(data stored in ACNUC8465 zone)

HOGENOM: HS19_PE318

ID   HS19_PE318                           STANDARD;      PRT;   400 AA.
AC   HS19_PE318; P36507;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Dual specificity mitogen-activated protein kinase kinase 2;
DE   Short=MAP kinase kinase 2; Short=MAPKK 2; EC=2.7.12 2;AltName: Full=ERK
DE   activator kinase 2;AltName: Full=MAPK/ERK kinase 2; Short=MEK 2;
DE   (HS19.PE318).
GN   Name=MAP2K2; Synonyms=MEK2, MKK2, PRKMK2;
OS   HOMO SAPIENS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini;
OC   Hominoidea; Hominidae; Homininae; Homo.
OX   NCBI_TaxID=9606;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS HS19.PE318.
CC       Homo sapiens chromosome 19 GRCh37  sequence 1..59118983 annotated by
CC       Ensembl
CC   -!- ANNOTATIONS ORIGIN:MP2K2_HUMAN
CC   -!- FUNCTION: Catalyzes the concomitant phosphorylation of a threonine
CC       and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP
CC       kinases. Activates the ERK1 and ERK2 MAP kinases (By similarity).
CC   -!- CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein.
CC   -!- SUBUNIT: Interacts with MORG1 (By similarity).
CC   -!- INTERACTION:
CC       P10398:ARAF; NbExp=3; IntAct=EBI-1056930, EBI-365961;
CC   -!- PTM: MAPKK is itself dependent on Ser/Thr phosphorylation for
CC       activity catalyzed by MAP kinase kinase kinases (RAF or MEKK1).
CC   -!- PTM: Acetylation of Ser-222 and Ser-226 by Yersinia yopJ prevents
CC       phosphorylation and activation, thus blocking the MAPK signaling
CC       pathway.
CC   -!- DISEASE: Defects in MAP2K2 are a cause of cardiofaciocutaneous
CC       syndrome (CFC syndrome) [MIM:115150]; also known as cardio-facio-
CC       cutaneous syndrome. CFC syndrome is characterized by a distinctive
CC       facial appearance, heart defects and mental retardation. Heart
CC       defects include pulmonic stenosis, atrial septal defects and
CC       hypertrophic cardiomyopathy. Some affected individuals present
CC       with ectodermal abnormalities such as sparse, friable hair,
CC       hyperkeratotic skin lesions and a generalized ichthyosis-like
CC       condition. Typical facial features are similar to Noonan syndrome.
CC       They include high forehead with bitemporal constriction,
CC       hypoplastic supraorbital ridges, downslanting palpebral fissures,
CC       a depressed nasal bridge, and posteriorly angulated ears with
CC       prominent helices. The inheritance of CFC syndrome is autosomal
CC       dominant.
CC   -!- SIMILARITY: Belongs to the protein kinase superfamily. STE Ser/Thr
CC       protein kinase family. MAP kinase kinase subfamily.
CC   -!- SIMILARITY: Contains 1 protein kinase domain.
CC   -!- WEB RESOURCE: Name=GeneReviews;
CC       URL="http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/MAP2K2";
CC   -!- GENE_FAMILY: HOG000234206 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Homo_sapiens;ENSG00000126934;ENST00000262948;ENSP00000262948.
DR   EMBL; AK093125; - ;
DR   EMBL; BC000471; - ;
DR   EMBL; BC018645; - ;
DR   EMBL; BX538081; - ;
DR   EMBL; CH471139; - ;
DR   EMBL; L11285; - ;
DR   UniProtKB/Swiss-Prot; P36507; -.
DR   EMBL; L11285; -; NOT_ANNOTATED_CDS; mRNA.
DR   EMBL; BC000471; AAH00471.1; -; mRNA.
DR   EMBL; BC018645; AAH18645.1; -; mRNA.
DR   IPI; IPI00003783; -.
