(data stored in ACNUC8465 zone)

HOGENOM: HS17_PE2822

ID   HS17_PE2822                          STANDARD;      PRT;   334 AA.
AC   HS17_PE2822; P52564;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Dual specificity mitogen-activated protein kinase kinase 6;
DE   Short=MAP kinase kinase 6; Short=MAPKK 6; EC=2.7.12 2;AltName:
DE   Full=MAPK/ERK kinase 6; Short=MEK 6;AltName: Full=SAPKK3; (HS17.PE2822).
GN   Name=MAP2K6; Synonyms=MEK6, MKK6, PRKMK6;
OS   HOMO SAPIENS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini;
OC   Hominoidea; Hominidae; Homininae; Homo.
OX   NCBI_TaxID=9606;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS HS17.PE2822.
CC       Homo sapiens chromosome 17 GRCh37  sequence 1..81195210 annotated by
CC       Ensembl
CC   -!- ANNOTATIONS ORIGIN:MP2K6_HUMAN
CC   -!- FUNCTION: Catalyzes the concomitant phosphorylation of a threonine
CC       and a tyrosine residue in MAP kinase p38 exclusively.
CC   -!- CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein.
CC   -!- ENZYME REGULATION: Probably activated by dual phosphorylation on
CC       Ser-207 and Thr-211.
CC   -!- SUBUNIT: Interacts with Yersinia yopJ.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1; Synonyms=MKK6b;
CC         IsoId=P52564-1; Sequence=Displayed;
CC       Name=2; Synonyms=MKK6;
CC         IsoId=P52564-2; Sequence=VSP_004882;
CC   -!- TISSUE SPECIFICITY: Isoform 2 is only expressed in skeletal
CC       muscle. Isoform 1 is expressed in skeletal muscle, heart, and in
CC       lesser extent in liver or pancreas.
CC   -!- INDUCTION: Strongly activated by UV, anisomycin, and osmotic shock
CC       but not by phorbol esters, NGF or EGF.
CC   -!- PTM: Weakly autophosphorylated. Phosphorylated by TAOK2.
CC   -!- PTM: Acetylation of Ser-207 and Thr-211 by Yersinia yopJ prevents
CC       phosphorylation and activation, thus blocking the MAPK signaling
CC       pathway.
CC   -!- SIMILARITY: Belongs to the protein kinase superfamily. STE Ser/Thr
CC       protein kinase family. MAP kinase kinase subfamily.
CC   -!- SIMILARITY: Contains 1 protein kinase domain.
CC   -!- GENE_FAMILY: HOG000234206 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Homo_sapiens;ENSG00000108984;ENST00000359094;ENSP00000351997.
DR   EMBL; AB451252; - ;
DR   EMBL; AB451376; - ;
DR   EMBL; AK290747; - ;
DR   EMBL; BC012009; - ;
DR   EMBL; CH471099; - ;
DR   EMBL; D87905; - ;
DR   EMBL; EU332850; - ;
DR   EMBL; U39064; - ;
DR   EMBL; U39065; - ;
DR   EMBL; U39656; - ;
DR   EMBL; U39657; - ;
DR   EMBL; U49732; - ;
DR   EMBL; X96757; - ;
DR   UniProtKB/Swiss-Prot; P52564; -.
DR   EMBL; U39657; AAC50389.1; -; mRNA.
DR   EMBL; U39656; AAC50388.1; -; mRNA.
DR   EMBL; U49732; AAB05035.1; -; mRNA.
DR   EMBL; U39065; AAB03705.1; -; mRNA.
DR   EMBL; U39064; AAB03708.1; -; mRNA.
DR   EMBL; D87905; BAA13496.1; -; mRNA.
DR   EMBL; X96757; CAA65532.1; -; mRNA.
DR   EMBL; BC012009; AAH12009.1; -; mRNA.
DR   IPI; IPI00003814; -.
DR   IPI; IPI00219569; -.
DR   PIR; S71631; S71631.
DR   RefSeq; NP_002749.2; NM_002758.3.
DR   UniGene; Hs.463978; -.
DR   PDB; 3ENM; X-ray; 2.35 A; A/B/C/D=45-332.
DR   PDB; 3FME; X-ray; 2.26 A; A=47-334.
DR   PDBsum; 3ENM; -.
DR   PDBsum; 3FME; -.
DR   ProteinModelPortal; P52564; -.
DR   SMR; P52564; 44-333.
DR   DIP; DIP-31346N; -.
DR   IntAct; P52564; 6.
DR   MINT; MINT-3019559; -.
DR   STRING; P52564; -.
DR   PhosphoSite; P52564; -.
DR   PRIDE; P52564; -.
DR   Ensembl; ENST00000359094; ENSP00000351997; ENSG00000108984.
DR   GeneID; 5608; -.
DR   KEGG; hsa:5608; -.
DR   UCSC; uc002jij.1; human.
DR   CTD; 5608; -.
DR   GeneCards; GC17P062796; -.
DR   H-InvDB; HIX0017658; -.
DR   HGNC; HGNC:6846; MAP2K6.
DR   HPA; CAB007744; -.
DR   HPA; HPA031134; -.
DR   MIM; 601254; gene.
DR   neXtProt; NX_P52564; -.
DR   eggNOG; prNOG16356; -.
DR   GeneTree; ENSGT00570000078767; -.
DR   InParanoid; P52564; -.
DR   OMA; ESAVAMV; -.
DR   OrthoDB; EOG4P2Q2M; -.
DR   PhylomeDB; P52564; -.
