(data stored in ACNUC29662 zone)

HOGENOM: HS17_PE101

ID   HS17_PE101                           STANDARD;      PRT;   730 AA.
AC   HS17_PE101; Q684P5; B2RTY5; Q684P4; Q6AI00; Q6ZVF0; Q9UPW2;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Rap1 GTPase-activating protein 2; Short=Rap1GAP2;AltName:
DE   Full=GTPase-activating Rap/Ran-GAP domain-like protein 4; (HS17.PE101).
GN   Name=RAP1GAP2; Synonyms=GARNL4, KIAA1039, RAP1GA2;
OS   HOMO SAPIENS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini;
OC   Hominoidea; Hominidae; Homininae; Homo.
OX   NCBI_TaxID=9606;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS HS17.PE101.
CC       Homo sapiens chromosome 17 GRCh37  sequence 1..81195210 annotated by
CC       Ensembl
CC   -!- ANNOTATIONS ORIGIN:RPGP2_HUMAN
CC   -!- FUNCTION: GTPase activator for the nuclear Ras-related regulatory
CC       protein RAP-1A (KREV-1), converting it to the putatively inactive
CC       GDP-bound state.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm. Cytoplasm, perinuclear region.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=3;
CC       Name=1; Synonyms=Rap1GAP2b;
CC         IsoId=Q684P5-1; Sequence=Displayed;
CC       Name=2; Synonyms=Rap1GAP2a;
CC         IsoId=Q684P5-2; Sequence=VSP_029889;
CC       Name=3; Synonyms=Rap1GAP2c;
CC         IsoId=Q684P5-3; Sequence=VSP_029888;
CC   -!- TISSUE SPECIFICITY: Isoform 1 and isoform 2 are expressed in
CC       platelets with isoform 2 being the predominant form. Expressed in
CC       lymphocytes, heart, testis and pancreas.
CC   -!- PTM: In vitro phosphorylated by cGMP-dependent protein kinase 1
CC       (cGKI) at Ser-7; the phosphorylation probably does not regulate
CC       GAP activity.
CC   -!- SIMILARITY: Contains 1 Rap-GAP domain.
CC   -!- GENE_FAMILY: HOG000231640 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Homo_sapiens;ENSG00000132359;ENST00000254695;ENSP00000254695.
DR   EMBL; AB028962; - ;
DR   EMBL; AJ628446; - ;
DR   EMBL; AJ628447; - ;
DR   EMBL; AK124640; - ;
DR   EMBL; BC140870; - ;
DR   EMBL; BC140871; - ;
DR   EMBL; CR627427; - ;
DR   UniProtKB/Swiss-Prot; Q684P5; B2RTY5; Q684P4; Q6AI00; Q6ZVF0; Q9UPW2; -.
DR   EMBL; AJ628446; CAF31652.1; -; mRNA.
DR   EMBL; AJ628447; CAF31653.1; -; mRNA.
DR   EMBL; AK124640; BAC85912.1; -; mRNA.
DR   EMBL; CR627427; CAH10514.1; -; mRNA.
DR   EMBL; BC140870; AAI40871.1; -; mRNA.
DR   EMBL; BC140871; AAI40872.1; -; mRNA.
DR   EMBL; AB028962; BAA82991.1; -; mRNA.
DR   IPI; IPI00401939; -.
DR   IPI; IPI00855987; -.
DR   IPI; IPI00877122; -.
DR   RefSeq; NP_001093868.1; NM_001100398.1.
DR   RefSeq; NP_055900.4; NM_015085.4.
DR   UniGene; Hs.499659; -.
