(data stored in ACNUC8465 zone)

HOGENOM: HS19_PE557

ID   HS19_PE557                           STANDARD;      PRT;   419 AA.
AC   HS19_PE557;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Dual specificity mitogen-activated protein kinase kinase 7;
DE   Short=MAP kinase kinase 7; Short=MAPKK 7; EC=2.7.12 2;AltName:
DE   Full=JNK-activating kinase 2;AltName: Full=MAPK/ERK kinase 7; Short=MEK
DE   7;AltName: Full=c-Jun N-terminal kinase kinase 2; Short=JNK kinase 2;
DE   Short=JNKK 2; (HS19.PE557).
GN   Name=MAP2K7; Synonyms=JNKK2, MEK7, MKK7, PRKMK7;
OS   HOMO SAPIENS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini;
OC   Hominoidea; Hominidae; Homininae; Homo.
OX   NCBI_TaxID=9606;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS HS19.PE557.
CC       Homo sapiens chromosome 19 GRCh37  sequence 1..59118983 annotated by
CC       Ensembl
CC   -!- ANNOTATIONS ORIGIN:MP2K7_HUMAN
CC   -!- FUNCTION: Stress activated, dual specificity kinase that activates
CC       the JUN kinases MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3.
CC   -!- CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein.
CC   -!- COFACTOR: Magnesium.
CC   -!- ENZYME REGULATION: Activated by phosphorylation by specific MAP
CC       kinase kinase kinases such as MAP3K1/MEKK1, MAP3K3/MEKK3,
CC       MAP3K11/MLK3 and MAP3K12/DLK.
CC   -!- INTERACTION:
CC       P45983:MAPK8; NbExp=3; IntAct=EBI-492627, EBI-286483;
CC   -!- SUBCELLULAR LOCATION: Nucleus. Cytoplasm (By similarity).
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=4;
CC       Name=1; Synonyms=A;
CC         IsoId=O14733-1; Sequence=Displayed;
CC       Name=2; Synonyms=B;
CC         IsoId=O14733-2; Sequence=VSP_004883;
CC       Name=3; Synonyms=gamma1;
CC         IsoId=O14733-3; Sequence=VSP_022309;
CC       Name=4;
CC         IsoId=O14733-4; Sequence=VSP_022310;
CC         Note=No experimental confirmation available;
CC   -!- TISSUE SPECIFICITY: Ubiquitous; with highest level of expression
CC       in skeletal muscle. Isoform 3 is found at low levels in placenta,
CC       fetal liver, and skeletal muscle.
CC   -!- PTM: Activated by phosphorylation on Ser/Thr.
CC   -!- SIMILARITY: Belongs to the protein kinase superfamily. STE Ser/Thr
CC       protein kinase family. MAP kinase kinase subfamily.
CC   -!- SIMILARITY: Contains 1 protein kinase domain.
CC   -!- GENE_FAMILY: HOG000234206 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Homo_sapiens;ENSG00000076984;ENST00000397979;ENSP00000381066.
DR   EMBL; AF003199; - ;
DR   EMBL; AF006689; - ;
DR   EMBL; AF013588; - ;
DR   EMBL; AF013589; - ;
DR   EMBL; AF014401; - ;
DR   EMBL; AF022805; - ;
DR   EMBL; AK313899; - ;
DR   EMBL; BC038295; - ;
DR   EMBL; CH471139; - ;
DR   EMBL; DQ445915; - ;
DR   UniProtKB/Swiss-Prot; O14733; B2R9S5; D6W659; O14648; O14816; O60452; O60453; Q1PG43; -.
DR   UniProtKB/Swiss-Prot; Q8IY10; -.
DR   EMBL; AF014401; AAB88048.1; -; mRNA.
DR   EMBL; AF006689; AAB97813.1; ALT_TERM; mRNA.
DR   EMBL; AF013588; AAC16272.1; -; mRNA.
DR   EMBL; AF013589; AAC16273.1; -; mRNA.
DR   EMBL; DQ445915; ABE03013.1; -; mRNA.
DR   EMBL; AF022805; AAC26142.1; -; mRNA.
DR   EMBL; AK313899; BAG36622.1; -; mRNA.
DR   EMBL; CH471139; EAW68964.1; -; Genomic_DNA.
DR   EMBL; CH471139; EAW68968.1; -; Genomic_DNA.
DR   EMBL; BC038295; AAH38295.1; -; mRNA.
DR   EMBL; AF003199; AAB63374.1; -; mRNA.
DR   IPI; IPI00023636; -.
DR   IPI; IPI00302112; -.
DR   IPI; IPI00745806; -.
DR   IPI; IPI00794495; -.
DR   RefSeq; NP_660186.1; NM_145185.2.
DR   UniGene; Hs.531754; -.
DR   PDB; 2DYL; X-ray; 2.45 A; A=101-405.
DR   PDBsum; 2DYL; -.
DR   ProteinModelPortal; O14733; -.
DR   SMR; O14733; 103-402.
DR   IntAct; O14733; 8.
DR   MINT; MINT-1378223; -.
DR   STRING; O14733; -.
DR   PhosphoSite; O14733; -.
DR   PRIDE; O14733; -.
DR   Ensembl; ENST00000397979; ENSP00000381066; ENSG00000076984.
DR   GeneID; 5609; -.
DR   KEGG; hsa:5609; -.
DR   UCSC; uc002mit.1; human.
