(data stored in ACNUC4482 zone)

HOGENOM: HS1_PE4125

ID   HS1_PE4125                           STANDARD;      PRT;   1167 AA.
AC   HS1_PE4125; O75578; B2RAM4; Q6UXJ6; Q9UHZ8;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Integrin alpha-10;Flags: Precursor; (HS1.PE4125).
GN   Name=ITGA10; ORFNames=UNQ468/PRO827;
OS   HOMO SAPIENS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini;
OC   Hominoidea; Hominidae; Homininae; Homo.
OX   NCBI_TaxID=9606;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS HS1.PE4125.
CC       Homo sapiens chromosome 1 GRCh37  sequence 1..249240621 annotated by
CC       Ensembl
CC   -!- ANNOTATIONS ORIGIN:ITA10_HUMAN
CC   -!- FUNCTION: Integrin alpha-10/beta-1 is a receptor for collagen.
CC   -!- SUBUNIT: Heterodimer of an alpha and a beta subunit. Alpha-10
CC       associates with beta-1.
CC   -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane
CC       protein.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=O75578-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=O75578-2; Sequence=VSP_013114, VSP_013115;
CC         Note=No experimental confirmation available;
CC   -!- TISSUE SPECIFICITY: Widely expressed with highest expression in
CC       muscle and heart. Found in articular cartilage.
CC   -!- DOMAIN: The integrin I-domain (insert) is a VWFA domain. Integrins
CC       with I-domains do not undergo protease cleavage.
CC   -!- SIMILARITY: Belongs to the integrin alpha chain family.
CC   -!- SIMILARITY: Contains 7 FG-GAP repeats.
CC   -!- SIMILARITY: Contains 1 VWFA domain.
CC   -!- GENE_FAMILY: HOG000059610 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Homo_sapiens;ENSG00000143127;ENST00000369304;ENSP00000358310.
DR   EMBL; AF074015; - ;
DR   EMBL; AF112345; - ;
DR   EMBL; AF172723; - ;
DR   EMBL; AK304155; - ;
DR   EMBL; AK314255; - ;
DR   EMBL; AY358325; - ;
DR   EMBL; BC140831; - ;
DR   EMBL; BC144637; - ;
DR   EMBL; CH471244; - ;
DR   UniProtKB/Swiss-Prot; O75578; B2RAM4; Q6UXJ6; Q9UHZ8; -.
DR   EMBL; AF074015; AAC31952.1; -; mRNA.
DR   EMBL; AF112345; AAF21944.1; -; mRNA.
DR   EMBL; AF172723; AAF61638.1; -; Genomic_DNA.
DR   EMBL; AY358325; AAQ88691.1; -; mRNA.
DR   EMBL; AK314255; BAG36921.1; -; mRNA.
DR   EMBL; CH471244; EAW71425.1; -; Genomic_DNA.
DR   IPI; IPI00026165; -.
DR   IPI; IPI00554717; -.
DR   RefSeq; NP_003628.2; NM_003637.3.
DR   UniGene; Hs.158237; -.
DR   ProteinModelPortal; O75578; -.
DR   SMR; O75578; 166-360, 373-642, 1117-1155.
DR   IntAct; O75578; 2.
DR   STRING; O75578; -.
DR   PRIDE; O75578; -.
DR   Ensembl; ENST00000369304; ENSP00000358310; ENSG00000143127.
DR   GeneID; 8515; -.
DR   KEGG; hsa:8515; -.
DR   UCSC; uc001enz.1; human.
DR   UCSC; uc001eoa.1; human.
DR   CTD; 8515; -.
DR   GeneCards; GC01P119488; -.
DR   H-InvDB; HIX0200017; -.
DR   HGNC; HGNC:6135; ITGA10.
DR   MIM; 604042; gene.
DR   neXtProt; NX_O75578; -.
DR   PharmGKB; PA29936; -.
DR   eggNOG; prNOG18692; -.
DR   GeneTree; ENSGT00600000084333; -.
DR   InParanoid; O75578; -.
DR   OMA; GAPRFRH; -.
DR   OrthoDB; EOG4RXXZD; -.
DR   PhylomeDB; O75578; -.