DR   HSSP; P47736; 1SRQ.
DR   ProteinModelPortal; Q684P5; -.
DR   SMR; Q684P5; 147-479.
DR   IntAct; Q684P5; 2.
DR   STRING; Q684P5; -.
DR   PhosphoSite; Q684P5; -.
DR   PRIDE; Q684P5; -.
DR   Ensembl; ENST00000254695; ENSP00000254695; ENSG00000132359.
DR   GeneID; 23108; -.
DR   KEGG; hsa:23108; -.
DR   NMPDR; fig|9606.3.peg.12855; -.
DR   UCSC; uc010ckd.1; human.
DR   UCSC; uc010cke.1; human.
DR   CTD; 23108; -.
DR   GeneCards; GC17P002646; -.
DR   H-InvDB; HIX0013424; -.
DR   HGNC; HGNC:29176; RAP1GAP2.
DR   HPA; HPA022148; -.
DR   HPA; HPA022896; -.
DR   neXtProt; NX_Q684P5; -.
DR   PharmGKB; PA134901801; -.
DR   PharmGKB; PA165432528; -.
DR   eggNOG; prNOG04485; -.
DR   GeneTree; ENSGT00550000074284; -.
DR   InParanoid; Q684P5; -.
DR   OMA; IYQKARQ; -.
DR   Reactome; REACT_6900; Immune System.
DR   NextBio; 44297; -.
DR   ArrayExpress; Q684P5; -.
DR   Bgee; Q684P5; -.
DR   CleanEx; HS_GARNL4; -.
DR   Genevestigator; Q684P5; -.
DR   GO; GO:0005813; C:centrosome; IDA:UniProtKB.
DR   GO; GO:0005829; C:cytosol; EXP:Reactome.
DR   GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005096; F:GTPase activator activity; TAS:Reactome.
DR   GO; GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.
DR   InterPro; IPR000331; Rap_GAP.
DR   Pfam; PF02145; Rap_GAP; 1.
DR   PROSITE; PS50085; RAPGAP; 1.
DR   HOGENOMDNA; HS17.PE101; -.
KW   ENSG000001323591755old_1320000031; ENSP000002546957901old_1320000031;
KW   AB028962; AJ628446; AJ628447; AK124640; BC140870; BC140871; CR627427;
KW   Alternative splicing; Complete proteome; Cytoplasm; GTPase activation;
KW   Phosphoprotein; Polymorphism; Reference proteome.
SQ   SEQUENCE   730 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MFGRKRSVSF GGFGWIDKTM LASLKVKKQE LANSSDATLP DRPLSPPLTA PPTMKSSEFF
     EMLEKMQGIK LEEQKPGPQK NKDDYIPYPS IDEVVEKGGP YPQVILPQFG GYWIEDPENV
     GTPTSLGSSI CEEEEEDNLS PNTFGYKLEC KGEARAYRRH FLGKDHLNFY CTGSSLGNLI
     LSVKCEEAEG IEYLRVILRS KLKTVHERIP LAGLSKLPSV PQIAKAFCDD AVGLRFNPVL
     YPKASQMIVS YDEHEVNNTF KFGVIYQKAR QTLEEELFGN NEESPAFKEF LDLLGDTITL
     QDFKGFRGGL DVTHGQTGVE SVYTTFRDRE IMFHVSTKLP FTDGDAQQLQ RKRHIGNDIV
     AIIFQEENTP FVPDMIASNF LHAYIVVQVE TPGTETPSYK VSVTAREDVP TFGPPLPSPP
     VFQKGPEFRE FLLTKLTNAE NACCKSDKFA KLEDRTRAAL LDNLHDELHA HTQAMLGLGP
     EEDKFENGGH GGFLESFKRA IRVRSHSMET MVGGQKKSHS GGIPGSLSGG ISHNSMEVTK
     TTFSPPVVAA TVKNQSRSPI KRRSGLFPRL HTGSEGQGDS RARCDSTSST PKTPDGGHSS
     QEIKSETSSN PSSPEICPNK EKPFMKLKEN GRAISRSSSS TSSVSSTAGE GEAMEEGDSG
     GSQPSTTSPF KQEVFVYSPS PSSESPSLGA AATPIIMSRS PTDAKSRNSP RSNLKFRFDK
     LSHASSGAGH
//

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