(data stored in ACNUC22795 zone)

HOGENOM: HS1_PE4646

ID   HS1_PE4646                           STANDARD;      PRT;   101 AA.
AC   HS1_PE4646; P31151; Q5SY67; Q6FGE3; Q9H1E2;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Protein S100-A7;AltName: Full=Psoriasin;AltName: Full=S100
DE   calcium-binding protein A7; (HS1.PE4646).
GN   Name=S100A7; Synonyms=PSOR1, S100A7C;
OS   HOMO SAPIENS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini;
OC   Hominoidea; Hominidae; Homininae; Homo.
OX   NCBI_TaxID=9606;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS HS1.PE4646.
CC       Homo sapiens chromosome 1 GRCh37  sequence 1..249240621 annotated by
CC       Ensembl
CC   -!- ANNOTATIONS ORIGIN:S10A7_HUMAN
CC   -!- SUBUNIT: Interacts with RANBP9.
CC   -!- INTERACTION:
CC       Q96S59:RANBP9; NbExp=3; IntAct=EBI-357520, EBI-636085;
CC   -!- SUBCELLULAR LOCATION: Cytoplasm. Secreted. Note=Secreted by a non-
CC       classical secretory pathway.
CC   -!- TISSUE SPECIFICITY: Fetal ear, skin, and tongue and human cell
CC       lines. Highly up-regulated in psoriatic epidermis. Also highly
CC       expressed in the urine of bladder squamous cell carcinoma (SCC)
CC       bearing patients.
CC   -!- MASS SPECTROMETRY: Mass=11365; Mass_error=0.7;
CC       Method=Electrospray; Range=2-101; Source=PubMed:8526920;
CC   -!- SIMILARITY: Belongs to the S-101 family.
CC   -!- SIMILARITY: Contains 2 EF-hand domains.
CC   -!- GENE_FAMILY: HOG000154231 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Homo_sapiens;ENSG00000143556;ENST00000368723;ENSP00000357712.
DR   EMBL; AJ012825; - ;
DR   EMBL; AL591704; - ;
DR   EMBL; BC034687; - ;
DR   EMBL; BR000043; - ;
DR   EMBL; CR542164; - ;
DR   EMBL; M86757; - ;
DR   UniProtKB/Swiss-Prot; P31151; Q5SY67; Q6FGE3; Q9H1E2; -.
DR   EMBL; M86757; AAA60210.1; -; mRNA.
DR   EMBL; CR542164; CAG46961.1; -; mRNA.
DR   EMBL; AL591704; CAI19502.1; -; Genomic_DNA.
DR   EMBL; BC034687; AAH34687.1; -; mRNA.
DR   EMBL; AJ012825; CAC20409.1; -; Genomic_DNA.
DR   EMBL; BR000043; FAA00017.1; -; Genomic_DNA.
DR   IPI; IPI00219806; -.
DR   PIR; A54327; A54327.
DR   RefSeq; NP_002954.2; NM_002963.3.
DR   UniGene; Hs.112408; -.
DR   PDB; 1PSR; X-ray; 1.05 A; A/B=2-101.
DR   PDB; 2PSR; X-ray; 2.05 A; A=2-101.
DR   PDB; 2WND; X-ray; 1.60 A; A=2-97.
DR   PDB; 2WOR; X-ray; 1.70 A; A=2-101.
DR   PDB; 2WOS; X-ray; 1.70 A; A=2-101.
DR   PDB; 3PSR; X-ray; 2.50 A; A/B=2-101.
DR   PDBsum; 1PSR; -.
DR   PDBsum; 2PSR; -.
DR   PDBsum; 2WND; -.
DR   PDBsum; 2WOR; -.
DR   PDBsum; 2WOS; -.
DR   PDBsum; 3PSR; -.
DR   ProteinModelPortal; P31151; -.
DR   SMR; P31151; 2-101.
DR   IntAct; P31151; 7.
DR   MINT; MINT-1156620; -.
DR   STRING; P31151; -.
DR   PhosphoSite; P31151; -.
DR   Aarhus/Ghent-2DPAGE; 3002; IEF.
DR   UCD-2DPAGE; P31151; -.
DR   PeptideAtlas; P31151; -.
DR   PRIDE; P31151; -.
DR   Ensembl; ENST00000368722; ENSP00000357711; ENSG00000143556.
DR   Ensembl; ENST00000368723; ENSP00000357712; ENSG00000143556.
