(data stored in ACNUC7421 zone)

HOGENOM: HS18_PE398

ID   HS18_PE398                           STANDARD;      PRT;   217 AA.
AC   HS18_PE398; Q99578; B2R9L1; O15295; Q8TD69; Q8WVF6; Q92964;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=GTP-binding protein Rit2;AltName: Full=Ras-like protein
DE   expressed in neurons;AltName: Full=Ras-like without CAAX protein 2;
DE   (HS18.PE398).
GN   Name=RIT2; Synonyms=RIN, ROC2;
OS   HOMO SAPIENS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini;
OC   Hominoidea; Hominidae; Homininae; Homo.
OX   NCBI_TaxID=9606;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS HS18.PE398.
CC       Homo sapiens chromosome 18 GRCh37  sequence 1..78017248 annotated by
CC       Ensembl
CC   -!- ANNOTATIONS ORIGIN:RIT2_HUMAN
CC   -!- FUNCTION: Binds and exchanges GTP and GDP (By similarity).
CC   -!- SUBUNIT: Interacts with MLLT4, the C-terminal domain of RALGDS and
CC       RLF, but not with RIN1 and PIK3CA. RLF binds exclusively to the
CC       active GTP-bound form (By similarity). Binds calmodulin.
CC   -!- SUBCELLULAR LOCATION: Cell membrane.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q99578-1; Sequence=Displayed;
CC       Name=2; Synonyms=RIBA;
CC         IsoId=Q99578-2; Sequence=VSP_018102, VSP_018103;
CC   -!- TISSUE SPECIFICITY: Neuron-specific.
CC   -!- MISCELLANEOUS: Shows rapid uncatalyzed guanine nucleotide
CC       dissociation rates, which are much faster than those of most Ras
CC       subfamily members (By similarity).
CC   -!- SIMILARITY: Belongs to the small GTPase superfamily. Ras family.
CC   -!- GENE_FAMILY: HOG000233973 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Homo_sapiens;ENSG00000152214;ENST00000326695;ENSP00000321805.
DR   EMBL; AF493922; - ;
DR   EMBL; AK313823; - ;
DR   EMBL; AY563951; - ;
DR   EMBL; BC018060; - ;
DR   EMBL; CH471088; - ;
DR   EMBL; U71204; - ;
DR   EMBL; U78164; - ;
DR   EMBL; U78166; - ;
DR   EMBL; Y07565; - ;
DR   UniProtKB/Swiss-Prot; Q99578; B2R9L1; O15295; Q8TD69; Q8WVF6; Q92964; -.
DR   EMBL; U71204; AAB42214.1; -; mRNA.
DR   EMBL; Y07565; CAA68850.1; -; mRNA.
DR   EMBL; U78164; AAB64245.1; -; mRNA.
DR   EMBL; U78166; AAB64247.1; -; mRNA.
DR   EMBL; AF493922; AAM12636.1; -; mRNA.
DR   EMBL; AY563951; AAS75332.1; -; mRNA.
DR   EMBL; AK313823; BAG36558.1; -; mRNA.
DR   EMBL; CH471088; EAX01432.1; -; Genomic_DNA.
DR   EMBL; BC018060; AAH18060.1; -; mRNA.
DR   IPI; IPI00163763; -.
DR   IPI; IPI00289566; -.
DR   RefSeq; NP_002921.1; NM_002930.2.
DR   UniGene; Hs.464985; -.
DR   ProteinModelPortal; Q99578; -.
DR   SMR; Q99578; 16-185.
DR   IntAct; Q99578; 1.
DR   STRING; Q99578; -.
DR   PRIDE; Q99578; -.
DR   Ensembl; ENST00000326695; ENSP00000321805; ENSG00000152214.
DR   GeneID; 6014; -.
DR   KEGG; hsa:6014; -.
DR   UCSC; uc002lav.1; human.
DR   UCSC; uc010dnf.1; human.
DR   CTD; 6014; -.
DR   GeneCards; GC18M037181; -.
DR   H-InvDB; HIX0014415; -.
DR   HGNC; HGNC:10017; RIT2.
DR   MIM; 609592; gene.
DR   neXtProt; NX_Q99578; -.
DR   PharmGKB; PA35527; -.
DR   eggNOG; prNOG06167; -.
DR   GeneTree; ENSGT00600000084306; -.
DR   InParanoid; Q99578; -.
DR   OMA; IRKKEST; -.
DR   OrthoDB; EOG4VDQ0C; -.
DR   PhylomeDB; Q99578; -.
DR   Pathway_Interaction_DB; trkrpathway; Neurotrophic factor-mediated Trk receptor signaling.
DR   Pathway_Interaction_DB; mapktrkpathway; Trk receptor signaling mediated by the MAPK pathway.
DR   Reactome; REACT_11061; Signalling by NGF.
DR   NextBio; 23463; -.
DR   ArrayExpress; Q99578; -.
DR   Bgee; Q99578; -.
DR   CleanEx; HS_RIT2; -.
DR   Genevestigator; Q99578; -.
DR   GermOnline; ENSG00000152214; Homo sapiens.
DR   GO; GO:0005622; C:intracellular; IEA:InterPro.
DR   GO; GO:0005886; C:plasma membrane; TAS:UniProtKB.
DR   GO; GO:0005516; F:calmodulin binding; TAS:ProtInc.
DR   GO; GO:0005525; F:GTP binding; TAS:ProtInc.
DR   GO; GO:0003924; F:GTPase activity; NAS:UniProtKB.
DR   GO; GO:0048011; P:nerve growth factor receptor signaling pathway; TAS:Reactome.
DR   GO; GO:0007264; P:small GTPase mediated signal transduction; NAS:UniProtKB.
DR   GO; GO:0007268; P:synaptic transmission; TAS:ProtInc.
DR   InterPro; IPR005225; Small_GTP-bd_dom.
DR   InterPro; IPR001806; Small_GTPase.
DR   InterPro; IPR020849; Small_GTPase_Ras.
DR   PANTHER; PTHR24070; PTHR24070; 1.
DR   Pfam; PF00071; Ras; 1.
DR   PRINTS; PR00449; RASTRNSFRMNG.
DR   SMART; SM00173; RAS; 1.
DR   TIGRFAMs; TIGR00231; Small_GTP; 1.
DR   PROSITE; PS51421; RAS; 1.
DR   HOGENOMDNA; HS18.PE398; -.
KW   ENSG000001522141755old_1320000031; ENSP000003218057901old_1320000031;
KW   AF493922; AK313823; AY563951; BC018060; CH471088; U71204; U78164; U78166;
KW   Y07565;
KW   Alternative splicing; Calmodulin-binding; Cell membrane;
KW   Complete proteome; GTP-binding; Membrane; Nucleotide-binding;
KW   Reference proteome.
SQ   SEQUENCE   217 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MEVENEASCS PGSASGGSRE YKVVMLGAGG VGKSAMTMQF ISHQFPDYHD PTIEDAYKTQ
     VRIDNEPAYL DILDTAGQAE FTAMREQYMR GGEGFIICYS VTDRQSFQEA AKFKELIFQV
     RHTYEIPLVL VGNKIDLEQF RQVSTEEGLS LAQEYNCGFF ETSAALRFCI DDAFHGLVRE
     IRKKESMPSL MEKKLKRKDS LWKKLKGSLK KKRENMT
//

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