(data stored in ACNUC30567 zone)

HOGENOM: HS1_PE3940

ID   HS1_PE3940                           STANDARD;      PRT;   207 AA.
AC   HS1_PE3940; Q9BRV8; Q5TEZ7; Q5TEZ9; Q68DZ4; Q9H778;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Suppressor of IKBKE 1;AltName: Full=Suppressor of
DE   IKK-epsilon; (HS1.PE3940).
GN   Name=SIKE1; Synonyms=SIKE;
OS   HOMO SAPIENS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini;
OC   Hominoidea; Hominidae; Homininae; Homo.
OX   NCBI_TaxID=9606;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS HS1.PE3940.
CC       Homo sapiens chromosome 1 GRCh37  sequence 1..249240621 annotated by
CC       Ensembl
CC   -!- ANNOTATIONS ORIGIN:SIKE1_HUMAN
CC   -!- FUNCTION: Physiological suppressor of IKK-epsilon and TBK1 that
CC       plays an inhibitory role in virus- and TLR3-triggered IRF3.
CC       Inhibits TLR3-mediated activation of interferon-stimulated
CC       response elements (ISRE) and the IFN-beta promoter. May act by
CC       disrupting the interactions of IKBKE or TBK1 with TICAM1/TRIF,
CC       IRF3 and DDX58/RIG-I. Does not inhibit NF-kappa-B activation
CC       pathways.
CC   -!- SUBUNIT: Interacts with IKBKE and TBK1 via its coiled coil region.
CC       Interaction with TBK1 is disrupted upon viral infection or TLR3
CC       stimulation.
CC   -!- INTERACTION:
CC       Q9Y228:TRAF3IP3; NbExp=2; IntAct=EBI-1773646, EBI-765817;
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q9BRV8-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q9BRV8-2; Sequence=VSP_027543;
CC         Note=No experimental confirmation available;
CC   -!- TISSUE SPECIFICITY: Widely expressed. Expressed in brain, heart,
CC       skeletal muscle, colon, thymus, spleen, kidney, liver, small
CC       intestine, placenta, lung and leukocytes. Present in all cell
CC       lines tested (at protein level).
CC   -!- PTM: Phosphorylated upon DNA damage, probably by ATM or ATR.
CC   -!- SIMILARITY: Belongs to the SIKE family.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAI18824.1; Type=Erroneous gene model prediction;
CC   -!- GENE_FAMILY: HOG000294110 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Homo_sapiens;ENSG00000052723;ENST00000060969;ENSP00000060969.
DR   EMBL; AK024821; - ;
DR   EMBL; AL096773; - ;
DR   EMBL; BC005934; - ;
DR   EMBL; CH471122; - ;
DR   EMBL; CR749219; - ;
DR   UniProtKB/Swiss-Prot; Q9BRV8; Q5TEZ7; Q5TEZ9; Q68DZ4; Q9H778; -.
DR   EMBL; AK024821; BAB15020.1; -; mRNA.
DR   EMBL; CR749219; CAH18076.1; -; mRNA.
DR   EMBL; AL096773; CAI18822.1; -; Genomic_DNA.
DR   EMBL; AL096773; CAI18823.1; -; Genomic_DNA.
DR   EMBL; AL096773; CAI18824.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; CH471122; EAW56620.1; -; Genomic_DNA.
DR   EMBL; BC005934; AAH05934.1; -; mRNA.
DR   IPI; IPI00305186; -.
DR   IPI; IPI00640464; -.
DR   RefSeq; NP_001095866.1; NM_001102396.1.
DR   RefSeq; NP_079349.2; NM_025073.2.
DR   UniGene; Hs.709277; -.
DR   ProteinModelPortal; Q9BRV8; -.
DR   IntAct; Q9BRV8; 23.
DR   STRING; Q9BRV8; -.
DR   PhosphoSite; Q9BRV8; -.
DR   PRIDE; Q9BRV8; -.
DR   Ensembl; ENST00000060969; ENSP00000060969; ENSG00000052723.
DR   GeneID; 80143; -.
DR   KEGG; hsa:80143; -.
DR   UCSC; uc001efo.2; human.
DR   UCSC; uc001efp.2; human.
DR   CTD; 80143; -.
DR   GeneCards; GC01M113170; -.
DR   H-InvDB; HIX0199839; -.
DR   HGNC; HGNC:26119; SIKE1.
DR   HPA; HPA024177; -.
DR   HPA; HPA025726; -.
DR   MIM; 611656; gene.
DR   neXtProt; NX_Q9BRV8; -.
DR   PharmGKB; PA165752371; -.
DR   eggNOG; prNOG16806; -.
DR   GeneTree; ENSGT00390000018003; -.
DR   OMA; QYQEDAS; -.
DR   OrthoDB; EOG4BG8X5; -.
DR   PhylomeDB; Q9BRV8; -.
DR   Reactome; REACT_6900; Immune System.
DR   NextBio; 70409; -.
DR   ArrayExpress; Q9BRV8; -.
DR   Bgee; Q9BRV8; -.
DR   Genevestigator; Q9BRV8; -.
DR   GO; GO:0005829; C:cytosol; TAS:Reactome.
DR   GO; GO:0005515; F:protein binding; IPI:IntAct.
DR   InterPro; IPR008555; DUF837.
DR   PANTHER; PTHR12186; DUF837; 1.
DR   Pfam; PF05769; DUF837; 1.
DR   HOGENOMDNA; HS1.PE3940; -.
KW   ENSG000000527231755old_1320000031; ENSP000000609697901old_1320000031;
KW   AK024821; AL096773; BC005934; CH471122; CR749219;
KW   Alternative splicing; Coiled coil; Complete proteome; Cytoplasm;
KW   Phosphoprotein; Reference proteome.
SQ   SEQUENCE   207 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MSCTIEKILT DAKTLLERLR EHDAAAESLV DQSAALHRRV AAMREAGTAL PDQYQEDASD
     MKDMSKYKPH ILLSQENTQI RDLQQENREL WISLEEHQDA LELIMSKYRK QMLQLMVAKK
     AVDAEPVLKA HQSHSAEIES QIDRICEMGE VMRKAVQVDD DQFCKIQEKL AQLELENKEL
     RELLSISSES LQARKENSMD TASQAIK
//

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