DR   BRENDA; 2.7.12.2; 2681.
DR   Pathway_Interaction_DB; anthraxpathway; Cellular roles of Anthrax toxin.
DR   Pathway_Interaction_DB; il1pathway; IL1-mediated signaling events.
DR   Pathway_Interaction_DB; il12_2pathway; IL12-mediated signaling events.
DR   Pathway_Interaction_DB; il6_7pathway; IL6-mediated signaling events.
DR   Pathway_Interaction_DB; p38_mkk3_6pathway; p38 MAPK signaling pathway.
DR   Pathway_Interaction_DB; ar_tf_pathway; Regulation of Androgen receptor activity.
DR   Pathway_Interaction_DB; p38alphabetapathway; Regulation of p38-alpha and p38-beta.
DR   Pathway_Interaction_DB; p38gammadeltapathway; Signaling mediated by p38-gamma and p38-delta.
DR   Pathway_Interaction_DB; mapktrkpathway; Trk receptor signaling mediated by the MAPK pathway.
DR   Reactome; REACT_21303; Myogenesis.
DR   Reactome; REACT_6900; Immune System.
DR   NextBio; 21798; -.
DR   PMAP-CutDB; P52564; -.
DR   ArrayExpress; P52564; -.
DR   Bgee; P52564; -.
DR   CleanEx; HS_MAP2K6; -.
DR   Genevestigator; P52564; -.
DR   GermOnline; ENSG00000108984; Homo sapiens.
DR   GO; GO:0005829; C:cytosol; EXP:Reactome.
DR   GO; GO:0005654; C:nucleoplasm; TAS:Reactome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004708; F:MAP kinase kinase activity; TAS:ProtInc.
DR   GO; GO:0005515; F:protein binding; IPI:IntAct.
DR   GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR   GO; GO:0004713; F:protein tyrosine kinase activity; IEA:UniProtKB-KW.
DR   GO; GO:0000187; P:activation of MAPK activity; TAS:Reactome.
DR   GO; GO:0007050; P:cell cycle arrest; TAS:ProtInc.
DR   GO; GO:0006975; P:DNA damage induced protein phosphorylation; TAS:ProtInc.
DR   GO; GO:0045087; P:innate immune response; TAS:Reactome.
DR   GO; GO:0042692; P:muscle cell differentiation; TAS:Reactome.
DR   GO; GO:0002755; P:MyD88-dependent toll-like receptor signaling pathway; EXP:Reactome.
DR   GO; GO:0002756; P:MyD88-independent toll-like receptor signaling pathway; EXP:Reactome.
DR   GO; GO:0051149; P:positive regulation of muscle cell differentiation; EXP:Reactome.
DR   GO; GO:0051403; P:stress-activated MAPK cascade; TAS:Reactome.
DR   GO; GO:0008063; P:Toll signaling pathway; TAS:Reactome.
DR   GO; GO:0034130; P:toll-like receptor 1 signaling pathway; TAS:Reactome.
DR   GO; GO:0034134; P:toll-like receptor 2 signaling pathway; TAS:Reactome.
DR   GO; GO:0034138; P:toll-like receptor 3 signaling pathway; TAS:Reactome.
DR   GO; GO:0034142; P:toll-like receptor 4 signaling pathway; TAS:Reactome.
DR   InterPro; IPR011009; Kinase-like_dom.
DR   InterPro; IPR000719; Prot_kinase_cat_dom.
DR   InterPro; IPR017441; Protein_kinase_ATP_BS.
DR   InterPro; IPR017442; Se/Thr_kinase-like_dom.
DR   InterPro; IPR008271; Ser/Thr_kinase_AS.
DR   InterPro; IPR002290; Ser/Thr_kinase_dom.
DR   Pfam; PF00069; Pkinase; 1.
DR   SMART; SM00220; S_TKc; 1.
DR   SUPFAM; SSF56112; Kinase_like; 1.
DR   PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
DR   HOGENOMDNA; HS17.PE2822; -.
KW   ENSG000001089841755old_1320000031; ENSP000003519977901old_1320000031;
KW   A8K3Y2_HUMAN; B5BU16_HUMAN; AB451252; AB451376; AK290747; BC012009;
KW   D87905; EU332850; U39064; U39065; U39656; U39657; U49732; X96757;
KW   3D-structure; Acetylation; Alternative splicing; ATP-binding;
KW   Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein;
KW   Reference proteome; Serine/threonine-protein kinase; Transferase;
KW   Tyrosine-protein kinase.
SQ   SEQUENCE   334 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MSQSKGKKRN PGLKIPKEAF EQPQTSSTPP RDLDSKACIS IGNQNFEVKA DDLEPIMELG
     RGAYGVVEKM RHVPSGQIMA VKRIRATVNS QEQKRLLMDL DISMRTVDCP FTVTFYGALF
     REGDVWICME LMDTSLDKFY KQVIDKGQTI PEDILGKIAV SIVKALEHLH SKLSVIHRDV
     KPSNVLINAL GQVKMCDFGI SGYLVDSVAK TIDAGCKPYM APERINPELN QKGYSVKSDI
     WSLGITMIEL AILRFPYDSW GTPFQQLKQV VEEPSPQLPA DKFSAEFVDF TSQCLKKNSK
     ERPTYPELMQ HPFFTLHESK GTDVASFVKL ILGD
//

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