(data stored in ACNUC31108 zone)

HOGENOM: HS1_PE3946

ID   HS1_PE3946                           STANDARD;      PRT;   221 AA.
AC   HS1_PE3946; O60636; Q5TET2; Q8WU05;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Tetraspanin-2; Short=Tspan-2;AltName: Full=Tetraspan NET-3;
DE   (HS1.PE3946).
GN   Name=TSPAN2;
OS   HOMO SAPIENS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini;
OC   Hominoidea; Hominidae; Homininae; Homo.
OX   NCBI_TaxID=9606;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS HS1.PE3946.
CC       Homo sapiens chromosome 1 GRCh37  sequence 1..249240621 annotated by
CC       Ensembl
CC   -!- ANNOTATIONS ORIGIN:TSN2_HUMAN
CC   -!- FUNCTION: May play a role in signalling in oligodendrocytes in the
CC       early stages of their terminal differentiation into myelin-forming
CC       glia and may also function in stabilizing the mature sheath (By
CC       similarity).
CC   -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein
CC       (Probable).
CC   -!- SIMILARITY: Belongs to the tetraspanin (TM4SF) family.
CC   -!- GENE_FAMILY: HOG000230651 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Homo_sapiens;ENSG00000134198;ENST00000369516;ENSP00000358529.
DR   EMBL; AF054839; - ;
DR   EMBL; AK315385; - ;
DR   EMBL; AL109660; - ;
DR   EMBL; BC021675; - ;
DR   UniProtKB/Swiss-Prot; O60636; Q5TET2; Q8WU05; -.
DR   EMBL; AF054839; AAC69715.1; -; mRNA.
DR   EMBL; AL109660; CAI22271.1; -; Genomic_DNA.
DR   EMBL; BC021675; AAH21675.1; -; mRNA.
DR   IPI; IPI00030938; -.
DR   PIR; A59263; A59263.
DR   RefSeq; NP_005716.2; NM_005725.4.
DR   UniGene; Hs.310458; -.
DR   ProteinModelPortal; O60636; -.
DR   SMR; O60636; 110-184.
DR   STRING; O60636; -.
DR   PRIDE; O60636; -.
DR   Ensembl; ENST00000369516; ENSP00000358529; ENSG00000134198.
DR   GeneID; 10100; -.
DR   KEGG; hsa:10100; -.
DR   UCSC; uc001eft.1; human.
DR   CTD; 10100; -.
DR   GeneCards; GC01M113448; -.
DR   H-InvDB; HIX0000918; -.
DR   HGNC; HGNC:20659; TSPAN2.
DR   HPA; HPA015640; -.
DR   MIM; 613133; gene.
DR   neXtProt; NX_O60636; -.
DR   PharmGKB; PA134938787; -.
DR   eggNOG; prNOG07138; -.
DR   GeneTree; ENSGT00590000082836; -.
DR   InParanoid; O60636; -.
DR   OMA; PEYFYMG; -.
DR   OrthoDB; EOG4DZ1W7; -.
DR   PhylomeDB; O60636; -.
DR   NextBio; 38205; -.
DR   ArrayExpress; O60636; -.
DR   Bgee; O60636; -.
DR   CleanEx; HS_TSPAN2; -.
DR   Genevestigator; O60636; -.
DR   GermOnline; ENSG00000134198; Homo sapiens.
DR   GO; GO:0016021; C:integral to membrane; TAS:ProtInc.
DR   InterPro; IPR023396; CD81_extracellular.
DR   InterPro; IPR018499; Tetraspanin.
DR   InterPro; IPR018503; Tetraspanin_CS.
DR   InterPro; IPR008952; Tetraspanin_EC2.
DR   InterPro; IPR000301; Tetraspanin_subgr.
DR   Gene3D; G3DSA:1.10.1450.10; G3DSA:1.10.1450.10; 1.
DR   Pfam; PF00335; Tetraspannin; 1.
DR   PRINTS; PR00259; TMFOUR.
DR   SUPFAM; SSF48652; Tetraspanin; 1.
DR   PROSITE; PS00421; TM4_1; 1.
DR   HOGENOMDNA; HS1.PE3946; -.
KW   ENSG000001341981755old_1320000031; ENSP000003585297901old_1320000031;
KW   B2RD31_HUMAN; AF054839; AK315385; AL109660; BC021675;
KW   Complete proteome; Glycoprotein; Membrane; Polymorphism;
KW   Reference proteome; Transmembrane; Transmembrane helix.
SQ   SEQUENCE   221 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MGRFRGGLRC IKYLLLGFNL LFWLAGSAVI AFGLWFRFGG AIKELSSEDK SPEYFYVGLY
     VLVGAGALMM AVGFFGCCGA MRESQCVLGS FFTCLLVIFA AEVTTGVFAF IGKGVAIRHV
     QTMYEEAYND YLKDRGKGNG TLITFHSTFQ CCGKESSEQV QPTCPKELLG HKNCIDEIET
     IISVKLQLIG IVGIGIAGLT IFGMIFSMVL CCAIRNSRDV I
//

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