(data stored in ACNUC30567 zone)

HOGENOM: HS1_PE3701

ID   HS1_PE3701                           STANDARD;      PRT;   879 AA.
AC   HS1_PE3701;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=AMP deaminase 2; EC=3.5.4 6;AltName: Full=AMP deaminase
DE   isoform L; (HS1.PE3701).
GN   Name=AMPD2;
OS   HOMO SAPIENS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini;
OC   Hominoidea; Hominidae; Homininae; Homo.
OX   NCBI_TaxID=9606;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS HS1.PE3701.
CC       Homo sapiens chromosome 1 GRCh37  sequence 1..249240621 annotated by
CC       Ensembl
CC   -!- ANNOTATIONS ORIGIN:AMPD2_HUMAN
CC   -!- FUNCTION: AMP deaminase plays a critical role in energy
CC       metabolism.
CC   -!- CATALYTIC ACTIVITY: AMP + H(2)O = IMP + NH(3).
CC   -!- COFACTOR: Binds 1 zinc ion per subunit (By similarity).
CC   -!- PATHWAY: Purine metabolism; IMP biosynthesis via salvage pathway;
CC       IMP from AMP: step 1/1.
CC   -!- SUBUNIT: Homotetramer.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=4;
CC       Name=Ex1B-2-3;
CC         IsoId=Q01433-1; Sequence=Displayed;
CC       Name=Ex1A-2-3;
CC         IsoId=Q01433-2; Sequence=VSP_001271, VSP_001272;
CC       Name=Ex1A-3;
CC         IsoId=Q01433-3; Sequence=VSP_001274;
CC       Name=Ex1B-3;
CC         IsoId=Q01433-4; Sequence=VSP_001273;
CC   -!- TISSUE SPECIFICITY: Three isoforms are present in mammals: AMP
CC       deaminase 1 is the predominant form in skeletal muscle; AMP
CC       deaminase 2 predominates in smooth muscle, non-muscle tissue,
CC       embryonic muscle and undifferentiated myoblasts; AMP deaminase 3
CC       is found in erythrocytes.
CC   -!- SIMILARITY: Belongs to the adenosine and AMP deaminases family.
CC   -!- GENE_FAMILY: HOG000092200 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Homo_sapiens;ENSG00000116337;ENST00000256578;ENSP00000256578.
DR   EMBL; AK296394; - ;
DR   EMBL; AK302939; - ;
DR   EMBL; AK314494; - ;
DR   EMBL; AL355310; - ;
DR   EMBL; BC007711; - ;
DR   EMBL; BC075844; - ;
DR   EMBL; CH471122; - ;
DR   EMBL; M91029; - ;
DR   EMBL; S47833; - ;
DR   EMBL; U16267; - ;
DR   EMBL; U16268; - ;
DR   EMBL; U16269; - ;
DR   EMBL; U16270; - ;
DR   EMBL; U16271; - ;
DR   EMBL; U16272; - ;
DR   UniProtKB/Swiss-Prot; Q01433; B4DZI5; Q14856; Q14857; Q16686; Q16687; Q16688; Q16729; -.
DR   UniProtKB/Swiss-Prot; Q5T693; Q5T695; Q96IA1; Q9UDX8; Q9UDX9; Q9UMU4; -.
DR   EMBL; M91029; AAA62127.1; -; mRNA.
DR   EMBL; M91029; AAA62126.1; -; mRNA.
DR   EMBL; S47833; AAA11725.1; -; mRNA.
DR   EMBL; U16267; AAC50306.1; -; mRNA.
DR   EMBL; U16268; AAC50307.1; -; mRNA.
DR   EMBL; U16269; AAB06511.1; -; Genomic_RNA.
DR   EMBL; U16270; AAC50308.1; -; mRNA.
DR   EMBL; U16272; AAD56302.1; -; Genomic_DNA.
DR   EMBL; U16271; AAD56302.1; JOINED; Genomic_DNA.
DR   EMBL; U16272; AAC50309.2; -; Genomic_DNA.
DR   EMBL; U16271; AAC50309.2; JOINED; Genomic_DNA.
DR   EMBL; U16272; AAD56303.1; -; Genomic_DNA.
DR   EMBL; U16271; AAD56303.1; JOINED; Genomic_DNA.
DR   EMBL; AK302939; BAG64097.1; -; mRNA.
DR   EMBL; AL355310; CAI19305.1; -; Genomic_DNA.
DR   EMBL; AL355310; CAI19307.1; -; Genomic_DNA.
DR   EMBL; CH471122; EAW56396.1; -; Genomic_DNA.
DR   EMBL; CH471122; EAW56399.1; -; Genomic_DNA.
DR   EMBL; CH471122; EAW56401.1; -; Genomic_DNA.
DR   EMBL; BC007711; AAH07711.1; -; mRNA.
DR   EMBL; BC075844; AAH75844.1; -; mRNA.
DR   IPI; IPI00184670; -.
DR   IPI; IPI00215826; -.
