(data stored in ACNUC7421 zone)

HOGENOM: HS17_PE726

ID   HS17_PE726                           STANDARD;      PRT;   281 AA.
AC   HS17_PE726; Q9Y272; B2R709; Q9NYB4;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Dexamethasone-induced Ras-related protein 1;AltName:
DE   Full=Activator of G-protein signaling 1;Flags: Precursor; (HS17.PE726).
GN   Name=RASD1; Synonyms=AGS1, DEXRAS1;
OS   HOMO SAPIENS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini;
OC   Hominoidea; Hominidae; Homininae; Homo.
OX   NCBI_TaxID=9606;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS HS17.PE726.
CC       Homo sapiens chromosome 17 GRCh37  sequence 1..81195210 annotated by
CC       Ensembl
CC   -!- ANNOTATIONS ORIGIN:RASD1_HUMAN
CC   -!- FUNCTION: Small GTPase. Negatively regulates the transcription
CC       regulation activity of the APBB1/FE65-APP complex via its
CC       interaction with APBB1/FE65 (By similarity).
CC   -!- SUBUNIT: Forms a ternary complex with CAPON and NOS1. Component of
CC       a complex, at least composed of APBB1, RASD1/DEXRAS1 and APP.
CC       Interacts with APBB1/FE65 (By similarity).
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor; Cytoplasmic
CC       side (Potential). Cytoplasm, perinuclear region (By similarity).
CC       Nucleus (By similarity).
CC   -!- TISSUE SPECIFICITY: Expressed in a variety of tissues including
CC       heart, cardiovascular tissues, brain, placenta, lung, liver,
CC       skeletal muscle, kidney, pancreas, gastrointestinal and
CC       reproductive tissues.
CC   -!- INDUCTION: By dexamethasone.
CC   -!- PTM: S-nitrosylation stimulates guanine-nucleotide exchange
CC       activity.
CC   -!- SIMILARITY: Belongs to the small GTPase superfamily. RasD family.
CC   -!- GENE_FAMILY: HOG000233973 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Homo_sapiens;ENSG00000108551;ENST00000225688;ENSP00000225688.
DR   EMBL; AF069506; - ;
DR   EMBL; AF153192; - ;
DR   EMBL; AF172846; - ;
DR   EMBL; AF177335; - ;
DR   EMBL; AF222979; - ;
DR   EMBL; AF262018; - ;
DR   EMBL; AF498923; - ;
DR   EMBL; AK312796; - ;
DR   EMBL; BC018041; - ;
DR   EMBL; CH471196; - ;
DR   UniProtKB/Swiss-Prot; Q9Y272; B2R709; Q9NYB4; -.
DR   EMBL; AF153192; AAD34621.1; -; mRNA.
DR   EMBL; AF172846; AAF01364.1; -; mRNA.
DR   EMBL; AF069506; AAD34206.1; -; mRNA.
DR   EMBL; AF222979; AAG44256.1; -; Genomic_DNA.
DR   EMBL; AF262018; AAF72997.1; -; Genomic_DNA.
DR   EMBL; AF498923; AAM21071.1; -; mRNA.
DR   EMBL; AK312796; BAG35656.1; -; mRNA.
DR   EMBL; CH471196; EAW55705.1; -; Genomic_DNA.
DR   EMBL; BC018041; AAH18041.1; -; mRNA.
DR   IPI; IPI00007111; -.
DR   RefSeq; NP_001186918.1; NM_001199989.1.
DR   RefSeq; NP_057168.1; NM_016084.4.
DR   UniGene; Hs.25829; -.
DR   ProteinModelPortal; Q9Y272; -.
DR   SMR; Q9Y272; 22-196.
DR   IntAct; Q9Y272; 1.
DR   MINT; MINT-1437311; -.
DR   STRING; Q9Y272; -.
DR   PRIDE; Q9Y272; -.
DR   Ensembl; ENST00000225688; ENSP00000225688; ENSG00000108551.
DR   GeneID; 51655; -.
DR   KEGG; hsa:51655; -.
DR   UCSC; uc002gri.1; human.
DR   CTD; 51655; -.
DR   GeneCards; GC17M017150; -.
DR   H-InvDB; HIX0013586; -.
DR   HGNC; HGNC:15828; RASD1.
DR   MIM; 605550; gene.
DR   neXtProt; NX_Q9Y272; -.
DR   PharmGKB; PA34236; -.
DR   GeneTree; ENSGT00600000084338; -.
DR   InParanoid; Q9Y272; -.
DR   OMA; DQMFQAL; -.
DR   OrthoDB; EOG4KWJTF; -.
DR   PhylomeDB; Q9Y272; -.
DR   NextBio; 55626; -.
DR   ArrayExpress; Q9Y272; -.
DR   Bgee; Q9Y272; -.
DR   CleanEx; HS_RASD1; -.
DR   Genevestigator; Q9Y272; -.
DR   GermOnline; ENSG00000108551; Homo sapiens.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003924; F:GTPase activity; TAS:ProtInc.
DR   GO; GO:0007186; P:G-protein coupled receptor protein signaling pathway; TAS:ProtInc.
DR   GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR   InterPro; IPR005225; Small_GTP-bd_dom.
DR   InterPro; IPR001806; Small_GTPase.
DR   InterPro; IPR020849; Small_GTPase_Ras.
DR   PANTHER; PTHR24070; PTHR24070; 1.
DR   Pfam; PF00071; Ras; 1.
DR   PRINTS; PR00449; RASTRNSFRMNG.
DR   SMART; SM00173; RAS; 1.
DR   TIGRFAMs; TIGR00231; Small_GTP; 1.
DR   PROSITE; PS51421; RAS; 1.
DR   HOGENOMDNA; HS17.PE726; -.
KW   ENSG000001085511755old_1320000031; ENSP000002256887901old_1320000031;
KW   Q9HC43_HUMAN; AF069506; AF153192; AF172846; AF177335; AF222979; AF262018;
KW   AK312796; BC018041; CH471196;
KW   Cell membrane; Complete proteome; Cytoplasm; GTP-binding; Lipoprotein;
KW   Membrane; Methylation; Nucleotide-binding; Nucleus; Prenylation;
KW   Reference proteome; S-nitrosylation.
SQ   SEQUENCE   281 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MKLAAMIKKM CPSDSELSIP AKNCYRMVIL GSSKVGKTAI VSRFLTGRFE DAYTPTIEDF
     HRKFYSIRGE VYQLDILDTS GNHPFPAMRR LSILTGDVFI LVFSLDNRDS FEEVQRLRQQ
     ILDTKSCLKN KTKENVDVPL VICGNKGDRD FYREVDQREI EQLVGDDPQR CAYFEISAKK
     NSSLDQMFRA LFAMAKLPSE MSPDLHRKVS VQYCDVLHKK ALRNKKLLRA GSGGGGGDPG
     DAFGIVAPFA RRPSVHSDLM YIREKASAGS QAKDKERCVI S
//

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