(data stored in ACNUC24361 zone)

HOGENOM: HS19_PE3661

ID   HS19_PE3661                          STANDARD;      PRT;   450 AA.
AC   HS19_PE3661; Q9NWS9;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Zinc finger protein 446;AltName: Full=Zinc finger protein
DE   with KRAB and SCAN domains 20; (HS19.PE3661).
GN   Name=ZNF446; Synonyms=ZKSCAN20;
OS   HOMO SAPIENS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini;
OC   Hominoidea; Hominidae; Homininae; Homo.
OX   NCBI_TaxID=9606;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS HS19.PE3661.
CC       Homo sapiens chromosome 19 GRCh37  sequence 1..59118983 annotated by
CC       Ensembl
CC   -!- ANNOTATIONS ORIGIN:ZN446_HUMAN
CC   -!- FUNCTION: May be involved in transcriptional regulation.
CC   -!- SUBCELLULAR LOCATION: Nucleus (Potential).
CC   -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC       family.
CC   -!- SIMILARITY: Contains 3 C2H2-type zinc fingers.
CC   -!- SIMILARITY: Contains 1 KRAB domain.
CC   -!- SIMILARITY: Contains 1 SCAN box domain.
CC   -!- GENE_FAMILY: HOG000234619 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Homo_sapiens;ENSG00000083838;ENST00000335841;ENSP00000336565.
DR   EMBL; AK000633; - ;
DR   EMBL; AL122108; - ;
DR   EMBL; AL833955; - ;
DR   EMBL; AY280800; - ;
DR   EMBL; BC017206; - ;
DR   UniProtKB/Swiss-Prot; Q9NWS9; -.
DR   EMBL; AK000633; BAA91298.1; -; mRNA.
DR   EMBL; AY280800; AAQ16304.1; -; mRNA.
DR   IPI; IPI00016671; -.
DR   RefSeq; NP_060378.1; NM_017908.2.
DR   UniGene; Hs.710284; -.
DR   ProteinModelPortal; Q9NWS9; -.
DR   SMR; Q9NWS9; 22-109, 206-246, 271-450.
DR   STRING; Q9NWS9; -.
DR   PhosphoSite; Q9NWS9; -.
DR   PRIDE; Q9NWS9; -.
DR   Ensembl; ENST00000335841; ENSP00000336565; ENSG00000083838.
DR   GeneID; 55663; -.
DR   KEGG; hsa:55663; -.
DR   UCSC; uc002qsz.1; human.
DR   CTD; 55663; -.
DR   GeneCards; GC19P055296; -.
DR   HGNC; HGNC:21036; ZNF446.
DR   neXtProt; NX_Q9NWS9; -.
DR   PharmGKB; PA134863395; -.
DR   InParanoid; Q9NWS9; -.
DR   OMA; RRHFCGD; -.
DR   OrthoDB; EOG4K3KWJ; -.
DR   PhylomeDB; Q9NWS9; -.
DR   Reactome; REACT_71; Gene Expression.
DR   NextBio; 60407; -.
DR   ArrayExpress; Q9NWS9; -.
DR   Bgee; Q9NWS9; -.
DR   CleanEx; HS_ZNF446; -.
DR   Genevestigator; Q9NWS9; -.
DR   GermOnline; ENSG00000083838; Homo sapiens.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0016032; P:viral reproduction; IEA:InterPro.
DR   InterPro; IPR001909; Krueppel-associated_box.
DR   InterPro; IPR008916; Retrov_capsid_C.
DR   InterPro; IPR003309; Tscrpt_reg_SCAN.
DR   InterPro; IPR007087; Znf_C2H2.
DR   InterPro; IPR015880; Znf_C2H2-like.
DR   InterPro; IPR013087; Znf_C2H2/integrase_DNA-bd.
DR   Gene3D; G3DSA:3.30.160.60; Znf_C2H2/integrase_DNA-bd; 3.
DR   Pfam; PF01352; KRAB; 1.
DR   Pfam; PF02023; SCAN; 1.
DR   Pfam; PF00096; zf-C2H2; 3.
DR   SMART; SM00349; KRAB; 1.
DR   SMART; SM00431; SCAN; 1.
DR   SMART; SM00355; ZnF_C2H2; 3.
DR   SUPFAM; SSF109640; Krueppel-associated_box; 1.
DR   SUPFAM; SSF47353; Retrov_capsid_C; 1.
DR   PROSITE; PS50805; KRAB; FALSE_NEG.
DR   PROSITE; PS50804; SCAN_BOX; 1.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 3.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 3.
DR   HOGENOMDNA; HS19.PE3661; -.
KW   ENSG000000838381755old_1320000031; ENSP000003365657901old_1320000031;
KW   Q8NDK2_HUMAN; Q96AF5_HUMAN; Q9UFF2_HUMAN; AK000633; AL122108; AL833955;
KW   BC017206;
KW   Complete proteome; DNA-binding; Metal-binding; Nucleus;
KW   Phosphoprotein; Polymorphism; Reference proteome; Repeat;
KW   Transcription; Transcription regulation; Zinc; Zinc-finger.
SQ   SEQUENCE   450 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MPSPLGPPCL PVMDPETTLE EPETARLRFR GFCYQEVAGP REALARLREL CCQWLQPEAH
     SKEQMLEMLV LEQFLGTLPP EIQAWVRGQR PGSPEEAAAL VEGLQHDPGQ LLGWITAHVL
     KQEVLPAAQK TEEPLGSPHP SGTVESPGEG PQDTRIEGSV QLSCSVKEEP NVDGQEVAPS
     SPPLAAQSPE GNHGHQEPAS TSFHPPRIQE EWGLLDRSQK ELYWDAMLEK YGTVVSLGLP
     PHQPEAQAQS ELGMLLTGTG VCRSLRSGNE SEGPPGCPEA QPPQGPGPAA WEGLSGAATP
     APTVRPGTPP VPTQPTPAET RLEPAATPRK PYTCEQCGRG FDWKSVFVIH HRTHTSGPGV
     QSPGLATGES TEKPPQGEVA FPHHPRRSLT GPRSYPCEEC GCSFSWKSQL VIHRKSHTGQ
     RRHFCSDCGR AFDWKSQLVI HRKGHRPEVP
//

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