(data stored in ACNUC8465 zone)

HOGENOM: HS17_PE581

ID   HS17_PE581                           STANDARD;      PRT;   399 AA.
AC   HS17_PE581;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Dual specificity mitogen-activated protein kinase kinase 4;
DE   Short=MAP kinase kinase 4; Short=MAPKK 4; EC=2.7.12 2;AltName:
DE   Full=JNK-activating kinase 1;AltName: Full=MAPK/ERK kinase 4; Short=MEK
DE   4;AltName: Full=SAPK/ERK kinase 1; Short=SEK1;AltName: Full=c-Jun
DE   N-terminal kinase kinase 1; Short=JNKK; (HS17.PE581).
GN   Name=MAP2K4; Synonyms=JNKK1, MEK4, MKK4, PRKMK4, SERK1;
OS   HOMO SAPIENS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini;
OC   Hominoidea; Hominidae; Homininae; Homo.
OX   NCBI_TaxID=9606;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS HS17.PE581.
CC       Homo sapiens chromosome 17 GRCh37  sequence 1..81195210 annotated by
CC       Ensembl
CC   -!- ANNOTATIONS ORIGIN:MP2K4_HUMAN
CC   -!- FUNCTION: Dual specificity kinase that activates the JUN kinases
CC       MAPK8 (JNK1) and MAPK9 (JNK2) as well as MAPK14 (p38) but not
CC       MAPK1 (ERK2) or MAPK3 (ERK1).
CC   -!- CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein.
CC   -!- SUBUNIT: Interacts with SPAG9 (By similarity). Interacts with
CC       ARRB2.
CC   -!- INTERACTION:
CC       Q13233:MAP3K1; NbExp=3; IntAct=EBI-447868, EBI-49776;
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=P45985-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=P45985-2; Sequence=VSP_038838;
CC         Note=No experimental confirmation available;
CC   -!- TISSUE SPECIFICITY: Abundant expression is seen in the skeletal
CC       muscle. It is also widely expressed in other tissues.
CC   -!- PTM: Activated by phosphorylation on Ser/Thr by MAP kinase kinase
CC       kinases (By similarity).
CC   -!- SIMILARITY: Belongs to the protein kinase superfamily. STE Ser/Thr
CC       protein kinase family. MAP kinase kinase subfamily.
CC   -!- SIMILARITY: Contains 1 protein kinase domain.
CC   -!- WEB RESOURCE: Name=NIEHS-SNPs;
CC       URL="http://egp.gs.washington.edu/data/map2k4/";
CC   -!- GENE_FAMILY: HOG000234206 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Homo_sapiens;ENSG00000065559;ENST00000353533;ENSP00000262445.
DR   EMBL; AC005244; - ;
DR   EMBL; AC005410; - ;
DR   EMBL; AF070080; - ;
DR   EMBL; AF070081; - ;
DR   EMBL; AF070082; - ;
DR   EMBL; AF070083; - ;
DR   EMBL; AF070084; - ;
DR   EMBL; AF070085; - ;
DR   EMBL; AF070086; - ;
DR   EMBL; AF070087; - ;
DR   EMBL; AF070088; - ;
DR   EMBL; AF070089; - ;
DR   EMBL; AF070090; - ;
DR   EMBL; AK131544; - ;
DR   EMBL; AK294923; - ;
DR   EMBL; AK313053; - ;
DR   EMBL; AK316100; - ;
DR   EMBL; AK316177; - ;
DR   EMBL; BC036032; - ;
DR   EMBL; BC060764; - ;
DR   EMBL; BT019676; - ;
DR   EMBL; CH471104; - ;
DR   EMBL; CH471108; - ;
DR   EMBL; CR536564; - ;
DR   EMBL; DQ015703; - ;
DR   EMBL; L36870; - ;
DR   EMBL; U17743; - ;
DR   UniProtKB/Swiss-Prot; P45985; B2R7N7; B3KYB2; D3DTS5; Q5U0B8; Q6FHX4; Q6P9H2; Q6PIE6; -.
DR   EMBL; L36870; AAC41719.1; -; mRNA.
DR   EMBL; U17743; AAC50127.1; -; mRNA.
DR   EMBL; AF070090; AAC24130.1; -; Genomic_DNA.
DR   EMBL; AF070080; AAC24130.1; JOINED; Genomic_DNA.
DR   EMBL; AF070081; AAC24130.1; JOINED; Genomic_DNA.
