(data stored in ACNUC30567 zone)

HOGENOM: HS1_PE3932

ID   HS1_PE3932                           STANDARD;      PRT;   189 AA.
AC   HS1_PE3932; P01111; Q14971; Q15104; Q15282;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=GTPase NRas;AltName: Full=Transforming protein N-Ras;Flags:
DE   Precursor; (HS1.PE3932).
GN   Name=NRAS; Synonyms=HRAS1;
OS   HOMO SAPIENS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini;
OC   Hominoidea; Hominidae; Homininae; Homo.
OX   NCBI_TaxID=9606;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS HS1.PE3932.
CC       Homo sapiens chromosome 1 GRCh37  sequence 1..249240621 annotated by
CC       Ensembl
CC   -!- ANNOTATIONS ORIGIN:RASN_HUMAN
CC   -!- FUNCTION: Ras proteins bind GDP/GTP and possess intrinsic GTPase
CC       activity.
CC   -!- ENZYME REGULATION: Alternate between an inactive form bound to GDP
CC       and an active form bound to GTP. Activated by a guanine
CC       nucleotide-exchange factor (GEF) and inactivated by a GTPase-
CC       activating protein (GAP).
CC   -!- SUBUNIT: Interacts (active GTP-bound form preferentially) with
CC       RGS14 (By similarity).
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor; Cytoplasmic
CC       side. Golgi apparatus membrane; Lipid-anchor. Note=Shuttles
CC       between the plasma membrane and the Golgi apparatus.
CC   -!- PTM: Palmitoylated by the ZDHHC9-GOLGA7 complex. A continuous
CC       cycle of de- and re-palmitoylation regulates rapid exchange
CC       between plasma membrane and Golgi.
CC   -!- DISEASE: Defects in NRAS are a cause of juvenile myelomonocytic
CC       leukemia (JMML) [MIM:607785]. JMML is a pediatric myelodysplastic
CC       syndrome that constitutes approximately 30% of childhood cases of
CC       myelodysplastic syndrome (MDS) and 2% of leukemia.
CC   -!- DISEASE: Defects in NRAS are the cause of Noonan syndrome type 6
CC       (NS6) [MIM:613224]. A syndrome characterized by facial dysmorphic
CC       features such as hypertelorism, a downward eyeslant and low-set
CC       posteriorly rotated ears. Other features can include short
CC       stature, a short neck with webbing or redundancy of skin, cardiac
CC       anomalies, deafness, motor delay and variable intellectual
CC       deficits.
CC   -!- MISCELLANEOUS: Mutations which change AA 12, 13 or 61 activate the
CC       potential of Ras to transform cultured cells and are implicated in
CC       a variety of human tumors.
CC   -!- SIMILARITY: Belongs to the small GTPase superfamily. Ras family.
CC   -!- WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology
CC       and Haematology;
CC       URL="http://atlasgeneticsoncology.org/Genes/NRASID92.html";
CC   -!- WEB RESOURCE: Name=NRASbase; Note=NRAS mutation db;
CC       URL="http://bioinf.uta.fi/NRASbase/";
CC   -!- WEB RESOURCE: Name=NIEHS-SNPs;
CC       URL="http://egp.gs.washington.edu/data/nras/";
CC   -!- WEB RESOURCE: Name=Wikipedia; Note=RAS proteins entry;
CC       URL="http://en.wikipedia.org/wiki/RAS_proteins";
CC   -!- GENE_FAMILY: HOG000233973 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Homo_sapiens;ENSG00000213281;ENST00000369535;ENSP00000358548.
DR   EMBL; AF285779; - ;
DR   EMBL; AF375987; - ;
DR   EMBL; AF493919; - ;
DR   EMBL; AL096773; - ;
DR   EMBL; AY428630; - ;
DR   EMBL; BC005219; - ;
DR   EMBL; BT019734; - ;
DR   EMBL; BT019735; - ;
DR   EMBL; CH471122; - ;
DR   EMBL; EF685661; - ;
DR   EMBL; EF685662; - ;
DR   EMBL; EU332857; - ;
DR   EMBL; K00654; - ;
DR   EMBL; K03211; - ;
DR   EMBL; L00040; - ;
DR   EMBL; L00041; - ;
DR   EMBL; L00042; - ;
DR   EMBL; L00043; - ;
DR   EMBL; M10055; - ;
DR   EMBL; M17087; - ;
DR   EMBL; M19990; - ;
DR   EMBL; M25898; - ;
DR   EMBL; M26261; - ;
DR   EMBL; S64261; - ;
DR   EMBL; S68580; - ;
DR   EMBL; X00642; - ;
DR   EMBL; X00643; - ;
DR   EMBL; X00644; - ;
DR   EMBL; X00645; - ;
DR   EMBL; X02751; - ;
DR   EMBL; X05564; - ;
DR   EMBL; X05565; - ;
DR   EMBL; X07440; - ;
DR   EMBL; X16438; - ;
DR   EMBL; X53291; - ;
DR   EMBL; X53292; - ;
DR   UniProtKB/Swiss-Prot; P01111; Q14971; Q15104; Q15282; -.
