(data stored in ACNUC9543 zone)

HOGENOM: HS17_PE268

ID   HS17_PE268                           STANDARD;      PRT;   707 AA.
AC   HS17_PE268; Q9H6R0; B4DHF9; Q4G149; Q5CZ73; Q9H5M9;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Putative ATP-dependent RNA helicase DHX33; EC=3.6.4
DE   13;AltName: Full=DEAH box protein 33; (HS17.PE268).
GN   Name=DHX33; Synonyms=DDX33;
OS   HOMO SAPIENS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini;
OC   Hominoidea; Hominidae; Homininae; Homo.
OX   NCBI_TaxID=9606;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS HS17.PE268.
CC       Homo sapiens chromosome 17 GRCh37  sequence 1..81195210 annotated by
CC       Ensembl
CC   -!- ANNOTATIONS ORIGIN:DHX33_HUMAN
CC   -!- CATALYTIC ACTIVITY: ATP + H(2)O = ADP + phosphate.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q9H6R0-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q9H6R0-2; Sequence=VSP_016256;
CC   -!- SIMILARITY: Belongs to the DEAD box helicase family. DEAH
CC       subfamily.
CC   -!- SIMILARITY: Contains 1 helicase ATP-binding domain.
CC   -!- SIMILARITY: Contains 1 helicase C-terminal domain.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAH30017.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
CC   -!- GENE_FAMILY: HOG000175261 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Homo_sapiens;ENSG00000005100;ENST00000225296;ENSP00000225296.
DR   EMBL; AC004148; - ;
DR   EMBL; AK025625; - ;
DR   EMBL; AK026944; - ;
DR   EMBL; AK295074; - ;
DR   EMBL; AL359945; - ;
DR   EMBL; BC030017; - ;
DR   EMBL; CH471108; - ;
DR   EMBL; CR936655; - ;
DR   UniProtKB/Swiss-Prot; Q9H6R0; B4DHF9; Q4G149; Q5CZ73; Q9H5M9; -.
DR   EMBL; AK025625; BAB15193.1; -; mRNA.
DR   EMBL; AK026944; BAB15596.1; -; mRNA.
DR   EMBL; AK295074; BAG58120.1; -; mRNA.
DR   EMBL; AC004148; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH471108; EAW90332.1; -; Genomic_DNA.
DR   EMBL; BC030017; AAH30017.1; ALT_INIT; mRNA.
DR   EMBL; CR936655; CAI56793.1; -; mRNA.
DR   IPI; IPI00302860; -.
DR   IPI; IPI00655950; -.
DR   RefSeq; NP_001186628.1; NM_001199699.1.
DR   RefSeq; NP_064547.2; NM_020162.3.
DR   UniGene; Hs.250456; -.
DR   ProteinModelPortal; Q9H6R0; -.
DR   SMR; Q9H6R0; 49-701.
DR   IntAct; Q9H6R0; 1.
DR   PhosphoSite; Q9H6R0; -.
DR   PRIDE; Q9H6R0; -.
DR   Ensembl; ENST00000225296; ENSP00000225296; ENSG00000005100.
DR   Ensembl; ENST00000457531; ENSP00000389066; ENSG00000005100.
DR   GeneID; 56919; -.
DR   KEGG; hsa:56919; -.
DR   UCSC; uc002gca.1; human.
DR   CTD; 56919; -.
DR   GeneCards; GC17M005236; -.
DR   HGNC; HGNC:16718; DHX33.
DR   neXtProt; NX_Q9H6R0; -.
DR   PharmGKB; PA27220; -.
DR   eggNOG; prNOG10668; -.
DR   InParanoid; Q9H6R0; -.
DR   OrthoDB; EOG46Q6S1; -.
DR   PhylomeDB; Q9H6R0; -.
DR   NextBio; 62420; -.
DR   ArrayExpress; Q9H6R0; -.
DR   Bgee; Q9H6R0; -.
DR   CleanEx; HS_DHX33; -.
DR   Genevestigator; Q9H6R0; -.
DR   GermOnline; ENSG00000005100; Homo sapiens.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0008026; F:ATP-dependent helicase activity; IEA:InterPro.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   InterPro; IPR014001; DEAD-like_helicase.
DR   InterPro; IPR011545; DNA/RNA_helicase_DEAD/DEAH_N.
DR   InterPro; IPR002464; DNA/RNA_helicase_DEAH_CS.
DR   InterPro; IPR011709; DUF1605.
DR   InterPro; IPR007502; Helicase-assoc_dom.
DR   InterPro; IPR001650; Helicase_C.
DR   Pfam; PF00270; DEAD; 1.
DR   Pfam; PF04408; HA2; 1.
DR   Pfam; PF00271; Helicase_C; 1.
DR   Pfam; PF07717; OB_NTP_bind; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM00847; HA2; 1.
DR   SMART; SM00490; HELICc; 1.
DR   PROSITE; PS00690; DEAH_ATP_HELICASE; 1.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
DR   HOGENOMDNA; HS17.PE268; -.
KW   ENSG000000051001755old_1320000031; ENSP000002252967901old_1320000031;
KW   Q9NPV4_HUMAN; AC004148; AK025625; AK026944; AK295074; AL359945; BC030017;
KW   CR936655;
KW   Alternative splicing; ATP-binding; Complete proteome;
KW   Direct protein sequencing; Helicase; Hydrolase; Nucleotide-binding;
KW   Nucleus; Phosphoprotein; Polymorphism; Reference proteome.
SQ   SEQUENCE   707 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MPEEAGFPPA KRFRPGSGPP SRAGSFPPGR QVVMLLTAGS GGRGGGGGRR QQPPLAQPSA
     SPYPEAVELQ RRSLPIFQAR GQLLAQLRNL DNAVLIGETG SGKTTQIPQY LYEGGISRQG
     IIAVTQPRRV AAISLATRVS DEKRTELGKL VGYTVRFDDV TSEDTRIKFL TDGMLLREAI
     SDSLLRKYSC VILDEAHERT IHTDVLFGVV KAAQKRRKEL GKLPLKVIVM SATMDVDLFS
     QYFNGAPVLY LEGRQHPIQV FYTKQPQNDY LHAALVSVFQ IHQEAPSSQD ILVFLTGQEE
     IEAMSKTCRD IAKHLPDGCP AMLVLPLYAS LPYAQQLRVF QGAPKGYRKV IISTNIAETS
     ITITGIKYVV DTGMVKAKKY NPDSGLEVLA VQRVSKTQAW QRTGRAGRED SGICYRLYTE
     DEFEKFDKMT VPEIQRCNLA SVMLQLLAMK VPNVLTFDFM SKPSPDHIQA AIAQLDLLGA
     LEHKDDQLTL TPMGRKMAAF PLEPKFAKTI LMSPKFHCTE EILTIVSLLS VDSVLHNPPS
     RREEVQGVRK KFISSEGDHM TLLNIYRTFK NLGGNKDWCK ENFVNSKNMT LVAEVRAQLR
     DICLKMSMPI ASSRGDVESV RRCLAHSLFM STAELQPDGT YATTDTHQPV AIHPSSVLFH
     CKPACVVYTE LLYTNKCYMR DLCVIDAQWL YEAAPEYFRR KLRTARN
//

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