(data stored in ACNUC30567 zone)

HOGENOM: HS1_PE3934

ID   HS1_PE3934                           STANDARD;      PRT;   798 AA.
AC   HS1_PE3934;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Cold shock domain-containing protein E1;AltName: Full=N-ras
DE   upstream gene protein;AltName: Full=Protein UNR; (HS1.PE3934).
GN   Name=CSDE1; Synonyms=D1S155E, KIAA0885, NRU, UNR;
OS   HOMO SAPIENS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini;
OC   Hominoidea; Hominidae; Homininae; Homo.
OX   NCBI_TaxID=9606;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS HS1.PE3934.
CC       Homo sapiens chromosome 1 GRCh37  sequence 1..249240621 annotated by
CC       Ensembl
CC   -!- ANNOTATIONS ORIGIN:CSDE1_HUMAN
CC   -!- FUNCTION: RNA-binding protein. Required for internal initiation of
CC       translation of human rhinovirus RNA. May be involved in
CC       translationally coupled mRNA turnover. Implicated with other RNA-
CC       binding proteins in the cytoplasmic deadenylation/translational
CC       and decay interplay of the FOS mRNA mediated by the major coding-
CC       region determinant of instability (mCRD) domain.
CC   -!- SUBUNIT: Component of a multi subunit autoregulatory
CC       ribonucleoprotein complex (ARC), at least composed of IGF2BP1,
CC       PABPC1 and CSDE1. Interacts with STRAP. Part of a complex
CC       associated with the FOS mCRD domain and consisting of PABPC1,
CC       PAIP1, HNRPD and SYNCRIP. The interaction with PABPC1 is direct
CC       and RNA-independent.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=Long;
CC         IsoId=O75534-1; Sequence=Displayed;
CC       Name=Short;
CC         IsoId=O75534-2; Sequence=VSP_001138;
CC         Note=No experimental confirmation available;
CC   -!- SIMILARITY: Contains 9 CSD (cold-shock) domains.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAA74908.2; Type=Erroneous initiation;
CC       Sequence=CAH18231.1; Type=Erroneous initiation;
CC   -!- GENE_FAMILY: HOG000013035 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Homo_sapiens;ENSG00000009307;ENST00000358528;ENSP00000351329.
DR   EMBL; AB020692; - ;
DR   EMBL; AF070542; - ;
DR   EMBL; AF077054; - ;
DR   EMBL; AK290146; - ;
DR   EMBL; AL050150; - ;
DR   EMBL; AL096773; - ;
DR   EMBL; AL110192; - ;
DR   EMBL; BC021692; - ;
DR   EMBL; BC032446; - ;
DR   EMBL; CH471122; - ;
DR   EMBL; CR749378; - ;
DR   UniProtKB/Swiss-Prot; O75534; A8K281; O94961; Q5TF04; Q5TF05; Q68DI9; Q9Y2S4; -.
DR   EMBL; AF077054; AAD27787.1; -; mRNA.
DR   EMBL; AB020692; BAA74908.2; ALT_INIT; mRNA.
DR   EMBL; AK290146; BAF82835.1; -; mRNA.
DR   EMBL; CR749378; CAH18231.1; ALT_INIT; mRNA.
DR   EMBL; AL096773; CAI18825.1; -; Genomic_DNA.
DR   EMBL; AL096773; CAI18826.1; -; Genomic_DNA.
DR   EMBL; CH471122; EAW56612.1; -; Genomic_DNA.
DR   EMBL; BC032446; AAH32446.1; -; mRNA.
DR   EMBL; AF070542; AAC28634.1; -; mRNA.
DR   IPI; IPI00470891; -.
DR   IPI; IPI00873244; -.
DR   PIR; S29815; S29815.
DR   RefSeq; NP_001007554.1; NM_001007553.2.
DR   RefSeq; NP_001229821.1; NM_001242892.1.
DR   RefSeq; NP_001229822.1; NM_001242893.1.
DR   RefSeq; NP_009089.4; NM_007158.5.
DR   UniGene; Hs.69855; -.
DR   PDB; 1WFQ; NMR; -; A=15-90.
