(data stored in ACNUC9543 zone)

HOGENOM: HS17_PE2571

ID   HS17_PE2571                          STANDARD;      PRT;   779 AA.
AC   HS17_PE2571;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Probable ATP-dependent RNA helicase DHX40; EC=3.6.4
DE   13;AltName: Full=DEAH box protein 40;AltName: Full=Protein PAD;
DE   (HS17.PE2571).
GN   Name=DHX40; Synonyms=DDX40; ORFNames=ARG147;
OS   HOMO SAPIENS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini;
OC   Hominoidea; Hominidae; Homininae; Homo.
OX   NCBI_TaxID=9606;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS HS17.PE2571.
CC       Homo sapiens chromosome 17 GRCh37  sequence 1..81195210 annotated by
CC       Ensembl
CC   -!- ANNOTATIONS ORIGIN:DHX40_HUMAN
CC   -!- FUNCTION: Probable ATP-dependent RNA helicase (By similarity).
CC   -!- CATALYTIC ACTIVITY: ATP + H(2)O = ADP + phosphate.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=3;
CC       Name=1;
CC         IsoId=Q8IX18-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q8IX18-2; Sequence=VSP_020932, VSP_020933;
CC         Note=No experimental confirmation available;
CC       Name=3;
CC         IsoId=Q8IX18-3; Sequence=VSP_020934, VSP_020935;
CC         Note=No experimental confirmation available;
CC   -!- TISSUE SPECIFICITY: Ubiquitously expressed.
CC   -!- SIMILARITY: Belongs to the DEAD box helicase family. DEAH
CC       subfamily.
CC   -!- SIMILARITY: Contains 1 helicase ATP-binding domain.
CC   -!- SIMILARITY: Contains 1 helicase C-terminal domain.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAF70326.1; Type=Frameshift; Positions=758;
CC       Sequence=AAK32122.1; Type=Erroneous initiation;
CC       Sequence=BAB15226.1; Type=Erroneous initiation;
CC   -!- GENE_FAMILY: HOG000175261 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Homo_sapiens;ENSG00000108406;ENST00000251241;ENSP00000251241.
DR   EMBL; AF260270; - ;
DR   EMBL; AF319521; - ;
DR   EMBL; AF461690; - ;
DR   EMBL; AK025713; - ;
DR   EMBL; AK091334; - ;
DR   EMBL; AK095681; - ;
DR   EMBL; AK299151; - ;
DR   EMBL; AL832510; - ;
DR   EMBL; BC024187; - ;
DR   UniProtKB/Swiss-Prot; Q8IX18; B3KTJ5; Q5JPH4; Q8TC86; Q8WY53; Q9BXM1; Q9H6M9; -.
DR   EMBL; AF461690; AAN77932.1; -; mRNA.
DR   EMBL; AF260270; AAF70326.1; ALT_FRAME; mRNA.
DR   EMBL; AK025713; BAB15226.1; ALT_INIT; mRNA.
DR   EMBL; AK095681; BAG53107.1; -; mRNA.
DR   EMBL; BC024187; AAH24187.1; -; mRNA.
DR   EMBL; AL832510; CAI46197.1; -; mRNA.
DR   EMBL; AF319521; AAK32122.1; ALT_INIT; mRNA.
DR   IPI; IPI00410110; -.
DR   IPI; IPI00797226; -.
DR   IPI; IPI01010408; -.
DR   RefSeq; NP_001159773.1; NM_001166301.1.
DR   RefSeq; NP_078888.4; NM_024612.4.
DR   UniGene; Hs.29403; -.
DR   ProteinModelPortal; Q8IX18; -.
DR   SMR; Q8IX18; 41-230, 456-705.
DR   IntAct; Q8IX18; 1.
DR   STRING; Q8IX18; -.
