(data stored in ACNUC16935 zone)


ID   HS17_PE674                           STANDARD;      PRT;   229 AA.
AC   HS17_PE674;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Polyubiquitin-B;Contains: RecName: Full=Ubiquitin;Flags:
DE   Precursor; (HS17.PE674).
GN   Name=UBB;
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini;
OC   Hominoidea; Hominidae; Homininae; Homo.
OX   NCBI_TaxID=9606;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS HS17.PE674.
CC       Homo sapiens chromosome 17 GRCh37  sequence 1..81195210 annotated by
CC       Ensembl
CC   -!- FUNCTION: Ubiquitin exists either covalently attached to another
CC       protein, or free (unanchored). When covalently bound, it is
CC       conjugated to target proteins via an isopeptide bond either as a
CC       monomer (monoubiquitin), a polymer linked via different Lys
CC       residues of the ubiquitin (polyubiquitin chains) or a linear
CC       polymer linked via the initiator Met of the ubiquitin (linear
CC       polyubiquitin chains). Polyubiquitin chains, when attached to a
CC       target protein, have different functions depending on the Lys
CC       residue of the ubiquitin that is linked: Lys-6-linked may be
CC       involved in DNA repair; Lys-11-linked is involved in ERAD
CC       (endoplasmic reticulum-associated degradation) and in cell-cycle
CC       regulation; Lys-29-linked is involved in lysosomal degradation;
CC       Lys-33-linked is involved in kinase modification; Lys-48-linked is
CC       involved in protein degradation via the proteasome; Lys-63-linked
CC       is involved in endocytosis, DNA-damage responses as well as in
CC       signaling processes leading to activation of the transcription
CC       factor NF-kappa-B. Linear polymer chains formed via attachment by
CC       the initiator Met lead to cell signaling. Ubiquitin is usually
CC       conjugated to Lys residues of target proteins, however, in rare
CC       cases, conjugation to Cys or Ser residues has been observed. When
CC       polyubiquitin is free (unanchored-polyubiquitin), it also has
CC       distinct roles, such as in activation of protein kinases, and in
CC       signaling.
CC       Q8IVM0:CCDC50; NbExp=2; IntAct=EBI-413034, EBI-723996;
CC       P28562:DUSP1; NbExp=2; IntAct=EBI-413034, EBI-975493;
CC       Q9UJY5:GGA1; NbExp=3; IntAct=EBI-413034, EBI-447141;
CC       Q9NZ52:GGA3; NbExp=2; IntAct=EBI-413034, EBI-447404;
CC       Q60592:Mast2 (xeno); NbExp=2; IntAct=EBI-413034, EBI-493888;
CC       P33993:MCM7; NbExp=2; IntAct=EBI-413034, EBI-355924;
CC       P24610:Pax3 (xeno); NbExp=2; IntAct=EBI-413034, EBI-1208116;
CC       Q9UJ41:RABGEF1; NbExp=6; IntAct=EBI-413034, EBI-913954;
CC       Q9Y3C5:RNF11; NbExp=2; IntAct=EBI-413034, EBI-396669;
CC       Q68DV7:RNF43; NbExp=2; IntAct=EBI-413034, EBI-1647060;
CC       Q9HAU4:SMURF2; NbExp=4; IntAct=EBI-413034, EBI-396727;
CC   -!- SUBCELLULAR LOCATION: Ubiquitin: Cytoplasm (By similarity).
CC       Nucleus (By similarity).
CC   -!- MISCELLANEOUS: Ubiquitin is encoded by 4 different genes. UBA52
CC       and RPS27A genes code for a single copy of ubiquitin fused to the
CC       ribosomal proteins L40 and S27a, respectively. UBB and UBC genes
CC       code for a polyubiquitin precursor with exact head to tail
CC       repeats, the number of repeats differ between species and strains.
CC   -!- MISCELLANEOUS: For a better understanding, features related to
CC       ubiquitin are only indicated for the first chain.
CC   -!- SIMILARITY: Belongs to the ubiquitin family.
CC   -!- SIMILARITY: Contains 3 ubiquitin-like domains.
CC   -!- GENE_FAMILY: HOG000233942 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Homo_sapiens;ENSG00000170315;ENST00000395837;ENSP00000379178.
