(data stored in ACNUC8465 zone)

HOGENOM: HS15_PE993

ID   HS15_PE993                           STANDARD;      PRT;   448 AA.
AC   HS15_PE993; Q13163; Q92961; Q92962;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Dual specificity mitogen-activated protein kinase kinase 5;
DE   Short=MAP kinase kinase 5; Short=MAPKK 5; EC=2.7.12 2;AltName:
DE   Full=MAPK/ERK kinase 5; Short=MEK 5; (HS15.PE993).
GN   Name=MAP2K5; Synonyms=MEK5, MKK5, PRKMK5;
OS   HOMO SAPIENS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini;
OC   Hominoidea; Hominidae; Homininae; Homo.
OX   NCBI_TaxID=9606;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS HS15.PE993.
CC       Homo sapiens chromosome 15 GRCh37  sequence 1..102521392 annotated by
CC       Ensembl
CC   -!- ANNOTATIONS ORIGIN:MP2K5_HUMAN
CC   -!- FUNCTION: Acts as a scaffold for the formation of a ternary
CC       MAP3K2/MAP3K3-MAP3K5-MAPK7 signaling complex. Activation of this
CC       pathway appear to play a critical role in protecting cells from
CC       stress-induced apopotosis, neuronal survival and cardiac
CC       development and angiogenesis.
CC   -!- CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein.
CC   -!- COFACTOR: Magnesium.
CC   -!- SUBUNIT: Interacts with PARD6A, MAP3K3 and MAPK7. Forms a complex
CC       with SQSTM1 and PRKCZ or PRKCI (By similarity). Interacts with
CC       Yersinia yopJ.
CC   -!- INTERACTION:
CC       P62993:GRB2; NbExp=2; IntAct=EBI-307294, EBI-401755;
CC       Q13164:MAPK7; NbExp=2; IntAct=EBI-307294, EBI-1213983;
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=3;
CC       Name=B;
CC         IsoId=Q13163-1; Sequence=Displayed;
CC       Name=A;
CC         IsoId=Q13163-2; Sequence=VSP_021825;
CC       Name=C;
CC         IsoId=Q13163-3; Sequence=VSP_021825, VSP_021826;
CC         Note=Incomplete sequence;
CC   -!- TISSUE SPECIFICITY: Expressed in many adult tissues. Abundant in
CC       heart and skeletal muscle.
CC   -!- DOMAIN: Binds MAP3K2/MAP3K3 and MAPK7 via non-overlapping residues
CC       of the OPR domain. This domain also mediates interactions with
CC       SQSTM1 and PARD6A (By similarity).
CC   -!- PTM: Activated by phosphorylation on Ser/Thr by MAP kinase kinase
CC       kinases (By similarity).
CC   -!- PTM: Yersinia yopJ may acetylate Ser/Thr residues, preventing
CC       phosphorylation and activation, thus blocking the MAPK signaling
CC       pathway.
CC   -!- SIMILARITY: Belongs to the protein kinase superfamily. STE Ser/Thr
CC       protein kinase family. MAP kinase kinase subfamily.
CC   -!- SIMILARITY: Contains 1 OPR domain.
CC   -!- SIMILARITY: Contains 1 protein kinase domain.
CC   -!- GENE_FAMILY: HOG000234206 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Homo_sapiens;ENSG00000137764;ENST00000178640;ENSP00000178640.
DR   EMBL; AK293459; - ;
DR   EMBL; AK315435; - ;
DR   EMBL; BC008838; - ;
DR   EMBL; BT006780; - ;
DR   EMBL; CR542229; - ;
DR   EMBL; U25265; - ;
DR   EMBL; U71087; - ;
DR   EMBL; U71088; - ;
DR   UniProtKB/Swiss-Prot; Q13163; Q92961; Q92962; -.
DR   EMBL; U25265; AAA96146.1; -; mRNA.
DR   EMBL; U71087; AAB16851.1; -; mRNA.
DR   EMBL; U71088; AAB16852.2; -; mRNA.
DR   EMBL; BT006780; AAP35426.1; -; mRNA.
DR   EMBL; CR542229; CAG47025.1; -; mRNA.
DR   EMBL; BC008838; AAH08838.1; -; mRNA.
DR   IPI; IPI00158248; -.
DR   IPI; IPI00185860; -.
DR   IPI; IPI00219607; -.
DR   RefSeq; NP_001193733.1; NM_001206804.1.
