(data stored in ACNUC23329 zone)

HOGENOM: HS16_PE1498

ID   HS16_PE1498                          STANDARD;      PRT;   397 AA.
AC   HS16_PE1498; P78423; O00672;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Fractalkine;AltName: Full=C-X3-C motif chemokine 1;AltName:
DE   Full=CX3C membrane-anchored chemokine;AltName: Full=Neurotactin;AltName:
DE   Full=Small-inducible cytokine D1;Contains: RecName: Full=Processed
DE   fractalkine;Flags: Precursor; (HS16.PE1498).
GN   Name=CX3CL1; Synonyms=FKN, NTT, SCYD1; ORFNames=A-152E5.2;
OS   HOMO SAPIENS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini;
OC   Hominoidea; Hominidae; Homininae; Homo.
OX   NCBI_TaxID=9606;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS HS16.PE1498.
CC       Homo sapiens chromosome 16 GRCh37  sequence 1..90294753 annotated by
CC       Ensembl
CC   -!- ANNOTATIONS ORIGIN:X3CL1_HUMAN
CC   -!- FUNCTION: The soluble form is chemotactic for T-cells and
CC       monocytes, but not for neutrophils. The membrane-bound form
CC       promotes adhesion of those leukocytes to endothelial cells. May
CC       play a role in regulating leukocyte adhesion and migration
CC       processes at the endothelium. Binds to CX3CR1.
CC   -!- SUBUNIT: Monomer.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane
CC       protein.
CC   -!- SUBCELLULAR LOCATION: Processed fractalkine: Secreted.
CC   -!- TISSUE SPECIFICITY: Small intestine, colon, testis, prostate,
CC       heart, brain, lung, skeletal muscle, kidney and pancreas.
CC   -!- INDUCTION: By TNF and IL1/interleukin-1 in pulmonary endothelial
CC       cells and umbilical vein endothelial cells.
CC   -!- PTM: A soluble short 95 kDa form may be released by proteolytic
CC       cleavage from the long membrane-anchored form (By similarity).
CC   -!- PTM: O-glycosylated with core 1 or possibly core 8 glycans.
CC   -!- SIMILARITY: Belongs to the intercrine delta family.
CC   -!- WEB RESOURCE: Name=Wikipedia; Note=CX3CL1 entry;
CC       URL="http://en.wikipedia.org/wiki/CX3CL1";
CC   -!- GENE_FAMILY: HOG000036946 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Homo_sapiens;ENSG00000006210;ENST00000006053;ENSP00000006053.
DR   EMBL; AB209037; - ;
DR   EMBL; AC004382; - ;
DR   EMBL; AK222692; - ;
DR   EMBL; AK223351; - ;
DR   EMBL; AK313806; - ;
DR   EMBL; BC001163; - ;
DR   EMBL; BC016164; - ;
DR   EMBL; CH471092; - ;
DR   EMBL; CR457426; - ;
DR   EMBL; EF064745; - ;
DR   EMBL; U84487; - ;
DR   EMBL; U91835; - ;
DR   UniProtKB/Swiss-Prot; P78423; O00672; -.
DR   EMBL; U91835; AAB50014.1; -; mRNA.
DR   EMBL; U84487; AAB49679.1; -; mRNA.
DR   EMBL; AC004382; AAC24307.1; -; Genomic_DNA.
DR   EMBL; BC001163; AAH01163.1; -; mRNA.
DR   EMBL; BC016164; AAH16164.1; -; mRNA.
DR   IPI; IPI00019771; -.
DR   RefSeq; NP_002987.1; NM_002996.3.
DR   UniGene; Hs.531668; -.
DR   PDB; 1B2T; NMR; -; A=25-100.
DR   PDB; 1F2L; X-ray; 2.00 A; A/B/C/D=25-98.
DR   PDBsum; 1B2T; -.
DR   PDBsum; 1F2L; -.
DR   ProteinModelPortal; P78423; -.