DR   EMBL; AF070082; AAC24130.1; JOINED; Genomic_DNA.
DR   EMBL; AF070083; AAC24130.1; JOINED; Genomic_DNA.
DR   EMBL; AF070084; AAC24130.1; JOINED; Genomic_DNA.
DR   EMBL; AF070085; AAC24130.1; JOINED; Genomic_DNA.
DR   EMBL; AF070086; AAC24130.1; JOINED; Genomic_DNA.
DR   EMBL; AF070087; AAC24130.1; JOINED; Genomic_DNA.
DR   EMBL; AF070088; AAC24130.1; JOINED; Genomic_DNA.
DR   EMBL; AF070089; AAC24130.1; JOINED; Genomic_DNA.
DR   EMBL; CR536564; CAG38801.1; -; mRNA.
DR   EMBL; BT019676; AAV38482.1; -; mRNA.
DR   EMBL; AK131544; BAG54774.1; -; mRNA.
DR   EMBL; AK313053; BAG35884.1; -; mRNA.
DR   EMBL; DQ015703; AAY22176.1; -; Genomic_DNA.
DR   EMBL; AC005244; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC005410; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH471108; EAW89975.1; -; Genomic_DNA.
DR   EMBL; CH471108; EAW89974.1; -; Genomic_DNA.
DR   EMBL; CH471108; EAW89976.1; -; Genomic_DNA.
DR   EMBL; BC036032; AAH36032.1; -; mRNA.
DR   EMBL; BC060764; AAH60764.1; -; mRNA.
DR   IPI; IPI00024674; -.
DR   IPI; IPI00942214; -.
DR   PIR; I38901; I38901.
DR   RefSeq; NP_003001.1; NM_003010.2.
DR   UniGene; Hs.514681; -.
DR   PDB; 3ALN; X-ray; 2.30 A; A/B/C=80-399.
DR   PDB; 3ALO; X-ray; 2.60 A; A=80-399.
DR   PDBsum; 3ALN; -.
DR   PDBsum; 3ALO; -.
DR   ProteinModelPortal; P45985; -.
DR   SMR; P45985; 95-388.
DR   IntAct; P45985; 4.
DR   MINT; MINT-151438; -.
DR   STRING; P45985; -.
DR   PhosphoSite; P45985; -.
DR   PRIDE; P45985; -.
DR   Ensembl; ENST00000353533; ENSP00000262445; ENSG00000065559.
DR   GeneID; 6416; -.
DR   KEGG; hsa:6416; -.
DR   NMPDR; fig|9606.3.peg.13149; -.
DR   UCSC; uc002gnj.1; human.
DR   CTD; 6416; -.
DR   GeneCards; GC17P011864; -.
DR   H-InvDB; HIX0027148; -.
DR   HGNC; HGNC:6844; MAP2K4.
DR   HPA; CAB007751; -.
DR   MIM; 601335; gene.
DR   neXtProt; NX_P45985; -.
DR   PharmGKB; PA30589; -.
DR   eggNOG; prNOG04261; -.
DR   GeneTree; ENSGT00570000078767; -.
DR   InParanoid; P45985; -.
DR   OMA; VMKSNDC; -.
DR   OrthoDB; EOG479F76; -.
DR   PhylomeDB; P45985; -.
DR   BRENDA; 2.7.12.2; 2681.
DR   Pathway_Interaction_DB; anthraxpathway; Cellular roles of Anthrax toxin.
DR   Pathway_Interaction_DB; ceramidepathway; Ceramide signaling pathway.
DR   Pathway_Interaction_DB; ephrinbrevpathway; Ephrin B reverse signaling.
DR   Pathway_Interaction_DB; faspathway; FAS signaling pathway (CD95).
DR   Pathway_Interaction_DB; fcer1pathway; Fc-epsilon receptor I signaling in mast cells.
DR   Pathway_Interaction_DB; il6_7pathway; IL6-mediated signaling events.
DR   Pathway_Interaction_DB; tcrjnkpathway; JNK signaling in the CD4+ TCR pathway.
DR   Pathway_Interaction_DB; ar_tf_pathway; Regulation of Androgen receptor activity.
DR   Pathway_Interaction_DB; p38alphabetapathway; Regulation of p38-alpha and p38-beta.
DR   Pathway_Interaction_DB; met_pathway; Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met).
DR   Pathway_Interaction_DB; trail_pathway; TRAIL signaling pathway.
