(data stored in ACNUC8465 zone)

HOGENOM: HS17_PE938

ID   HS17_PE938                           STANDARD;      PRT;   347 AA.
AC   HS17_PE938; P46734; B3KSK7; Q99441; Q9UE71; Q9UE72;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Dual specificity mitogen-activated protein kinase kinase 3;
DE   Short=MAP kinase kinase 3; Short=MAPKK 3; EC=2.7.12 2;AltName:
DE   Full=MAPK/ERK kinase 3; Short=MEK 3; (HS17.PE938).
GN   Name=MAP2K3; Synonyms=MEK3, MKK3, PRKMK3;
OS   HOMO SAPIENS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini;
OC   Hominoidea; Hominidae; Homininae; Homo.
OX   NCBI_TaxID=9606;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS HS17.PE938.
CC       Homo sapiens chromosome 17 GRCh37  sequence 1..81195210 annotated by
CC       Ensembl
CC   -!- ANNOTATIONS ORIGIN:MP2K3_HUMAN
CC   -!- FUNCTION: Dual specificity kinase. Is activated by cytokines and
CC       environmental stress in vivo. Catalyzes the concomitant
CC       phosphorylation of a threonine and a tyrosine residue in the MAP
CC       kinase p38.
CC   -!- CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein.
CC   -!- ENZYME REGULATION: Activated by dual phosphorylation on Ser-218
CC       and Thr-222.
CC   -!- SUBUNIT: Binds to DYRK1B/MIRK and increases its kinase activity.
CC       Part of a complex with MAP3K3, RAC1 and CCM2. Interacts with
CC       ARRB1. Interacts with Yersinia yopJ.
CC   -!- INTERACTION:
CC       Q9Y463:DYRK1B; NbExp=2; IntAct=EBI-602462, EBI-634187;
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=3;
CC       Name=3; Synonyms=3b;
CC         IsoId=P46734-1; Sequence=Displayed;
CC       Name=1;
CC         IsoId=P46734-2; Sequence=VSP_004878;
CC       Name=2; Synonyms=3c;
CC         IsoId=P46734-3; Sequence=VSP_004877;
CC   -!- TISSUE SPECIFICITY: Abundant expression is seen in the skeletal
CC       muscle. It is also widely expressed in other tissues.
CC   -!- PTM: Autophosphorylated. Phosphorylation on Ser-218 and Thr-222 by
CC       MAP kinase kinase kinases regulates positively the kinase
CC       activity. Phosphorylated by TAOK2.
CC   -!- PTM: Yersinia yopJ may acetylate Ser/Thr residues, preventing
CC       phosphorylation and activation, thus blocking the MAPK signaling
CC       pathway.
CC   -!- DISEASE: Note=Defects in MAP2K3 may be involved in colon cancer.
CC   -!- SIMILARITY: Belongs to the protein kinase superfamily. STE Ser/Thr
CC       protein kinase family. MAP kinase kinase subfamily.
CC   -!- SIMILARITY: Contains 1 protein kinase domain.
CC   -!- GENE_FAMILY: HOG000234206 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Homo_sapiens;ENSG00000034152;ENST00000342679;ENSP00000345083.
DR   EMBL; AB451226; - ;
DR   EMBL; AB451349; - ;
DR   EMBL; AK093838; - ;
DR   EMBL; AK223490; - ;
DR   EMBL; AK315505; - ;
DR   EMBL; BC032478; - ;
DR   EMBL; CH471210; - ;
DR   EMBL; CR536514; - ;
DR   EMBL; CR541793; - ;
DR   EMBL; D87116; - ;
DR   EMBL; GQ225578; - ;
DR   EMBL; L36719; - ;
DR   EMBL; U66839; - ;
DR   EMBL; U66840; - ;
DR   UniProtKB/Swiss-Prot; P46734; B3KSK7; Q99441; Q9UE71; Q9UE72; -.
DR   EMBL; L36719; AAC41718.1; -; mRNA.
DR   EMBL; D87116; BAA13248.1; -; mRNA.
DR   EMBL; U66839; AAB40652.1; -; mRNA.
DR   EMBL; U66840; AAB40653.1; -; Genomic_DNA.
DR   EMBL; AK093838; BAG52769.1; -; mRNA.
DR   EMBL; BC032478; AAH32478.1; -; mRNA.
DR   IPI; IPI00218857; -.
DR   IPI; IPI00218858; -.
DR   IPI; IPI00220438; -.
DR   RefSeq; NP_002747.2; NM_002756.4.
DR   RefSeq; NP_659731.1; NM_145109.2.
DR   UniGene; Hs.514012; -.
DR   ProteinModelPortal; P46734; -.
DR   SMR; P46734; 56-344.
DR   DIP; DIP-34242N; -.
DR   IntAct; P46734; 2.
DR   MINT; MINT-4300215; -.
DR   STRING; P46734; -.
DR   PhosphoSite; P46734; -.
DR   PRIDE; P46734; -.
DR   Ensembl; ENST00000342679; ENSP00000345083; ENSG00000034152.
DR   GeneID; 5606; -.
DR   KEGG; hsa:5606; -.
DR   UCSC; uc002gys.1; human.
DR   UCSC; uc002gyt.1; human.
DR   CTD; 5606; -.
DR   GeneCards; GC17P020390; -.