DR   PhosphoSite; Q8IX18; -.
DR   PRIDE; Q8IX18; -.
DR   Ensembl; ENST00000251241; ENSP00000251241; ENSG00000108406.
DR   GeneID; 79665; -.
DR   KEGG; hsa:79665; -.
DR   UCSC; uc002ixn.1; human.
DR   CTD; 79665; -.
DR   GeneCards; GC17P053003; -.
DR   HGNC; HGNC:18018; DHX40.
DR   MIM; 607570; gene.
DR   neXtProt; NX_Q8IX18; -.
DR   eggNOG; prNOG09239; -.
DR   GeneTree; ENSGT00600000084522; -.
DR   InParanoid; Q8IX18; -.
DR   OMA; CTSQEGG; -.
DR   PhylomeDB; Q8IX18; -.
DR   NextBio; 68866; -.
DR   ArrayExpress; Q8IX18; -.
DR   Bgee; Q8IX18; -.
DR   CleanEx; HS_DHX40; -.
DR   Genevestigator; Q8IX18; -.
DR   GermOnline; ENSG00000108406; Homo sapiens.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0008026; F:ATP-dependent helicase activity; IEA:InterPro.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   InterPro; IPR014001; DEAD-like_helicase.
DR   InterPro; IPR011545; DNA/RNA_helicase_DEAD/DEAH_N.
DR   InterPro; IPR002464; DNA/RNA_helicase_DEAH_CS.
DR   InterPro; IPR011709; DUF1605.
DR   InterPro; IPR007502; Helicase-assoc_dom.
DR   InterPro; IPR001650; Helicase_C.
DR   Pfam; PF00270; DEAD; 1.
DR   Pfam; PF04408; HA2; 1.
DR   Pfam; PF00271; Helicase_C; 1.
DR   Pfam; PF07717; OB_NTP_bind; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM00847; HA2; 1.
DR   SMART; SM00490; HELICc; 1.
DR   PROSITE; PS00690; DEAH_ATP_HELICASE; 1.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
DR   HOGENOMDNA; HS17.PE2571; -.
KW   ENSG000001084061755old_1320000031; ENSP000002512417901old_1320000031;
KW   B3KRC7_HUMAN; B4DR88_HUMAN; AF260270; AF319521; AF461690; AK025713;
KW   AK095681; AK299151; AL832510; BC024187;
KW   Alternative splicing; ATP-binding; Complete proteome; Helicase;
KW   Hydrolase; Nucleotide-binding; Reference proteome.
SQ   SEQUENCE   779 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MSRFPAVAGR APRRQEEGER SRDLQEERLS AVCIADREEK GCTSQEGGTT PTFPIQKQRK
     KIIQAVRDNS FLIVTGNTGS GKTTQLPKYL YEAGFSQHGM IGVTQPRKVA AISVAQRVAE
     EMKCTLGSKV GYQVRFDDCS SKETAIKYMT DGCLLKHILG DPNLTKFSVI ILDEAHERTL
     TTDILFGLLK KLFQEKSPNR KEHLKVVVMS ATMELAKLSA FFGNCPIFDI PGRLYPVREK
     FCNLIGPRDR ENTAYIQAIV KVTMDIHLNE MAGDILVFLT GQFEIEKSCE LLFQMAESVD
     YDYDVQDTTL DGLLILPCYG SMTTDQQRRI FLPPPPGIRK CVISTNISAT SLTIDGIRYV
     VDGGFVKQLN HNPRLGLDIL EVVPISKSEA LQRSGRAGRT SSGKCFRIYS KDFWNQCMPD
     HVIPEIKRTS LTSVVLTLKC LAIHDVIRFP YLDPPNERLI LEALKQLYQC DAIDRSGHVT
     RLGLSMVEFP LPPHLTCAVI KAASLDCEDL LLPIAAMLSV ENVFIRPVDP EYQKEAEQRH
     RELAAKAGGF NDFATLAVIF EQCKSSGAPA SWCQKHWIHW RCLFSAFRVE AQLRELIRKL
     KQQSDFPKET FEGPKHEVLR RCLCAGYFKN VARRSVGRTF CTMDGRGSPV HIHPSSALHE
     QETKLEWIIF HEVLVTTKVY ARIVCPIRYE WVRDLLPKLH EFNAHDLSSV ARREVREDAR
     RRWTNKENVK QLKDGISKDV LKKMQRRNDD KSISDARARF LERKQQRTQD HSDTRKETG
//

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