(data stored in ACNUC31183 zone)

HOGENOM: HS1_PE1130

ID   HS1_PE1130                           STANDARD;      PRT;   694 AA.
AC   HS1_PE1130; P47736; O75062; Q5T3S9; Q5T3T4; Q9UQ51;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Rap1 GTPase-activating protein 1; Short=Rap1GAP;
DE   Short=Rap1GAP1; (HS1.PE1130).
GN   Name=RAP1GAP; Synonyms=KIAA0474, RAP1GA1;
OS   HOMO SAPIENS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini;
OC   Hominoidea; Hominidae; Homininae; Homo.
OX   NCBI_TaxID=9606;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS HS1.PE1130.
CC       Homo sapiens chromosome 1 GRCh37  sequence 1..249240621 annotated by
CC       Ensembl
CC   -!- ANNOTATIONS ORIGIN:RPGP1_HUMAN
CC   -!- FUNCTION: GTPase activator for the nuclear Ras-related regulatory
CC       protein RAP-1A (KREV-1), converting it to the putatively inactive
CC       GDP-bound state.
CC   -!- SUBUNIT: Homodimer and heterodimer with RAP1B.
CC   -!- SUBCELLULAR LOCATION: Golgi apparatus membrane; Peripheral
CC       membrane protein.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=3;
CC       Name=1;
CC         IsoId=P47736-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=P47736-2; Sequence=VSP_035256, VSP_035257;
CC       Name=3;
CC         IsoId=P47736-3; Sequence=VSP_040260, VSP_040261;
CC   -!- TISSUE SPECIFICITY: Significant expression seen in the brain,
CC       kidney and pancreas. Abundant in the cerebral cortex and expressed
CC       at much lower levels in the spinal cord. Not detected in the
CC       lymphoid tissues.
CC   -!- INDUCTION: By 12-O-tetradecanoylphorbol-13-acetate (TPA) in
CC       promyelocytic HL-60 cells.
CC   -!- SIMILARITY: Contains 1 GoLoco domain.
CC   -!- SIMILARITY: Contains 1 Rap-GAP domain.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAA32319.3; Type=Erroneous initiation; Note=Translation N-terminally shortened;
CC   -!- GENE_FAMILY: HOG000231640 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Homo_sapiens;ENSG00000076864;ENST00000374761;ENSP00000363893.
DR   EMBL; AB003930; - ;
DR   EMBL; AB007943; - ;
DR   EMBL; AL359815; - ;
DR   EMBL; BC054490; - ;
DR   EMBL; CH471134; - ;
DR   EMBL; M64788; - ;
DR   UniProtKB/Swiss-Prot; P47736; O75062; Q5T3S9; Q5T3T4; Q9UQ51; -.
DR   EMBL; M64788; AAA60252.1; -; mRNA.
DR   EMBL; AB003930; BAA83674.1; -; mRNA.
DR   EMBL; AB007943; BAA32319.3; ALT_INIT; mRNA.
DR   EMBL; AL359815; CAI16250.1; -; Genomic_DNA.
DR   EMBL; AL359815; CAI16255.1; -; Genomic_DNA.
DR   EMBL; CH471134; EAW94980.1; -; Genomic_DNA.
DR   IPI; IPI00386930; -.
DR   IPI; IPI00843926; -.
DR   IPI; IPI01013142; -.
DR   PIR; A39897; A39897.
DR   PIR; B39897; B39897.
DR   RefSeq; NP_001139129.1; NM_001145657.1.
DR   RefSeq; NP_002876.2; NM_002885.2.
DR   UniGene; Hs.148178; -.
DR   PDB; 1SRQ; X-ray; 2.90 A; A/B/C/D=75-415.
DR   PDB; 3BRW; X-ray; 3.40 A; A/B/C=75-415.
DR   PDBsum; 1SRQ; -.
DR   PDBsum; 3BRW; -.
DR   ProteinModelPortal; P47736; -.
DR   SMR; P47736; 78-414.
DR   IntAct; P47736; 2.
DR   MINT; MINT-3308298; -.
DR   STRING; P47736; -.
DR   PhosphoSite; P47736; -.
DR   PRIDE; P47736; -.
DR   Ensembl; ENST00000290101; ENSP00000290101; ENSG00000076864.
DR   Ensembl; ENST00000317967; ENSP00000315420; ENSG00000076864.