DR   RefSeq; NP_002748.1; NM_002757.3.
DR   RefSeq; NP_660143.1; NM_145160.2.
DR   UniGene; Hs.114198; -.
DR   PDB; 2NPT; X-ray; 1.75 A; A/C=5-108.
DR   PDB; 2O2V; X-ray; 1.83 A; A=5-108.
DR   PDBsum; 2NPT; -.
DR   PDBsum; 2O2V; -.
DR   ProteinModelPortal; Q13163; -.
DR   SMR; Q13163; 16-108, 159-437.
DR   DIP; DIP-27558N; -.
DR   IntAct; Q13163; 5.
DR   MINT; MINT-1155433; -.
DR   STRING; Q13163; -.
DR   PhosphoSite; Q13163; -.
DR   PRIDE; Q13163; -.
DR   Ensembl; ENST00000178640; ENSP00000178640; ENSG00000137764.
DR   GeneID; 5607; -.
DR   KEGG; hsa:5607; -.
DR   UCSC; uc002aqu.1; human.
DR   UCSC; uc002aqv.1; human.
DR   CTD; 5607; -.
DR   GeneCards; GC15P044669; -.
DR   H-InvDB; HIX0012373; -.
DR   HGNC; HGNC:6845; MAP2K5.
DR   HPA; CAB022094; -.
DR   HPA; HPA027347; -.
DR   HPA; HPA027755; -.
DR   MIM; 602520; gene.
DR   neXtProt; NX_Q13163; -.
DR   PharmGKB; PA30590; -.
DR   eggNOG; prNOG04411; -.
DR   GeneTree; ENSGT00570000078767; -.
DR   InParanoid; Q13163; -.
DR   OMA; HAMENQV; -.
DR   OrthoDB; EOG49GKGK; -.
DR   PhylomeDB; Q13163; -.
DR   BRENDA; 2.7.12.2; 2681.
DR   Pathway_Interaction_DB; mapktrkpathway; Trk receptor signaling mediated by the MAPK pathway.
DR   Reactome; REACT_11061; Signalling by NGF.
DR   NextBio; 21792; -.
DR   ArrayExpress; Q13163; -.
DR   Bgee; Q13163; -.
DR   CleanEx; HS_MAP2K5; -.
DR   Genevestigator; Q13163; -.
DR   GermOnline; ENSG00000137764; Homo sapiens.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0005515; F:protein binding; IPI:IntAct.
DR   GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR   GO; GO:0004713; F:protein tyrosine kinase activity; IEA:UniProtKB-KW.
DR   GO; GO:0048011; P:nerve growth factor receptor signaling pathway; TAS:Reactome.
DR   InterPro; IPR011009; Kinase-like_dom.
DR   InterPro; IPR000270; OPR_PB1.
DR   InterPro; IPR000719; Prot_kinase_cat_dom.
DR   InterPro; IPR017441; Protein_kinase_ATP_BS.
DR   InterPro; IPR017442; Se/Thr_kinase-like_dom.
DR   InterPro; IPR008271; Ser/Thr_kinase_AS.
DR   InterPro; IPR002290; Ser/Thr_kinase_dom.
DR   Pfam; PF00564; PB1; 1.
DR   Pfam; PF00069; Pkinase; 1.
DR   SMART; SM00666; PB1; 1.
DR   SMART; SM00220; S_TKc; 1.
DR   SUPFAM; SSF56112; Kinase_like; 1.
DR   PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
DR   HOGENOMDNA; HS15.PE993; -.
KW   ENSG000001377641755old_1320000031; ENSP000001786407901old_1320000031;
KW   B2RD76_HUMAN; B4DE43_HUMAN; AK293459; AK315435; BC008838; BT006780;
KW   U25265; U71087; U71088;
KW   3D-structure; Acetylation; Alternative splicing; ATP-binding;
KW   Complete proteome; Kinase; Magnesium; Metal-binding;
KW   Nucleotide-binding; Phosphoprotein; Polymorphism; Reference proteome;
KW   Serine/threonine-protein kinase; Transferase; Tyrosine-protein kinase.
SQ   SEQUENCE   448 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MLWLALGPFP AMENQVLVIR IKIPNSGAVD WTVHSGPQLL FRDVLDVIGQ VLPEATTTAF
     EYEDEDGDRI TVRSDEEMKA MLSYYYSTVM EQQVNGQLIE PLQIFPRACK PPGERNIHGL
     KVNTRAGPSQ HSSPAVSDSL PSNSLKKSSA ELKKILANGQ MNEQDIRYRD TLGHGNGGTV
     YKAYHVPSGK ILAVKVILLD ITLELQKQIM SELEILYKCD SSYIIGFYGA FFVENRISIC
     TEFMDGGSLD VYRKMPEHVL GRIAVAVVKG LTYLWSLKIL HRDVKPSNML VNTRGQVKLC
     DFGVSTQLVN SIAKTYVGTN AYMAPERISG EQYGIHSDVW SLGISFMELA LGRFPYPQIQ
     KNQGSLMPLQ LLQCIVDEDS PVLPVGEFSE PFVHFITQCM RKQPKERPAP EELMGHPFIV
     QFNDGNAAVV SMWVCRALEE RRSQQGPP
//

If you have problems or comments...

PBIL Back to PBIL home page