(data stored in ACNUC7421 zone)

HOGENOM: HS1_PE3803

ID   HS1_PE3803                           STANDARD;      PRT;   184 AA.
AC   HS1_PE3803; P62834; P10113;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Ras-related protein Rap-1A;AltName: Full=C21KG;AltName:
DE   Full=G-22K;AltName: Full=GTP-binding protein smg p21A;AltName:
DE   Full=Ras-related protein Krev-1;Flags: Precursor; (HS1.PE3803).
GN   Name=RAP1A; Synonyms=KREV1;
OS   HOMO SAPIENS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini;
OC   Hominoidea; Hominidae; Homininae; Homo.
OX   NCBI_TaxID=9606;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS HS1.PE3803.
CC       Homo sapiens chromosome 1 GRCh37  sequence 1..249240621 annotated by
CC       Ensembl
CC   -!- ANNOTATIONS ORIGIN:RAP1A_HUMAN
CC   -!- FUNCTION: Induces morphological reversion of a cell line
CC       transformed by a Ras oncogene. Counteracts the mitogenic function
CC       of Ras, at least partly because it can interact with Ras GAPs and
CC       RAF in a competitive manner.
CC   -!- ENZYME REGULATION: Activated by guanine nucleotide-exchange
CC       factors (GEF) EPAC and EPAC2 in a cAMP-dependent manner, and GFR.
CC   -!- SUBUNIT: In its GTP-bound form interacts with PLCE1 and RADIL.
CC       Interacts with SGSM1, SGSM2 and SGSM3.
CC   -!- INTERACTION:
CC       P04049:RAF1; NbExp=2; IntAct=EBI-491414, EBI-365996;
CC       Q8WWW0-2:RASSF5; NbExp=3; IntAct=EBI-491414, EBI-960502;
CC       Q5EBH1:Rassf5 (xeno); NbExp=2; IntAct=EBI-491414, EBI-960530;
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor.
CC   -!- SIMILARITY: Belongs to the small GTPase superfamily. Ras family.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAB55685.2; Type=Erroneous gene model prediction;
CC   -!- WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology
CC       and Haematology;
CC       URL="http://atlasgeneticsoncology.org/Genes/RAP1AID272.html";
CC   -!- GENE_FAMILY: HOG000233973 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Homo_sapiens;ENSG00000116473;ENST00000369709;ENSP00000358723.
DR   EMBL; AB451235; - ;
DR   EMBL; AB451360; - ;
DR   EMBL; AF493912; - ;
DR   EMBL; AK293044; - ;
DR   EMBL; AL049557; - ;
DR   EMBL; BC014086; - ;
DR   EMBL; BT019666; - ;
DR   EMBL; CH471122; - ;
DR   EMBL; M22995; - ;
DR   EMBL; X12533; - ;
DR   UniProtKB/Swiss-Prot; P62834; P10113; -.
DR   EMBL; X12533; CAA31051.1; -; mRNA.
DR   EMBL; M22995; AAA36150.1; -; mRNA.
DR   EMBL; AF493912; AAM12626.1; -; mRNA.
DR   EMBL; AL049557; CAB55685.2; ALT_SEQ; Genomic_DNA.
DR   EMBL; BC014086; AAH14086.1; -; mRNA.
DR   IPI; IPI00019345; -.
DR   PIR; A32342; A32342.
DR   RefSeq; NP_001010935.1; NM_001010935.1.
DR   RefSeq; NP_002875.1; NM_002884.2.
DR   UniGene; Hs.190334; -.
DR   PDB; 1C1Y; X-ray; 1.90 A; A=1-167.
DR   PDB; 1GUA; X-ray; 2.00 A; A=1-167.
DR   PDB; 3KUC; X-ray; 1.92 A; A=1-167.
DR   PDBsum; 1C1Y; -.
DR   PDBsum; 1GUA; -.
DR   PDBsum; 3KUC; -.
DR   ProteinModelPortal; P62834; -.
DR   SMR; P62834; 1-167.
DR   DIP; DIP-29106N; -.
DR   IntAct; P62834; 8.
DR   STRING; P62834; -.
DR   PhosphoSite; P62834; -.
DR   OGP; P62834; -.
DR   PRIDE; P62834; -.
DR   Ensembl; ENST00000356415; ENSP00000348786; ENSG00000116473.
DR   Ensembl; ENST00000369709; ENSP00000358723; ENSG00000116473.
DR   Ensembl; ENST00000436150; ENSP00000394318; ENSG00000116473.
DR   GeneID; 5906; -.
DR   KEGG; hsa:5906; -.
DR   UCSC; uc001ebi.1; human.