DR   UCSC; uc002miu.1; human.
DR   UCSC; uc002miv.1; human.
DR   CTD; 5609; -.
DR   GeneCards; GC19P007641; -.
DR   H-InvDB; HIX0202887; -.
DR   HGNC; HGNC:6847; MAP2K7.
DR   HPA; CAB004262; -.
DR   HPA; HPA001633; -.
DR   MIM; 603014; gene.
DR   neXtProt; NX_O14733; -.
DR   PharmGKB; PA284; -.
DR   GeneTree; ENSGT00570000078767; -.
DR   PhylomeDB; O14733; -.
DR   BRENDA; 2.7.12.2; 2681.
DR   Pathway_Interaction_DB; anthraxpathway; Cellular roles of Anthrax toxin.
DR   Pathway_Interaction_DB; fcer1pathway; Fc-epsilon receptor I signaling in mast cells.
DR   Pathway_Interaction_DB; hivnefpathway; HIV-1 Nef: Negative effector of Fas and TNF-alpha.
DR   Pathway_Interaction_DB; reelinpathway; Reelin signaling pathway.
DR   Pathway_Interaction_DB; tnfpathway; TNF receptor signaling pathway.
DR   Reactome; REACT_6900; Immune System.
DR   DrugBank; DB00773; Etoposide.
DR   NextBio; 21802; -.
DR   PMAP-CutDB; O14733; -.
DR   ArrayExpress; O14733; -.
DR   Bgee; O14733; -.
DR   CleanEx; HS_MAP2K7; -.
DR   Genevestigator; O14733; -.
DR   GO; GO:0005829; C:cytosol; TAS:Reactome.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0008545; F:JUN kinase kinase activity; TAS:Reactome.
DR   GO; GO:0000287; F:magnesium ion binding; IDA:UniProtKB.
DR   GO; GO:0005515; F:protein binding; IPI:IntAct.
DR   GO; GO:0019901; F:protein kinase binding; IPI:UniProtKB.
DR   GO; GO:0019903; F:protein phosphatase binding; ISS:BHF-UCL.
DR   GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR   GO; GO:0004713; F:protein tyrosine kinase activity; IEA:UniProtKB-KW.
DR   GO; GO:0007257; P:activation of JUN kinase activity; ISS:BHF-UCL.
DR   GO; GO:0045087; P:innate immune response; TAS:Reactome.
DR   GO; GO:0002755; P:MyD88-dependent toll-like receptor signaling pathway; EXP:Reactome.
DR   GO; GO:0002756; P:MyD88-independent toll-like receptor signaling pathway; EXP:Reactome.
DR   GO; GO:0051403; P:stress-activated MAPK cascade; IDA:UniProtKB.
DR   GO; GO:0008063; P:Toll signaling pathway; TAS:Reactome.
DR   GO; GO:0034130; P:toll-like receptor 1 signaling pathway; TAS:Reactome.
DR   GO; GO:0034134; P:toll-like receptor 2 signaling pathway; TAS:Reactome.
DR   GO; GO:0034138; P:toll-like receptor 3 signaling pathway; TAS:Reactome.
DR   GO; GO:0034142; P:toll-like receptor 4 signaling pathway; TAS:Reactome.
DR   InterPro; IPR011009; Kinase-like_dom.
DR   InterPro; IPR000719; Prot_kinase_cat_dom.
DR   InterPro; IPR017442; Se/Thr_kinase-like_dom.
DR   InterPro; IPR008271; Ser/Thr_kinase_AS.
DR   InterPro; IPR002290; Ser/Thr_kinase_dom.
DR   Pfam; PF00069; Pkinase; 1.
DR   SMART; SM00220; S_TKc; 1.
DR   SUPFAM; SSF56112; Kinase_like; 1.
DR   PROSITE; PS00107; PROTEIN_KINASE_ATP; FALSE_NEG.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
DR   HOGENOMDNA; HS19.PE557; -.
KW   ENSG000000769841755old_1320000031; ENSP000003810667901old_1320000031;
KW   D6W659_HUMAN; D6W660_HUMAN; AF003199; AF006689; AF013588; AF013589;
KW   AF022805; AK313899; BC038295; CH471139; DQ445915;
KW   3D-structure; Acetylation; Alternative splicing; ATP-binding;
KW   Coiled coil; Complete proteome; Cytoplasm; Kinase; Magnesium;
KW   Metal-binding; Nucleotide-binding; Nucleus; Phosphoprotein;
KW   Polymorphism; Reference proteome; Serine/threonine-protein kinase;
KW   Transferase; Tyrosine-protein kinase.
SQ   SEQUENCE   419 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MAASSLEQKL SRLEAKLKQE NREARRRIDL NLDISPQRPR PTLQLPLAND GGSRSPSSES
     SPQHPTPPAR PRHMLGLPST LFTPRSMESI EIDQKLQEIM KQTGYLTIGG QRYQAEINDL
     ENLGEMGSGT CGQVWKMRFR KTGHVIAVKQ MRRSGNKEEN KRILMDLDVV LKSHDCPYIV
     QCFGTFITNT DVFIAMELMG TCAEKLKKRM QGPIPERILG KMTVAIVKAL YYLKEKHGVI
     HRDVKPSNIL LDERGQIKLC DFGISGRLVD SKAKTRSAGC AAYMAPERID PPDPTKPDYD
     IRADVWSLGI SLVELATGQF PYKNCKTDFE VLTKVLQEEP PLLPGHMGFS GDFQSFVKDC
     LTKDHRKRPK YNKLLEHSFI KRYETLEVDV ASWFKDVMAK TESPRTSGVL SQPHLPFFR
//

If you have problems or comments...

PBIL Back to PBIL home page