(data stored in ACNUC16935 zone)

HOGENOM: HS1_PE23

ID   HS1_PE23                             STANDARD;      PRT;   165 AA.
AC   HS1_PE23; P05161; Q5SVA4; Q7Z2G2; Q96GF0;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Ubiquitin-like protein ISG15;AltName:
DE   Full=Interferon-induced 15 kDa protein;AltName: Full=Interferon-induced
DE   17 kDa protein; Short=IP17;AltName: Full=Ubiquitin cross-reactive
DE   protein; Short=hUCRP;Flags: Precursor; (HS1.PE23).
GN   Name=ISG15; Synonyms=G1P2, UCRP;
OS   HOMO SAPIENS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini;
OC   Hominoidea; Hominidae; Homininae; Homo.
OX   NCBI_TaxID=9606;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS HS1.PE23.
CC       Homo sapiens chromosome 1 GRCh37  sequence 1..249240621 annotated by
CC       Ensembl
CC   -!- ANNOTATIONS ORIGIN:ISG15_HUMAN
CC   -!- FUNCTION: Ubiquitin-like protein that is conjugated to
CC       intracellular target proteins after IFN-alpha or IFN-beta
CC       stimulation. Its enzymatic pathway is partially distinct from that
CC       of ubiquitin, differing in substrate specificity and interaction
CC       with ligating enzymes. ISG15 conjugation pathway uses a dedicated
CC       E1 enzyme, but seems to converge with the Ub conjugation pathway
CC       at the level of a specific E2 enzyme. Targets include STAT1,
CC       SERPINA3G/SPI2A, JAK1, MAPK3/ERK1, PLCG1, EIF2AK2/PKR, MX1/MxA,
CC       and RIG-1. Deconjugated by USP18/UBP43. Shows specific chemotactic
CC       activity towards neutrophils and activates them to induce release
CC       of eosinophil chemotactic factors. May serve as a trans-acting
CC       binding factor directing the association of ligated target
CC       proteins to intermediate filaments. May also be involved in
CC       autocrine, paracrine and endocrine mechanisms, as in cell-to-cell
CC       signaling, possibly partly by inducing IFN-gamma secretion by
CC       monocytes and macrophages. Seems to display antiviral activity
CC       during viral infections.
CC   -!- FUNCTION: In response to IFN-tau secreted by the conceptus, may
CC       ligate to and regulate proteins involved in the release of
CC       prostaglandin F2-alpha (PGF), and thus prevent lysis of the corpus
CC       luteum and maintain the pregnancy (By similarity).
CC   -!- SUBUNIT: Interacts with, and is conjugated to its targets by the
CC       UBE1L (E1 enzyme) and UBE2E2 (E2 enzyme) (Probable). Interaction
CC       with influenza B NS1 protein inhibits this conjugation.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm. Secreted. Note=UCRP conjugates
CC       seem to be noncovalently associated with the intermediate
CC       filaments and distributed in a punctate pattern. Also secreted.
CC   -!- TISSUE SPECIFICITY: Detected in lymphoid cells, striated and
CC       smooth muscle, several epithelia and neurons.
CC   -!- INDUCTION: By type I interferons.
CC   -!- SIMILARITY: Contains 2 ubiquitin-like domains.
CC   -!- GENE_FAMILY: HOG000233942 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Homo_sapiens;ENSG00000187608;ENST00000379389;ENSP00000368699.
DR   EMBL; AL645608; - ;
DR   EMBL; AY168648; - ;
DR   EMBL; BC009507; - ;
DR   EMBL; BT007297; - ;
DR   EMBL; CH471183; - ;
DR   EMBL; M13755; - ;
DR   EMBL; M21786; - ;
DR   UniProtKB/Swiss-Prot; P05161; Q5SVA4; Q7Z2G2; Q96GF0; -.
