(data stored in ACNUC24361 zone)

HOGENOM: HS16_PE503

ID   HS16_PE503                           STANDARD;      PRT;   407 AA.
AC   HS16_PE503; Q15697; Q53Y68; Q9BQ34;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Zinc finger protein 174;AltName: Full=AW-1;AltName:
DE   Full=Zinc finger and SCAN domain-containing protein 8; (HS16.PE503).
GN   Name=ZNF174; Synonyms=ZSCAN8;
OS   HOMO SAPIENS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini;
OC   Hominoidea; Hominidae; Homininae; Homo.
OX   NCBI_TaxID=9606;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS HS16.PE503.
CC       Homo sapiens chromosome 16 GRCh37  sequence 1..90294753 annotated by
CC       Ensembl
CC   -!- ANNOTATIONS ORIGIN:ZN174_HUMAN
CC   -!- FUNCTION: Transcriptional repressor.
CC   -!- SUBUNIT: Homodimer.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q15697-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q15697-2; Sequence=VSP_006897, VSP_006898;
CC   -!- TISSUE SPECIFICITY: Expressed in a variety of organs, but most
CC       strongly in adult testis and ovary followed by small intestine,
CC       colon, prostate, thymus, spleen, pancreas, skeletal muscle, heart,
CC       brain and kidney. Also expressed in umbilical vein endothelial
CC       cells, foreskin fibroblast and HEPG2 cells.
CC   -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC       family.
CC   -!- SIMILARITY: Contains 3 C2H2-type zinc fingers.
CC   -!- SIMILARITY: Contains 1 SCAN box domain.
CC   -!- GENE_FAMILY: HOG000234619 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Homo_sapiens;ENSG00000103343;ENST00000268655;ENSP00000268655.
DR   EMBL; AF542096; - ;
DR   EMBL; BC000876; - ;
DR   EMBL; BC001161; - ;
DR   EMBL; BT006923; - ;
DR   EMBL; U31248; - ;
DR   UniProtKB/Swiss-Prot; Q15697; Q53Y68; Q9BQ34; -.
DR   EMBL; U31248; AAB04897.1; -; mRNA.
DR   EMBL; BT006923; AAP35569.1; -; mRNA.
DR   EMBL; BC000876; AAH00876.1; -; mRNA.
DR   EMBL; BC001161; AAH01161.1; -; mRNA.
DR   IPI; IPI00018955; -.
DR   IPI; IPI00029669; -.
DR   PIR; I39152; I39152.
DR   RefSeq; NP_001027463.1; NM_001032292.2.
DR   RefSeq; NP_003441.1; NM_003450.2.
DR   UniGene; Hs.155204; -.
DR   PDB; 1Y7Q; NMR; -; A/B=37-132.
DR   PDBsum; 1Y7Q; -.
DR   ProteinModelPortal; Q15697; -.
DR   SMR; Q15697; 37-132, 275-407.
DR   IntAct; Q15697; 1.
DR   STRING; Q15697; -.
DR   PhosphoSite; Q15697; -.
DR   PRIDE; Q15697; -.
DR   Ensembl; ENST00000268655; ENSP00000268655; ENSG00000103343.
DR   GeneID; 7727; -.
DR   KEGG; hsa:7727; -.
DR   UCSC; uc002cvc.1; human.
DR   CTD; 7727; -.
DR   GeneCards; GC16P003420; -.
DR   HGNC; HGNC:12963; ZNF174.
DR   HPA; HPA009656; -.
DR   MIM; 603900; gene.
DR   neXtProt; NX_Q15697; -.
DR   PharmGKB; PA37545; -.
DR   eggNOG; prNOG05290; -.
DR   InParanoid; Q15697; -.
DR   OMA; ENPQQEG; -.
DR   OrthoDB; EOG4QRH42; -.
DR   PhylomeDB; Q15697; -.
DR   NextBio; 29924; -.
DR   ArrayExpress; Q15697; -.
DR   Bgee; Q15697; -.
DR   CleanEx; HS_ZNF174; -.
DR   Genevestigator; Q15697; -.
DR   GermOnline; ENSG00000103343; Homo sapiens.
DR   GO; GO:0015629; C:actin cytoskeleton; IDA:HPA.
DR   GO; GO:0005737; C:cytoplasm; IDA:HPA.
DR   GO; GO:0005634; C:nucleus; NAS:UniProtKB.
DR   GO; GO:0042803; F:protein homodimerization activity; IPI:UniProtKB.
DR   GO; GO:0003700; F:sequence-specific DNA binding transcription factor activity; IDA:UniProtKB.
DR   GO; GO:0044212; F:transcription regulatory region DNA binding; IDA:UniProtKB.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IDA:UniProtKB.
DR   GO; GO:0016032; P:viral reproduction; IEA:InterPro.
DR   InterPro; IPR008916; Retrov_capsid_C.
DR   InterPro; IPR003309; Tscrpt_reg_SCAN.
DR   InterPro; IPR007087; Znf_C2H2.
DR   InterPro; IPR015880; Znf_C2H2-like.
DR   InterPro; IPR013087; Znf_C2H2/integrase_DNA-bd.
DR   Gene3D; G3DSA:3.30.160.60; Znf_C2H2/integrase_DNA-bd; 3.
DR   Pfam; PF02023; SCAN; 1.
DR   Pfam; PF00096; zf-C2H2; 3.
DR   SMART; SM00431; SCAN; 1.
DR   SMART; SM00355; ZnF_C2H2; 3.
DR   SUPFAM; SSF47353; Retrov_capsid_C; 1.
DR   PROSITE; PS50804; SCAN_BOX; 1.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 3.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 3.
DR   HOGENOMDNA; HS16.PE503; -.
KW   ENSG000001033431755old_1320000031; ENSP000002686557901old_1320000031;
KW   Q8IZN5_HUMAN; AF542096; BC000876; BC001161; BT006923; U31248;
KW   3D-structure; Alternative splicing; Complete proteome; DNA-binding;
KW   Metal-binding; Nucleus; Phosphoprotein; Reference proteome; Repeat;
KW   Repressor; Transcription; Transcription regulation; Zinc; Zinc-finger.
SQ   SEQUENCE   407 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MAAKMEITLS SNTEASSKQE RHIIAKLEEK RGPPLQKNCP DPELCRQSFR RFCYQEVSGP
     QEALSQLRQL CRQWLQPELH TKEQILELLV MEQFLTILPP EIQARVRHRC PMSSKEIVTL
     VEDFHRASKK PKQWVAVCMQ GQKVLLEKTG SQLGEQELPD FQPQTPRRDL RESSPAEPSQ
     AGAYDRLSPH HWEKSPLLQE PTPKLAGTEA PRMRSDNKEN PQQEGAKGAK PCAVSAGRSK
     GNGLQNPEPR GANMSEPRLS RRQVSSPNAQ KPFAHYQRHC RVEYISSPLK SHPLRELKKS
     KGGKRSLSNR LQHLGHQPTR SAKKPYKCDD CGKSFTWNSE LKRHKRVHTG ERPYTCGECG
     NCFGRQSTLK LHQRIHTGEK PYQCGQCGKS FRQSSNLHQH HRLHHGD
//

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