(data stored in ACNUC7421 zone)

HOGENOM: HS19_PE961

ID   HS19_PE961                           STANDARD;      PRT;   369 AA.
AC   HS19_PE961; Q9BV20; Q8NDC9;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Methylthioribose-1-phosphate isomerase; Short=M1Pi;
DE   Short=MTR-1-P isomerase; EC=5.3.1 23;AltName: Full=Mediator of
DE   RhoA-dependent invasion;AltName: Full=S-methyl-5-thioribose-1-phosphate
DE   isomerase;AltName: Full=Translation initiation factor eIF-2B subunit
DE   alpha/beta/delta-like protein; (HS19.PE961).
GN   Name=MRI1; Synonyms=MRDI; ORFNames=UNQ6390/PRO21135;
OS   HOMO SAPIENS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini;
OC   Hominoidea; Hominidae; Homininae; Homo.
OX   NCBI_TaxID=9606;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS HS19.PE961.
CC       Homo sapiens chromosome 19 GRCh37  sequence 1..59118983 annotated by
CC       Ensembl
CC   -!- ANNOTATIONS ORIGIN:MTNA_HUMAN
CC   -!- FUNCTION: Catalyzes the interconversion of methylthioribose-1-
CC       phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-
CC       P). Independently from catalytic activity, promotes cell invasion
CC       in response to constitutive RhoA activation by promoting FAK
CC       tyrosine phosphorylation and stress fiber turnover.
CC   -!- CATALYTIC ACTIVITY: S-methyl-5-thio-alpha-D-ribose 1-phosphate =
CC       S-methyl-5-thio-D-ribulose 1-phosphate.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-methionine biosynthesis via
CC       salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose
CC       1-phosphate: step 1/6.
CC   -!- INTERACTION:
CC       Self; NbExp=3; IntAct=EBI-747381, EBI-747381;
CC   -!- SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Cell projection.
CC       Note=Primarily nuclear, but cytoplasmic in cancer cells, with
CC       enrichment at leading edge of the plasma membrane in late stage
CC       tumor cells.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q9BV20-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q9BV20-2; Sequence=VSP_030935;
CC   -!- INDUCTION: By RhoA activation in cancer cells (at protein level).
CC   -!- SIMILARITY: Belongs to the eIF-2B alpha/beta/delta subunits
CC       family. MtnA subfamily.
CC   -!- GENE_FAMILY: HOG000224730 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Homo_sapiens;ENSG00000037757;ENST00000445479;ENSP00000391825.
DR   EMBL; AL834276; - ;
DR   EMBL; AY358176; - ;
DR   EMBL; BC001703; - ;
DR   EMBL; CH471106; - ;
DR   UniProtKB/Swiss-Prot; Q9BV20; Q8NDC9; -.
DR   EMBL; AY358176; AAQ88543.1; -; mRNA.
DR   EMBL; AL834276; CAD38951.1; -; mRNA.
DR   EMBL; CH471106; EAW84370.1; -; Genomic_DNA.
DR   EMBL; CH471106; EAW84371.1; -; Genomic_DNA.
DR   EMBL; BC001703; AAH01703.1; -; mRNA.
DR   IPI; IPI00005948; -.
DR   IPI; IPI00184525; -.
DR   RefSeq; NP_001026897.1; NM_001031727.2.
DR   RefSeq; NP_115661.1; NM_032285.2.
DR   UniGene; Hs.439370; -.
DR   HSSP; Q06489; 1W2W.
DR   ProteinModelPortal; Q9BV20; -.
DR   SMR; Q9BV20; 2-357.
DR   IntAct; Q9BV20; 1.
DR   MINT; MINT-1197605; -.
DR   STRING; Q9BV20; -.
DR   PeptideAtlas; Q9BV20; -.
DR   PRIDE; Q9BV20; -.
DR   Ensembl; ENST00000040663; ENSP00000040663; ENSG00000037757.
DR   Ensembl; ENST00000445479; ENSP00000391825; ENSG00000037757.
DR   GeneID; 84245; -.
DR   KEGG; hsa:84245; -.
DR   NMPDR; fig|9606.3.peg.15817; -.
DR   UCSC; uc002mxe.1; human.
DR   UCSC; uc002mxf.1; human.
DR   CTD; 84245; -.
DR   GeneCards; GC19P013447; -.
DR   H-InvDB; HIX0202802; -.
DR   HGNC; HGNC:28469; MRI1.
DR   neXtProt; NX_Q9BV20; -.
DR   PharmGKB; PA164723110; -.
DR   eggNOG; prNOG18939; -.
DR   GeneTree; ENSGT00390000013732; -.
DR   InParanoid; Q9BV20; -.
DR   OMA; EDGWKVI; -.
DR   OrthoDB; EOG41C6WN; -.
DR   PhylomeDB; Q9BV20; -.
DR   Reactome; REACT_13; Metabolism of amino acids and derivatives.
DR   NextBio; 73721; -.
DR   ArrayExpress; Q9BV20; -.
DR   Bgee; Q9BV20; -.
DR   Genevestigator; Q9BV20; -.
DR   GO; GO:0042995; C:cell projection; IEA:UniProtKB-SubCell.
DR   GO; GO:0005737; C:cytoplasm; IBA:RefGenome.
DR   GO; GO:0005634; C:nucleus; IBA:RefGenome.
DR   GO; GO:0042802; F:identical protein binding; IPI:IntAct.
DR   GO; GO:0046523; F:S-methyl-5-thioribose-1-phosphate isomerase activity; IBA:RefGenome.
DR   GO; GO:0019509; P:L-methionine salvage from methylthioadenosine; IBA:RefGenome.
DR   InterPro; IPR000649; IF-2B-related.
DR   InterPro; IPR005251; IF-2BI_MTNA.
DR   InterPro; IPR011559; Initiation_fac_2B_a/b/d.
DR   PANTHER; PTHR10233; IF-2B_related; 1.
DR   Pfam; PF01008; IF-2B; 1.
DR   TIGRFAMs; TIGR00524; EIF-2B_rel; 1.
DR   TIGRFAMs; TIGR00512; Salvage_mtnA; 1.
DR   HOGENOMDNA; HS19.PE961; -.
KW   ENSG000000377571755old_1320000031; ENSP000003918257901old_1320000031;
KW   AL834276; AY358176; BC001703; CH471106;
KW   Alternative splicing; Amino-acid biosynthesis; Cell projection;
KW   Complete proteome; Cytoplasm; Isomerase; Methionine biosynthesis;
KW   Nucleus; Polymorphism; Reference proteome.
SQ   SEQUENCE   369 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MTLEAIRYSR GSLQILDQLL LPKQSRYEAV GSVHQAWEAI RAMKVRGAPA IALVGCLSLA
     VELQAGAGGP GLAALVAFVR DKLSFLVTAR PTAVNMARAA RDLADVAARE AEREGATEEA
     VRERVICCTE DMLEKDLRDN RSIGDLGARH LLERVAPSGG KVTVLTHCNT GALATAGYGT
     ALGVIRSLHS LGRLEHAFCT ETRPYNQGAR LTAFELVYEQ IPATLITDSM VAAAMAHRGV
     SAVVVGADRV VANGDTANKV GTYQLAIVAK HHGIPFYVAA PSSSCDLRLE TGKEIIIEER
     PGQELTDVNG VRIAAPGIGV WNPAFDVTPH DLITGGIITE LGVFAPEELR TALTTTISSR
     DGTLDGPQM
//

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