(data stored in ACNUC13314 zone)

HOGENOM: HS1_PE4538

ID   HS1_PE4538                           STANDARD;      PRT;   561 AA.
AC   HS1_PE4538; Q9Y2W6; D3DV24; Q5SZR3; Q8N582; Q9NYV5;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Tudor and KH domain-containing protein;AltName: Full=Tudor
DE   domain-containing protein 2; (HS1.PE4538).
GN   Name=TDRKH; Synonyms=TDRD2;
OS   HOMO SAPIENS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini;
OC   Hominoidea; Hominidae; Homininae; Homo.
OX   NCBI_TaxID=9606;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS HS1.PE4538.
CC       Homo sapiens chromosome 1 GRCh37  sequence 1..249240621 annotated by
CC       Ensembl
CC   -!- ANNOTATIONS ORIGIN:TDRKH_HUMAN
CC   -!- SUBUNIT: Interacts with PIWIL1 and PIWIL4 (By similarity).
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q9Y2W6-2; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q9Y2W6-3; Sequence=VSP_040981;
CC   -!- SIMILARITY: Contains 2 KH domains.
CC   -!- SIMILARITY: Contains 1 Tudor domain.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAD30971.1; Type=Erroneous termination; Positions=562; Note=Translated as stop;
CC       Sequence=BC022467; Type=Erroneous termination; Positions=175; Note=Translated as Lys;
CC   -!- GENE_FAMILY: HOG000037932 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Homo_sapiens;ENSG00000182134;ENST00000368827;ENSP00000357819.
DR   EMBL; AF119121; - ;
DR   EMBL; AF227192; - ;
DR   EMBL; AF227634; - ;
DR   EMBL; AK295948; - ;
DR   EMBL; AK303063; - ;
DR   EMBL; AL589765; - ;
DR   EMBL; CH471121; - ;
DR   UniProtKB/Swiss-Prot; Q9Y2W6; D3DV24; Q5SZR3; Q8N582; Q9NYV5; -.
DR   EMBL; AF119121; AAD30971.1; ALT_SEQ; mRNA.
DR   EMBL; AF227192; AAF36701.1; -; mRNA.
DR   EMBL; AL589765; CAI17177.1; -; Genomic_DNA.
DR   EMBL; CH471121; EAW53411.1; -; Genomic_DNA.
DR   EMBL; CH471121; EAW53409.1; -; Genomic_DNA.
DR   EMBL; BC022467; -; NOT_ANNOTATED_CDS; mRNA.
DR   IPI; IPI00009982; -.
DR   IPI; IPI01013931; -.
DR   RefSeq; NP_001077432.1; NM_001083963.1.
DR   RefSeq; NP_001077434.1; NM_001083965.1.
DR   RefSeq; NP_006853.2; NM_006862.3.
DR   UniGene; Hs.144439; -.
DR   PDB; 2DIQ; NMR; -; A=329-425.
DR   PDB; 3FDR; X-ray; 1.75 A; A=327-420.
DR   PDBsum; 2DIQ; -.
DR   PDBsum; 3FDR; -.
DR   ProteinModelPortal; Q9Y2W6; -.
DR   SMR; Q9Y2W6; 52-208, 306-494.
DR   STRING; Q9Y2W6; -.
DR   PhosphoSite; Q9Y2W6; -.
DR   PRIDE; Q9Y2W6; -.
DR   Ensembl; ENST00000368822; ENSP00000357812; ENSG00000182134.
DR   Ensembl; ENST00000368824; ENSP00000357815; ENSG00000182134.
DR   Ensembl; ENST00000368827; ENSP00000357819; ENSG00000182134.
DR   Ensembl; ENST00000458431; ENSP00000395718; ENSG00000182134.
DR   GeneID; 11022; -.
DR   KEGG; hsa:11022; -.
DR   UCSC; uc001eza.2; human.
DR   CTD; 11022; -.
DR   GeneCards; GC01M123120; -.
DR   H-InvDB; HIX0001068; -.
DR   HGNC; HGNC:11713; TDRKH.
DR   HPA; HPA016419; -.
DR   HPA; HPA019625; -.
DR   MIM; 609501; gene.
DR   neXtProt; NX_Q9Y2W6; -.
DR   GeneTree; ENSGT00530000063224; -.
DR   InParanoid; Q9Y2W6; -.
DR   OMA; YFVDFGD; -.
DR   OrthoDB; EOG4T4CV4; -.
DR   NextBio; 41878; -.
DR   ArrayExpress; Q9Y2W6; -.
DR   Bgee; Q9Y2W6; -.
DR   CleanEx; HS_TDRKH; -.
DR   Genevestigator; Q9Y2W6; -.
DR   GermOnline; ENSG00000182134; Homo sapiens.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   InterPro; IPR004087; KH.
DR   InterPro; IPR004088; KH_type_1.
DR   InterPro; IPR018111; KH_type_1_subgr.
DR   InterPro; IPR008191; Maternal_tudor.
DR   InterPro; IPR002999; Tudor.
DR   InterPro; IPR018351; Tudor_subgr.
DR   Pfam; PF00013; KH_1; 2.
DR   Pfam; PF00567; TUDOR; 1.
DR   SMART; SM00322; KH; 2.
DR   SMART; SM00333; TUDOR; 1.
DR   PROSITE; PS50084; KH_TYPE_1; 2.
DR   PROSITE; PS50304; TUDOR; 1.
DR   HOGENOMDNA; HS1.PE4538; -.
KW   ENSG000001821341755old_1320000031; ENSP000003578197901old_1320000031;
KW   B4DJ68_HUMAN; B4DZR8_HUMAN; D3DV24_HUMAN; Q9NYV3_HUMAN; AF119121;
KW   AF227634; AK295948; AK303063; AL589765; CH471121;
KW   3D-structure; Alternative splicing; Complete proteome; Polymorphism;
KW   Reference proteome; Repeat; RNA-binding.
SQ   SEQUENCE   561 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MSTERTSWTS LSTIQKIALG LGIPASATVA YILYRRYRES REERLTFVGE DDIEIEMRVP
     QEAVKLIIGR QGANIKQLRK QTGARIDVDT EDVGDERVLL ISGFPVQVCK AKAAIHQILT
     ENTPVSEQLS VPQRSVGRII GRGGETIRSI CKASGAKITC DKESEGTLLL SRLIKISGTQ
     KEVAAAKHLI LEKVSEDEEL RKRIAHSAET RVPRKQPISV RREDMTEPGG AGEPALWKNT
     SSSMEPTAPL VTPPPKGGGD MAVVVSKEGS WEKPSDDSFQ KSEAQAIPEM PMFEIPSPDF
     SFHADEYLEV YVSASEHPNH FWIQIVGSRS LQLDKLVNEM TQHYENSVPE DLTVHVGDIV
     AAPLPTNGSW YRARVLGTLE NGNLDLYFVD FGDNGDCPLK DLRALRSDFL SLPFQAIECS
     LARIAPSGDQ WEEEALDEFD RLTHCADWKP LVAKISSYVQ TGISTWPKIY LYDTSNGKKL
     DIGLELVHKG YAIELPEDIE ENRAVPDMLK DMATETDASL STLLTETKKS SGEITHTLSC
     LSLSEAASMS GDDNLEDDYL L
//

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