(data stored in ACNUC8465 zone)

HOGENOM: HS1_PE3839

ID   HS1_PE3839                           STANDARD;      PRT;   193 AA.
AC   HS1_PE3839; P08134; B3KSW1; Q6ICN3;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Rho-related GTP-binding protein RhoC;AltName: Full=Rho cDNA
DE   clone 9; Short=h9;Flags: Precursor; (HS1.PE3839).
GN   Name=RHOC; Synonyms=ARH9, ARHC;
OS   HOMO SAPIENS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini;
OC   Hominoidea; Hominidae; Homininae; Homo.
OX   NCBI_TaxID=9606;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS HS1.PE3839.
CC       Homo sapiens chromosome 1 GRCh37  sequence 1..249240621 annotated by
CC       Ensembl
CC   -!- ANNOTATIONS ORIGIN:RHOC_HUMAN
CC   -!- FUNCTION: Regulates a signal transduction pathway linking plasma
CC       membrane receptors to the assembly of focal adhesions and actin
CC       stress fibers.
CC   -!- SUBUNIT: Interacts with DIAPH1, ROCK1, ROCK2 and RTKN. Interacts
CC       with AKAP13.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor; Cytoplasmic
CC       side (Potential).
CC   -!- SIMILARITY: Belongs to the small GTPase superfamily. Rho family.
CC   -!- WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology
CC       and Haematology;
CC       URL="http://atlasgeneticsoncology.org/Genes/RHOCID42110ch1p13.html";
CC   -!- GENE_FAMILY: HOG000233974 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Homo_sapiens;ENSG00000155366;ENST00000285735;ENSP00000285735.
DR   EMBL; AF498972; - ;
DR   EMBL; AK094474; - ;
DR   EMBL; AL603832; - ;
DR   EMBL; BC007245; - ;
DR   EMBL; BC009177; - ;
DR   EMBL; BC052808; - ;
DR   EMBL; BT019448; - ;
DR   EMBL; CH471122; - ;
DR   EMBL; CR450360; - ;
DR   EMBL; L25081; - ;
DR   EMBL; X06821; - ;
DR   UniProtKB/Swiss-Prot; P08134; B3KSW1; Q6ICN3; -.
DR   EMBL; X06821; CAA29969.1; -; mRNA.
DR   EMBL; L25081; AAC33179.1; -; mRNA.
DR   EMBL; AF498972; AAM21119.1; -; mRNA.
DR   EMBL; CR450360; CAG29356.1; -; mRNA.
DR   EMBL; BT019448; AAV38255.1; -; mRNA.
DR   EMBL; AK094474; BAG52873.1; -; mRNA.
DR   EMBL; AL603832; CAI14058.1; -; Genomic_DNA.
DR   EMBL; CH471122; EAW56534.1; -; Genomic_DNA.
DR   EMBL; BC007245; AAH07245.1; -; mRNA.
DR   EMBL; BC009177; AAH09177.1; -; mRNA.
DR   EMBL; BC052808; AAH52808.1; -; mRNA.
DR   IPI; IPI00027434; -.
DR   PIR; S01029; TVHURC.
DR   RefSeq; NP_001036143.1; NM_001042678.1.
DR   RefSeq; NP_001036144.1; NM_001042679.1.
DR   RefSeq; NP_786886.1; NM_175744.4.
DR   UniGene; Hs.502659; -.
DR   UniGene; Hs.658289; -.
DR   PDB; 1Z2C; X-ray; 3.00 A; A/C=1-193.
DR   PDB; 2GCN; X-ray; 1.85 A; A=1-181.
DR   PDB; 2GCO; X-ray; 1.40 A; A/B=1-181.
DR   PDBsum; 1Z2C; -.
DR   PDBsum; 2GCN; -.
DR   PDBsum; 2GCO; -.
DR   ProteinModelPortal; P08134; -.
DR   SMR; P08134; 3-179.
DR   IntAct; P08134; 5.
DR   MINT; MINT-1216716; -.
DR   STRING; P08134; -.
DR   PhosphoSite; P08134; -.
DR   PRIDE; P08134; -.
DR   Ensembl; ENST00000285735; ENSP00000285735; ENSG00000155366.