DR   Ensembl; ENST00000359708; ENSP00000352739; ENSG00000076864.
DR   Ensembl; ENST00000374757; ENSP00000363889; ENSG00000076864.
DR   Ensembl; ENST00000374758; ENSP00000363890; ENSG00000076864.
DR   Ensembl; ENST00000374761; ENSP00000363893; ENSG00000076864.
DR   Ensembl; ENST00000374763; ENSP00000363895; ENSG00000076864.
DR   Ensembl; ENST00000374765; ENSP00000363897; ENSG00000076864.
DR   Ensembl; ENST00000374772; ENSP00000363904; ENSG00000076864.
DR   Ensembl; ENST00000447293; ENSP00000392717; ENSG00000076864.
DR   GeneID; 5909; -.
DR   KEGG; hsa:5909; -.
DR   UCSC; uc001bex.1; human.
DR   CTD; 5909; -.
DR   GeneCards; GC01M020166; -.
DR   HGNC; HGNC:9858; RAP1GAP.
DR   HPA; CAB003851; -.
DR   HPA; HPA001922; -.
DR   MIM; 600278; gene.
DR   neXtProt; NX_P47736; -.
DR   PharmGKB; PA34220; -.
DR   OrthoDB; EOG43FGWB; -.
DR   PhylomeDB; P47736; -.
DR   Reactome; REACT_6900; Immune System.
DR   NextBio; 22986; -.
DR   ArrayExpress; P47736; -.
DR   Bgee; P47736; -.
DR   CleanEx; HS_RAP1GAP; -.
DR   Genevestigator; P47736; -.
DR   GermOnline; ENSG00000076864; Homo sapiens.
DR   GO; GO:0005829; C:cytosol; IDA:UniProtKB.
DR   GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005624; C:membrane fraction; IDA:UniProtKB.
DR   GO; GO:0005096; F:GTPase activator activity; TAS:Reactome.
DR   GO; GO:0003924; F:GTPase activity; NAS:UniProtKB.
DR   GO; GO:0042803; F:protein homodimerization activity; IPI:UniProtKB.
DR   GO; GO:0017016; F:Ras GTPase binding; IPI:UniProtKB.
DR   GO; GO:0032318; P:regulation of Ras GTPase activity; IDA:UniProtKB.
DR   GO; GO:0007165; P:signal transduction; NAS:UniProtKB.
DR   InterPro; IPR003109; GoLoco_motif.
DR   InterPro; IPR000331; Rap_GAP.
DR   Pfam; PF02188; GoLoco; 1.
DR   Pfam; PF02145; Rap_GAP; 1.
DR   SMART; SM00390; GoLoco; 1.
DR   PROSITE; PS50877; GOLOCO; 1.
DR   PROSITE; PS50085; RAPGAP; 1.
DR   HOGENOMDNA; HS1.PE1130; -.
KW   ENSG000000768641755old_1320000031; ENSP000003638937901old_1320000031;
KW   Q5T3T0_HUMAN; Q5T3T1_HUMAN; Q7Z5S8_HUMAN; Q9UQ51_HUMAN; AB003930;
KW   AL359815; BC054490; CH471134; M64788;
KW   3D-structure; Acetylation; Alternative splicing; Complete proteome;
KW   Golgi apparatus; GTPase activation; Membrane; Phosphoprotein;
KW   Polymorphism; Reference proteome.
SQ   SEQUENCE   694 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MAQLRPAVPP GRPRRGSLPA GASWQNTDLF EMIEKMQGSR MDEQRCSFPP PLKTEEDYIP
     YPSVHEVLGR EGPFPLILLP QFGGYWIEGT NHEITSIPET EPLQSPTTKV KLECNPTARI
     YRKHFLGKEH FNYYSLDAAL GHLVFSLKYD VIGDQEHLRL LLRTKCRTYH DVIPISCLTE
     FPNVVQMAKL VCEDVNVDRF YPVLYPKASR LIVTFDEHVI SNNFKFGVIY QKLGQTSEEE
     LFSTNEESPA FVEFLEFLGQ KVKLQDFKGF RGGLDVTHGQ TGTESVYCNF RNKEIMFHVS
     TKLPYTEGDA QQLQRKRHIG NDIVAVVFQD ENTPFVPDMI ASNFLHAYVV VQAEGGGPDG
     PLYKVSVTAR DDVPFFGPPL PDPAVFRKGP EFQEFLLTKL INAEYACYKA EKFAKLEERT
     RAALLETLYE ELHIHSQSMM GLGGDEDKME NGSGGGGFFE SFKRVIRSRS QSMDAMGLSN
     KKPNTVSTSH SGSFAPNNPD LAKAAGISLI VPGKSPTRKK SGPFGSRRSS AIGIENIQEV
     QEKRESPPAG QKTPDSGHVS QEPKSENSST QSSPEMPTTK NRAETAAQRA EALKDFSRSS
     SSASSFASVV EETEGVDGED TGLESVSSSG TPHKRDSFIY STWLEDSVST TSGGSSPGPS
     RSPHPDAGKL GDPACPEIKI QLEASEQHMP QLGC
//

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