(data stored in ACNUC1829 zone)

HOGENOM: HS1_PE3761

ID   HS1_PE3761                           STANDARD;      PRT;   219 AA.
AC   HS1_PE3761; P19397; B2R905; Q5U0D6;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Leukocyte surface antigen CD53;AltName: Full=Cell surface
DE   glycoprotein CD53;AltName: Full=Tetraspanin-25; Short=Tspan-25;AltName:
DE   CD_antigen=CD53; (HS1.PE3761).
GN   Name=CD53; Synonyms=MOX44, TSPAN25;
OS   HOMO SAPIENS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini;
OC   Hominoidea; Hominidae; Homininae; Homo.
OX   NCBI_TaxID=9606;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS HS1.PE3761.
CC       Homo sapiens chromosome 1 GRCh37  sequence 1..249240621 annotated by
CC       Ensembl
CC   -!- ANNOTATIONS ORIGIN:CD53_HUMAN
CC   -!- FUNCTION: May be involved in growth regulation in hematopoietic
CC       cells.
CC   -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC   -!- TISSUE SPECIFICITY: B-cells, monocytes, macrophages, neutrophils,
CC       single (CD4 or CD8) positive thymocytes and peripheral T-cells.
CC   -!- SIMILARITY: Belongs to the tetraspanin (TM4SF) family.
CC   -!- WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology
CC       and Haematology;
CC       URL="http://atlasgeneticsoncology.org/Genes/CD53ID983ch1p13.html";
CC   -!- GENE_FAMILY: HOG000230651 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Homo_sapiens;ENSG00000143119;ENST00000271324;ENSP00000271324.
DR   EMBL; AK313582; - ;
DR   EMBL; AL391064; - ;
DR   EMBL; BC040693; - ;
DR   EMBL; BT019643; - ;
DR   EMBL; CH471122; - ;
DR   EMBL; M37033; - ;
DR   EMBL; M60871; - ;
DR   UniProtKB/Swiss-Prot; P19397; B2R905; Q5U0D6; -.
DR   EMBL; M37033; AAA35663.1; -; mRNA.
DR   EMBL; M60871; AAA51951.1; -; mRNA.
DR   EMBL; BT019643; AAV38449.1; -; mRNA.
DR   EMBL; AK313582; BAG36352.1; -; mRNA.
DR   EMBL; AL391064; CAH73292.1; -; Genomic_DNA.
DR   EMBL; CH471122; EAW56459.1; -; Genomic_DNA.
DR   EMBL; BC040693; AAH40693.1; -; mRNA.
DR   IPI; IPI00018307; -.
DR   PIR; A37243; A37243.
DR   RefSeq; NP_000551.1; NM_000560.3.
DR   RefSeq; NP_001035122.1; NM_001040033.1.
DR   UniGene; Hs.443057; -.
DR   ProteinModelPortal; P19397; -.
DR   SMR; P19397; 104-180.
DR   STRING; P19397; -.
DR   PRIDE; P19397; -.
DR   Ensembl; ENST00000271324; ENSP00000271324; ENSG00000143119.
DR   GeneID; 963; -.
DR   KEGG; hsa:963; -.
DR   UCSC; uc001dzw.1; human.
DR   CTD; 963; -.
DR   GeneCards; GC01P109285; -.
DR   H-InvDB; HIX0023631; -.
DR   HGNC; HGNC:1686; CD53.
DR   MIM; 151525; gene.
DR   neXtProt; NX_P19397; -.
DR   PharmGKB; PA26225; -.
DR   eggNOG; prNOG12394; -.
DR   GeneTree; ENSGT00590000082914; -.
DR   InParanoid; P19397; -.
DR   OMA; VIQVLGM; -.
DR   OrthoDB; EOG4ZS94F; -.
DR   PhylomeDB; P19397; -.
DR   NextBio; 4024; -.
DR   ArrayExpress; P19397; -.
DR   Bgee; P19397; -.
DR   CleanEx; HS_CD53; -.
DR   Genevestigator; P19397; -.
DR   GermOnline; ENSG00000143119; Homo sapiens.
DR   GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; TAS:ProtInc.
DR   GO; GO:0007165; P:signal transduction; NAS:ProtInc.
DR   InterPro; IPR018499; Tetraspanin.
DR   InterPro; IPR018503; Tetraspanin_CS.
DR   InterPro; IPR008952; Tetraspanin_EC2.
DR   InterPro; IPR000301; Tetraspanin_subgr.
DR   Pfam; PF00335; Tetraspannin; 1.
DR   PRINTS; PR00259; TMFOUR.
DR   SUPFAM; SSF48652; Tetraspanin; 1.
DR   PROSITE; PS00421; TM4_1; 1.
DR   HOGENOMDNA; HS1.PE3761; -.
KW   ENSG000001431191755old_1320000031; ENSP000002713247901old_1320000031;
KW   AK313582; AL391064; BC040693; BT019643; CH471122; M37033; M60871;
KW   Complete proteome; Glycoprotein; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix.
SQ   SEQUENCE   219 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MGMSSLKLLK YVLFFFNLLF WICGCCILGF GIYLLIHNNF GVLFHNLPSL TLGNVFVIVG
     SIIMVVAFLG CMGSIKENKC LLMSFFILLL IILLAEVTLA ILLFVYEQKL NEYVAKGLTD
     SIHRYHSDNS TKAAWDSIQS FLQCCGINGT SDWTSGPPAS CPSDRKVEGC YAKARLWFHS
     NFLYIGIITI CVCVIEVLGM SFALTLNCQI DKTSQTIGL
//

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