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ID HS1_PE3839 STANDARD; PRT; 193 AA.
AC HS1_PE3839; P08134; B3KSW1; Q6ICN3;
DT 00-JAN-0000 (Rel. 1, Created)
DT 00-JAN-0000 (Rel. 2, Last sequence update)
DT 00-JAN-0000 (Rel. 3, Last annotation update)
DE RecName: Full=Rho-related GTP-binding protein RhoC;AltName: Full=Rho cDNA
DE clone 9; Short=h9;Flags: Precursor; (HS1.PE3839).
GN Name=RHOC; Synonyms=ARH9, ARHC;
OS HOMO SAPIENS.
OC Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini;
OC Hominoidea; Hominidae; Homininae; Homo.
OX NCBI_TaxID=9606;
RN [0]
RP -.;
RG -.;
RL -.;
CC -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS HS1.PE3839.
CC Homo sapiens chromosome 1 GRCh37 sequence 1..249240621 annotated by
CC Ensembl
CC -!- ANNOTATIONS ORIGIN:RHOC_HUMAN
CC -!- FUNCTION: Regulates a signal transduction pathway linking plasma
CC membrane receptors to the assembly of focal adhesions and actin
CC stress fibers.
CC -!- SUBUNIT: Interacts with DIAPH1, ROCK1, ROCK2 and RTKN. Interacts
CC with AKAP13.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor; Cytoplasmic
CC side (Potential).
CC -!- SIMILARITY: Belongs to the small GTPase superfamily. Rho family.
CC -!- WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology
CC and Haematology;
CC URL="http://atlasgeneticsoncology.org/Genes/RHOCID42110ch1p13.html";
CC -!- GENE_FAMILY: HOG000233974 [ FAMILY / ALN / TREE ]
DR HOGENOM:Homo_sapiens;ENSG00000155366;ENST00000285735;ENSP00000285735.
DR EMBL; AF498972; - ;
DR EMBL; AK094474; - ;
DR EMBL; AL603832; - ;
DR EMBL; BC007245; - ;
DR EMBL; BC009177; - ;
DR EMBL; BC052808; - ;
DR EMBL; BT019448; - ;
DR EMBL; CH471122; - ;
DR EMBL; CR450360; - ;
DR EMBL; L25081; - ;
DR EMBL; X06821; - ;
DR UniProtKB/Swiss-Prot; P08134; B3KSW1; Q6ICN3; -.
DR EMBL; X06821; CAA29969.1; -; mRNA.
DR EMBL; L25081; AAC33179.1; -; mRNA.
DR EMBL; AF498972; AAM21119.1; -; mRNA.
DR EMBL; CR450360; CAG29356.1; -; mRNA.
DR EMBL; BT019448; AAV38255.1; -; mRNA.
DR EMBL; AK094474; BAG52873.1; -; mRNA.
DR EMBL; AL603832; CAI14058.1; -; Genomic_DNA.
DR EMBL; CH471122; EAW56534.1; -; Genomic_DNA.
DR EMBL; BC007245; AAH07245.1; -; mRNA.
DR EMBL; BC009177; AAH09177.1; -; mRNA.
DR EMBL; BC052808; AAH52808.1; -; mRNA.
DR IPI; IPI00027434; -.
DR PIR; S01029; TVHURC.
DR RefSeq; NP_001036143.1; NM_001042678.1.
DR RefSeq; NP_001036144.1; NM_001042679.1.
DR RefSeq; NP_786886.1; NM_175744.4.
DR UniGene; Hs.502659; -.
DR UniGene; Hs.658289; -.
DR PDB; 1Z2C; X-ray; 3.00 A; A/C=1-193.
DR PDB; 2GCN; X-ray; 1.85 A; A=1-181.
DR PDB; 2GCO; X-ray; 1.40 A; A/B=1-181.
DR PDBsum; 1Z2C; -.
DR PDBsum; 2GCN; -.
DR PDBsum; 2GCO; -.
DR ProteinModelPortal; P08134; -.
DR SMR; P08134; 3-179.
DR IntAct; P08134; 5.
DR MINT; MINT-1216716; -.
DR STRING; P08134; -.
DR PhosphoSite; P08134; -.
