(data stored in ACNUC13365 zone)

HOGENOM: HS1_PE3635

ID   HS1_PE3635                           STANDARD;      PRT;   551 AA.
AC   HS1_PE3635; Q96S66; O94861; Q8WYP8; Q8WYP9; Q9BU25;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Chloride channel CLIC-like protein 1;AltName:
DE   Full=Mid-1-related chloride channel protein 1;Flags: Precursor;
DE   (HS1.PE3635).
GN   Name=CLCC1; Synonyms=KIAA0761, MCLC;
OS   HOMO SAPIENS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini;
OC   Hominoidea; Hominidae; Homininae; Homo.
OX   NCBI_TaxID=9606;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS HS1.PE3635.
CC       Homo sapiens chromosome 1 GRCh37  sequence 1..249240621 annotated by
CC       Ensembl
CC   -!- ANNOTATIONS ORIGIN:CLCC1_HUMAN
CC   -!- FUNCTION: Seems to act as a chloride ion channel (By similarity).
CC   -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein
CC       (Potential). Endoplasmic reticulum. Golgi apparatus. Nucleus (By
CC       similarity).
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=4;
CC       Name=1; Synonyms=hMCLC-1;
CC         IsoId=Q96S66-1; Sequence=Displayed;
CC       Name=2; Synonyms=hMCLC-2;
CC         IsoId=Q96S66-2; Sequence=VSP_027349;
CC       Name=3; Synonyms=hMCLC-3;
CC         IsoId=Q96S66-3; Sequence=VSP_027348;
CC       Name=4; Synonyms=hMCLC-4;
CC         IsoId=Q96S66-4; Sequence=VSP_027347;
CC   -!- SIMILARITY: Belongs to the chloride channel MCLC family.
CC   -!- GENE_FAMILY: HOG000231351 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Homo_sapiens;ENSG00000121940;ENST00000423586;ENSP00000391304.
DR   EMBL; AB018304; - ;
DR   EMBL; AB052915; - ;
DR   EMBL; AB052916; - ;
DR   EMBL; AB052917; - ;
DR   EMBL; AB052918; - ;
DR   EMBL; AL449266; - ;
DR   EMBL; BC002939; - ;
DR   EMBL; CH471122; - ;
DR   UniProtKB/Swiss-Prot; Q96S66; O94861; Q8WYP8; Q8WYP9; Q9BU25; -.
DR   EMBL; AB052915; BAB59018.1; -; mRNA.
DR   EMBL; AB052916; BAB79261.1; -; mRNA.
DR   EMBL; AB052917; BAB79262.1; -; mRNA.
DR   EMBL; AB052918; BAB79263.1; -; mRNA.
DR   EMBL; AB018304; BAA34481.2; -; mRNA.
DR   EMBL; AL449266; CAI14363.1; -; Genomic_DNA.
DR   EMBL; AL449266; CAI14364.1; -; Genomic_DNA.
DR   EMBL; AL449266; CAI14365.1; -; Genomic_DNA.
DR   EMBL; AL449266; CAI14366.1; -; Genomic_DNA.
DR   EMBL; CH471122; EAW56345.1; -; Genomic_DNA.
DR   EMBL; CH471122; EAW56346.1; -; Genomic_DNA.
DR   EMBL; BC002939; AAH02939.1; -; mRNA.
DR   IPI; IPI00045511; -.
DR   IPI; IPI00103756; -.
DR   IPI; IPI00103757; -.
DR   IPI; IPI00396547; -.
DR   RefSeq; NP_001041675.1; NM_001048210.1.
DR   RefSeq; NP_055942.1; NM_015127.3.
DR   UniGene; Hs.658489; -.
DR   ProteinModelPortal; Q96S66; -.
DR   IntAct; Q96S66; 1.
DR   STRING; Q96S66; -.
DR   TCDB; 1.A.36.1.1; intracellular chloride channel (ICC) family.
DR   PhosphoSite; Q96S66; -.
DR   PRIDE; Q96S66; -.
DR   Ensembl; ENST00000356970; ENSP00000349456; ENSG00000121940.
DR   Ensembl; ENST00000369971; ENSP00000358988; ENSG00000121940.
DR   Ensembl; ENST00000423586; ENSP00000391304; ENSG00000121940.
DR   GeneID; 23155; -.
DR   KEGG; hsa:23155; -.
DR   UCSC; uc001dwe.1; human.
DR   UCSC; uc001dwg.1; human.
DR   UCSC; uc009wes.1; human.
DR   UCSC; uc009wet.1; human.
DR   CTD; 23155; -.
DR   GeneCards; GC01M107364; -.
DR   H-InvDB; HIX0000838; -.
DR   HGNC; HGNC:29675; CLCC1.
DR   HPA; HPA009087; -.
DR   HPA; HPA013210; -.
DR   neXtProt; NX_Q96S66; -.
DR   PharmGKB; PA142672105; -.
DR   GeneTree; ENSGT00390000016611; -.
DR   InParanoid; Q96S66; -.
DR   OMA; SWTYKDD; -.
DR   OrthoDB; EOG4CC41V; -.
DR   PhylomeDB; Q96S66; -.
DR   NextBio; 44493; -.
DR   ArrayExpress; Q96S66; -.
DR   Bgee; Q96S66; -.
DR   CleanEx; HS_CLCC1; -.
DR   Genevestigator; Q96S66; -.
DR   GO; GO:0005783; C:endoplasmic reticulum; IDA:HPA.
DR   GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   InterPro; IPR009231; Chloride_chnl_CLIC-like.
DR   Pfam; PF05934; MCLC; 1.
DR   HOGENOMDNA; HS1.PE3635; -.
KW   ENSG000001219401755old_1320000031; ENSP000003913047901old_1320000031;
KW   AB018304; AB052915; AB052916; AB052917; AB052918; AL449266; BC002939;
KW   CH471122;
KW   Alternative splicing; Complete proteome; Endoplasmic reticulum;
KW   Golgi apparatus; Membrane; Nucleus; Phosphoprotein; Polymorphism;
KW   Reference proteome; Signal; Transmembrane; Transmembrane helix.
SQ   SEQUENCE   551 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MLCSLLLCEC LLLVAGYAHD DDWIDPTDML NYDAASGTMR KSQAKYGISG EKDVSPDLSC
     ADEISECYHK LDSLTYKIDE CEKKKREDYE SQSNPVFRRY LNKILIEAGK LGLPDENKGD
     MHYDAEIILK RETLLEIQKF LNGEDWKPGA LDDALSDILI NFKFHDFETW KWRFEDSFGV
     DPYNVLMVLL CLLCIVVLVA TELWTYVRWY TQLRRVLIIS FLFSLGWNWM YLYKLAFAQH
     QAEVAKMEPL NNVCAKKMDW TGSIWEWFRS SWTYKDDPCQ KYYELLLVNP IWLVPPTKAL
     AVTFTTFVTE PLKHIGKGTG EFIKALMKEI PALLHLPVLI IMALAILSFC YGAGKSVHVL
     RHIGGPESEP PQALRPRDRR RQEEIDYRPD GGAGDADFHY RGQMGPTEQG PYAKTYEGRR
     EILRERDVDL RFQTGNKSPE VLRAFDVPDA EAREHPTVVP SHKSPVLDTK PKETGGILGE
     GTPKESSTES SQSAKPVSGQ DTSGNTEGSP AAEKAQLKSE AAGSPDQGST YSPARGVAGP
     RGQDPVSSPC G
//

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