DR   Ensembl; ENST00000339083; ENSP00000345236; ENSG00000155366.
DR   Ensembl; ENST00000369632; ENSP00000358646; ENSG00000155366.
DR   Ensembl; ENST00000369633; ENSP00000358647; ENSG00000155366.
DR   Ensembl; ENST00000369637; ENSP00000358651; ENSG00000155366.
DR   Ensembl; ENST00000369638; ENSP00000358652; ENSG00000155366.
DR   Ensembl; ENST00000369642; ENSP00000358656; ENSG00000155366.
DR   GeneID; 389; -.
DR   KEGG; hsa:389; -.
DR   UCSC; uc001ecp.1; human.
DR   CTD; 389; -.
DR   GeneCards; GC01M111103; -.
DR   H-InvDB; HIX0000895; -.
DR   HGNC; HGNC:669; RHOC.
DR   HPA; CAB010821; -.
DR   MIM; 165380; gene.
DR   neXtProt; NX_P08134; -.
DR   PharmGKB; PA24951; -.
DR   eggNOG; prNOG07689; -.
DR   OMA; RRGCPLL; -.
DR   OrthoDB; EOG4G4GRD; -.
DR   PhylomeDB; P08134; -.
DR   Pathway_Interaction_DB; p75ntrpathway; p75(NTR)-mediated signaling.
DR   Pathway_Interaction_DB; prlsignalingeventspathway; Signaling events mediated by PRL.
DR   Reactome; REACT_11044; Signaling by Rho GTPases.
DR   Reactome; REACT_14797; Signaling by GPCR.
DR   Reactome; REACT_18266; Axon guidance.
DR   NextBio; 1619; -.
DR   ArrayExpress; P08134; -.
DR   Bgee; P08134; -.
DR   CleanEx; HS_RHOC; -.
DR   Genevestigator; P08134; -.
DR   GermOnline; ENSG00000155366; Homo sapiens.
DR   GO; GO:0005829; C:cytosol; TAS:Reactome.
DR   GO; GO:0005886; C:plasma membrane; EXP:Reactome.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003924; F:GTPase activity; TAS:ProtInc.
DR   GO; GO:0004871; F:signal transducer activity; IMP:UniProtKB.
DR   GO; GO:0007411; P:axon guidance; TAS:Reactome.
DR   GO; GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB cascade; IMP:UniProtKB.
DR   GO; GO:0051056; P:regulation of small GTPase mediated signal transduction; TAS:Reactome.
DR   GO; GO:0007264; P:small GTPase mediated signal transduction; TAS:Reactome.
DR   InterPro; IPR005225; Small_GTP-bd_dom.
DR   InterPro; IPR001806; Small_GTPase.
DR   InterPro; IPR003578; Small_GTPase_Rho.
DR   Pfam; PF00071; Ras; 1.
DR   PRINTS; PR00449; RASTRNSFRMNG.
DR   SMART; SM00174; RHO; 1.
DR   TIGRFAMs; TIGR00231; Small_GTP; 1.
DR   PROSITE; PS51420; RHO; 1.
DR   HOGENOMDNA; HS1.PE3839; -.
KW   ENSG000001553661755old_1320000031; ENSP000002857357901old_1320000031;
KW   Q5JR06_HUMAN; Q5JR07_HUMAN; Q5JR08_HUMAN; AF498972; AK094474; AL603832;
KW   BC009177; BC052808; BT019448; CH471122; CR450360; L25081; X06821;
KW   3D-structure; ADP-ribosylation; Cell membrane; Complete proteome;
KW   GTP-binding; Lipoprotein; Membrane; Methylation; Nucleotide-binding;
KW   Phosphoprotein; Polymorphism; Prenylation; Reference proteome.
SQ   SEQUENCE   193 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MAAIRKKLVI VGDGACGKTC LLIVFSKDQF PEVYVPTVFE NYIADIEVDG KQVELALWDT
     AGQEDYDRLR PLSYPDTDVI LMCFSIDSPD SLENIPEKWT PEVKHFCPNV PIILVGNKKD
     LRQDEHTRRE LAKMKQEPVR SEEGRDMANR ISAFGYLECS AKTKEGVREV FEMATRAGLQ
     VRKNKRRRGC PIL
//

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