DR   IPI; IPI00215827; -.
DR   IPI; IPI00942246; -.
DR   PIR; A44313; A44313.
DR   PIR; S59994; S59994.
DR   PIR; S59995; S59995.
DR   PIR; S59998; S59998.
DR   PIR; S59999; S59999.
DR   PIR; S60000; S60000.
DR   RefSeq; NP_004028.3; NM_004037.6.
DR   RefSeq; NP_631895.1; NM_139156.2.
DR   RefSeq; NP_981949.1; NM_203404.1.
DR   UniGene; Hs.82927; -.
DR   ProteinModelPortal; Q01433; -.
DR   SMR; Q01433; 217-865.
DR   STRING; Q01433; -.
DR   PhosphoSite; Q01433; -.
DR   PRIDE; Q01433; -.
DR   Ensembl; ENST00000256578; ENSP00000256578; ENSG00000116337.
DR   GeneID; 271; -.
DR   KEGG; hsa:271; -.
DR   UCSC; uc001dyc.1; human.
DR   CTD; 271; -.
DR   GeneCards; GC01P108054; -.
DR   HGNC; HGNC:469; AMPD2.
DR   MIM; 102771; gene.
DR   neXtProt; NX_Q01433; -.
DR   PharmGKB; PA24777; -.
DR   eggNOG; prNOG17328; -.
DR   GeneTree; ENSGT00390000008190; -.
DR   PhylomeDB; Q01433; -.
DR   BioCyc; MetaCyc:MONOMER-15179; -.
DR   Reactome; REACT_1698; Metabolism of nucleotides.
DR   NextBio; 1065; -.
DR   ArrayExpress; Q01433; -.
DR   Bgee; Q01433; -.
DR   Genevestigator; Q01433; -.
DR   GermOnline; ENSG00000116337; Homo sapiens.
DR   GO; GO:0005829; C:cytosol; TAS:Reactome.
DR   GO; GO:0003876; F:AMP deaminase activity; NAS:UniProtKB.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006144; P:purine base metabolic process; TAS:Reactome.
DR   GO; GO:0009168; P:purine ribonucleoside monophosphate biosynthetic process; IEA:InterPro.
DR   GO; GO:0043101; P:purine-containing compound salvage; TAS:Reactome.
DR   InterPro; IPR006650; A/AMP_deam_AS.
DR   InterPro; IPR001365; A/AMP_deaminase.
DR   InterPro; IPR006329; AMP_deaminase.
DR   InterPro; IPR016297; AMP_deaminase_met.
DR   Pfam; PF00962; A_deaminase; 1.
DR   PIRSF; PIRSF001251; AMP_deaminase_met; 1.
DR   TIGRFAMs; TIGR01429; AMP_deaminase; 1.
DR   PROSITE; PS00485; A_DEAMINASE; 1.
DR   HOGENOMDNA; HS1.PE3701; -.
KW   ENSG000001163371755old_1320000031; ENSP000002565787901old_1320000031;
KW   B2RB47_HUMAN; B4DK50_HUMAN; AK296394; AK302939; AK314494; AL355310;
KW   BC075844; CH471122; M91029; S47833; U16267; U16268; U16269; U16270;
KW   U16272;
KW   Acetylation; Alternative splicing; Complete proteome; Hydrolase;
KW   Metal-binding; Nucleotide metabolism; Phosphoprotein;
KW   Reference proteome; Zinc.
SQ   SEQUENCE   879 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MRNRGQGLFR LRSRCFLHQS LPLGAGRRKG LDVAEPGPSR CRSDSPAVAA VVPAMASYPS
     GSGKPKAKYP FKKRASLQAS TAAPEARGGL GAPPLQSARS LPGPAPCLKH FPLDLRTSMD
     GKCKEIAEEL FTRSLAESEL RSAPYEFPEE SPIEQLEERR QRLERQISQD VKLEPDILLR
     AKQDFLKTDS DSDLQLYKEQ GEGQGDRSLR ERDVLEREFQ RVTISGEEKC GVPFTDLLDA
     AKSVVRALFI REKYMALSLQ SFCPTTRRYL QQLAEKPLET RTYEQGPDTP VSADAPVHPP
     ALEQHPYEHC EPSTMPGDLG LGLRMVRGVV HVYTRREPDE HCSEVELPYP DLQEFVADVN
     VLMALIINGP IKSFCYRRLQ YLSSKFQMHV LLNEMKELAA QKKVPHRDFY NIRKVDTHIH
     ASSCMNQKHL LRFIKRAMKR HLEEIVHVEQ GREQTLREVF ESMNLTAYDL SVDTLDVHAD
     RNTFHRFDKF NAKYNPIGES VLREIFIKTD NRVSGKYFAH IIKEVMSDLE ESKYQNAELR
     LSIYGRSRDE WDKLARWAVM HRVHSPNVRW LVQVPRLFDV YRTKGQLANF QEMLENIFLP
     LFEATVHPAS HPELHLFLEH VDGFDSVDDE SKPENHVFNL ESPLPEAWVE EDNPPYAYYL
     YYTFANMAML NHLRRQRGFH TFVLRPHCGE AGPIHHLVSA FMLAENISHG LLLRKAPVLQ
     YLYYLAQIGI AMSPLSNNSL FLSYHRNPLP EYLSRGLMVS LSTDDPLQFH FTKEPLMEEY
     SIATQVWKLS SCDMCELARN SVLMSGFSHK VKSHWLGPNY TKEGPEGNDI RRTNVPDIRV
     GYRYETLCQE LALITQAVQS EMLETIPEEA GITMSPGPQ
//

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