DR   EMBL; AB089617; - ;
DR   EMBL; AB362574; - ;
DR   EMBL; AC093484; - ;
DR   EMBL; AK300882; - ;
DR   EMBL; BC000379; - ;
DR   EMBL; BC009301; - ;
DR   EMBL; BC015127; - ;
DR   EMBL; BC026301; - ;
DR   EMBL; BC031027; - ;
DR   EMBL; BC038999; - ;
DR   EMBL; BC046123; - ;
DR   EMBL; BT020104; - ;
DR   EMBL; CH471222; - ;
DR   EMBL; X04803; - ;
DR   UniProtKB/Swiss-Prot; P0CG47; P02248; P02249; P02250; P62988; Q29120; Q6LBL4; Q6LDU5; -.
DR   UniProtKB/Swiss-Prot; Q8WYN8; Q91887; Q91888; Q9BWD6; Q9BX98; Q9UEF2; Q9UEG1; Q9UEK8; -.
DR   UniProtKB/Swiss-Prot; Q9UPK7; -.
DR   EMBL; X04803; CAA28495.1; -; Genomic_DNA.
DR   EMBL; AB089617; BAC56955.1; -; Genomic_DNA.
DR   EMBL; AC093484; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC000379; AAH00379.1; -; mRNA.
DR   EMBL; BC009301; AAH09301.1; -; mRNA.
DR   EMBL; BC015127; AAH15127.1; -; mRNA.
DR   EMBL; BC026301; AAH26301.1; -; mRNA.
DR   EMBL; BC031027; AAH31027.1; -; mRNA.
DR   EMBL; BC046123; AAH46123.1; -; mRNA.
DR   IPI; IPI00719280; -.
DR   PIR; A26437; UQHUB.
DR   RefSeq; NP_061828.1; NM_018955.2.
DR   UniGene; Hs.356190; -.
DR   ProteinModelPortal; P0CG47; -.
DR   SMR; P0CG47; 1-224.
DR   IntAct; P0CG47; 62.
DR   PhosphoSite; P0CG47; -.
DR   PRIDE; P0CG47; -.
DR   Ensembl; ENST00000302182; ENSP00000304697; ENSG00000170315.
DR   Ensembl; ENST00000395837; ENSP00000379178; ENSG00000170315.
DR   Ensembl; ENST00000395839; ENSP00000379180; ENSG00000170315.
DR   GeneID; 7314; -.
DR   KEGG; hsa:7314; -.
DR   CTD; 7314; -.
DR   GeneCards; GC17P016150; -.
DR   HGNC; HGNC:12463; UBB.
DR   HPA; CAB013048; -.
DR   MIM; 191339; gene.
DR   neXtProt; NX_P0CG47; -.
DR   OrthoDB; EOG4WDDB6; -.
DR   Reactome; REACT_11045; Signaling by Wnt.
DR   Reactome; REACT_11061; Signalling by NGF.
DR   Reactome; REACT_11123; Membrane Trafficking.
DR   Reactome; REACT_13505; Proteasome mediated degradation of PAK-2p34.
DR   Reactome; REACT_152; Cell Cycle, Mitotic.
DR   Reactome; REACT_1538; Cell Cycle Checkpoints.
DR   Reactome; REACT_21257; Metabolism of RNA.
DR   Reactome; REACT_216; DNA Repair.
DR   Reactome; REACT_24941; Circadian Clock.
DR   Reactome; REACT_25177; RNF125 mediated ubiquitination of RIG-I, MDA5 and IPS-1.
DR   Reactome; REACT_383; DNA Replication.
DR   Reactome; REACT_578; Apoptosis.
DR   Reactome; REACT_6185; HIV Infection.
DR   Reactome; REACT_6850; Cdc20:Phospho-APC/C mediated degradation of Cyclin A.
DR   Reactome; REACT_6900; Immune System.
DR   Reactome; REACT_8017; APC-Cdc20 mediated degradation of Nek2A.
DR   Reactome; REACT_9417; Signaling by EGFR.
DR   Bgee; P0CG47; -.
DR   GermOnline; ENSG00000170315; Homo sapiens.
DR   GO; GO:0005829; C:cytosol; EXP:Reactome.
DR   GO; GO:0030666; C:endocytic vesicle membrane; TAS:Reactome.
DR   GO; GO:0010008; C:endosome membrane; EXP:Reactome.
DR   GO; GO:0005654; C:nucleoplasm; EXP:Reactome.
DR   GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR   GO; GO:0005515; F:protein binding; IPI:IntAct.