DR   EMBL; X02751; CAA26529.1; -; mRNA.
DR   EMBL; X00642; CAA25269.1; -; Genomic_DNA.
DR   EMBL; X00643; CAA25270.1; -; Genomic_DNA.
DR   EMBL; X00644; CAA25271.1; -; Genomic_DNA.
DR   EMBL; X00645; CAA25272.1; -; Genomic_DNA.
DR   EMBL; L00043; AAA60255.1; -; Genomic_DNA.
DR   EMBL; L00040; AAA60255.1; JOINED; Genomic_DNA.
DR   EMBL; L00041; AAA60255.1; JOINED; Genomic_DNA.
DR   EMBL; L00042; AAA60255.1; JOINED; Genomic_DNA.
DR   EMBL; AF493919; AAM12633.1; -; mRNA.
DR   EMBL; AY428630; AAQ94397.1; -; Genomic_DNA.
DR   EMBL; BC005219; AAH05219.1; -; mRNA.
DR   EMBL; M25898; AAA36548.1; -; Genomic_DNA.
DR   EMBL; X53291; CAA37384.1; -; Genomic_DNA.
DR   EMBL; X53292; CAA37384.1; JOINED; Genomic_DNA.
DR   EMBL; K03211; AAA36556.1; -; Genomic_DNA.
DR   EMBL; M10055; AAA36556.1; JOINED; Genomic_DNA.
DR   EMBL; X05565; CAA29079.1; -; Genomic_DNA.
DR   EMBL; X07440; CAA30320.1; -; Genomic_DNA.
DR   IPI; IPI00000005; -.
DR   PIR; A90839; TVHURA.
DR   PIR; I38149; I38149.
DR   RefSeq; NP_002515.1; NM_002524.4.
DR   UniGene; Hs.486502; -.
DR   PDB; 3CON; X-ray; 1.65 A; A=1-172.
DR   PDBsum; 3CON; -.
DR   ProteinModelPortal; P01111; -.
DR   SMR; P01111; 1-167.
DR   DIP; DIP-1058N; -.
DR   IntAct; P01111; 5.
DR   MINT; MINT-131535; -.
DR   STRING; P01111; -.
DR   PhosphoSite; P01111; -.
DR   OGP; P01111; -.
DR   PeptideAtlas; P01111; -.
DR   PRIDE; P01111; -.
DR   Ensembl; ENST00000369535; ENSP00000358548; ENSG00000213281.
DR   GeneID; 4893; -.
DR   KEGG; hsa:4893; -.
DR   UCSC; uc009wgu.1; human.
DR   CTD; 4893; -.
DR   GeneCards; GC01M113105; -.
DR   HGNC; HGNC:7989; NRAS.
DR   HPA; CAB010157; -.
DR   MIM; 164790; gene.
DR   MIM; 607785; phenotype.
DR   MIM; 613224; phenotype.
DR   neXtProt; NX_P01111; -.
DR   Orphanet; 3261; Autoimmune lymphoproliferative syndrome.
DR   Orphanet; 648; Noonan syndrome.
DR   PharmGKB; PA31768; -.
DR   InParanoid; P01111; -.
DR   OMA; DIGTYRE; -.
DR   OrthoDB; EOG4BRWMX; -.
DR   PhylomeDB; P01111; -.
DR   Pathway_Interaction_DB; pi3kcipathway; Class I PI3K signaling events.
DR   Pathway_Interaction_DB; cd8tcrdownstreampathway; Downstream signaling in naive CD8+ T cells.
DR   Pathway_Interaction_DB; ephbfwdpathway; EPHB forward signaling.
DR   Pathway_Interaction_DB; il2_1pathway; IL2-mediated signaling events.
DR   Pathway_Interaction_DB; trkrpathway; Neurotrophic factor-mediated Trk receptor signaling.