DR PRIDE; P08134; -.
DR Ensembl; ENST00000285735; ENSP00000285735; ENSG00000155366.
DR Ensembl; ENST00000339083; ENSP00000345236; ENSG00000155366.
DR Ensembl; ENST00000369632; ENSP00000358646; ENSG00000155366.
DR Ensembl; ENST00000369633; ENSP00000358647; ENSG00000155366.
DR Ensembl; ENST00000369637; ENSP00000358651; ENSG00000155366.
DR Ensembl; ENST00000369638; ENSP00000358652; ENSG00000155366.
DR Ensembl; ENST00000369642; ENSP00000358656; ENSG00000155366.
DR GeneID; 389; -.
DR KEGG; hsa:389; -.
DR UCSC; uc001ecp.1; human.
DR CTD; 389; -.
DR GeneCards; GC01M111103; -.
DR H-InvDB; HIX0000895; -.
DR HGNC; HGNC:669; RHOC.
DR HPA; CAB010821; -.
DR MIM; 165380; gene.
DR neXtProt; NX_P08134; -.
DR PharmGKB; PA24951; -.
DR eggNOG; prNOG07689; -.
DR OMA; RRGCPLL; -.
DR OrthoDB; EOG4G4GRD; -.
DR PhylomeDB; P08134; -.
DR Pathway_Interaction_DB; p75ntrpathway; p75(NTR)-mediated signaling.
DR Pathway_Interaction_DB; prlsignalingeventspathway; Signaling events mediated by PRL.
DR Reactome; REACT_11044; Signaling by Rho GTPases.
DR Reactome; REACT_14797; Signaling by GPCR.
DR Reactome; REACT_18266; Axon guidance.
DR NextBio; 1619; -.
DR ArrayExpress; P08134; -.
DR Bgee; P08134; -.
DR CleanEx; HS_RHOC; -.
DR Genevestigator; P08134; -.
DR GermOnline; ENSG00000155366; Homo sapiens.
DR GO; GO:0005829; C:cytosol; TAS:Reactome.
DR GO; GO:0005886; C:plasma membrane; EXP:Reactome.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; TAS:ProtInc.
DR GO; GO:0004871; F:signal transducer activity; IMP:UniProtKB.
DR GO; GO:0007411; P:axon guidance; TAS:Reactome.
DR GO; GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB cascade; IMP:UniProtKB.
DR GO; GO:0051056; P:regulation of small GTPase mediated signal transduction; TAS:Reactome.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; TAS:Reactome.
DR InterPro; IPR005225; Small_GTP-bd_dom.
DR InterPro; IPR001806; Small_GTPase.
DR InterPro; IPR003578; Small_GTPase_Rho.
DR Pfam; PF00071; Ras; 1.
DR PRINTS; PR00449; RASTRNSFRMNG.
DR SMART; SM00174; RHO; 1.
DR TIGRFAMs; TIGR00231; Small_GTP; 1.
DR PROSITE; PS51420; RHO; 1.
DR HOGENOMDNA; HS1.PE3839; -.
KW ENSG000001553661755old_1320000031; ENSP000002857357901old_1320000031;
KW Q5JR06_HUMAN; Q5JR07_HUMAN; Q5JR08_HUMAN; AF498972; AK094474; AL603832;
KW BC009177; BC052808; BT019448; CH471122; CR450360; L25081; X06821;
KW 3D-structure; ADP-ribosylation; Cell membrane; Complete proteome;
KW GTP-binding; Lipoprotein; Membrane; Methylation; Nucleotide-binding;
KW Phosphoprotein; Polymorphism; Prenylation; Reference proteome.
SQ SEQUENCE 193 AA; UNKNOWN MW; UNKNOWN CRC64;
MAAIRKKLVI VGDGACGKTC LLIVFSKDQF PEVYVPTVFE NYIADIEVDG KQVELALWDT
AGQEDYDRLR PLSYPDTDVI LMCFSIDSPD SLENIPEKWT PEVKHFCPNV PIILVGNKKD
LRQDEHTRRE LAKMKQEPVR SEEGRDMANR ISAFGYLECS AKTKEGVREV FEMATRAGLQ
VRKNKRRRGC PIL
//
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