DR   PDB; 1X65; NMR; -; A=348-423.
DR   PDB; 2YTV; NMR; -; A=673-738.
DR   PDB; 2YTX; NMR; -; A=175-259.
DR   PDB; 2YTY; NMR; -; A=508-582.
DR   PDBsum; 1WFQ; -.
DR   PDBsum; 1X65; -.
DR   PDBsum; 2YTV; -.
DR   PDBsum; 2YTX; -.
DR   PDBsum; 2YTY; -.
DR   ProteinModelPortal; O75534; -.
DR   SMR; O75534; 16-90, 124-259, 345-424, 508-582, 673-744.
DR   IntAct; O75534; 10.
DR   STRING; O75534; -.
DR   PhosphoSite; O75534; -.
DR   PRIDE; O75534; -.
DR   Ensembl; ENST00000358528; ENSP00000351329; ENSG00000009307.
DR   GeneID; 7812; -.
DR   KEGG; hsa:7812; -.
DR   UCSC; uc001efk.1; human.
DR   UCSC; uc001efl.1; human.
DR   CTD; 7812; -.
DR   GeneCards; GC01M113117; -.
DR   H-InvDB; HIX0000915; -.
DR   HGNC; HGNC:29905; CSDE1.
DR   HPA; HPA018846; -.
DR   MIM; 191510; gene.
DR   neXtProt; NX_O75534; -.
DR   PharmGKB; PA142672072; -.
DR   eggNOG; prNOG07818; -.
DR   OrthoDB; EOG41JZBK; -.
DR   NextBio; 30207; -.
DR   ArrayExpress; O75534; -.
DR   Bgee; O75534; -.
DR   CleanEx; HS_CSDE1; -.
DR   Genevestigator; O75534; -.
DR   GermOnline; ENSG00000009307; Homo sapiens.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0005515; F:protein binding; IPI:IntAct.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0008584; P:male gonad development; TAS:ProtInc.
DR   GO; GO:0006355; P:regulation of transcription, DNA-dependent; IEA:InterPro.
DR   InterPro; IPR019844; Cold-shock_CS.
DR   InterPro; IPR011129; Cold_shock_prot.
DR   InterPro; IPR002059; CSP_DNA-bd.
DR   InterPro; IPR012340; NA-bd_OB-fold.
DR   InterPro; IPR016027; NA-bd_OB-fold-like.
DR   Gene3D; G3DSA:2.40.50.140; OB_NA_bd_sub; 4.
DR   Pfam; PF00313; CSD; 5.
DR   SMART; SM00357; CSP; 5.
DR   SUPFAM; SSF50249; Nucleic_acid_OB; 5.
DR   PROSITE; PS00352; COLD_SHOCK; 4.
DR   HOGENOMDNA; HS1.PE3934; -.
KW   ENSG000000093071755old_1320000031; ENSP000003513297901old_1320000031;
KW   Q8WU01_HUMAN; Q9UG12_HUMAN; Q9UG93_HUMAN; AB020692; AF070542; AF077054;
KW   AL050150; AL096773; AL110192; BC021692; BC032446; CH471122; CR749378;
KW   3D-structure; Acetylation; Alternative splicing; Complete proteome;
KW   Cytoplasm; Phosphoprotein; Reference proteome; Repeat; RNA-binding.
SQ   SEQUENCE   798 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MSFDPNLLHN NGHNGYPNGT SAALRETGVI EKLLTSYGFI QCSERQARLF FHCSQYNGNL
     QDLKVGDDVE FEVSSDRRTG KPIAVKLVKI KQEILPEERM NGQVVCAVPH NLESKSPAAP
     GQSPTGSVCY ERNGEVFYLT YTPEDVEGNV QLETGDKINF VIDNNKHTGA VSARNIMLLK
     KKQARCQGVV CAMKEAFGFI ERGDVVKEIF FHYSEFKGDL ETLQPGDDVE FTIKDRNGKE
     VATDVRLLPQ GTVIFEDISI EHFEGTVTKV IPKVPSKNQN DPLPGRIKVD FVIPKELPFG
     DKDTKSKVTL LEGDHVRFNI STDRRDKLER ATNIEVLSNT FQFTNEAREM GVIAAMRDGF
     GFIKCVDRDV RMFFHFSEIL DGNQLHIADE VEFTVVPDML SAQRNHAIRI KKLPKGTVSF
     HSHSDHRFLG TVEKEATFSN PKTTSPNKGK EKEAEDGIIA YDDCGVKLTI AFQAKDVEGS
     TSPQIGDKVE FSISDKQRPG QQVATCVRLL GRNSNSKRLL GYVATLKDNF GFIETANHDK
     EIFFHYSEFS GDVDSLELGD MVEYSLSKGK GNKVSAEKVN KTHSVNGITE EADPTIYSGK
     VIRPLRSVDP TQTEYQGMIE IVEEGDMKGE VYPFGIVGMA NKGDCLQKGE SVKFQLCVLG
     QNAQTMAYNI TPLRRATVEC VKDQFGFINY EVGDSKKLFF HVKEVQDGIE LQAGDEVEFS
     VILNQRTGKC SACNVWRVCE GPKAVAAPRP DRLVNRLKNI TLDDASAPRL MVLRQPRGPD
     NSMGFGAERK IRQAGVID
//

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