(data stored in ACNUC9543 zone)

HOGENOM: HS16_PE1936

ID   HS16_PE1936                          STANDARD;      PRT;   1227 AA.
AC   HS16_PE1936; Q92620; D3DWS7; O75212; Q96HN7;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16;
DE   EC=3.6.4 13;AltName: Full=ATP-dependent RNA helicase DHX38;AltName:
DE   Full=DEAH box protein 38; (HS16.PE1936).
GN   Name=DHX38; Synonyms=DDX38, KIAA0224, PRP16;
OS   HOMO SAPIENS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini;
OC   Hominoidea; Hominidae; Homininae; Homo.
OX   NCBI_TaxID=9606;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS HS16.PE1936.
CC       Homo sapiens chromosome 16 GRCh37  sequence 1..90294753 annotated by
CC       Ensembl
CC   -!- ANNOTATIONS ORIGIN:PRP16_HUMAN
CC   -!- FUNCTION: Probable ATP-binding RNA helicase involved in pre-mRNA
CC       splicing.
CC   -!- CATALYTIC ACTIVITY: ATP + H(2)O = ADP + phosphate.
CC   -!- SUBUNIT: Identified in the spliceosome C complex.
CC   -!- SUBCELLULAR LOCATION: Nucleus (By similarity).
CC   -!- SIMILARITY: Belongs to the DEAD box helicase family. DEAH
CC       subfamily. PRP16 sub-subfamily.
CC   -!- SIMILARITY: Contains 1 helicase ATP-binding domain.
CC   -!- SIMILARITY: Contains 1 helicase C-terminal domain.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAA13213.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
CC   -!- GENE_FAMILY: HOG000175261 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Homo_sapiens;ENSG00000140829;ENST00000268482;ENSP00000268482.
DR   EMBL; AC004682; - ;
DR   EMBL; AF038391; - ;
DR   EMBL; AK291634; - ;
DR   EMBL; AK293776; - ;
DR   EMBL; AK297269; - ;
DR   EMBL; AK297791; - ;
DR   EMBL; BC004235; - ;
DR   EMBL; BC008340; - ;
DR   EMBL; CH471166; - ;
DR   EMBL; D86977; - ;
DR   UniProtKB/Swiss-Prot; Q92620; D3DWS7; O75212; Q96HN7; -.
DR   EMBL; AF038391; AAC39729.1; -; mRNA.
DR   EMBL; D86977; BAA13213.2; ALT_INIT; mRNA.
DR   EMBL; AC004682; AAC27431.1; -; Genomic_DNA.
DR   EMBL; CH471166; EAW59180.1; -; Genomic_DNA.
DR   EMBL; CH471166; EAW59190.1; -; Genomic_DNA.
DR   EMBL; BC004235; AAH04235.1; -; mRNA.
DR   EMBL; BC008340; AAH08340.1; -; mRNA.
DR   IPI; IPI00294211; -.
DR   RefSeq; NP_054722.2; NM_014003.3.
DR   UniGene; Hs.151218; -.
DR   ProteinModelPortal; Q92620; -.
DR   SMR; Q92620; 519-1156.
DR   IntAct; Q92620; 5.
DR   STRING; Q92620; -.
DR   PhosphoSite; Q92620; -.
DR   PeptideAtlas; Q92620; -.
DR   PRIDE; Q92620; -.
DR   Ensembl; ENST00000268482; ENSP00000268482; ENSG00000140829.
DR   GeneID; 9785; -.
DR   KEGG; hsa:9785; -.
DR   UCSC; uc002fcb.1; human.
DR   CTD; 9785; -.
DR   GeneCards; GC16P057894; -.
DR   H-InvDB; HIX0013224; -.
DR   HGNC; HGNC:17211; DHX38.
DR   HPA; HPA041347; -.
DR   MIM; 605584; gene.
DR   neXtProt; NX_Q92620; -.
DR   PharmGKB; PA27225; -.
DR   eggNOG; prNOG05628; -.
DR   GeneTree; ENSGT00590000083174; -.
DR   InParanoid; Q92620; -.
DR   OMA; DYDRKRD; -.
DR   OrthoDB; EOG4Z62MS; -.
DR   PhylomeDB; Q92620; -.
DR   Reactome; REACT_1675; mRNA Processing.
DR   Reactome; REACT_1788; Transcription.
DR   Reactome; REACT_71; Gene Expression.
DR   Reactome; REACT_78; Post-Elongation Processing of the Transcript.
DR   NextBio; 36846; -.
DR   ArrayExpress; Q92620; -.
DR   Bgee; Q92620; -.
DR   CleanEx; HS_DHX38; -.
DR   Genevestigator; Q92620; -.
DR   GermOnline; ENSG00000140829; Homo sapiens.
