(data stored in ACNUC7421 zone)

HOGENOM: HS19_PE1862

ID   HS19_PE1862                          STANDARD;      PRT;   328 AA.
AC   HS19_PE1862; Q13011; A8K745; Q8WVX0; Q96EZ9;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial;
DE   EC=5.3.3 -;Flags: Precursor; (HS19.PE1862).
GN   Name=ECH1;
OS   HOMO SAPIENS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini;
OC   Hominoidea; Hominidae; Homininae; Homo.
OX   NCBI_TaxID=9606;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS HS19.PE1862.
CC       Homo sapiens chromosome 19 GRCh37  sequence 1..59118983 annotated by
CC       Ensembl
CC   -!- ANNOTATIONS ORIGIN:ECH1_HUMAN
CC   -!- FUNCTION: Isomerization of 3-trans,5-cis-dienoyl-CoA to 2-trans,4-
CC       trans-dienoyl-CoA (By similarity).
CC   -!- PATHWAY: Lipid metabolism; fatty acid beta-oxidation.
CC   -!- SUBUNIT: Homohexamer (By similarity).
CC   -!- INTERACTION:
CC       P42858:HTT; NbExp=2; IntAct=EBI-711968, EBI-466029;
CC   -!- SUBCELLULAR LOCATION: Mitochondrion (By similarity). Peroxisome
CC       (By similarity).
CC   -!- SIMILARITY: Belongs to the enoyl-CoA hydratase/isomerase family.
CC   -!- GENE_FAMILY: HOG000027939 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Homo_sapiens;ENSG00000104823;ENST00000221418;ENSP00000221418.
DR   EMBL; AF030246; - ;
DR   EMBL; AF030247; - ;
DR   EMBL; AF030248; - ;
DR   EMBL; AF030249; - ;
DR   EMBL; AK291860; - ;
DR   EMBL; BC011792; - ;
DR   EMBL; BC017408; - ;
DR   EMBL; CH471126; - ;
DR   EMBL; U16660; - ;
DR   UniProtKB/Swiss-Prot; Q13011; A8K745; Q8WVX0; Q96EZ9; -.
DR   EMBL; U16660; AAC50222.1; -; mRNA.
DR   EMBL; AF030249; AAB86485.1; -; Genomic_DNA.
DR   EMBL; AF030246; AAB86485.1; JOINED; Genomic_DNA.
DR   EMBL; AF030247; AAB86485.1; JOINED; Genomic_DNA.
DR   EMBL; AF030248; AAB86485.1; JOINED; Genomic_DNA.
DR   EMBL; AK291860; BAF84549.1; -; mRNA.
DR   EMBL; CH471126; EAW56824.1; -; Genomic_DNA.
DR   EMBL; BC011792; AAH11792.1; -; mRNA.
DR   EMBL; BC017408; AAH17408.1; -; mRNA.
DR   IPI; IPI00011416; -.
DR   PIR; I38882; I38882.
DR   RefSeq; NP_001389.2; NM_001398.2.
DR   UniGene; Hs.196176; -.
DR   PDB; 2VRE; X-ray; 1.95 A; A/B/C=50-322.
DR   PDBsum; 2VRE; -.
DR   ProteinModelPortal; Q13011; -.
DR   SMR; Q13011; 50-315.
DR   IntAct; Q13011; 9.
DR   MINT; MINT-1393158; -.
DR   STRING; Q13011; -.
DR   PhosphoSite; Q13011; -.
DR   REPRODUCTION-2DPAGE; IPI00011416; -.
DR   UCD-2DPAGE; Q13011; -.
DR   PeptideAtlas; Q13011; -.
DR   PRIDE; Q13011; -.
DR   Ensembl; ENST00000221418; ENSP00000221418; ENSG00000104823.
DR   GeneID; 1891; -.
DR   KEGG; hsa:1891; -.
DR   UCSC; uc002oji.1; human.
DR   CTD; 1891; -.
DR   GeneCards; GC19M035752; -.
DR   H-InvDB; HIX0015101; -.
DR   HGNC; HGNC:3149; ECH1.
DR   HPA; HPA002907; -.
DR   HPA; HPA005835; -.
DR   MIM; 600696; gene.
DR   neXtProt; NX_Q13011; -.
DR   PharmGKB; PA27596; -.
DR   eggNOG; prNOG07488; -.
DR   GeneTree; ENSGT00580000081296; -.
DR   InParanoid; Q13011; -.
DR   OMA; HTNQEGL; -.
DR   OrthoDB; EOG4VQ9PW; -.
DR   PhylomeDB; Q13011; -.
DR   NextBio; 7711; -.
DR   ArrayExpress; Q13011; -.
DR   Bgee; Q13011; -.
DR   CleanEx; HS_ECH1; -.
DR   Genevestigator; Q13011; -.
DR   GermOnline; ENSG00000104823; Homo sapiens.
DR   GO; GO:0005739; C:mitochondrion; IDA:HPA.
DR   GO; GO:0005777; C:peroxisome; TAS:ProtInc.
DR   GO; GO:0004300; F:enoyl-CoA hydratase activity; TAS:ProtInc.
DR   GO; GO:0016853; F:isomerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0005515; F:protein binding; IPI:IntAct.
DR   GO; GO:0006635; P:fatty acid beta-oxidation; TAS:ProtInc.
DR   GO; GO:0006091; P:generation of precursor metabolites and energy; TAS:ProtInc.
DR   InterPro; IPR001753; Crotonase_core.
DR   InterPro; IPR018376; Enoyl-CoA_hyd/isom_CS.
DR   Pfam; PF00378; ECH; 1.
DR   PROSITE; PS00166; ENOYL_COA_HYDRATASE; 1.
DR   HOGENOMDNA; HS19.PE1862; -.
KW   ENSG000001048231755old_1320000031; ENSP000002214187901old_1320000031;
KW   AF030246; AF030247; AF030248; AF030249; AK291860; BC011792; BC017408;
KW   U16660;
KW   3D-structure; Acetylation; Complete proteome;
KW   Direct protein sequencing; Fatty acid metabolism; Isomerase;
KW   Lipid metabolism; Mitochondrion; Peroxisome; Phosphoprotein;
KW   Polymorphism; Reference proteome; Transit peptide.
SQ   SEQUENCE   328 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MAAGIVASRR LRDLLTRRLT GSNYPGLSIS LRLTGSSAQE EASGVALGEA PDHSYESLRV
     TSAQKHVLHV QLNRPNKRNA MNKVFWREMV ECFNKISRDA DCRAVVISGA GKMFTAGIDL
     MDMASDILQP KGDDVARISW YLRDIITRYQ ETFNVIERCP KPVIAAVHGG CIGGGVDLVT
     ACDIRYCAQD AFFQVKEVDV GLAADVGTLQ RLPKVIGNQS LVNELAFTAR KMMADEALGS
     GLVSRVFPDK EVMLDAALAL AAEISSKSPV AVQSTKVNLL YSRDHSVAES LNYVASWNMS
     MLQTQDLVKS VQATTENKEL KTVTFSKL
//

If you have problems or comments...

PBIL Back to PBIL home page