DR   HGNC; HGNC:6843; MAP2K3.
DR   HPA; CAB018548; -.
DR   MIM; 602315; gene.
DR   neXtProt; NX_P46734; -.
DR   PharmGKB; PA30588; -.
DR   eggNOG; prNOG09859; -.
DR   OrthoDB; EOG4P2Q2M; -.
DR   PhylomeDB; P46734; -.
DR   BRENDA; 2.7.12.2; 2681.
DR   Pathway_Interaction_DB; anthraxpathway; Cellular roles of Anthrax toxin.
DR   Pathway_Interaction_DB; il12_2pathway; IL12-mediated signaling events.
DR   Pathway_Interaction_DB; p38_mkk3_6pathway; p38 MAPK signaling pathway.
DR   Pathway_Interaction_DB; p38alphabetapathway; Regulation of p38-alpha and p38-beta.
DR   Pathway_Interaction_DB; vegfr1_2_pathway; Signaling events mediated by VEGFR1 and VEGFR2.
DR   Pathway_Interaction_DB; p38gammadeltapathway; Signaling mediated by p38-gamma and p38-delta.
DR   Pathway_Interaction_DB; tnfpathway; TNF receptor signaling pathway.
DR   Pathway_Interaction_DB; mapktrkpathway; Trk receptor signaling mediated by the MAPK pathway.
DR   Reactome; REACT_6900; Immune System.
DR   NextBio; 21784; -.
DR   PMAP-CutDB; P46734; -.
DR   ArrayExpress; P46734; -.
DR   Bgee; P46734; -.
DR   CleanEx; HS_MAP2K3; -.
DR   Genevestigator; P46734; -.
DR   GermOnline; ENSG00000034152; Homo sapiens.
DR   GO; GO:0005829; C:cytosol; TAS:Reactome.
DR   GO; GO:0005654; C:nucleoplasm; TAS:Reactome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004708; F:MAP kinase kinase activity; TAS:ProtInc.
DR   GO; GO:0005515; F:protein binding; IPI:UniProtKB.
DR   GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR   GO; GO:0004713; F:protein tyrosine kinase activity; IEA:UniProtKB-KW.
DR   GO; GO:0000187; P:activation of MAPK activity; TAS:Reactome.
DR   GO; GO:0045087; P:innate immune response; TAS:Reactome.
DR   GO; GO:0002755; P:MyD88-dependent toll-like receptor signaling pathway; EXP:Reactome.
DR   GO; GO:0002756; P:MyD88-independent toll-like receptor signaling pathway; EXP:Reactome.
DR   GO; GO:0045893; P:positive regulation of transcription, DNA-dependent; IDA:UniProtKB.
DR   GO; GO:0051403; P:stress-activated MAPK cascade; TAS:Reactome.
DR   GO; GO:0008063; P:Toll signaling pathway; TAS:Reactome.
DR   GO; GO:0034130; P:toll-like receptor 1 signaling pathway; TAS:Reactome.
DR   GO; GO:0034134; P:toll-like receptor 2 signaling pathway; TAS:Reactome.
DR   GO; GO:0034138; P:toll-like receptor 3 signaling pathway; TAS:Reactome.
DR   GO; GO:0034142; P:toll-like receptor 4 signaling pathway; TAS:Reactome.
DR   InterPro; IPR011009; Kinase-like_dom.
DR   InterPro; IPR000719; Prot_kinase_cat_dom.
DR   InterPro; IPR017441; Protein_kinase_ATP_BS.
DR   InterPro; IPR017442; Se/Thr_kinase-like_dom.
DR   InterPro; IPR008271; Ser/Thr_kinase_AS.
DR   InterPro; IPR002290; Ser/Thr_kinase_dom.
DR   Pfam; PF00069; Pkinase; 1.
DR   SMART; SM00220; S_TKc; 1.
DR   SUPFAM; SSF56112; Kinase_like; 1.
DR   PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
DR   HOGENOMDNA; HS17.PE938; -.
KW   ENSG000000341521755old_1320000031; ENSP000003450837901old_1320000031;
KW   C7DUW4_HUMAN; D3DXI2_HUMAN; Q53EZ9_HUMAN; Q6FHG1_HUMAN; Q6FI23_HUMAN;
KW   AB451349; AK093838; AK223490; AK315505; BC032478; CH471210; CR536514;
KW   D87116; GQ225578; L36719; U66839; U66840;
KW   Acetylation; Alternative splicing; ATP-binding; Complete proteome;
KW   Disease mutation; Kinase; Nucleotide-binding; Phosphoprotein;
KW   Polymorphism; Reference proteome; Serine/threonine-protein kinase;
KW   Transferase; Tyrosine-protein kinase.
SQ   SEQUENCE   347 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MESPASSQPA SMPQSKGKSK RKKDLRISCM SKPPAPNPTP PRNLDSRTFI TIGDRNFEVE
     ADDLVTISEL GRGAYGVVEK VRHAQSGTIM AVKRIRATVN SQEQKRLLMD LDINMRTVDC
     FYTVTFYGAL FREGDVWICM ELMDTSLDKF YRKVLDKNMT IPEDILGEIA VSIVRALEHL
     HSKLSVIHRD VKPSNVLINK EGHVKMCDFG ISGYLVDSVA KTMDAGCKPY MAPERINPEL
     NQKGYNVKSD VWSLGITMIE MAILRFPYES WGTPFQQLKQ VVEEPSPQLP ADRFSPEFVD
     FTAQCLRKNP AERMSYLELM EHPFFTLHKT KKTDIAAFVK EILGEDS
//

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