DR   GeneID; 6278; -.
DR   KEGG; hsa:6278; -.
DR   UCSC; uc001fbv.1; human.
DR   CTD; 6278; -.
DR   GeneCards; GC01M124793; -.
DR   HGNC; HGNC:10497; S100A7.
DR   HPA; CAB001453; -.
DR   HPA; HPA006997; -.
DR   MIM; 600353; gene.
DR   neXtProt; NX_P31151; -.
DR   PharmGKB; PA34909; -.
DR   eggNOG; prNOG21615; -.
DR   GeneTree; ENSGT00390000017320; -.
DR   InParanoid; P31151; -.
DR   OMA; ACDKKGT; -.
DR   OrthoDB; EOG49GKJ6; -.
DR   PhylomeDB; P31151; -.
DR   NextBio; 24369; -.
DR   ArrayExpress; P31151; -.
DR   Bgee; P31151; -.
DR   CleanEx; HS_S100A7; -.
DR   Genevestigator; P31151; -.
DR   GermOnline; ENSG00000143556; Homo sapiens.
DR   GO; GO:0005829; C:cytosol; IDA:UniProtKB.
DR   GO; GO:0005783; C:endoplasmic reticulum; IDA:UniProtKB.
DR   GO; GO:0005576; C:extracellular region; IDA:UniProtKB.
DR   GO; GO:0005925; C:focal adhesion; NAS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR   GO; GO:0005509; F:calcium ion binding; IDA:UniProtKB.
DR   GO; GO:0050786; F:RAGE receptor binding; IPI:UniProtKB.
DR   GO; GO:0008270; F:zinc ion binding; NAS:UniProtKB.
DR   GO; GO:0001525; P:angiogenesis; NAS:UniProtKB.
DR   GO; GO:0050829; P:defense response to Gram-negative bacterium; IMP:UniProtKB.
DR   GO; GO:0045087; P:innate immune response; NAS:UniProtKB.
DR   GO; GO:0030216; P:keratinocyte differentiation; NAS:UniProtKB.
DR   GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IDA:UniProtKB.
DR   GO; GO:0071624; P:positive regulation of granulocyte chemotaxis; IDA:UniProtKB.
DR   GO; GO:0090026; P:positive regulation of monocyte chemotaxis; IDA:UniProtKB.
DR   GO; GO:0010820; P:positive regulation of T cell chemotaxis; IDA:UniProtKB.
DR   GO; GO:0032496; P:response to lipopolysaccharide; IEP:UniProtKB.
DR   GO; GO:0000302; P:response to reactive oxygen species; IDA:UniProtKB.
DR   GO; GO:0051238; P:sequestering of metal ion; IDA:UniProtKB.
DR   InterPro; IPR011992; EF-hand-like_dom.
DR   InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR   InterPro; IPR018249; EF_HAND_2.
DR   InterPro; IPR001751; S100/CaBP-9k_CS.
DR   InterPro; IPR013787; S100_Ca-bd_sub.
DR   Gene3D; G3DSA:1.10.238.10; EF-Hand_type; 1.
DR   Pfam; PF01023; S_100; 1.
DR   PROSITE; PS00018; EF_HAND_1; 1.
DR   PROSITE; PS50222; EF_HAND_2; 1.
DR   PROSITE; PS00303; S100_CABP; 1.
DR   HOGENOMDNA; HS1.PE4646; -.
KW   ENSG000001435561755old_1320000031; ENSP000003577127901old_1320000031;
KW   AJ012825; AL591704; BC034687; BR000043; CR542164; M86757;
KW   3D-structure; Acetylation; Calcium; Complete proteome; Cytoplasm;
KW   Direct protein sequencing; Disulfide bond; Metal-binding;
KW   Polymorphism; Reference proteome; Repeat; Secreted; Zinc.
SQ   SEQUENCE   101 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MSNTQAERSI IGMIDMFHKY TRRDDKIEKP SLLTMMKENF PNFLSACDKK GTNYLADVFE
     KKDKNEDKKI DFSEFLSLLG DIATDYHKQS HGAAPCSGGS Q
//

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