(data stored in ACNUC9543 zone)

HOGENOM: HS17_PE1869

ID   HS17_PE1869                          STANDARD;      PRT;   1220 AA.
AC   HS17_PE1869; Q14562;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=ATP-dependent RNA helicase DHX8; EC=3.6.4 13;AltName:
DE   Full=DEAH box protein 8;AltName: Full=RNA helicase HRH1; (HS17.PE1869).
GN   Name=DHX8; Synonyms=DDX8;
OS   HOMO SAPIENS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini;
OC   Hominoidea; Hominidae; Homininae; Homo.
OX   NCBI_TaxID=9606;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS HS17.PE1869.
CC       Homo sapiens chromosome 17 GRCh37  sequence 1..81195210 annotated by
CC       Ensembl
CC   -!- ANNOTATIONS ORIGIN:DHX8_HUMAN
CC   -!- FUNCTION: Facilitates nuclear export of spliced mRNA by releasing
CC       the RNA from the spliceosome.
CC   -!- CATALYTIC ACTIVITY: ATP + H(2)O = ADP + phosphate.
CC   -!- SUBUNIT: Identified in the spliceosome C complex. Interacts with
CC       ARRB2; the interaction is detected in the nucleus upon OR1D2
CC       stimulation.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- DOMAIN: The RS domain confers a nuclear localization signal, and
CC       appears to facilitate the interaction with the spliceosome.
CC   -!- SIMILARITY: Belongs to the DEAD box helicase family. DEAH
CC       subfamily. DDX8/PRP22 sub-subfamily.
CC   -!- SIMILARITY: Contains 1 helicase ATP-binding domain.
CC   -!- SIMILARITY: Contains 1 helicase C-terminal domain.
CC   -!- SIMILARITY: Contains 1 S1 motif domain.
CC   -!- GENE_FAMILY: HOG000175261 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Homo_sapiens;ENSG00000067596;ENST00000262415;ENSP00000262415.
DR   EMBL; AK291664; - ;
DR   EMBL; AK294046; - ;
DR   EMBL; AK303319; - ;
DR   EMBL; BC020697; - ;
DR   EMBL; BC044586; - ;
DR   EMBL; BC047327; - ;
DR   EMBL; D50487; - ;
DR   UniProtKB/Swiss-Prot; Q14562; -.
DR   EMBL; D50487; BAA09078.1; -; mRNA.
DR   IPI; IPI00031508; -.
DR   PIR; A56236; A56236.
DR   RefSeq; NP_004932.1; NM_004941.1.
DR   UniGene; Hs.463105; -.
DR   PDB; 2EQS; NMR; -; A=260-355.
DR   PDB; 3I4U; X-ray; 2.10 A; A=950-1183.
DR   PDBsum; 2EQS; -.
DR   PDBsum; 3I4U; -.
DR   ProteinModelPortal; Q14562; -.
DR   SMR; Q14562; 260-355, 555-1186.
DR   IntAct; Q14562; 4.
DR   STRING; Q14562; -.
DR   PhosphoSite; Q14562; -.
DR   PeptideAtlas; Q14562; -.
DR   PRIDE; Q14562; -.
DR   Ensembl; ENST00000262415; ENSP00000262415; ENSG00000067596.
DR   GeneID; 1659; -.
DR   KEGG; hsa:1659; -.
DR   UCSC; uc002idu.1; human.
DR   CTD; 1659; -.
DR   GeneCards; GC17P037326; -.
DR   H-InvDB; HIX0027177; -.
DR   HGNC; HGNC:2749; DHX8.
DR   MIM; 600396; gene.
DR   neXtProt; NX_Q14562; -.
DR   PharmGKB; PA27231; -.
DR   InParanoid; Q14562; -.
DR   OMA; KTMGIND; -.
DR   OrthoDB; EOG4D26P2; -.
DR   PhylomeDB; Q14562; -.
DR   NextBio; 6828; -.
DR   ArrayExpress; Q14562; -.
DR   Bgee; Q14562; -.
DR   CleanEx; HS_DHX8; -.
DR   Genevestigator; Q14562; -.
DR   GermOnline; ENSG00000067596; Homo sapiens.
DR   GO; GO:0071013; C:catalytic step 2 spliceosome; IDA:UniProtKB.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004004; F:ATP-dependent RNA helicase activity; TAS:ProtInc.