DR   EMBL; M13755; AAA36038.1; -; mRNA.
DR   EMBL; M21786; AAA36128.1; -; Genomic_DNA.
DR   EMBL; AY168648; AAN86983.1; -; mRNA.
DR   EMBL; BT007297; AAP35961.1; -; mRNA.
DR   EMBL; AL645608; CAI15574.1; -; Genomic_DNA.
DR   EMBL; CH471183; EAW56295.1; -; Genomic_DNA.
DR   EMBL; BC009507; AAH09507.1; -; mRNA.
DR   IPI; IPI00375631; -.
DR   PIR; A28304; A28138.
DR   RefSeq; NP_005092.1; NM_005101.3.
DR   UniGene; Hs.458485; -.
DR   PDB; 1Z2M; X-ray; 2.50 A; A=1-155.
DR   PDB; 2HJ8; NMR; -; A=79-157.
DR   PDB; 3PHX; X-ray; 1.60 A; B=79-156.
DR   PDB; 3PSE; X-ray; 2.30 A; B=1-156.
DR   PDB; 3R66; X-ray; 2.30 A; C/D=1-157.
DR   PDBsum; 1Z2M; -.
DR   PDBsum; 2HJ8; -.
DR   PDBsum; 3PHX; -.
DR   PDBsum; 3PSE; -.
DR   PDBsum; 3R66; -.
DR   ProteinModelPortal; P05161; -.
DR   SMR; P05161; 3-156.
DR   DIP; DIP-29814N; -.
DR   IntAct; P05161; 3.
DR   MINT; MINT-1440156; -.
DR   STRING; P05161; -.
DR   PhosphoSite; P05161; -.
DR   PeptideAtlas; P05161; -.
DR   PRIDE; P05161; -.
DR   Ensembl; ENST00000379389; ENSP00000368699; ENSG00000187608.
DR   GeneID; 9636; -.
DR   KEGG; hsa:9636; -.
DR   UCSC; uc001acj.2; human.
DR   CTD; 9636; -.
DR   GeneCards; GC01P000220; -.
DR   H-InvDB; HIX0000011; -.
DR   HGNC; HGNC:4053; ISG15.
DR   HPA; HPA004627; -.
DR   MIM; 147571; gene.
DR   neXtProt; NX_P05161; -.
DR   PharmGKB; PA28465; -.
DR   eggNOG; prNOG12926; -.
DR   GeneTree; ENSGT00550000074658; -.
DR   InParanoid; P05161; -.
DR   OMA; FMNLRLR; -.
DR   OrthoDB; EOG4CNQSF; -.
DR   PhylomeDB; P05161; -.
DR   Reactome; REACT_6900; Immune System.
DR   NextBio; 36167; -.
DR   ArrayExpress; P05161; -.
DR   Bgee; P05161; -.
DR   CleanEx; HS_ISG15; -.
DR   Genevestigator; P05161; -.
DR   GermOnline; ENSG00000187608; Homo sapiens.
DR   GO; GO:0005829; C:cytosol; EXP:Reactome.
DR   GO; GO:0005615; C:extracellular space; NAS:UniProtKB.
DR   GO; GO:0005515; F:protein binding; IPI:IntAct.
DR   GO; GO:0007267; P:cell-cell signaling; NAS:UniProtKB.
DR   GO; GO:0044419; P:interspecies interaction between organisms; IEA:UniProtKB-KW.
DR   GO; GO:0032020; P:ISG15-protein conjugation; IDA:HGNC.
DR   GO; GO:0032480; P:negative regulation of type I interferon production; TAS:Reactome.
DR   GO; GO:0009615; P:response to virus; IEA:UniProtKB-KW.
DR   GO; GO:0060337; P:type I interferon-mediated signaling pathway; TAS:Reactome.
DR   InterPro; IPR000626; Ubiquitin.
DR   InterPro; IPR019956; Ubiquitin_subgr.
DR   InterPro; IPR019955; Ubiquitin_supergroup.
DR   Pfam; PF00240; ubiquitin; 2.
DR   PRINTS; PR00348; UBIQUITIN.
DR   SMART; SM00213; UBQ; 2.
DR   PROSITE; PS50053; UBIQUITIN_2; 2.
DR   HOGENOMDNA; HS1.PE23; -.
KW   ENSG000001876081755old_1320000031; ENSP000003686997901old_1320000031;
KW   AL645608; AY168648; BC009507; BT007297; CH471183; M13755; M21786;
KW   3D-structure; Antiviral defense; Complete proteome; Cytoplasm;
KW   Direct protein sequencing; Host-virus interaction; Isopeptide bond;
KW   Polymorphism; Reference proteome; Repeat; Secreted;
KW   Ubl conjugation pathway.
SQ   SEQUENCE   165 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MGWDLTVKML AGNEFQVSLS SSMSVSELKA QITQKIGVHA FQQRLAVHPS GVALQDRVPL
     ASQGLGPGST VLLVVDKCDE PLSILVRNNK GRSSTYEVRL TQTVAHLKQQ VSGLEGVQDD
     LFWLTFEGKP LEDQLPLGEY GLKPLSTVFM NLRLRGGGTE PGGRS
//

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