DR   PIR; A46723; A46723.
DR   RefSeq; NP_109587.1; NM_030662.3.
DR   UniGene; Hs.465627; -.
DR   PDB; 1S9I; X-ray; 3.20 A; A/B=55-400.
DR   PDBsum; 1S9I; -.
DR   ProteinModelPortal; P36507; -.
DR   SMR; P36507; 60-393.
DR   DIP; DIP-29119N; -.
DR   IntAct; P36507; 9.
DR   MINT; MINT-99667; -.
DR   STRING; P36507; -.
DR   PhosphoSite; P36507; -.
DR   REPRODUCTION-2DPAGE; IPI00003783; -.
DR   PeptideAtlas; P36507; -.
DR   PRIDE; P36507; -.
DR   Ensembl; ENST00000262948; ENSP00000262948; ENSG00000126934.
DR   GeneID; 5605; -.
DR   KEGG; hsa:5605; -.
DR   UCSC; uc002lzk.1; human.
DR   CTD; 5605; -.
DR   GeneCards; GC19M003854; -.
DR   H-InvDB; HIX0014653; -.
DR   H-InvDB; HIX0033655; -.
DR   HGNC; HGNC:6842; MAP2K2.
DR   HPA; CAB003835; -.
DR   MIM; 115150; phenotype.
DR   MIM; 601263; gene.
DR   neXtProt; NX_P36507; -.
DR   Orphanet; 1340; Cardiofaciocutaneous syndrome.
DR   PharmGKB; PA30587; -.
DR   eggNOG; prNOG06383; -.
DR   InParanoid; P36507; -.
DR   OMA; PVSGHGM; -.
DR   OrthoDB; EOG4SF965; -.
DR   PhylomeDB; P36507; -.
DR   BRENDA; 2.7.12.2; 2681.
DR   Pathway_Interaction_DB; anthraxpathway; Cellular roles of Anthrax toxin.
DR   Pathway_Interaction_DB; ceramidepathway; Ceramide signaling pathway.
DR   Pathway_Interaction_DB; cd8tcrdownstreampathway; Downstream signaling in naive CD8+ T cells.
DR   Pathway_Interaction_DB; endothelinpathway; Endothelins.
DR   Pathway_Interaction_DB; fcer1pathway; Fc-epsilon receptor I signaling in mast cells.
DR   Pathway_Interaction_DB; il2_1pathway; IL2-mediated signaling events.
DR   Pathway_Interaction_DB; met_pathway; Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met).
DR   Pathway_Interaction_DB; kitpathway; Signaling events mediated by Stem cell factor receptor (c-Kit).
DR   Reactome; REACT_11061; Signalling by NGF.
DR   Reactome; REACT_16888; Signaling by PDGF.
DR   Reactome; REACT_18266; Axon guidance.
DR   Reactome; REACT_498; Signaling by Insulin receptor.
DR   Reactome; REACT_6900; Immune System.
DR   Reactome; REACT_9417; Signaling by EGFR.
DR   NextBio; 21780; -.
DR   PMAP-CutDB; P36507; -.
DR   ArrayExpress; P36507; -.
DR   Bgee; P36507; -.
DR   CleanEx; HS_MAP2K2; -.
DR   Genevestigator; P36507; -.
DR   GermOnline; ENSG00000126934; Homo sapiens.
DR   GO; GO:0005829; C:cytosol; EXP:Reactome.
DR   GO; GO:0005576; C:extracellular region; NAS:UniProtKB.
DR   GO; GO:0005524; F:ATP binding; NAS:UniProtKB.
DR   GO; GO:0005515; F:protein binding; IPI:IntAct.
DR   GO; GO:0004674; F:protein serine/threonine kinase activity; NAS:UniProtKB.
DR   GO; GO:0004713; F:protein tyrosine kinase activity; IEA:UniProtKB-KW.
DR   GO; GO:0000187; P:activation of MAPK activity; TAS:Reactome.