DR   GO; GO:0005515; F:protein binding; IPI:UniProtKB.
DR   GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR   InterPro; IPR014001; DEAD-like_helicase.
DR   InterPro; IPR011545; DNA/RNA_helicase_DEAD/DEAH_N.
DR   InterPro; IPR002464; DNA/RNA_helicase_DEAH_CS.
DR   InterPro; IPR011709; DUF1605.
DR   InterPro; IPR007502; Helicase-assoc_dom.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR012340; NA-bd_OB-fold.
DR   InterPro; IPR016027; NA-bd_OB-fold-like.
DR   InterPro; IPR003029; Rbsml_prot_S1_RNA-bd_dom.
DR   InterPro; IPR022967; RNA-binding_domain_S1.
DR   Gene3D; G3DSA:2.40.50.140; OB_NA_bd_sub; 1.
DR   Pfam; PF00270; DEAD; 1.
DR   Pfam; PF04408; HA2; 1.
DR   Pfam; PF00271; Helicase_C; 1.
DR   Pfam; PF07717; OB_NTP_bind; 1.
DR   Pfam; PF00575; S1; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM00847; HA2; 1.
DR   SMART; SM00490; HELICc; 1.
DR   SMART; SM00316; S1; 1.
DR   SUPFAM; SSF50249; Nucleic_acid_OB; 1.
DR   PROSITE; PS00690; DEAH_ATP_HELICASE; 1.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
DR   PROSITE; PS50126; S1; 1.
DR   HOGENOMDNA; HS17.PE1869; -.
KW   ENSG000000675961755old_1320000031; ENSP000002624157901old_1320000031;
KW   A8K6J9_HUMAN; B4DFD7_HUMAN; B7Z8F4_HUMAN; Q05CV4_HUMAN; Q86X36_HUMAN;
KW   AK291664; AK294046; AK303319; BC020697; BC044586; BC047327; D50487;
KW   3D-structure; Acetylation; ATP-binding; Complete proteome; Helicase;
KW   Hydrolase; mRNA processing; mRNA splicing; Nucleotide-binding;
KW   Nucleus; Phosphoprotein; Polymorphism; Reference proteome;
KW   Spliceosome.
SQ   SEQUENCE   1220 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MAVAVAMAGA LIGSEPGPAE ELAKLEYLSL VSKVCTELDN HLGINDKDLA EFVISLAEKN
     TTFDTFKASL VKNGAEFTDS LISNLLRLIQ TMRPPAKPST SKDPVVKPKT EKEKLKELFP
     VLCQPDNPSV RTMLDEDDVK VAVDVLKELE ALMPSAAGQE KQRDAEHRDR TKKKKRSRSR
     DRNRDRDRDR ERNRDRDHKR RHRSRSRSRS RTRERNKVKS RYRSRSRSQS PPKDRKDRDK
     YGERNLDRWR DKHVDRPPPE EPTIGDIYNG KVTSIMQFGC FVQLEGLRKR WEGLVHISEL
     RREGRVANVA DVVSKGQRVK VKVLSFTGTK TSLSMKDVDQ ETGEDLNPNR RRNLVGETNE
     ETSMRNPDRP THLSLVSAPE VEDDSLERKR LTRISDPEKW EIKQMIAANV LSKEEFPDFD
     EETGILPKVD DEEDEDLEIE LVEEEPPFLR GHTKQSMDMS PIKIVKNPDG SLSQAAMMQS
     ALAKERRELK QAQREAEMDS IPMGLNKHWV DPLPDAEGRQ IAANMRGIGM MPNDIPEWKK
     HAFGGNKASY GKKTQMSILE QRESLPIYKL KEQLVQAVHD NQILIVIGET GSGKTTQITQ
     YLAEAGYTSR GKIGCTQPRR VAAMSVAKRV SEEFGCCLGQ EVGYTIRFED CTSPETVIKY
     MTDGMLLREC LIDPDLTQYA IIMLDEAHER TIHTDVLFGL LKKTVQKRQD MKLIVTSATL
     DAVKFSQYFY EAPIFTIPGR TYPVEILYTK EPETDYLDAS LITVMQIHLT EPPGDILVFL
     TGQEEIDTAC EILYERMKSL GPDVPELIIL PVYSALPSEM QTRIFDPAPP GSRKVVIATN
     IAETSLTIDG IYYVVDPGFV KQKVYNSKTG IDQLVVTPIS QAQAKQRAGR AGRTGPGKCY
     RLYTERAYRD EMLTTNVPEI QRTNLASTVL SLKAMGINDL LSFDFMDAPP METLITAMEQ
     LYTLGALDDE GLLTRLGRRM AEFPLEPMLC KMLIMSVHLG CSEEMLTIVS MLSVQNVFYR
     PKDKQALADQ KKAKFHQTEG DHLTLLAVYN SWKNNKFSNP WCYENFIQAR SLRRAQDIRK
     QMLGIMDRHK LDVVSCGKST VRVQKAICSG FFRNAAKKDP QEGYRTLIDQ QVVYIHPSSA
     LFNRQPEWVV YHELVLTTKE YMREVTTIDP RWLVEFAPAF FKVSDPTKLS KQKKQQRLEP
     LYNRYEEPNA WRISRAFRRR
//

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