DR   Pathway_Interaction_DB; lymphangiogenesis_pathway; VEGFR3 signaling in lymphatic endothelium.
DR   Reactome; REACT_6900; Immune System.
DR   NextBio; 24922; -.
DR   PMAP-CutDB; P45985; -.
DR   ArrayExpress; P45985; -.
DR   Bgee; P45985; -.
DR   CleanEx; HS_MAP2K4; -.
DR   Genevestigator; P45985; -.
DR   GO; GO:0005829; C:cytosol; TAS:Reactome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0008545; F:JUN kinase kinase activity; TAS:Reactome.
DR   GO; GO:0005515; F:protein binding; IPI:IntAct.
DR   GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR   GO; GO:0004713; F:protein tyrosine kinase activity; IEA:UniProtKB-KW.
DR   GO; GO:0071260; P:cellular response to mechanical stimulus; IEP:UniProtKB.
DR   GO; GO:0045087; P:innate immune response; TAS:Reactome.
DR   GO; GO:0007254; P:JNK cascade; TAS:Reactome.
DR   GO; GO:0002755; P:MyD88-dependent toll-like receptor signaling pathway; EXP:Reactome.
DR   GO; GO:0002756; P:MyD88-independent toll-like receptor signaling pathway; EXP:Reactome.
DR   GO; GO:0051403; P:stress-activated MAPK cascade; TAS:Reactome.
DR   GO; GO:0008063; P:Toll signaling pathway; TAS:Reactome.
DR   GO; GO:0034130; P:toll-like receptor 1 signaling pathway; TAS:Reactome.
DR   GO; GO:0034134; P:toll-like receptor 2 signaling pathway; TAS:Reactome.
DR   GO; GO:0034138; P:toll-like receptor 3 signaling pathway; TAS:Reactome.
DR   GO; GO:0034142; P:toll-like receptor 4 signaling pathway; TAS:Reactome.
DR   InterPro; IPR011009; Kinase-like_dom.
DR   InterPro; IPR000719; Prot_kinase_cat_dom.
DR   InterPro; IPR017441; Protein_kinase_ATP_BS.
DR   InterPro; IPR017442; Se/Thr_kinase-like_dom.
DR   InterPro; IPR008271; Ser/Thr_kinase_AS.
DR   InterPro; IPR002290; Ser/Thr_kinase_dom.
DR   Pfam; PF00069; Pkinase; 1.
DR   SMART; SM00220; S_TKc; 1.
DR   SUPFAM; SSF56112; Kinase_like; 1.
DR   PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
DR   HOGENOMDNA; HS17.PE581; -.
KW   ENSG000000655591755old_1320000031; ENSP000002624457901old_1320000031;
KW   B4DH44_HUMAN; B7Z9Y5_HUMAN; B7ZA62_HUMAN; D3DTD6_HUMAN; D3DTS5_HUMAN;
KW   AC005410; AF070080; AF070081; AF070082; AF070083; AF070084; AF070085;
KW   AF070087; AF070088; AF070089; AF070090; AK131544; AK294923; AK313053;
KW   AK316177; BC036032; BC060764; BT019676; CH471104; CH471108; CR536564;
KW   L36870; U17743;
KW   3D-structure; Acetylation; Alternative splicing; ATP-binding;
KW   Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein;
KW   Polymorphism; Reference proteome; Serine/threonine-protein kinase;
KW   Transferase; Tyrosine-protein kinase.
SQ   SEQUENCE   399 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MAAPSPSGGG GSGGGSGSGT PGPVGSPAPG HPAVSSMQGK RKALKLNFAN PPFKSTARFT
     LNPNPTGVQN PHIERLRTHS IESSGKLKIS PEQHWDFTAE DLKDLGEIGR GAYGSVNKMV
     HKPSGQIMAV KRIRSTVDEK EQKQLLMDLD VVMRSSDCPY IVQFYGALFR EGDCWICMEL
     MSTSFDKFYK YVYSVLDDVI PEEILGKITL ATVKALNHLK ENLKIIHRDI KPSNILLDRS
     GNIKLCDFGI SGQLVDSIAK TRDAGCRPYM APERIDPSAS RQGYDVRSDV WSLGITLYEL
     ATGRFPYPKW NSVFDQLTQV VKGDPPQLSN SEEREFSPSF INFVNLCLTK DESKRPKYKE
     LLKHPFILMY EERAVEVACY VCKILDQMPA TPSSPMYVD
//

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