DR   Pathway_Interaction_DB; er_nongenomic_pathway; Plasma membrane estrogen receptor signaling.
DR   Pathway_Interaction_DB; tcrraspathway; Ras signaling in the CD4+ TCR pathway.
DR   Pathway_Interaction_DB; tcrpathway; TCR signaling in naive CD4+ T cells.
DR   Pathway_Interaction_DB; cd8tcrpathway; TCR signaling in naive CD8+ T cells.
DR   Pathway_Interaction_DB; pi3kplctrkpathway; Trk receptor signaling mediated by PI3K and PLC-gamma.
DR   Pathway_Interaction_DB; mapktrkpathway; Trk receptor signaling mediated by the MAPK pathway.
DR   Reactome; REACT_11061; Signalling by NGF.
DR   Reactome; REACT_16888; Signaling by PDGF.
DR   Reactome; REACT_18266; Axon guidance.
DR   Reactome; REACT_498; Signaling by Insulin receptor.
DR   Reactome; REACT_604; Hemostasis.
DR   Reactome; REACT_6900; Immune System.
DR   Reactome; REACT_9417; Signaling by EGFR.
DR   NextBio; 18835; -.
DR   ArrayExpress; P01111; -.
DR   Bgee; P01111; -.
DR   CleanEx; HS_NRAS; -.
DR   Genevestigator; P01111; -.
DR   GermOnline; ENSG00000009307; Homo sapiens.
DR   GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005886; C:plasma membrane; EXP:Reactome.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR   GO; GO:0000186; P:activation of MAPKK activity; TAS:Reactome.
DR   GO; GO:0007411; P:axon guidance; TAS:Reactome.
DR   GO; GO:0007596; P:blood coagulation; TAS:Reactome.
DR   GO; GO:0007173; P:epidermal growth factor receptor signaling pathway; TAS:Reactome.
DR   GO; GO:0008286; P:insulin receptor signaling pathway; TAS:Reactome.
DR   GO; GO:0050900; P:leukocyte migration; TAS:Reactome.
DR   GO; GO:0048011; P:nerve growth factor receptor signaling pathway; TAS:Reactome.
DR   GO; GO:0007265; P:Ras protein signal transduction; EXP:Reactome.
DR   InterPro; IPR005225; Small_GTP-bd_dom.
DR   InterPro; IPR001806; Small_GTPase.
DR   InterPro; IPR020849; Small_GTPase_Ras.
DR   PANTHER; PTHR24070; PTHR24070; 1.
DR   Pfam; PF00071; Ras; 1.
DR   PRINTS; PR00449; RASTRNSFRMNG.
DR   SMART; SM00173; RAS; 1.
DR   TIGRFAMs; TIGR00231; Small_GTP; 1.
DR   PROSITE; PS51421; RAS; 1.
DR   HOGENOMDNA; HS1.PE3932; -.
KW   ENSG000002132811755old_1320000031; ENSP000003585487901old_1320000031;
KW   P78460_HUMAN; Q14007_HUMAN; Q15285_HUMAN; Q16525_HUMAN; Q5U091_HUMAN;
KW   Q7KZ06_HUMAN; Q92668_HUMAN; Q96T27_HUMAN; Q9UM97_HUMAN; AF285779;
KW   AF493919; AL096773; AY428630; BC005219; BT019734; BT019735; CH471122;
KW   EF685662; EU332857; K00654; K03211; L00040; L00041; L00042; L00043;
KW   M17087; M19990; M25898; M26261; S64261; S68580; X00642; X00643; X00644;
KW   X02751; X05564; X05565; X07440; X16438; X53291; X53292;
KW   3D-structure; Cell membrane; Complete proteome; Disease mutation;
KW   Golgi apparatus; GTP-binding; Lipoprotein; Membrane; Methylation;
KW   Nucleotide-binding; Palmitate; Phosphoprotein; Prenylation;
KW   Proto-oncogene; Reference proteome.
SQ   SEQUENCE   189 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MTEYKLVVVG AGGVGKSALT IQLIQNHFVD EYDPTIEDSY RKQVVIDGET CLLDILDTAG
     QEEYSAMRDQ YMRTGEGFLC VFAINNSKSF ADINLYREQI KRVKDSDDVP MVLVGNKCDL
     PTRTVDTKQA HELAKSYGIP FIETSAKTRQ GVEDAFYTLV REIRQYRMKK LNSSDDGTQG
     CMGLPCVVM
//

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