DR   GO; GO:0000186; P:activation of MAPKK activity; TAS:Reactome.
DR   GO; GO:0007411; P:axon guidance; TAS:Reactome.
DR   GO; GO:0007173; P:epidermal growth factor receptor signaling pathway; TAS:Reactome.
DR   GO; GO:0070371; P:ERK1 and ERK2 cascade; TAS:Reactome.
DR   GO; GO:0045087; P:innate immune response; TAS:Reactome.
DR   GO; GO:0008286; P:insulin receptor signaling pathway; TAS:Reactome.
DR   GO; GO:0002755; P:MyD88-dependent toll-like receptor signaling pathway; EXP:Reactome.
DR   GO; GO:0002756; P:MyD88-independent toll-like receptor signaling pathway; EXP:Reactome.
DR   GO; GO:0048011; P:nerve growth factor receptor signaling pathway; TAS:Reactome.
DR   GO; GO:0007265; P:Ras protein signal transduction; EXP:Reactome.
DR   GO; GO:0051403; P:stress-activated MAPK cascade; TAS:Reactome.
DR   GO; GO:0008063; P:Toll signaling pathway; TAS:Reactome.
DR   GO; GO:0034130; P:toll-like receptor 1 signaling pathway; TAS:Reactome.
DR   GO; GO:0034134; P:toll-like receptor 2 signaling pathway; TAS:Reactome.
DR   GO; GO:0034138; P:toll-like receptor 3 signaling pathway; TAS:Reactome.
DR   GO; GO:0034142; P:toll-like receptor 4 signaling pathway; TAS:Reactome.
DR   InterPro; IPR011009; Kinase-like_dom.
DR   InterPro; IPR000719; Prot_kinase_cat_dom.
DR   InterPro; IPR017441; Protein_kinase_ATP_BS.
DR   InterPro; IPR017442; Se/Thr_kinase-like_dom.
DR   InterPro; IPR008271; Ser/Thr_kinase_AS.
DR   InterPro; IPR002290; Ser/Thr_kinase_dom.
DR   Pfam; PF00069; Pkinase; 1.
DR   SMART; SM00220; S_TKc; 1.
DR   SUPFAM; SSF56112; Kinase_like; 1.
DR   PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
DR   HOGENOMDNA; HS19.PE318; -.
KW   ENSG000001269341755old_1320000031; ENSP000002629487901old_1320000031;
KW   B3KS97_HUMAN; Q7Z370_HUMAN; AK093125; BC000471; BC018645; BX538081;
KW   L11285;
KW   3D-structure; Acetylation; ATP-binding; Complete proteome;
KW   Direct protein sequencing; Disease mutation; Kinase;
KW   Nucleotide-binding; Phosphoprotein; Reference proteome;
KW   Serine/threonine-protein kinase; Transferase; Tyrosine-protein kinase.
SQ   SEQUENCE   400 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MLARRKPVLP ALTINPTIAE GPSPTSEGAS EANLVDLQKK LEELELDEQQ KKRLEAFLTQ
     KAKVGELKDD DFERISELGA GNGGVVTKVQ HRPSGLIMAR KLIHLEIKPA IRNQIIRELQ
     VLHECNSPYI VGFYGAFYSD GEISICMEHM DGGSLDQVLK EAKRIPEEIL GKVSIAVLRG
     LAYLREKHQI MHRDVKPSNI LVNSRGEIKL CDFGVSGQLI DSMANSFVGT RSYMAPERLQ
     GTHYSVQSDI WSMGLSLVEL AVGRYPIPPP DAKELEAIFG RPVVDGEEGE PHSISPRPRP
     PGRPVSGHGM DSRPAMAIFE LLDYIVNEPP PKLPNGVFTP DFQEFVNKCL IKNPAERADL
     KMLTNHTFIK RSEVEEVDFA GWLCKTLRLN QPGTPTRTAV
//

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