DR   SMR; P78423; 25-100.
DR   DIP; DIP-5878N; -.
DR   STRING; P78423; -.
DR   PhosphoSite; P78423; -.
DR   PeptideAtlas; P78423; -.
DR   PRIDE; P78423; -.
DR   Ensembl; ENST00000006053; ENSP00000006053; ENSG00000006210.
DR   GeneID; 6376; -.
DR   KEGG; hsa:6376; -.
DR   UCSC; uc002eli.1; human.
DR   CTD; 6376; -.
DR   GeneCards; GC16P043274; -.
DR   H-InvDB; HIX0013072; -.
DR   HGNC; HGNC:10647; CX3CL1.
DR   HPA; CAB026192; -.
DR   HPA; HPA040361; -.
DR   MIM; 601880; gene.
DR   neXtProt; NX_P78423; -.
DR   InParanoid; P78423; -.
DR   OMA; YQSLQGC; -.
DR   OrthoDB; EOG415GDN; -.
DR   PhylomeDB; P78423; -.
DR   Reactome; REACT_14797; Signaling by GPCR.
DR   NextBio; 24772; -.
DR   PMAP-CutDB; P78423; -.
DR   ArrayExpress; P78423; -.
DR   Bgee; P78423; -.
DR   CleanEx; HS_CX3CL1; -.
DR   Genevestigator; P78423; -.
DR   GermOnline; ENSG00000006210; Homo sapiens.
DR   GO; GO:0009986; C:cell surface; IDA:UniProtKB.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0016021; C:integral to membrane; IDA:UniProtKB.
DR   GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR   GO; GO:0008009; F:chemokine activity; TAS:UniProtKB.
DR   GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR   GO; GO:0019221; P:cytokine-mediated signaling pathway; TAS:UniProtKB.
DR   GO; GO:0006952; P:defense response; TAS:UniProtKB.
DR   GO; GO:0006955; P:immune response; TAS:UniProtKB.
DR   GO; GO:0050902; P:leukocyte adhesive activation; TAS:UniProtKB.
DR   GO; GO:0051041; P:positive regulation of calcium-independent cell-cell adhesion; IDA:UniProtKB.
DR   GO; GO:0050729; P:positive regulation of inflammatory response; IEP:UniProtKB.
DR   InterPro; IPR008097; Chemokine_fractalkine_CX3CL1.
DR   InterPro; IPR001811; Chemokine_IL8-like_dom.
DR   Pfam; PF00048; IL8; 1.
DR   PRINTS; PR01721; FRACTALKINE.
DR   SMART; SM00199; SCY; 1.
DR   SUPFAM; SSF54117; Chemokine_IL8; 1.
DR   HOGENOMDNA; HS16.PE1498; -.
KW   ENSG000000062101755old_1320000031; ENSP000000060537901old_1320000031;
KW   A0N0N7_HUMAN; Q53FD8_HUMAN; Q53H89_HUMAN; Q59GS2_HUMAN; Q6I9S9_HUMAN;
KW   AC004382; AK222692; AK223351; AK313806; BC001163; BC016164; CH471092;
KW   EF064745; U84487; U91835;
KW   3D-structure; Cell adhesion; Cell membrane; Complete proteome;
KW   Cytokine; Disulfide bond; Glycoprotein; Membrane; Polymorphism;
KW   Reference proteome; Secreted; Signal; Transmembrane;
KW   Transmembrane helix.
SQ   SEQUENCE   397 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MAPISLSWLL RLATFCHLTV LLAGQHHGVT KCNITCSKMT SKIPVALLIH YQQNQASCGK
     RAIILETRQH RLFCADPKEQ WVKDAMQHLD RQAAALTRNG GTFEKQIGEV KPRTTPAAGG
     MDESVVLEPE ATGESSSLEP TPSSQEAQRA LGTSPELPTG VTGSSGTRLP PTPKAQDGGP
     VGTELFRVPP VSTAATWQSS APHQPGPSLW AEAKTSEAPS TQDPSTQAST ASSPAPEENA
     PSEGQRVWGQ GQSPRPENSL EREEMGPVPA HTDAFQDWGP GSMAHVSVVP VSSEGTPSRE
     PVASGSWTPK AEEPIHATMD PQRLGVLITP VPDAQAATRR QAVGLLAFLG LLFCLGVAMF
     TYQSLQGCPR KMAGEMAEGL RYIPRSCGSN SYVLVPV
//

If you have problems or comments...

PBIL Back to PBIL home page