DR   GO; GO:0000187; P:activation of MAPK activity; TAS:Reactome.
DR   GO; GO:0031145; P:anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; EDR   GO; GO:0006916; P:anti-apoptosis; EXP:Reactome.
DR   GO; GO:0006916; P:anti-apoptosis; EXP:Reactome.
DR   GO; GO:0006915; P:apoptosis; EXP:Reactome.
DR   GO; GO:0016044; P:cellular membrane organization; EXP:Reactome.
DR   GO; GO:0006977; P:DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; TADR   GO; GO:0006281; P:DNA repair; TAS:Reactome.
DR   GO; GO:0006281; P:DNA repair; TAS:Reactome.
DR   GO; GO:0016197; P:endosome transport; TAS:Reactome.
DR   GO; GO:0007173; P:epidermal growth factor receptor signaling pathway; TAS:Reactome.
DR   GO; GO:0000082; P:G1/S transition of mitotic cell cycle; TAS:Reactome.
DR   GO; GO:0007249; P:I-kappaB kinase/NF-kappaB cascade; TAS:Reactome.
DR   GO; GO:0008624; P:induction of apoptosis by extracellular signals; EXP:Reactome.
DR   GO; GO:0045087; P:innate immune response; TAS:Reactome.
DR   GO; GO:0007254; P:JNK cascade; TAS:Reactome.
DR   GO; GO:0000216; P:M/G1 transition of mitotic cell cycle; TAS:Reactome.
DR   GO; GO:0016071; P:mRNA metabolic process; TAS:Reactome.
DR   GO; GO:0002755; P:MyD88-dependent toll-like receptor signaling pathway; EXP:Reactome.
DR   GO; GO:0002756; P:MyD88-independent toll-like receptor signaling pathway; EXP:Reactome.
DR   GO; GO:0042059; P:negative regulation of epidermal growth factor receptor signaling pathway; TAS:Reactome.
DR   GO; GO:0032480; P:negative regulation of type I interferon production; TAS:Reactome.
DR   GO; GO:0051436; P:negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; EXP:ReacDR   GO; GO:0048011; P:nerve growth factor receptor signaling pathway; TAS:Reactome.
DR   GO; GO:0048011; P:nerve growth factor receptor signaling pathway; TAS:Reactome.
DR   GO; GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB cascade; TAS:Reactome.
DR   GO; GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; TAS:Reactome.
DR   GO; GO:0051437; P:positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; EXP:ReacDR   GO; GO:0000084; P:S phase of mitotic cell cycle; TAS:Reactome.
DR   GO; GO:0000084; P:S phase of mitotic cell cycle; TAS:Reactome.
DR   GO; GO:0051403; P:stress-activated MAPK cascade; TAS:Reactome.
DR   GO; GO:0050852; P:T cell receptor signaling pathway; TAS:Reactome.
DR   GO; GO:0008063; P:Toll signaling pathway; TAS:Reactome.
DR   GO; GO:0034130; P:toll-like receptor 1 signaling pathway; TAS:Reactome.
DR   GO; GO:0034134; P:toll-like receptor 2 signaling pathway; TAS:Reactome.
DR   GO; GO:0034138; P:toll-like receptor 3 signaling pathway; TAS:Reactome.
DR   GO; GO:0034142; P:toll-like receptor 4 signaling pathway; TAS:Reactome.
DR   GO; GO:0016032; P:viral reproduction; TAS:Reactome.
DR   InterPro; IPR000626; Ubiquitin.
DR   InterPro; IPR019954; Ubiquitin_CS.
DR   InterPro; IPR019956; Ubiquitin_subgr.
DR   InterPro; IPR019955; Ubiquitin_supergroup.
DR   Pfam; PF00240; ubiquitin; 3.
DR   SMART; SM00213; UBQ; 3.
KW   ENSG000001703151755old_1320000031; ENSP000003791787901old_1320000031;
KW   A8CGI2_HUMAN; B4DV12_HUMAN; Q5U5U6_HUMAN; AB089617; AB362574; AC093484;
KW   BC000379; BC009301; BC015127; BC026301; BC031027; BC038999; BC046123;
KW   CH471222; X04803;
KW   Acetylation; Complete proteome; Cytoplasm; Direct protein sequencing;
KW   Isopeptide bond; Nucleus; Phosphoprotein; Reference proteome; Repeat;
KW   Ubl conjugation.

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