DR   Pathway_Interaction_DB; arf6_traffickingpathway; Arf6 trafficking events.
DR   Reactome; REACT_13552; Integrin cell surface interactions.
DR   NextBio; 31874; -.
DR   ArrayExpress; O75578; -.
DR   Bgee; O75578; -.
DR   CleanEx; HS_ITGA10; -.
DR   Genevestigator; O75578; -.
DR   GermOnline; ENSG00000143127; Homo sapiens.
DR   GO; GO:0008305; C:integrin complex; TAS:ProtInc.
DR   GO; GO:0005518; F:collagen binding; TAS:ProtInc.
DR   GO; GO:0004872; F:receptor activity; IEA:UniProtKB-KW.
DR   GO; GO:0007160; P:cell-matrix adhesion; TAS:ProtInc.
DR   GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:UniProtKB-KW.
DR   InterPro; IPR013517; FG-GAP.
DR   InterPro; IPR013519; Int_alpha_beta-p.
DR   InterPro; IPR000413; Integrin_alpha.
DR   InterPro; IPR013649; Integrin_alpha-2.
DR   InterPro; IPR002035; VWF_A.
DR   Pfam; PF01839; FG-GAP; 1.
DR   Pfam; PF08441; Integrin_alpha2; 1.
DR   Pfam; PF00092; VWA; 1.
DR   PRINTS; PR01185; INTEGRINA.
DR   SMART; SM00191; Int_alpha; 5.
DR   SMART; SM00327; VWA; 1.
DR   PROSITE; PS51470; FG_GAP; 7.
DR   PROSITE; PS00242; INTEGRIN_ALPHA; FALSE_NEG.
DR   PROSITE; PS50234; VWFA; 1.
DR   HOGENOMDNA; HS1.PE4125; -.
KW   ENSG000001431271755old_1320000031; ENSP000003583107901old_1320000031;
KW   B2RTV5_HUMAN; B4E282_HUMAN; AF074015; AF112345; AF172723; AK304155;
KW   AY358325; BC140831; BC144637; CH471244;
KW   Alternative splicing; Calcium; Cell adhesion; Complete proteome;
KW   Disulfide bond; Glycoprotein; Integrin; Magnesium; Membrane;
KW   Polymorphism; Receptor; Reference proteome; Repeat; Signal;
KW   Transmembrane; Transmembrane helix.
SQ   SEQUENCE   1167 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MELPFVTHLF LPLVFLTGLC SPFNLDEHHP RLFPGPPEAE FGYSVLQHVG GGQRWMLVGA
     PWDGPSGDRR GDVYRCPVGG AHNAPCAKGH LGDYQLGNSS HPAVNMHLGM SLLETDGDGG
     FMACAPLWSR ACGSSVFSSG ICARVDASFQ PQGSLAPTAQ RCPTYMDVVI VLDGSNSIYP
     WSEVQTFLRR LVGKLFIDPE QIQVGLVQYG ESPVHEWSLG DFRTKEEVVR AAKNLSRREG
     RETKTAQAIM VACTEGFSQS HGGRPEAARL LVVVTDGESH DGEELPAALK ACEAGRVTRY
     GIAVLGHYLR RQRDPSSFLR EIRTIASDPD ERFFFNVTDE AALTDIVDAL GDRIFGLEGS
     HAENESSFGL EMSQIGFSTH RLKDGILFGM VGAYDWGGSV LWLEGGHRLF PPRMALEDEF
     PPALQNHAAY LGYSVSSMLL RGGRRLFLSG APRFRHRGKV IAFQLKKDGA VRVAQSLQGE
     QIGSYFGSEL CPLDTDRDGT TDVLLVAAPM FLGPQNKETG RVYVYLVGQQ SLLTLQGTLQ
     PEPPQDARFG FAMGALPDLN QDGFADVAVG APLEDGHQGA LYLYHGTQSG VRPHPAQRIA
     AASMPHALSY FGRSVDGRLD LDGDDLVDVA VGAQGAAILL SSRPIVHLTP SLEVTPQAIS
     VVQRDCRRRG QEAVCLTAAL CFQVTSRTPG RWDHQFYMRF TASLDEWTAG ARAAFDGSGQ
     RLSPRRLRLS VGNVTCEQLH FHVLDTSDYL RPVALTVTFA LDNTTKPGPV LNEGSPTSIQ
     KLVPFSKDCG PDNECVTDLV LQVNMDIRGS RKAPFVVRGG RRKVLVSTTL ENRKENAYNT
     SLSLIFSRNL HLASLTPQRE SPIKVECAAP SAHARLCSVG HPVFQTGAKV TFLLEFEFSC
     SSLLSQVFVK LTASSDSLER NGTLQDNTAQ TSAYIQYEPH LLFSSESTLH RYEVHPYGTL
     PVGPGPEFKT TLRVQNLGCY VVSGLIISAL LPAVAHGGNY FLSLSQVITN NASCIVQNLT
     EPPGPPVHPE ELQHTNRLNG SNTQCQVVRC HLGQLAKGTE VSVGLLRLVH NEFFRRAKFK
     SLTVVSTFEL GTEEGSVLQL TEASRWSESL LEVVQTRPIL ISLWILIGSV LGGLLLLALL
     VFCLWKLGFF AHKKIPEEEK REEKLEQ
//

If you have problems or comments...

PBIL Back to PBIL home page