC       poly-N-acetyllactosaminoglycans, leading to introduce the blood
CC       group I antigen during embryonic development.
CC   -!- CATALYTIC ACTIVITY: UDP-N-acetyl-D-glucosamine + beta-D-
CC       galactosyl-1,3-N-acetyl-D-galactosaminyl-R = UDP + beta-D-
CC       galactosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,6)-N-acetyl-D-
CC       galactosaminyl-R.
CC   -!- CATALYTIC ACTIVITY: UDP-N-acetyl-D-glucosamine + beta-D-
CC       galactosyl-1,4-N-acetyl-D-glucosaminyl-R = UDP + N-acetyl-beta-D-
CC       glucosaminyl-1,6-beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-R.
CC   -!- PATHWAY: Protein modification; protein glycosylation.
CC   -!- SUBCELLULAR LOCATION: Golgi apparatus membrane; Single-pass type
CC       II membrane protein (By similarity).
CC   -!- TISSUE SPECIFICITY: Primarily expressed in mucus-secreting
CC       tissues. Expressed in colon, kidney, small intestine, trachea, and
CC       stomach, where mucin is produced.
CC   -!- INDUCTION: By all-trans retinoic acid (ATRA), TNF and
CC       IL13/interleukin-13. Strongly down-regulated in colorectal cancer.
CC   -!- PTM: N-glycosylated (By similarity).
CC   -!- SIMILARITY: Belongs to the glycosyltransferase 14 family.
CC   -!- WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology
CC       and Haematology;
CC       URL="http://atlasgeneticsoncology.org/Genes/GCNT3ID44105ch15q21.html";
CC   -!- WEB RESOURCE: Name=GGDB; Note=GlycoGene database;
CC       URL="http://riodb.ibase.aist.go.jp/rcmg/ggdb/Homolog?cat=symbol&symbol=GCNT3";
CC   -!- WEB RESOURCE: Name=Functional Glycomics Gateway - GTase; Note=Core
CC       2/core 4 beta-1,6-N-acetylglucosaminyltransferase;
CC       URL="http://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_hum_544";
CC   -!- GENE_FAMILY: HOG000293251 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Homo_sapiens;ENSG00000140297;ENST00000396065;ENSP00000379377.
DR   EMBL; AF038650; - ;
DR   EMBL; AF102542; - ;
DR   EMBL; AK312852; - ;
DR   EMBL; BC017032; - ;
DR   EMBL; EF152283; - ;
DR   UniProtKB/Swiss-Prot; O95395; -.
DR   EMBL; AF102542; AAD10824.1; -; mRNA.
DR   EMBL; AF038650; AAD21525.1; -; mRNA.
DR   EMBL; EF152283; ABM21534.1; -; mRNA.
DR   EMBL; BC017032; AAH17032.1; -; mRNA.
DR   IPI; IPI00006248; -.
DR   RefSeq; NP_004742.1; NM_004751.2.
DR   UniGene; Hs.194710; -.
DR   ProteinModelPortal; O95395; -.
DR   SMR; O95395; 62-433.
DR   STRING; O95395; -.
DR   CAZy; GT14; Glycosyltransferase Family 14.
DR   PRIDE; O95395; -.
DR   Ensembl; ENST00000267857; ENSP00000267857; ENSG00000140297.
DR   Ensembl; ENST00000396065; ENSP00000379377; ENSG00000140297.
DR   GeneID; 9245; -.
DR   KEGG; hsa:9245; -.
DR   UCSC; uc002agd.1; human.
DR   CTD; 9245; -.
DR   GeneCards; GC15P036725; -.
DR   H-InvDB; HIX0012295; -.
DR   HGNC; HGNC:4205; GCNT3.
DR   HPA; HPA011154; -.
DR   MIM; 606836; gene.
DR   neXtProt; NX_O95395; -.
DR   PharmGKB; PA28620; -.
DR   eggNOG; prNOG11348; -.
DR   GeneTree; ENSGT00550000074330; -.
DR   InParanoid; O95395; -.
DR   OMA; LWALGCY; -.
DR   OrthoDB; EOG4X6C8B; -.
DR   PhylomeDB; O95395; -.
DR   NextBio; 34657; -.
DR   ArrayExpress; O95395; -.
DR   Bgee; O95395; -.
DR   CleanEx; HS_GCNT3; -.
DR   Genevestigator; O95395; -.
DR   GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005624; C:membrane fraction; TAS:ProtInc.
DR   GO; GO:0003829; F:beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity; IEDR   GO; GO:0008109; F:N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity; TAS:ProtInc.
DR   GO; GO:0008109; F:N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity; TAS:ProtInc.
DR   GO; GO:0006493; P:protein O-linked glycosylation; TAS:ProtInc.
DR   InterPro; IPR003406; Glyco_trans_14.
DR   Pfam; PF02485; Branch; 1.
DR   HOGENOMDNA; HS15.PE807; -.
KW   ENSG000001402971755old_1320000031; ENSP000003793777901old_1320000031;
KW   B2R758_HUMAN; AF038650; AF102542; AK312852; BC017032; EF152283;
KW   Complete proteome; Disulfide bond; Glycoprotein; Glycosyltransferase;
KW   Golgi apparatus; Membrane; Reference proteome; Signal-anchor;
KW   Transferase; Transmembrane; Transmembrane helix.
SQ   SEQUENCE   438 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MVQWKRLCQL HYLWALGCYM LLATVALKLS FRLKCDSDHL GLESRESQSQ YCRNILYNFL
     KLPAKRSINC SGVTRGDQEA VLQAILNNLE VKKKREPFTD THYLSLTRDC EHFKAERKFI
     QFPLSKEEVE FPIAYSMVIH EKIENFERLL RAVYAPQNIY CVHVDEKSPE TFKEAVKAII
     SCFPNVFIAS KLVRVVYASW SRVQADLNCM EDLLQSSVPW KYFLNTCGTD FPIKSNAEMV
     QALKMLNGRN SMESEVPPKH KETRWKYHFE VVRDTLHLTN KKKDPPPYNL TMFTGNAYIV
     ASRDFVQHVL KNPKSQQLIE WVKDTYSPDE HLWATLQRAR WMPGSVPNHP KYDISDMTSI
     ARLVKWQGHE GDIDKGAPYA PCSGIHQRAI CVYGAGDLNW MLQNHHLLAN KFDPKVDDNA
     LQCLEEYLRY KAIYGTEL
//

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