DR   CTD; 5906; -.
DR   GeneCards; GC01P110105; -.
DR   H-InvDB; HIX0000882; -.
DR   HGNC; HGNC:9855; RAP1A.
DR   HPA; CAB018335; -.
DR   MIM; 179520; gene.
DR   neXtProt; NX_P62834; -.
DR   eggNOG; prNOG14833; -.
DR   InParanoid; P62834; -.
DR   OMA; DSIGTHE; -.
DR   OrthoDB; EOG45MN6H; -.
DR   PhylomeDB; P62834; -.
DR   Pathway_Interaction_DB; amb2_neutrophils_pathway; amb2 Integrin signaling.
DR   Pathway_Interaction_DB; pi3kcipathway; Class I PI3K signaling events.
DR   Pathway_Interaction_DB; ephbfwdpathway; EPHB forward signaling.
DR   Pathway_Interaction_DB; epopathway; EPO signaling pathway.
DR   Pathway_Interaction_DB; ifngpathway; IFN-gamma pathway.
DR   Pathway_Interaction_DB; trkrpathway; Neurotrophic factor-mediated Trk receptor signaling.
DR   Pathway_Interaction_DB; reelinpathway; Reelin signaling pathway.
DR   Pathway_Interaction_DB; met_pathway; Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met).
DR   Pathway_Interaction_DB; ret_pathway; Signaling events regulated by Ret tyrosine kinase.
DR   Pathway_Interaction_DB; tcrpathway; TCR signaling in naive CD4+ T cells.
DR   Pathway_Interaction_DB; cd8tcrpathway; TCR signaling in naive CD8+ T cells.
DR   Pathway_Interaction_DB; mapktrkpathway; Trk receptor signaling mediated by the MAPK pathway.
DR   Reactome; REACT_11061; Signalling by NGF.
DR   Reactome; REACT_13552; Integrin cell surface interactions.
DR   Reactome; REACT_1505; Integration of energy metabolism.
DR   Reactome; REACT_15380; Diabetes pathways.
DR   Reactome; REACT_604; Hemostasis.
DR   Reactome; REACT_6900; Immune System.
DR   NextBio; 22972; -.
DR   ArrayExpress; P62834; -.
DR   Bgee; P62834; -.
DR   CleanEx; HS_RAP1A; -.
DR   Genevestigator; P62834; -.
DR   GO; GO:0005829; C:cytosol; EXP:Reactome.
DR   GO; GO:0005886; C:plasma membrane; EXP:Reactome.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003924; F:GTPase activity; TAS:ProtInc.
DR   GO; GO:0000186; P:activation of MAPKK activity; TAS:Reactome.
DR   GO; GO:0007596; P:blood coagulation; TAS:Reactome.
DR   GO; GO:0006112; P:energy reserve metabolic process; TAS:Reactome.
DR   GO; GO:0048011; P:nerve growth factor receptor signaling pathway; TAS:Reactome.
DR   GO; GO:0050796; P:regulation of insulin secretion; TAS:Reactome.
DR   InterPro; IPR005225; Small_GTP-bd_dom.
DR   InterPro; IPR001806; Small_GTPase.
DR   InterPro; IPR020849; Small_GTPase_Ras.
DR   PANTHER; PTHR24070; PTHR24070; 1.
DR   Pfam; PF00071; Ras; 1.
DR   PRINTS; PR00449; RASTRNSFRMNG.
DR   SMART; SM00173; RAS; 1.
DR   TIGRFAMs; TIGR00231; Small_GTP; 1.
DR   PROSITE; PS51421; RAS; 1.
DR   HOGENOMDNA; HS1.PE3803; -.
KW   ENSG000001164731755old_1320000031; ENSP000003587237901old_1320000031;
KW   A8KAH9_HUMAN; Q5U0C3_HUMAN; AB451235; AB451360; AF493912; AK293044;
KW   BC014086; BT019666; CH471122; M22995; X12533;
KW   3D-structure; Cell membrane; Complete proteome;
KW   Direct protein sequencing; GTP-binding; Lipoprotein; Membrane;
KW   Methylation; Nucleotide-binding; Prenylation; Reference proteome;
KW   Tumor suppressor.
SQ   SEQUENCE   184 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MREYKLVVLG SGGVGKSALT VQFVQGIFVE KYDPTIEDSY RKQVEVDCQQ CMLEILDTAG
     TEQFTAMRDL YMKNGQGFAL VYSITAQSTF NDLQDLREQI LRVKDTEDVP MILVGNKCDL
     EDERVVGKEQ GQNLARQWCN CAFLESSAKS KINVNEIFYD LVRQINRKTP VEKKKPKKKS
     CLLL
//

If you have problems or comments...

PBIL Back to PBIL home page