DR   GO; GO:0071013; C:catalytic step 2 spliceosome; IDA:UniProtKB.
DR   GO; GO:0005654; C:nucleoplasm; TAS:Reactome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0008026; F:ATP-dependent helicase activity; IEA:InterPro.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0005515; F:protein binding; IPI:IntAct.
DR   GO; GO:0031124; P:mRNA 3'-end processing; TAS:Reactome.
DR   GO; GO:0006406; P:mRNA export from nucleus; TAS:Reactome.
DR   GO; GO:0000398; P:nuclear mRNA splicing, via spliceosome; IDA:UniProtKB.
DR   GO; GO:0006369; P:termination of RNA polymerase II transcription; TAS:Reactome.
DR   InterPro; IPR014001; DEAD-like_helicase.
DR   InterPro; IPR011545; DNA/RNA_helicase_DEAD/DEAH_N.
DR   InterPro; IPR002464; DNA/RNA_helicase_DEAH_CS.
DR   InterPro; IPR011709; DUF1605.
DR   InterPro; IPR007502; Helicase-assoc_dom.
DR   InterPro; IPR001650; Helicase_C.
DR   Pfam; PF00270; DEAD; 1.
DR   Pfam; PF04408; HA2; 1.
DR   Pfam; PF00271; Helicase_C; 1.
DR   Pfam; PF07717; OB_NTP_bind; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM00847; HA2; 1.
DR   SMART; SM00490; HELICc; 1.
DR   PROSITE; PS00690; DEAH_ATP_HELICASE; 1.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
DR   HOGENOMDNA; HS16.PE1936; -.
KW   ENSG000001408291755old_1320000031; ENSP000002684827901old_1320000031;
KW   A8K6G9_HUMAN; B4DET0_HUMAN; B4DM30_HUMAN; B4DN69_HUMAN; D3DWS7_HUMAN;
KW   AF038391; AK291634; AK293776; AK297269; AK297791; BC004235; BC008340;
KW   D86977;
KW   Acetylation; ATP-binding; Complete proteome;
KW   Direct protein sequencing; Helicase; Hydrolase; mRNA processing;
KW   mRNA splicing; Nucleotide-binding; Nucleus; Phosphoprotein;
KW   Polymorphism; Reference proteome; Spliceosome.
SQ   SEQUENCE   1227 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MGDTSEDASI HRLEGTDLDC QVGGLICKSK SAASEQHVFK APAPRPSLLG LDLLASLKRR
     EREEKDDGED KKKSKVSSYK DWEESKDDQK DAEEEGGDQA GQNIRKDRHY RSARVETPSH
     PGGVSEEFWE RSRQRERERR EHGVYASSKE EKDWKKEKSR DRDYDRKRDR DERDRSRHSS
     RSERDGGSER SSRRNEPESP RHRPKDAATP SRSTWEEEDS GYGSSRRSQW ESPSPTPSYR
     DSERSHRLST RDRDRSVRGK YSDDTPLPTP SYKYNEWADD RRHLGSTPRL SRGRGRREEG
     EEGISFDTEE ERQQWEDDQR QADRDWYMMD EGYDEFHNPL AYSSEDYVRR REQHLHKQKQ
     KRISAQRRQI NEDNERWETN RMLTSGVVHR LEVDEDFEED NAAKVHLMVH NLVPPFLDGR
     IVFTKQPEPV IPVKDATSDL AIIARKGSQT VRKHREQKER KKAQHKHWEL AGTKLGDIMG
     VKKEEEPDKA VTEDGKVDYR TEQKFADHMK RKSEASSEFA KKKSILEQRQ YLPIFAVQQE
     LLTIIRDNSI VIVVGETGSG KTTQLTQYLH EDGYTDYGMI GCTQPRRVAA MSVAKRVSEE
     MGGNLGEEVG YAIRFEDCTS ENTLIKYMTD GILLRESLRE ADLDHYSAII MDEAHERSLN
     TDVLFGLLRE VVARRSDLKL IVTSATMDAE KFAAFFGNVP IFHIPGRTFP VDILFSKTPQ
     EDYVEAAVKQ SLQVHLSGAP GDILIFMPGQ EDIEVTSDQI VEHLEELENA PALAVLPIYS
     QLPSDLQAKI FQKAPDGVRK CIVATNIAET SLTVDGIMFV IDSGYCKLKV FNPRIGMDAL
     QIYPISQANA NQRSGRAGRT GPGQCFRLYT QSAYKNELLT TTVPEIQRTN LANVVLLLKS
     LGVQDLLQFH FMDPPPEDNM LNSMYQLWIL GALDNTGGLT STGRLMVEFP LDPALSKMLI
     VSCDMGCSSE ILLIVSMLSV PAIFYRPKGR EEESDQIREK FAVPESDHLT YLNVYLQWKN
     NNYSTIWCND HFIHAKAMRK VREVRAQLKD IMVQQRMSLA SCGTDWDIVR KCICAAYFHQ
     AAKLKGIGEY VNIRTGMPCH LHPTSSLFGM GYTPDYIVYH ELVMTTKEYM QCVTAVDGEW
     LAELGPMFYS VKQAGKSRQE NRRRAKEEAS AMEEEMALAE EQLRARRQEQ EKRSPLGSVR
     STKIYTPGRK EQGEPMTPRR TPARFGL
//

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